Editorials:

An Essay on Rearranging the Deck Chairs: What's Wrong with the Cancer Trials System?

Derek Raghavan
Clin Cancer Res 2006 12: 1949-1950. [Full Text] [PDF]  

Identifying Sources of Interindividual Pharmacokinetic Variability with Population Modeling

Alex Sparreboom and William D. Figg
Clin Cancer Res 2006 12: 1951-1953. [Full Text] [PDF]  

Genomic Testing for Sensitivity of Breast Cancer to Hormonal Therapy

W. Fraser Symmans
Clin Cancer Res 2006 12: 1954-1955. [Full Text] [PDF]  

Cancer Treatment and the Older Patient

Edward L. Trimble and Michaele C. Christian
Clin Cancer Res 2006 12: 1956-1957. [Full Text] [PDF]  

The Biology Behind:

Potential of Immuno–Positron Emission Tomography for Tumor Imaging and Immunotherapy Planning

Michael R. Zalutsky
Clin Cancer Res 2006 12: 1958-1960. [Full Text] [PDF]  

Molecular Pathways:

A Matter of Life or Death (or Both): Understanding Autophagy in Cancer

William N. Hait, Shengkan Jin, and Jin-Ming Yang
Clin Cancer Res 2006 12: 1961-1965. [Full Text] [PDF]  

Cooperative Group Bulletin Board:

Phase II Clinical Trial Design: Methods in Translational Research from the Genitourinary Committee at the Eastern Cooperative Oncology Group

Robert Gray, Judith Manola, Scott Saxman, John Wright, Jan Dutcher, Michael Atkins, Michael Carducci, William See, Christopher Sweeney, Glenn Liu, Mark Stein, Robert Dreicer, George Wilding, and Robert S. DiPaola
Clin Cancer Res 2006 12: 1966-1969. [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Glioblastoma Multiforme

Chien-Tsun Kuan, Kenji Wakiya, Jeannette M. Dowell, James E. Herndon, II, David A. Reardon, Michael W. Graner, Gregory J. Riggins, Carol J. Wikstrand, and Darell D. Bigner
Clin Cancer Res 2006 12: 1970-1982. [Abstract] [Full Text] [PDF]  

Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation

Thomas J. Giordano, Amy Y.M. Au, Rork Kuick, Dafydd G. Thomas, Daniel R. Rhodes, Kenneth G. Wilhelm, Jr., Michelle Vinco, David E. Misek, Donita Sanders, Zhaowen Zhu, Raffaele Ciampi, Samir Hanash, Arul Chinnaiyan, Roderick J. Clifton-Bligh, Bruce G. Robinson, Yuri E. Nikiforov, and Ronald J. Koenig
Clin Cancer Res 2006 12: 1983-1993. [Abstract] [Full Text] [PDF]  

Coengagement of CD16 and CD94 Receptors Mediates Secretion of Chemokines and Induces Apoptotic Death of Naive Natural Killer Cells

Anahid Jewett, Nicholas A. Cacalano, Christian Head, and Antonia Teruel
Clin Cancer Res 2006 12: 1994-2003. [Abstract] [Full Text] [PDF]  

Altered Nuclear Receptor Corepressor Expression Attenuates Vitamin D Receptor Signaling in Breast Cancer Cells

Claire M. Banwell, Donia P. MacCartney, Michelle Guy, Alice E. Miles, Milan R. Uskokovic, Janine Mansi, Paul M. Stewart, Laura P. O'Neill, Bryan M. Turner, Kay W. Colston, and Moray J. Campbell
Clin Cancer Res 2006 12: 2004-2013. [Abstract] [Full Text] [PDF]  

Differentially Regulated Micro-RNAs and Actively Translated Messenger RNA Transcripts by Tumor Suppressor p53 in Colon Cancer

Yaguang Xi, Reut Shalgi, Oystein Fodstad, Yitzhak Pilpel, and Jingfang Ju
Clin Cancer Res 2006 12: 2014-2024. [Abstract] [Full Text] [PDF]  

Inhibition of Phosphotyrosine Phosphatase 1B Causes Resistance in BCR-ABL-Positive Leukemia Cells to the ABL Kinase Inhibitor STI571

Noriko Koyama, Steffen Koschmieder, Sandhya Tyagi, Ignacio Portero-Robles, Jörg Chromic, Silke Myloch, Heike Nürnberger, Tanja Rossmanith, Wolf-Karsten Hofmann, Dieter Hoelzer, and Oliver Gerhard Ottmann
Clin Cancer Res 2006 12: 2025-2031. [Abstract] [Full Text] [PDF]  

Reversal of the Malignant Phenotype of Cervical Cancer CaSki Cells through Adeno-Associated Virus–Mediated Delivery of HPV16 E7 Antisense RNA

Sufang Wu, Li Meng, Shixuan Wang, Wei Wang, Ling Xi, Xun Tian, Gang Chen, Ying Wu, Jianfeng Zhou, Gang Xu, Yunping Lu, and Ding Ma
Clin Cancer Res 2006 12: 2032-2037. [Abstract] [Full Text] [PDF]  

Physiologic Levels of 2-Methoxyestradiol Interfere with Nongenomic Signaling of 17ß-Estradiol in Human Breast Cancer Cells

Veena Vijayanathan, Sripriya Venkiteswaran, Sandhya K. Nair, Arti Verma, T.J. Thomas, Bao Ting Zhu, and Thresia Thomas
Clin Cancer Res 2006 12: 2038-2048. [Abstract] [Full Text] [PDF]  

Pediatric Cancers Are Infiltrated Predominantly by Macrophages and Contain a Paucity of Dendritic Cells: a Major Nosologic Difference with Adult Tumors

Jukka Vakkila, Ronald Jaffe, Marilyn Michelow, and Michael T. Lotze
Clin Cancer Res 2006 12: 2049-2054. [Abstract] [Full Text] [PDF]  

Celecoxib Up-Regulates the Expression of the Chain of T Cell Receptor Complex in Tumor-Infiltrating Lymphocytes in Human Cervical Cancer

Gabriella Ferrandina, Franco Oreste Ranelletti, Francesco Legge, Vanda Salutari, Enrica Martinelli, Andrea Fattorossi, Domenica Lorusso, Gianfranco Zannoni, Valerio Vellone, Amelia Paglia, and Giovanni Scambia
Clin Cancer Res 2006 12: 2055-2060. [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Ribosomal Protein L19 Is a Prognostic Marker for Human Prostate Cancer

Alix Bee, Youqianq Ke, Shiva Forootan, Ke Lin, Carol Beesley, Sharon E. Forrest, and Christopher S. Foster
Clin Cancer Res 2006 12: 2061-2065. [Abstract] [Full Text] [PDF]  

Quantitative Analysis of Human Telomerase Reverse Transcriptase in Pancreatic Cancer

Kenoki Ohuchida, Kazuhiro Mizumoto, Daisuke Yamada, Hiroshi Yamaguchi, Hiroyuki Konomi, Eishi Nagai, Koji Yamaguchi, Masazumi Tsuneyoshi, and Masao Tanaka
Clin Cancer Res 2006 12: 2066-2069. [Abstract] [Full Text] [PDF]  

Identification of Gains on 1q and Epidermal Growth Factor Receptor Overexpression as Independent Prognostic Markers in Intracranial Ependymoma

Frank Mendrzyk, Andrey Korshunov, Axel Benner, Grischa Toedt, Stefan Pfister, Bernhard Radlwimmer, and Peter Lichter
Clin Cancer Res 2006 12: 2070-2079. [Abstract] [Full Text] [PDF]  

A Two-Gene Expression Ratio of Homeobox 13 and Interleukin-17B Receptor for Prediction of Recurrence and Survival in Women Receiving Adjuvant Tamoxifen

Matthew P. Goetz, Vera J. Suman, James N. Ingle, Andrea M. Nibbe, Dan W. Visscher, Carol A. Reynolds, Wilma L. Lingle, Mark Erlander, Xiao-Jun Ma, Dennis C. Sgroi, Edith A. Perez, and Fergus J. Couch
Clin Cancer Res 2006 12: 2080-2087. [Abstract] [Full Text] [PDF]  

Messenger RNA Expression of Leptin and Leptin Receptors and their Prognostic Value in 322 Human Primary Breast Cancers

Françoise Révillion, Madia Charlier, Valérie Lhotellier, Louis Hornez, Sylvia Giard, Marie-Christine Baranzelli, Jean Djiane, and Jean-Philippe Peyrat
Clin Cancer Res 2006 12: 2088-2094. [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Messenger RNA Expression in Plasma from Patients with Colon Cancer: Prognostic Potential

Vanesa Garcia, José M. García, Cristina Peña, Javier Silva, Gemma Domínguez, Alicia Hurtado, Isabel Alonso, Rufo Rodriguez, Mariano Provencio, and Félix Bonilla
Clin Cancer Res 2006 12: 2095-2100. [Abstract] [Full Text] [PDF]  

Polymorphisms in Genes of Nucleotide and Base Excision Repair: Risk and Prognosis of Colorectal Cancer

Victor Moreno, Federica Gemignani, Stefano Landi, Lydie Gioia-Patricola, Amélie Chabrier, Ignacio Blanco, Sara González, Elisabet Guino, Gabriel Capellà, Federico Canzian Bellvitge Colorectal Cancer Study Group
Clin Cancer Res 2006 12: 2101-2108. [Abstract] [Full Text] [PDF]  

Combination Analysis of Hypermethylated Wnt-Antagonist Family Genes as a Novel Epigenetic Biomarker Panel for Bladder Cancer Detection

Shinji Urakami, Hiroaki Shiina, Hideki Enokida, Toshifumi Kawakami, Ken Kawamoto, Hiroshi Hirata, Yuichiro Tanaka, Nobuyuki Kikuno, Masayuki Nakagawa, Mikio Igawa, and Rajvir Dahiya
Clin Cancer Res 2006 12: 2109-2116. [Abstract] [Full Text] [PDF]  

Bead-Based ELISA for Validation of Ovarian Cancer Early Detection Markers

Nathalie Scholler, Meghan Crawford, Alicia Sato, Charles W. Drescher, Kathy C. O'Briant, Nancy Kiviat, Garnet L. Anderson, and Nicole Urban
Clin Cancer Res 2006 12: 2117-2124. [Abstract] [Full Text] [PDF]  

Diffuse Large B-Cell Lymphoma with Overexpression of Cyclin E Substantiates Poor Standard Treatment Response and Inferior Outcome

Alexandar Tzankov, Andreas Gschwendtner, Florian Augustin, Michael Fiegl, Ellen C. Obermann, Stephan Dirnhofer, and Philip Went
Clin Cancer Res 2006 12: 2125-2132. [Abstract] [Full Text] [PDF]  

Performance of Immuno–Positron Emission Tomography with Zirconium-89-Labeled Chimeric Monoclonal Antibody U36 in the Detection of Lymph Node Metastases in Head and Neck Cancer Patients

Pontus K.E. Börjesson, Yvonne W.S. Jauw, Ronald Boellaard, Remco de Bree, Emile F.I. Comans, Jan C. Roos, Jonas A. Castelijns, Maria J.W.D. Vosjan, J. Alain Kummer, C. René Leemans, Adriaan A. Lammertsma, and Guus A.M.S. van Dongen
Clin Cancer Res 2006 12: 2133-2140. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Evaluation of Adverse Events Experienced by Older Patients Participating in Studies of Molecularly Targeted Agents Alone or in Combination

Carol A. Townsley, Gregory R. Pond, Amit M. Oza, Hal W. Hirte, Eric Winquist, Glenwood Goss, Pamela Degendorfer, Malcolm J. Moore, and Lillian L. Siu
Clin Cancer Res 2006 12: 2141-2149. [Abstract] [Full Text] [PDF]  

Quantitative Effect of Gender, Age, Liver Function, and Body Size on the Population Pharmacokinetics of Paclitaxel in Patients with Solid Tumors

Markus Joerger, Alwin D.R. Huitema, Desiree H.J.G. van den Bongard, Jan H.M. Schellens, and Jos H. Beijnen
Clin Cancer Res 2006 12: 2150-2157. [Abstract] [Full Text] [PDF]  

Population Pharmacokinetics of Troxacitabine, a Novel Dioxolane Nucleoside Analogue

Carlton K. K. Lee, Eric K. Rowinsky, Jing Li, Francis Giles, Malcolm J. Moore, Manuel Hidalgo, Edmund Capparelli, Jacques Jolivet, and Sharyn D. Baker
Clin Cancer Res 2006 12: 2158-2165. [Abstract] [Full Text] [PDF]  

Effects of Smoking on the Pharmacokinetics of Erlotinib

Marta Hamilton, Julie L. Wolf, Jason Rusk, Shannon E. Beard, Gary M. Clark, Karsten Witt, and Pablo J. Cagnoni
Clin Cancer Res 2006 12: 2166-2171. [Abstract] [Full Text] [PDF]  

Phase II Trial of Celecoxib in Prostate-Specific Antigen Recurrent Prostate Cancer after Definitive Radiation Therapy or Radical Prostatectomy

Raj S. Pruthi, J. Eric Derksen, Dominic Moore, Culley C. Carson, Gayle Grigson, Cathy Watkins, and Eric Wallen
Clin Cancer Res 2006 12: 2172-2177. [Abstract] [Full Text] [PDF]  

Selenium Accumulation in Prostate Tissue During a Randomized, Controlled Short-term Trial of l-Selenomethionine: a Southwest Oncology Group Study

Anita L. Sabichi, J. Jack Lee, Robert J. Taylor, Ian M. Thompson, Brian J. Miles, Catherine M. Tangen, Lori M. Minasian, Louis L. Pisters, John R. Caton, Joseph W. Basler, Seth P. Lerner, David G. Menter, James R. Marshall, E. David Crawford, and Scott M. Lippman
Clin Cancer Res 2006 12: 2178-2184. [Abstract] [Full Text] [PDF]  

Carbon Beam Therapy Overcomes the Radiation Resistance of Uterine Cervical Cancer Originating from Hypoxia

Takashi Nakano, Yoshiyuki Suzuki, Tatsuya Ohno, Shingo Kato, Michiya Suzuki, Shinroku Morita, Shinichiro Sato, Kuniyuki Oka, and Hirohiko Tsujii
Clin Cancer Res 2006 12: 2185-2190. [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Low and High Tenascin-Expressing Tumors Are Efficiently Targeted by ST2146 Monoclonal Antibody

Rita De Santis, Claudio Albertoni, Fiorella Petronzelli, Silvia Campo, Valeria D'Alessio, Antonio Rosi, Anna Maria Anastasi, Ragnar Lindstedt, Nadia Caroni, Brunilde Arseni, Pierino Chiodi, Antonio Verdoliva, Giovanni Cassani, Marco Chinol, Giovanni Paganelli, and Paolo Carminati
Clin Cancer Res 2006 12: 2191-2196. [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Effects of Combined Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor-2 Targeted Therapy

James R. Tonra, Dhanvanthri S. Deevi, Erik Corcoran, Huiling Li, Su Wang, Francine E. Carrick, and Daniel J. Hicklin
Clin Cancer Res 2006 12: 2197-2207. [Abstract] [Full Text] [PDF] Supplementary Data  

Allogeneic MHC Gene Transfer Enhances Antitumor Activity of Allogeneic Hematopoietic Stem Cell Transplantation without Exacerbating Graft-versus-Host Disease

Masaki Ohashi, Akihiko Kobayashi, Hidehiko Hara, Yoshiaki Miura, Kimiko Yoshida, Miwa Kushida, Yoshinori Ikarashi, Masaki Mandai, Masaki Kitajima, Teruhiko Yoshida, and Kazunori Aoki
Clin Cancer Res 2006 12: 2208-2215. [Abstract] [Full Text] [PDF]  

Antisense Suppression of Pygopus2 Results in Growth Arrest of Epithelial Ovarian Cancer

Cathy M. Popadiuk, Jieying Xiong, Malcolm G. Wells, Phillip G. Andrews, Kweku Dankwa, Kensuke Hirasawa, Blue B. Lake, and Kenneth R. Kao
Clin Cancer Res 2006 12: 2216-2223. [Abstract] [Full Text] [PDF]  

Targeting Gastrin-Releasing Peptide Receptors on Small Cell Lung Cancer Cells with a Bispecific Molecule that Activates Polyclonal T Lymphocytes

Jiehua Zhou, Jian Chen, Ruikun Zhong, Michael Mokotoff, Leonard D. Shultz, and Edward D. Ball
Clin Cancer Res 2006 12: 2224-2231. [Abstract] [Full Text] [PDF]  

Erythropoietin Fails to Interfere with the Antiproliferative and Cytotoxic Effects of Antitumor Drugs

David A. Gewirtz, Xu Di, Teneille D. Walker, and Stephen T. Sawyer
Clin Cancer Res 2006 12: 2232-2238. [Abstract] [Full Text] [PDF]  

Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl⁺ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate

Tri K. Nguyen, Mohamed Rahmani, Ning Gao, Lora Kramer, Amie S. Corbin, Brian J. Druker, Paul Dent, and Steven Grant
Clin Cancer Res 2006 12: 2239-2247. [Abstract] [Full Text] [PDF]  

Preclinical Efficacy and Pharmacokinetics of AP5346, A Novel Diaminocyclohexane-Platinum Tumor-Targeting Drug Delivery System

John R. Rice, Jennifer L. Gerberich, David P. Nowotnik, and Stephen B. Howell
Clin Cancer Res 2006 12: 2248-2254. [Abstract] [Full Text] [PDF]  

Development and Therapeutic Options for the Treatment of Raloxifene-Stimulated Breast Cancer in Athymic Mice

Ruth M. O'Regan, Clodia Osipo, Eric Ariazi, Eun Sook Lee, Kathleen Meeke, Caroline Morris, Anne Bertucci, Mohammad A.B. Sarker, Ronald Grigg, and V. Craig Jordan
Clin Cancer Res 2006 12: 2255-2263. [Abstract] [Full Text] [PDF]  

Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response

Jann N. Sarkaria, Brett L. Carlson, Mark A. Schroeder, Patrick Grogan, Paul D. Brown, Caterina Giannini, Karla V. Ballman, Gaspar J. Kitange, Abjahit Guha, Ajay Pandita, and C. David James
Clin Cancer Res 2006 12: 2264-2271. [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Prevention of Ultraviolet Radiation–Induced Immunosuppression by (–)-Epigallocatechin-3-Gallate in Mice Is Mediated through Interleukin 12–Dependent DNA Repair

Syed M. Meeran, Sudheer K. Mantena, and Santosh K. Katiyar
Clin Cancer Res 2006 12: 2272-2280. [Abstract] [Full Text] [PDF]  

Analysis of c-ErbB1/Epidermal Growth Factor Receptor and c-ErbB2/HER-2 Expression in Bronchial Dysplasia: Evaluation of Potential Targets for Chemoprevention of Lung Cancer

Daniel T. Merrick, John Kittelson, Ralph Winterhalder, Georgia Kotantoulas, Steen Ingeberg, Robert L. Keith, Timothy C. Kennedy, York E. Miller, Wilbur A. Franklin, and Fred R. Hirsch
Clin Cancer Res 2006 12: 2281-2288. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Interaction between p53 Staining and High-Dose Chemotherapy in Breast Cancer

Per Eystein Lønning and Anne-Lise Børresen-Dale
Clin Cancer Res 2006 12: 2289. [Full Text] [PDF]  

Innovations and Challenges in Melanoma:

Innovations and Challenges in Melanoma: Summary Statement from the First Cambridge Conference

Michael B. Atkins, David E. Elder, Richard Essner, Keith T. Flaherty, Thomas F. Gajewski, Frank G. Haluska, Patrick Hwu, Ulrich Keilholz, John M. Kirkwood, James W. Mier, Merrick I. Ross, Craig L. Slingluff, Vernon K. Sondak, Jeffrey A. Sosman, Martin A. Weinstock, and Laura King
Clin Cancer Res 2006 12: 2291s-2296s. [Abstract] [Full Text] [PDF]  

Progress and Prospects on Melanoma: The Way Forward for Early Detection and Reduced Mortality

Martin A. Weinstock
Clin Cancer Res 2006 12: 2297s-2300s. [Abstract] [Full Text] [PDF]  

Genetic Alterations in Signaling Pathways in Melanoma

Frank G. Haluska, Hensin Tsao, Helen Wu, Frank S. Haluska, Alexander Lazar, and Vikas Goel
Clin Cancer Res 2006 12: 2301s-2307s. [Abstract] [Full Text] [PDF]  

Pathology of Melanoma

David E. Elder
Clin Cancer Res 2006 12: 2308s-2311s. [Abstract] [Full Text] [PDF]  

Early-Stage Melanoma: Staging Criteria and Prognostic Modeling

Merrick I. Ross
Clin Cancer Res 2006 12: 2312s-2319s. [Abstract] [Full Text] [PDF]  

Sentinel Lymph Node Biopsy and Melanoma Biology

Richard Essner
Clin Cancer Res 2006 12: 2320s-2325s. [Abstract] [Full Text] [PDF]  

Identifying and Overcoming Immune Resistance Mechanisms in the Melanoma Tumor Microenvironment

Thomas F. Gajewski
Clin Cancer Res 2006 12: 2326s-2330s. [Abstract] [Full Text] [PDF]  

Strategies for the Development of More Effective Adjuvant Therapy of Melanoma: Current and Future Explorations of Antibodies, Cytokines, Vaccines, and Combinations

John M. Kirkwood, Stergios Moschos, and Wenjun Wang
Clin Cancer Res 2006 12: 2331s-2336s. [Abstract] [Full Text] [PDF]  

Allogeneic and Autologous Melanoma Vaccines: Where Have We Been and Where Are We Going?

Vernon K. Sondak, Michael S. Sabel, and James J. Mulé
Clin Cancer Res 2006 12: 2337s-2341s. [Abstract] [Full Text] [PDF]  

Peptide and Dendritic Cell Vaccines

Craig L. Slingluff, Jr., Victor H. Engelhard, and Soldano Ferrone
Clin Cancer Res 2006 12: 2342s-2345s. [Abstract] [Full Text] [PDF]  

Immune Monitoring of T-Cell Responses in Cancer Vaccine Development

Ulrich Keilholz, Peter Martus, and Carmen Scheibenbogen
Clin Cancer Res 2006 12: 2346s-2352s. [Abstract] [Full Text] [PDF]  

Cytokine-Based Therapy and Biochemotherapy for Advanced Melanoma

Michael B. Atkins
Clin Cancer Res 2006 12: 2353s-2358s. [Abstract] [Full Text] [PDF]  

Immunosuppression in Melanoma Immunotherapy: Potential Opportunities for Intervention

Gregory Lizée, Laszlo G. Radvanyi, Willem W. Overwijk, and Patrick Hwu
Clin Cancer Res 2006 12: 2359s-2365s. [Abstract] [Full Text] [PDF]  

Chemotherapy and Targeted Therapy Combinations in Advanced Melanoma

Keith T. Flaherty
Clin Cancer Res 2006 12: 2366s-2370s. [Abstract] [Full Text] [PDF]  

Targeting the Mitogen-Activated Protein Kinase Pathway in the Treatment of Malignant Melanoma

David J. Panka, Michael B. Atkins, and James W. Mier
Clin Cancer Res 2006 12: 2371s-2375s. [Abstract] [Full Text] [PDF]  

Molecular Targets in Melanoma from Angiogenesis to Apoptosis

Jeffrey A. Sosman and Igor Puzanov
Clin Cancer Res 2006 12: 2376s-2383s. [Abstract] [Full Text] [PDF]  

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