Epidermal growth factor receptor (EGFR) expression in clear cell sarcoma of the kidney (CCSK; magnification x 200). Screening of a pediatric renal tumour tissue microarray for EGFR expression by immunohistochemistry revealed a striking predilection for CCSK. More detailed investigation of these cases revealed instances of EGFR gene amplification and mutation, as well as mutations in PTEN and downstream pathway activation by means of phosphorylated Akt up-regulation. These data provide evidence for an activated EGFR pathway in these childhood tumours and the possibility of targeted therapeutic intervention. For further details, please see Little and associates on page 4360 of this issue.

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