The Biology Behind:

Microphthalmic-Associated Transcription Factor Integrates Melanocyte Biology and Melanoma Progression

Colin Goding and Frank L. Meyskens, Jr.
Clin Cancer Res 2006 12: 1069-1073. [Full Text] [PDF]  

Molecular Pathways:

Notch Signaling

Lucio Miele
Clin Cancer Res 2006 12: 1074-1079. [Full Text] [PDF]  

Human Cancer Biology:

Overexpression and Nuclear Translocation of Hypoxia-Inducible Factor Prolyl Hydroxylase PHD2 in Head and Neck Squamous Cell Carcinoma Is Associated with Tumor Aggressiveness

Terhi Jokilehto, Krista Rantanen, Marjaana Luukkaa, Pekka Heikkinen, Reidar Grenman, Heikki Minn, Pauliina Kronqvist, and Panu M. Jaakkola
Clin Cancer Res 2006 12: 1080-1087. [Abstract] [Full Text] [PDF]  

The Role of Interleukin 1 in Growth and Metastasis of Human Cancer Xenografts

Dina M. Elaraj, David M. Weinreich, Sheelu Varghese, Markus Puhlmann, Stephen M. Hewitt, Nancy M. Carroll, Elizabeth D. Feldman, Ewa M. Turner, and H. Richard Alexander
Clin Cancer Res 2006 12: 1088-1096. [Abstract] [Full Text] [PDF]  

Genetic Characterization of Fas-Associated Phosphatase-1 as a Putative Tumor Suppressor Gene on Chromosome 4q21.3 in Hepatocellular Carcinoma

Shiou-Hwei Yeh, Dai-Chen Wu, Ching-Yi Tsai, Ti-Jung Kuo, Wei-Che Yu, Yuan-Shau Chang, Chi-Ling Chen, Ching-Fang Chang, Ding-Shinn Chen, and Pei-Jer Chen
Clin Cancer Res 2006 12: 1097-1108. [Abstract] [Full Text] [PDF]  

Gene Expression Profiles of Head and Neck Carcinomas from Sudanese and Norwegian Patients Reveal Common Biological Pathways Regardless of Race and Lifestyle

Bjarte Dysvik, Endre N. Vasstrand, Roger Løvlie, Osman A-Aziz Elgindi, Kenneth W. Kross, Hans J. Aarstad, Anne Chr. Johannessen, Inge Jonassen, and Salah O. Ibrahim
Clin Cancer Res 2006 12: 1109-1120. [Abstract] [Full Text] [PDF]  

Expression of Targeting Protein for Xklp2 Associated with Both Malignant Transformation of Respiratory Epithelium and Progression of Squamous Cell Lung Cancer

Ying Ma, Dongmei Lin, Wenyue Sun, Ting Xiao, Jinsong Yuan, Naijun Han, Suping Guo, Xiaoli Feng, Kai Su, Yousheng Mao, Shujun Cheng, and Yanning Gao
Clin Cancer Res 2006 12: 1121-1127. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

PDLIM4 Repression by Hypermethylation as a Potential Biomarker for Prostate Cancer

Donkena Krishna Vanaja, Karla V. Ballman, Bruce W. Morlan, John C. Cheville, Roxann M. Neumann, Michael M. Lieber, Donald J. Tindall, and Charles Y.F. Young
Clin Cancer Res 2006 12: 1128-1136. [Abstract] [Full Text] [PDF]  

Microphthalmia Transcription Factor as a Molecular Marker for Circulating Tumor Cell Detection in Blood of Melanoma Patients

Kazuo Koyanagi, Steven J. O'Day, Rene Gonzalez, Karl Lewis, William A. Robinson, Thomas T. Amatruda, Christine Kuo, He-Jing Wang, Robert Milford, Donald L. Morton, and Dave S.B. Hoon
Clin Cancer Res 2006 12: 1137-1143. [Abstract] [Full Text] [PDF]  

Prognostic Value of Indoleamine 2,3-Dioxygenase Expression in Colorectal Cancer: Effect on Tumor-Infiltrating T Cells

Gerald Brandacher, Alexander Perathoner, Ruth Ladurner, Stefan Schneeberger, Peter Obrist, Christiana Winkler, Ernst R. Werner, Gabriele Werner-Felmayer, Helmut G. Weiss, Georg Göbel, Raimund Margreiter, Alfred Königsrainer, Dietmar Fuchs, and Albert Amberger
Clin Cancer Res 2006 12: 1144-1151. [Abstract] [Full Text] [PDF]  

Comparison of the Expression and Prognostic Significance of Differentiation Markers between Diffuse Large B-Cell Lymphoma of Central Nervous System Origin and Peripheral Nodal Origin

Ching-Hung Lin, Kuan-Ting Kuo, Shih-Sung Chuang, Sung-Hsin Kuo, Julia Hueimei Chang, Kung-Chao Chang, Hui-Chen Hsu, Hwei-Fang Tien, and Ann-Lii Cheng
Clin Cancer Res 2006 12: 1152-1156. [Abstract] [Full Text] [PDF]  

The Clinical Value of Somatic TP53 Gene Mutations in 1,794 Patients with Breast Cancer

Magali Olivier, Anita Langerød, Patrizia Carrieri, Jonas Bergh, Sigrid Klaar, Jorunn Eyfjord, Charles Theillet, Carmen Rodriguez, Rosette Lidereau, Ivan Bièche, Jennifer Varley, Yves Bignon, Nancy Uhrhammer, Robert Winqvist, Arja Jukkola-Vuorinen, Dieter Niederacher, Shunsuke Kato, Chikashi Ishioka, Pierre Hainaut, and Anne-Lise Børresen-Dale
Clin Cancer Res 2006 12: 1157-1167. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Enhancer of Zeste Homologue 2 Is Significantly Associated with Increased Tumor Cell Proliferation and Is a Marker of Aggressive Breast Cancer

Karin Collett, Geir E. Eide, Jarle Arnes, Ingunn M. Stefansson, Johan Eide, Audun Braaten, Turid Aas, Ariel P. Otte, and Lars A. Akslen
Clin Cancer Res 2006 12: 1168-1174. [Abstract] [Full Text] [PDF]  

A Multimarker Model to Predict Outcome in Tamoxifen-Treated Breast Cancer Patients

Steven P. Linke, Troy M. Bremer, Christopher D. Herold, Guido Sauter, and Cornelius Diamond
Clin Cancer Res 2006 12: 1175-1183. [Abstract] [Full Text] [PDF]  

Profiling Markers of Prognosis in Colorectal Cancer

Matthew S. Lyall, Sinclair R. Dundas, Stephanie Curran, and Graeme I. Murray
Clin Cancer Res 2006 12: 1184-1191. [Abstract] [Full Text] [PDF]  

Association of S100A4 and Osteopontin with Specific Prognostic Factors and Survival of Patients with Minimally Invasive Breast Cancer

Suzete de Silva Rudland, Lee Martin, Chandeene Roshanlall, John Winstanley, Samuel Leinster, Angela Platt-Higgins, Joe Carroll, Christopher West, Roger Barraclough, and Philip Rudland
Clin Cancer Res 2006 12: 1192-1200. [Abstract] [Full Text] [PDF]  

Nitric Oxide in Breast Cancer: Induction of Vascular Endothelial Growth Factor-C and Correlation with Metastasis and Poor Prognosis

Yasushi Nakamura, Hironao Yasuoka, Masahiko Tsujimoto, Katsuhide Yoshidome, Masaaki Nakahara, Kazuyasu Nakao, Misa Nakamura, and Kennichi Kakudo
Clin Cancer Res 2006 12: 1201-1207. [Abstract] [Full Text] [PDF]  

The Relationship of Insulin-Like Growth Factor-II, Insulin-Like Growth Factor Binding Protein-3, and Estrogen Receptor- Expression to Disease Progression in Epithelial Ovarian Cancer

Lingeng Lu, Dionyssios Katsaros, Andrew Wiley, Irene A. Rigault de la Longrais, Harvey A. Risch, Manuela Puopolo, and Herbert Yu
Clin Cancer Res 2006 12: 1208-1214. [Abstract] [Full Text] [PDF]  

Significance of Skp2 Expression in Primary Breast Cancer

Hideto Sonoda, Hiroshi Inoue, Kazuhiko Ogawa, Tohru Utsunomiya, Taka-aki Masuda, and Masaki Mori
Clin Cancer Res 2006 12: 1215-1220. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Study of the Biological Receptor Activator of Nuclear Factor-B Ligand Inhibitor, Denosumab, in Patients with Multiple Myeloma or Bone Metastases from Breast Cancer

Jean-Jacques Body, Thierry Facon, Robert E. Coleman, Allan Lipton, Filip Geurs, Michelle Fan, Donna Holloway, Mark C. Peterson, and Pirow J. Bekker
Clin Cancer Res 2006 12: 1221-1228. [Abstract] [Full Text] [PDF]  

Adoptive Transfer of Allogeneic Cytotoxic T Lymphocytes Equipped with a HLA-A2 Restricted MART-1 T-Cell Receptor: A Phase I Trial in Metastatic Melanoma

Lone Duval, Henrik Schmidt, Keld Kaltoft, Kirsten Fode, Jens Jorgen Jensen, Steen Mellerup Sorensen, Michael I. Nishimura, and Hans von der Maase
Clin Cancer Res 2006 12: 1229-1236. [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Fixed-Dose Selenomethionine and Irinotecan in Solid Tumors

Marwan G. Fakih, Lakshmi Pendyala, Patrick F. Smith, Patrick J. Creaven, Mary E. Reid, Vladimir Badmaev, Rami G. Azrak, Joshua D. Prey, David Lawrence, and Youcef M. Rustum
Clin Cancer Res 2006 12: 1237-1244. [Abstract] [Full Text] [PDF]  

Anastrozole versus Tamoxifen Treatment in Postmenopausal Women with Endocrine-Responsive Breast Cancer and Tamoxifen-Induced Endometrial Pathology

Bernd Gerber, Annette Krause, Toralf Reimer, Ionas Mylonas, Josef Makovitzky, Günther Kundt, and Wolfgang Janni
Clin Cancer Res 2006 12: 1245-1250. [Abstract] [Full Text] [PDF]  

Phase I Study of Liposome-Encapsulated c-raf Antisense Oligodeoxyribonucleotide Infusion in Combination with Radiation Therapy in Patients with Advanced Malignancies

Anatoly Dritschilo, Chao H. Huang, Charles M. Rudin, John Marshall, Brian Collins, Jeanne L. Dul, Chuanbo Zhang, Deepak Kumar, Prafulla C. Gokhale, Ateeq Ahmad, Imran Ahmad, Jeffrey W. Sherman, and Usha N. Kasid
Clin Cancer Res 2006 12: 1251-1259. [Abstract] [Full Text] [PDF]  

A Randomized Phase II Study of Concurrent Docetaxel Plus Vaccine Versus Vaccine Alone in Metastatic Androgen-Independent Prostate Cancer

Philip M. Arlen, James L. Gulley, Catherine Parker, Lisa Skarupa, Mary Pazdur, Dennis Panicali, Patricia Beetham, Kwong Y. Tsang, Douglas W. Grosenbach, Jarett Feldman, Seth M. Steinberg, Elizabeth Jones, Clara Chen, Jennifer Marte, Jeffrey Schlom, and William Dahut
Clin Cancer Res 2006 12: 1260-1269. [Abstract] [Full Text] [PDF]  

Phase I Trial of Bortezomib in Combination with Docetaxel in Patients with Advanced Solid Tumors

Wells A. Messersmith, Sharyn D. Baker, Lance Lassiter, Rana A. Sullivan, Kimberly Dinh, Virna I. Almuete, John J. Wright, Ross C. Donehower, Michael A. Carducci, and Deborah K. Armstrong
Clin Cancer Res 2006 12: 1270-1275. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Botulinum Toxin Potentiates Cancer Radiotherapy and Chemotherapy

Réginald Ansiaux, Christine Baudelet, Greg O. Cron, Jérôme Segers, Chantal Dessy, Philippe Martinive, Julie De Wever, Julien Verrax, Valérie Wauthier, Nelson Beghein, Vincent Grégoire, Pedro Buc Calderon, Olivier Feron, and Bernard Gallez
Clin Cancer Res 2006 12: 1276-1283. [Abstract] [Full Text] [PDF]  

Variant Diphtheria Toxin–Interleukin-3 Fusion Proteins with Increased Receptor Affinity Have Enhanced Cytotoxicity against Acute Myeloid Leukemia Progenitors

Donna E. Hogge, Leman Yalcintepe, Siaw-Hui Wong, Brigitte Gerhard, and Arthur E. Frankel
Clin Cancer Res 2006 12: 1284-1291. [Abstract] [Full Text] [PDF]  

Systemic Anti–Hepatocyte Growth Factor Monoclonal Antibody Therapy Induces the Regression of Intracranial Glioma Xenografts

K. Jin Kim, Lihong Wang, Yi-Chi Su, G. Yancey Gillespie, Amandeep Salhotra, Bachchu Lal, and John Laterra
Clin Cancer Res 2006 12: 1292-1298. [Abstract] [Full Text] [PDF]  

Intestinal Microflora and Digestive Toxicity of Irinotecan in Mice

Giovanni Brandi, Jean Dabard, Pierre Raibaud, Monica Di Battista, Chantal Bridonneau, Anna Maria Pisi, Antonio Maria Morselli Labate, Maria Abbondanza Pantaleo, Antonello De Vivo, and Guido Biasco
Clin Cancer Res 2006 12: 1299-1307. [Abstract] [Full Text] [PDF]  

An Inducible Short-Hairpin RNA Vector against Osteopontin Reduces Metastatic Potential of Human Esophageal Squamous Cell Carcinoma In vitro and In vivo

Tetsuo Ito, Yosuke Hashimoto, Eiji Tanaka, Takatsugu Kan, Shigeru Tsunoda, Fumiaki Sato, Motoshige Higashiyama, Tomoyuki Okumura, and Yutaka Shimada
Clin Cancer Res 2006 12: 1308-1316. [Abstract] [Full Text] [PDF] Supplementary Data  

Increased Antitumor Activity, Intratumor Paclitaxel Concentrations, and Endothelial Cell Transport of Cremophor-Free, Albumin-Bound Paclitaxel, ABI-007, Compared with Cremophor-Based Paclitaxel

Neil Desai, Vuong Trieu, Zhiwen Yao, Leslie Louie, Sherry Ci, Andrew Yang, Chunlin Tao, Tapas De, Bridget Beals, Donald Dykes, Patricia Noker, Rosie Yao, Elizabeth Labao, Michael Hawkins, and Patrick Soon-Shiong
Clin Cancer Res 2006 12: 1317-1324. [Abstract] [Full Text] [PDF]  

Antitumor Effects of Systemic and Local Immunization with a CTL-Directed Peptide in Combination with a Local Injection of OK-432

Takeharu Ono, Mamoru Harada, Akira Yamada, Masahiro Tanaka, Yukari Takao, Yasuaki Tanaka, Takashi Mine, Kikuo Sakamoto, Tadashi Nakashima, and Kyogo Itoh
Clin Cancer Res 2006 12: 1325-1332. [Abstract] [Full Text] [PDF]  

Allogeneic Tumor Cells Expressing Fusogenic Membrane Glycoproteins as a Platform for Clinical Cancer Immunotherapy

Fiona Errington, Andrew Bateman, Tim Kottke, Jill Thompson, Kevin Harrington, Alison Merrick, Paul Hatfield, Peter Selby, Richard Vile, and Alan Melcher
Clin Cancer Res 2006 12: 1333-1341. [Abstract] [Full Text] [PDF]  

Effective Cancer Therapy with the -Particle Emitter [²¹¹At]Astatine in a Mouse Model of Genetically Modified Sodium/Iodide Symporter–Expressing Tumors

Thorsten Petrich, Leticia Quintanilla-Martinez, Zekiye Korkmaz, Elenore Samson, Hans Jürgen Helmeke, Geerd Jürgen Meyer, Wolfram H. Knapp, and Eyck Pötter
Clin Cancer Res 2006 12: 1342-1348. [Abstract] [Full Text] [PDF]  

Targeted Therapy for Glioblastoma Multiforme Neoplastic Meningitis with Intrathecal Delivery of an Oncolytic Recombinant Poliovirus

Hidenobu Ochiai, Stephanie A. Campbell, Gary E. Archer, Tracy A. Chewning, Eugenia Dragunsky, Alexander Ivanov, Matthias Gromeier, and John H. Sampson
Clin Cancer Res 2006 12: 1349-1354. [Abstract] [Full Text] [PDF]  

Human Melanoma Cells Selected for Resistance to Apoptosis by Prolonged Exposure to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Are More Vulnerable to Necrotic Cell Death Induced by Cisplatin

Xu Dong Zhang, Jing Jing Wu, Susan Gillespie, Jodie Borrow, and Peter Hersey
Clin Cancer Res 2006 12: 1355-1364. [Abstract] [Full Text] [PDF]  

Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer

Boris Kubuschok, Frank Neumann, Rainer Breit, Martina Sester, Claudia Schormann, Claudia Wagner, Urban Sester, Frank Hartmann, Mathias Wagner, Klaus Remberger, Martin Schilling, and Michael Pfreundschuh
Clin Cancer Res 2006 12: 1365-1372. [Abstract] [Full Text] [PDF]  

CR011, a Fully Human Monoclonal Antibody-Auristatin E Conjugate, for the Treatment of Melanoma

Kam Fai Tse, Michael Jeffers, Vincent A. Pollack, Denise A. McCabe, Melanie L. Shadish, Nikolai V. Khramtsov, Craig S. Hackett, Suresh G. Shenoy, Bing Kuang, Ferenc L. Boldog, John R. MacDougall, Luca Rastelli, John Herrmann, Michael Gallo, Gadi Gazit-Bornstein, Peter D. Senter, Damon L. Meyer, Henri S. Lichenstein, and William J. LaRochelle
Clin Cancer Res 2006 12: 1373-1382. [Abstract] [Full Text] [PDF]  

The Insulin-Like Growth Factor-I Receptor Inhibitor Picropodophyllin Causes Tumor Regression and Attenuates Mechanisms Involved in Invasion of Uveal Melanoma Cells

Ada Girnita, Charlotta All-Ericsson, Mario A. Economou, Kristina Åström, Magnus Axelson, Stefan Seregard, Olle Larsson, and Leonard Girnita
Clin Cancer Res 2006 12: 1383-1391. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk

Uwe Langsenlehner, Babak Yazdani-Biuki, Tanja Eder, Wilfried Renner, Thomas C. Wascher, Bernhard Paulweber, Werner Weitzer, Hellmut Samonigg, and Peter Krippl
Clin Cancer Res 2006 12: 1392-1394. [Abstract] [Full Text] [PDF]  

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