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Three-dimensional display of NY-BR-1 protein expression in invasive breast cancer cells by confocal microscopy. NY-BR-1 is a differentiation antigen of mammary epithelial cells and a potential target for immunotherapy of breast carcinoma. Nuclear chromatin is stained in red. Diffuse cytoplasmic (green) and also nuclear (yellow; superimposed) staining of NY-BR-1 protein can be seen. The expression of NY-BR-1 is lost with tumor progression. For further details, see Varga et al. on page 2745 of this issue.