The Biology Behind:

"No Turning Bax" in the Combined Battle against Prostate Cancer:

Ramji R. Rajendran and Gary D. Kao
Clin Cancer Res 2007 13: 3435 -3438 doi: 10.1158/1078-0432.CCR-07-0810 [Full Text] [PDF]  

Molecular Pathways:

Therapeutic Implications of Leukemia Stem Cell Development

Matthew C. Stubbs and Scott A. Armstrong
Clin Cancer Res 2007 13: 3439-3442 doi: 10.1158/1078-0432.CCR-06-3090 [Abstract] [Full Text] [PDF]  

CCR Focus:

Imaging Update: New Windows, New Views

Ronald G. Blasberg
Clin Cancer Res 2007 13: 3444-3448 doi: 10.1158/1078-0432.CCR-07-0936 [Full Text] [PDF]  

Imaging Tumor Vascular Heterogeneity and Angiogenesis using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Alan Jackson, James P.B. O'Connor, Geoff J.M. Parker, and Gordon C. Jayson
Clin Cancer Res 2007 13: 3449-3459 doi: 10.1158/1078-0432.CCR-07-0238 [Abstract] [Full Text] [PDF]  

Tumor-Specific Positron Emission Tomography Imaging in Patients: [¹⁸F] Fluorodeoxyglucose and Beyond

David A. Mankoff, Janet F. Eary, Jeanne M. Link, Mark Muzi, Joseph G. Rajendran, Alexander M. Spence, and Kenneth A. Krohn
Clin Cancer Res 2007 13: 3460-3469 doi: 10.1158/1078-0432.CCR-07-0074 [Abstract] [Full Text] [PDF]  

Nuclear Imaging Probes: from Bench to Bedside

Hans-Jürgen Wester
Clin Cancer Res 2007 13: 3470-3481 doi: 10.1158/1078-0432.CCR-07-0264 [Abstract] [Full Text] [PDF]  

Spatio-Temporal Control of Gene Expression and Cancer Treatment Using Magnetic Resonance Imaging–Guided Focused Ultrasound

Chrit T.W. Moonen
Clin Cancer Res 2007 13: 3482-3489 doi: 10.1158/1078-0432.CCR-07-0204 [Abstract] [Full Text] [PDF]  

Whole-Body Optical Imaging in Animal Models to Assess Cancer Development and Progression

Eric L. Kaijzel, Gabri van der Pluijm, and Clemens W.G.M. Löwik
Clin Cancer Res 2007 13: 3490-3497 doi: 10.1158/1078-0432.CCR-07-0402 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Prominent Microvascular Proliferation in Clinically Aggressive Neuroblastoma

Radhika Peddinti, Rana Zeine, Dragos Luca, Roopa Seshadri, Alexandre Chlenski, Kristina Cole, Bruce Pawel, Helen R. Salwen, John M. Maris, and Susan L. Cohn
Clin Cancer Res 2007 13: 3499-3506 doi: 10.1158/1078-0432.CCR-07-0237 [Abstract] [Full Text] [PDF]  

Restoration of Tissue Factor Pathway Inhibitor-2 in a Human Glioblastoma Cell Line Triggers Caspase-Mediated Pathway and Apoptosis

Joseph George, Christopher S. Gondi, Dzung H. Dinh, Meena Gujrati, and Jasti S. Rao
Clin Cancer Res 2007 13: 3507-3517 doi: 10.1158/1078-0432.CCR-06-3023 [Abstract] [Full Text] [PDF]  

Neutrophils Promote Aerogenous Spread of Lung Adenocarcinoma with Bronchioloalveolar Carcinoma Features

Marie Wislez, Martine Antoine, Nathalie Rabbe, Valérie Gounant, Virginie Poulot, Armelle Lavolé, Jocelyne Fleury-Feith, and Jacques Cadranel
Clin Cancer Res 2007 13: 3518-3527 doi: 10.1158/1078-0432.CCR-06-2558 [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of the Bone Morphogenetic Protein-6 Gene in Malignant Lymphoma

Masanori Daibata, Yuiko Nemoto, Kentaro Bandobashi, Norihiro Kotani, Masayuki Kuroda, Mutsumi Tsuchiya, Heiwa Okuda, Tetsuya Takakuwa, Shosuke Imai, Taro Shuin, and Hirokuni Taguchi
Clin Cancer Res 2007 13: 3528-3535 doi: 10.1158/1078-0432.CCR-06-2766 [Abstract] [Full Text] [PDF]  

Expression of Erythropoietin Receptor and In vitro Functional Effects of Epoetins in B-Cell Malignancies

Parviz Kokhaei, Amir Osman Abdalla, Lotta Hansson, Eva Mikaelsson, Manfred Kubbies, Anton Haselbeck, Helena Jernberg-Wiklund, Håkan Mellstedt, and Anders Österborg
Clin Cancer Res 2007 13: 3536-3544 doi: 10.1158/1078-0432.CCR-06-2828 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Gene Expression Signatures Predict Outcome in Non–Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Lars Dyrskjøt, Karsten Zieger, Francisco X. Real, Núria Malats, Alfredo Carrato, Carolyn Hurst, Sanjeev Kotwal, Margaret Knowles, Per-Uno Malmström, Manuel de la Torre, Kenneth Wester, Yves Allory, Dimitri Vordos, Aurélie Caillault, François Radvanyi, Anne-Mette K. Hein, Jens L. Jensen, Klaus M.E. Jensen, Niels Marcussen, and Torben F. Ørntoft
Clin Cancer Res 2007 13: 3545-3551 doi: 10.1158/1078-0432.CCR-06-2940 [Abstract] [Full Text] [PDF] Supplementary Data  

Early Response Assessment Using 3'-Deoxy-3'-[¹⁸F]Fluorothymidine-Positron Emission Tomography in High-Grade Non-Hodgkin's Lymphoma

Ken Herrmann, Hinrich A. Wieder, Andreas K. Buck, Marion Schöffel, Bernd-Joachim Krause, Falko Fend, Tibor Schuster, Christian Meyer zum Büschenfelde, Hans-Jürgen Wester, Justus Duyster, Christian Peschel, Markus Schwaiger, and Tobias Dechow
Clin Cancer Res 2007 13: 3552-3558 doi: 10.1158/1078-0432.CCR-06-3025 [Abstract] [Full Text] [PDF]  

Cytochrome P450 1B1 Expression in Glial Cell Tumors: An Immunotherapeutic Target

Julia A. Barnett, Diana L. Urbauer, Graeme I. Murray, Gregory N. Fuller, and Amy B. Heimberger
Clin Cancer Res 2007 13: 3559-3567 doi: 10.1158/1078-0432.CCR-06-2430 [Abstract] [Full Text] [PDF]  

Matriptase-2 Inhibits Breast Tumor Growth and Invasion and Correlates with Favorable Prognosis for Breast Cancer Patients

Christian Parr, Andrew J. Sanders, Gaynor Davies, Tracey Martin, Jane Lane, Malcolm D. Mason, Robert E. Mansel, and Wen G. Jiang
Clin Cancer Res 2007 13: 3568-3576 doi: 10.1158/1078-0432.CCR-06-2357 [Abstract] [Full Text] [PDF]  

PIK3CA Mutations and PTEN Loss Correlate with Similar Prognostic Factors and Are Not Mutually Exclusive in Breast Cancer

Gizeh Pérez-Tenorio, Liza Alkhori, Birgit Olsson, Marie Ahnström Waltersson, Bo Nordenskjöld, Lars Erik Rutqvist, Lambert Skoog, and Olle Stål
Clin Cancer Res 2007 13: 3577-3584 doi: 10.1158/1078-0432.CCR-06-1609 [Abstract] [Full Text] [PDF]  

Bcl-2 and Bax Expression Predict Prostate Cancer Outcome in Men Treated with Androgen Deprivation and Radiotherapy on Radiation Therapy Oncology Group Protocol 92-02

Li Yan Khor, Jennifer Moughan, Tahseen Al-Saleem, Elizabeth H. Hammond, Varagur Venkatesan, Seth A. Rosenthal, Mark A. Ritter, Howard M. Sandler, Gerald E. Hanks, William U. Shipley, and Alan Pollack
Clin Cancer Res 2007 13: 3585-3590 doi: 10.1158/1078-0432.CCR-06-2972 [Abstract] [Full Text] [PDF]  

Human Leukocyte Antigen Class I Antigen Expression Is an Independent Prognostic Factor in Ovarian Cancer

Phil Rolland, Suha Deen, Ian Scott, Lindy Durrant, and Ian Spendlove
Clin Cancer Res 2007 13: 3591-3596 doi: 10.1158/1078-0432.CCR-06-2087 [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor R497K Polymorphism Is a Favorable Prognostic Factor for Patients with Colorectal Carcinoma

Wei-Shu Wang, Po-Min Chen, Tzeon-Jye Chiou, Jin-Hwang Liu, Jen-Kou Lin, Tzu-Chen Lin, Huann-Sheng Wang, and Yeu Su
Clin Cancer Res 2007 13: 3597-3604 doi: 10.1158/1078-0432.CCR-06-2601 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I and Pharmacokinetic Study of Vorinostat, A Histone Deacetylase Inhibitor, in Combination with Carboplatin and Paclitaxel for Advanced Solid Malignancies

Suresh S. Ramalingam, Robert A. Parise, Ramesh K. Ramananthan, Theodore F. Lagattuta, Lori A. Musguire, Ronald G. Stoller, Douglas M. Potter, Athanassios E. Argiris, James A. Zwiebel, Merrill J. Egorin, and Chandra P. Belani
Clin Cancer Res 2007 13: 3605-3610 Published Online First May 17, 2007. doi: 10.1158/1078-0432.CCR-07-0162 [Abstract] [Full Text] [PDF]  

Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor

Johann S. de Bono, Gerhardt Attard, Alex Adjei, Michael N. Pollak, Peter C. Fong, Paul Haluska, Luisa Roberts, Carrie Melvin, Madeline Repollet, David Chianese, Mark Connely, Leon W.M.M. Terstappen, and Antonio Gualberto
Clin Cancer Res 2007 13: 3611-3616 doi: 10.1158/1078-0432.CCR-07-0268 [Abstract] [Full Text] [PDF]  

Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients

John F. Smyth, Charlie Gourley, Graeme Walker, Melanie J. MacKean, Alan Stevenson, Alistair R.W. Williams, Awatif Al Nafussi, Tzyvia Rye, Ron Rye, Moira Stewart, Janet McCurdy, Max Mano, Nick Reed, Tracey McMahon, Paul Vasey, Hani Gabra, and Simon P. Langdon
Clin Cancer Res 2007 13: 3617-3622 doi: 10.1158/1078-0432.CCR-06-2878 [Abstract] [Full Text] [PDF]  

Phase I Trial of Weekly Paclitaxel and BMS-214662 in Patients with Advanced Solid Tumors

Howard H. Bailey, Dona B. Alberti, James P. Thomas, Daniel L. Mulkerin, Kimberly A. Binger, Marco M. Gottardis, Robert E. Martell, and George Wilding
Clin Cancer Res 2007 13: 3623-3629 Published Online First May 17, 2007. doi: 10.1158/1078-0432.CCR-07-0158 [Abstract] [Full Text] [PDF]  

An Open-Label, Two-Arm, Phase I Trial of Recombinant Human Interleukin-21 in Patients with Metastatic Melanoma

Ian D. Davis, Birte K. Skrumsager, Jonathan Cebon, Theo Nicholaou, John W. Barlow, Niels Peter Hundahl Moller, Kresten Skak, Dorthe Lundsgaard, Klaus Stensgaard Frederiksen, Peter Thygesen, and Grant A. McArthur
Clin Cancer Res 2007 13: 3630-3636 doi: 10.1158/1078-0432.CCR-07-0410 [Abstract] [Full Text] [PDF]  

Treatment of Single Brain Metastasis with Resection, Intracavity Carmustine Polymer Wafers, and Radiation Therapy Is Safe and Provides Excellent Local Control

Matthew G. Ewend, Steven Brem, Mark Gilbert, Robert Goodkin, Paul L. Penar, Mahesh Varia, Sharon Cush, and Lisa A. Carey
Clin Cancer Res 2007 13: 3637-3641 doi: 10.1158/1078-0432.CCR-06-2095 [Abstract] [Full Text] [PDF]  

A Parallel Dose-Escalation Study of Weekly and Twice-Weekly Bortezomib in Combination with Gemcitabine and Cisplatin in the First-Line Treatment of Patients with Advanced Solid Tumors

Jens Voortman, Egbert F. Smit, Richard Honeywell, Bart C. Kuenen, Godefridus J. Peters, Helgi van de Velde, and Giuseppe Giaccone
Clin Cancer Res 2007 13: 3642-3651 doi: 10.1158/1078-0432.CCR-07-0061 [Abstract] [Full Text] [PDF]  

A Randomized, Double-Blind, Phase II Study of Two Doses of Pemetrexed as First-Line Chemotherapy for Advanced Breast Cancer

Antonio Llombart-Cussac, Miguel Martin, Nadia Harbeck, Rodica M. Anghel, Alexandra E. Eniu, Mark W. Verrill, Patrick Neven, Jacques De Grève, Allen S. Melemed, Romnee Clark, Lorinda Simms, Christopher J. Kaiser, and Doreen Ma
Clin Cancer Res 2007 13: 3652-3659 doi: 10.1158/1078-0432.CCR-06-2377 [Abstract] [Full Text] [PDF]  

Dose-Escalating and Pharmacologic Study of Oxaliplatin in Adult Cancer Patients with Impaired Hepatic Function: A National Cancer Institute Organ Dysfunction Working Group Study

Timothy W. Synold, Chris H. Takimoto, James H. Doroshow, David Gandara, Sridhar Mani, Scot C. Remick, Daniel L. Mulkerin, Anne Hamilton, Sunil Sharma, Ramesh K. Ramanathan, Heinz Josef Lenz, Martin Graham, Jeffrey Longmate, Bennett M. Kaufman, and Percy Ivy
Clin Cancer Res 2007 13: 3660-3666 doi: 10.1158/1078-0432.CCR-06-2385 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Proteomic Analysis Identifies Oxidative Stress Induction by Adaphostin

Luke H. Stockwin, Maja A. Bumke, Sherry X. Yu, Simon P. Webb, Jack R. Collins, Melinda G. Hollingshead, and Dianne L. Newton
Clin Cancer Res 2007 13: 3667-3681 doi: 10.1158/1078-0432.CCR-07-0025 [Abstract] [Full Text] [PDF]  

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Robert W. Wilkinson, Rajesh Odedra, Simon P. Heaton, Stephen R. Wedge, Nicholas J. Keen, Claire Crafter, John R. Foster, Madeleine C. Brady, Alison Bigley, Elaine Brown, Kate F. Byth, Nigel C. Barrass, Kirsten E. Mundt, Kevin M. Foote, Nicola M. Heron, Frederic H. Jung, Andrew A. Mortlock, F. Thomas Boyle, and Stephen Green
Clin Cancer Res 2007 13: 3682-3688 doi: 10.1158/1078-0432.CCR-06-2979 [Abstract] [Full Text] [PDF]  

_v Integrin-Targeted Immunoconjugates Regress Established Human Tumors in Xenograft Models

Qiming Chen, Hillary J. Millar, Francis L. McCabe, Carol D. Manning, Rita Steeves, Kate Lai, Brenda Kellogg, Robert J. Lutz, Mohit Trikha, Marian T. Nakada, and G. Mark Anderson
Clin Cancer Res 2007 13: 3689-3695 doi: 10.1158/1078-0432.CCR-07-0026 [Abstract] [Full Text] [PDF]  

[Lys⁴⁰(Ahx-DTPA-¹¹¹In)NH₂]-Exendin-4 Is a Highly Efficient Radiotherapeutic for Glucagon-Like Peptide-1 Receptor–Targeted Therapy for Insulinoma

Andreas Wicki, Damian Wild, Daniel Storch, Christian Seemayer, Martin Gotthardt, Martin Behe, Stefan Kneifel, Michael J. Mihatsch, Jean-Claude Reubi, Helmut R. Mäcke, and Gerhard Christofori
Clin Cancer Res 2007 13: 3696-3705 doi: 10.1158/1078-0432.CCR-06-2965 [Abstract] [Full Text] [PDF]  

Ex vivo Nicotine Stimulation Augments the Efficacy of Therapeutic Bone Marrow–Derived Dendritic Cell Vaccination

Feng Guang Gao, Da Fang Wan, and Jian Ren Gu
Clin Cancer Res 2007 13: 3706-3712 doi: 10.1158/1078-0432.CCR-07-0028 [Abstract] [Full Text] [PDF]  

Inhibition of the T790M Gatekeeper Mutant of the Epidermal Growth Factor Receptor by EXEL-7647

Steven B. Gendreau, Richard Ventura, Paul Keast, A. Douglas Laird, F. Michael Yakes, Wentao Zhang, Frauke Bentzien, Belinda Cancilla, Jeffery Lutman, Felix Chu, Lisa Jackman, Yongchang Shi, Peiwen Yu, Jing Wang, Dana T. Aftab, Christopher T. Jaeger, Stephanie M. Meyer, Anushka De Costa, Kelly Engell, Jason Chen, Jean-Francois Martini, and Alison H. Joly
Clin Cancer Res 2007 13: 3713-3723 doi: 10.1158/1078-0432.CCR-06-2590 [Abstract] [Full Text] [PDF]  

Hyperglycemia-Induced Thioredoxin-Interacting Protein Expression Differs in Breast Cancer–Derived Cells and Regulates Paclitaxel IC₅₀

Francesco Turturro, Gary Von Burton, and Ellen Friday
Clin Cancer Res 2007 13: 3724-3730 doi: 10.1158/1078-0432.CCR-07-0244 [Abstract] [Full Text] [PDF]  

Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes

Jing Li, Ming Zhao, Ping He, Manuel Hidalgo, and Sharyn D. Baker
Clin Cancer Res 2007 13: 3731-3737 doi: 10.1158/1078-0432.CCR-07-0088 [Abstract] [Full Text] [PDF]  

In vivo ¹⁹F Magnetic Resonance Spectroscopy and Chemical Shift Imaging of Tri-Fluoro-Nitroimidazole as a Potential Hypoxia Reporter in Solid Tumors

Daniel Procissi, Filip Claus, Paul Burgman, Jacek Koziorowski, J. Donald Chapman, Sunitha B. Thakur, Cornelia Matei, C. Clifton Ling, and Jason A. Koutcher
Clin Cancer Res 2007 13: 3738-3747 doi: 10.1158/1078-0432.CCR-06-1563 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Lack of an Association between the TGFBR1*6A Variant and Colorectal Cancer Risk

Johanna Skoglund, Bo Song, Johan Dalén, Stefan Dedorson, David Edler, Fredrik Hjern, Jörn Holm, Claes Lenander, Ulrik Lindforss, Nils Lundqvist, Hans Olivecrona, Louise Olsson, Lars Påhlman, Jörgen Rutegård, Kennet Smedh, Anders Törnqvist, Richard S. Houlston, and Annika Lindblom
Clin Cancer Res 2007 13: 3748-3752 doi: 10.1158/1078-0432.CCR-06-2865 [Abstract] [Full Text] [PDF]  

Nucleotide Excision Repair Pathway Genes and Oral Premalignant Lesions

Yunfei Wang, Margaret R. Spitz, J. Jack Lee, Maosheng Huang, Scott M. Lippman, and Xifeng Wu
Clin Cancer Res 2007 13: 3753-3758 doi: 10.1158/1078-0432.CCR-06-1911 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Mechanisms of egfr Gene Transcription

Clin Cancer Res 2007 13: 3759 doi: 10.1158/1078-0432.CCR-13-12-COR [Full Text] [PDF]  

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