Tumor blood vessels are disorganized because of dysregulated angiogenesis. The investigators have shown that microvascular proliferation in neuroblastoma is significantly associated with Schwannian stroma–poor histology and worse outcome. These results provide further rationale for using antiangiogenic treatment strategies in clinically aggressive disease. The cover figure shows blood vessels with immunoflourescence double labeling of endothelial cells (red) and vascular mural cells (green). For further details, please see Peddinti et al. on page 3499 in this issue.

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