Editorials:

Is There a Future for Ductal Lavage?

Carol J. Fabian
Clin Cancer Res 2007 13: 4655-4656 doi: 10.1158/1078-0432.CCR-07-1056 [Full Text] [PDF]  

ErbB-Dependent Signaling as a Determinant of Trastuzumab Resistance

Rakesh Kumar
Clin Cancer Res 2007 13: 4657-4659 doi: 10.1158/1078-0432.CCR-07-1401 [Full Text] [PDF]  

The Biology Behind:

Loss of Secreted Frizzled-Related Protein-1 Expression in Renal Cell Carcinoma Reveals a Critical Tumor Suppressor Function

Jeffrey S. Rubin and Donald P. Bottaro
Clin Cancer Res 2007 13: 4660 -4663 doi: 10.1158/1078-0432.CCR-07-1077 [Full Text] [PDF]  

CCR Drug Updates:

Panitumumab, a Monoclonal Anti–Epidermal Growth Factor Receptor Antibody in Colorectal Cancer: Another One or the One?

Wells A. Messersmith and Manuel Hidalgo
Clin Cancer Res 2007 13: 4664-4666 doi: 10.1158/1078-0432.CCR-07-0065 [Full Text] [PDF]  

Molecular Pathways:

Pseudohypoxic Pathways in Renal Cell Carcinoma

Gennady Bratslavsky, Sunil Sudarshan, Len Neckers, and W. Marston Linehan
Clin Cancer Res 2007 13: 4667-4671 doi: 10.1158/1078-0432.CCR-06-2510 [Abstract] [Full Text] [PDF]  

Membrane-Associated Estrogen Receptor Signaling Pathways in Human Cancers

Richard J. Pietras and Diana C. Márquez-Garbán
Clin Cancer Res 2007 13: 4672-4676 doi: 10.1158/1078-0432.CCR-07-1373 [Full Text] [PDF]  

Review:

Interleukin-12: Biological Properties and Clinical Application

Michele Del Vecchio, Emilio Bajetta, Stefania Canova, Michael T. Lotze, Amy Wesa, Giorgio Parmiani, and Andrea Anichini
Clin Cancer Res 2007 13: 4677-4685 doi: 10.1158/1078-0432.CCR-07-0776 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Nicotine Induces Hypoxia-Inducible Factor-1 Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor–Mediated Signaling Pathways

Qunzhou Zhang, Xudong Tang, Zuo-Feng Zhang, Rita Velikina, Shihong Shi, and Anh D. Le
Clin Cancer Res 2007 13: 4686-4694 doi: 10.1158/1078-0432.CCR-06-2898 [Abstract] [Full Text] [PDF]  

High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN Status

Frank Westermann, Kai-Oliver Henrich, Jun S. Wei, Werner Lutz, Matthias Fischer, Rainer König, Ruprecht Wiedemeyer, Volker Ehemann, Benedikt Brors, Karen Ernestus, Ivo Leuschner, Axel Benner, Javed Khan, and Manfred Schwab
Clin Cancer Res 2007 13: 4695-4703 Published Online First July 25, 2007. doi: 10.1158/1078-0432.CCR-06-2818 [Abstract] [Full Text] [PDF] Supplementary Data  

The Development and Characterization of a Human Midgut Carcinoid Cell Line

George Van Buren, II, Asif Rashid, Anthony D. Yang, Eddie K. Abdalla, Michael J. Gray, Wenbiao Liu, Ray Somcio, Fan Fan, E. Ramsay Camp, James C. Yao, and Lee M. Ellis
Clin Cancer Res 2007 13: 4704-4712 doi: 10.1158/1078-0432.CCR-06-2723 [Abstract] [Full Text] [PDF]  

The Cancer/Testis Antigen Melanoma-Associated Antigen-A3/A6 Is a Novel Target of Fibroblast Growth Factor Receptor 2-IIIb through Histone H3 Modifications in Thyroid Cancer

Tetsuo Kondo, Xuegong Zhu, Sylvia L. Asa, and Shereen Ezzat
Clin Cancer Res 2007 13: 4713-4720 doi: 10.1158/1078-0432.CCR-07-0618 [Abstract] [Full Text] [PDF]  

INI1 Induces Interferon Signaling and Spindle Checkpoint in Rhabdoid Tumors

Alexei Morozov, Seung Jae Lee, Zhi-Kai Zhang, Velasco Cimica, David Zagzag, and Ganjam V. Kalpana
Clin Cancer Res 2007 13: 4721-4730 doi: 10.1158/1078-0432.CCR-07-0054 [Abstract] [Full Text] [PDF] Supplementary Data  

High-Resolution Single Nucleotide Polymorphism Array Analysis of Epithelial Ovarian Cancer Reveals Numerous Microdeletions and Amplifications

Kylie L. Gorringe, Sharoni Jacobs, Ella R. Thompson, Anita Sridhar, Wen Qiu, David Y.H. Choong, and Ian G. Campbell
Clin Cancer Res 2007 13: 4731-4739 doi: 10.1158/1078-0432.CCR-07-0502 [Abstract] [Full Text] [PDF] Supplementary Data  

Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma

Michelle L. Gumz, Hongzhi Zou, Pamela A. Kreinest, April C. Childs, Leandra S. Belmonte, Shauna N. LeGrand, Kevin J. Wu, Bruce A. Luxon, Mala Sinha, Alexander S. Parker, L-Z. Sun, David A. Ahlquist, Christopher G. Wood, and John A. Copland
Clin Cancer Res 2007 13: 4740-4749 doi: 10.1158/1078-0432.CCR-07-0143 [Abstract] [Full Text] [PDF]  

OSU-03012, a Novel Celecoxib Derivative, Is Cytotoxic to Myeloma Cells and Acts through Multiple Mechanisms

Shuhong Zhang, Attaya Suvannasankha, Colin D. Crean, Valerie L. White, Amy Johnson, Ching-Shih Chen, and Sherif S. Farag
Clin Cancer Res 2007 13: 4750-4758 doi: 10.1158/1078-0432.CCR-07-0136 [Abstract] [Full Text] [PDF]  

Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer

Tse-Ming Hong, Yuh-Ling Chen, Yi-Ying Wu, Ang Yuan, Yu-Chih Chao, Yi-Chuan Chung, Ming-Heng Wu, Shuenn-Chen Yang, Szu-Hua Pan, Jin-Yuan Shih, Wing-Kai Chan, and Pan-Chyr Yang
Clin Cancer Res 2007 13: 4759-4768 doi: 10.1158/1078-0432.CCR-07-0001 [Abstract] [Full Text] [PDF] Supplementary Data  

Epithelial to Mesenchymal Transition: Expression of the Regulators Snail, Slug, and Twist in Pancreatic Cancer

Birgit Hotz, Marco Arndt, Sonja Dullat, Sarah Bhargava, Heinz-J. Buhr, and Hubert G. Hotz
Clin Cancer Res 2007 13: 4769-4776 doi: 10.1158/1078-0432.CCR-06-2926 [Abstract] [Full Text] [PDF]  

Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis

Charles W. Ross, Peter D. Ouillette, Chris M. Saddler, Kerby A. Shedden, and Sami N. Malek
Clin Cancer Res 2007 13: 4777-4785 doi: 10.1158/1078-0432.CCR-07-0456 [Abstract] [Full Text] [PDF]  

PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer

Yoshiyuki Watanabe, Minoru Toyota, Yutaka Kondo, Hiromu Suzuki, Takashi Imai, Mutsumi Ohe-Toyota, Reo Maruyama, Masanori Nojima, Yasushi Sasaki, Yoshitaka Sekido, Hiroyoshi Hiratsuka, Yasuhisa Shinomura, Kohzoh Imai, Fumio Itoh, and Takashi Tokino
Clin Cancer Res 2007 13: 4786-4794 doi: 10.1158/1078-0432.CCR-07-0305 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Activated Mammalian Target of Rapamycin Is an Adverse Prognostic Factor in Patients with Biliary Tract Adenocarcinoma

Beata Herberger, Harald Puhalla, Martina Lehnert, Fritz Wrba, Sabine Novak, Anita Brandstetter, Birgit Gruenberger, Thomas Gruenberger, Robert Pirker, and Martin Filipits
Clin Cancer Res 2007 13: 4795-4799 doi: 10.1158/1078-0432.CCR-07-0738 [Abstract] [Full Text] [PDF]  

Cyclin E–Associated Kinase Activity Predicts Response to Platinum-Based Chemotherapy

Isabelle Bedrosian, Christine Lee, Susan L. Tucker, Shana L. Palla, Karen Lu, and Khandan Keyomarsi
Clin Cancer Res 2007 13: 4800-4806 doi: 10.1158/1078-0432.CCR-07-0142 [Abstract] [Full Text] [PDF]  

One-step Nucleic Acid Amplification for Intraoperative Detection of Lymph Node Metastasis in Breast Cancer Patients

Masahiko Tsujimoto, Kadzuki Nakabayashi, Katsuhide Yoshidome, Tomoyo Kaneko, Takuji Iwase, Futoshi Akiyama, Yo Kato, Hitoshi Tsuda, Shigeto Ueda, Kazuhiko Sato, Yasuhiro Tamaki, Shinzaburo Noguchi, Tatsuki R. Kataoka, Hiromu Nakajima, Yoshifumi Komoike, Hideo Inaji, Koichiro Tsugawa, Koyu Suzuki, Seigo Nakamura, Motonari Daitoh, Yasuhiro Otomo, and Nariaki Matsuura
Clin Cancer Res 2007 13: 4807-4816 doi: 10.1158/1078-0432.CCR-06-2512 [Abstract] [Full Text] [PDF]  

Decreased Expression of Retinoid Receptors in Melanoma: Entailment in Tumorigenesis and Prognosis

Nitin Chakravarti, Reuben Lotan, Abdul H. Diwan, Carla L. Warneke, Marcella M. Johnson, and Victor G. Prieto
Clin Cancer Res 2007 13: 4817-4824 doi: 10.1158/1078-0432.CCR-06-3026 [Abstract] [Full Text] [PDF]  

Erythropoietin and Erythropoietin Receptor Coexpression Is Associated with Poor Survival in Stage I Non–Small Cell Lung Cancer

Pierre Saintigny, Benjamin Besse, Patrice Callard, Anne-Claire Vergnaud, Sébastien Czernichow, Magali Colombat, Philippe Girard, Pierre Validire, Jean-Luc Breau, Jean-François Bernaudin, and Jean-Charles Soria
Clin Cancer Res 2007 13: 4825-4831 doi: 10.1158/1078-0432.CCR-06-3061 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Oxaliplatin Pharmacokinetics and Pharmacodynamics in Adult Cancer Patients with Impaired Renal Function

Chris H. Takimoto, Martin A. Graham, Graham Lockwood, Chee M. Ng, Andrew Goetz, Dennis Greenslade, Scot C. Remick, Sunil Sharma, Sridhar Mani, Ramesh K. Ramanathan, Timothy W. Synold, James H. Doroshow, Anne Hamilton, Daniel L. Mulkerin, Percy Ivy, Merrill J. Egorin, and Jean L. Grem
Clin Cancer Res 2007 13: 4832-4839 doi: 10.1158/1078-0432.CCR-07-0475 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses

Ingo Fricke, Noweeda Mirza, Jakob Dupont, Craig Lockhart, Autumn Jackson, Ji-Hyun Lee, Jeffrey A. Sosman, and Dmitry I. Gabrilovich
Clin Cancer Res 2007 13: 4840-4848 doi: 10.1158/1078-0432.CCR-07-0409 [Abstract] [Full Text] [PDF]  

Phase I Targeted Combination Trial of Sorafenib and Erlotinib in Patients with Advanced Solid Tumors

Ignacio Duran, Sebastien J. Hotté, Holger Hirte, Eric X. Chen, Martha MacLean, Sandra Turner, Lixia Duan, Gregory R. Pond, Chetan Lathia, Scott Walsh, John J. Wright, Janet Dancey, and Lillian L. Siu
Clin Cancer Res 2007 13: 4849-4857 doi: 10.1158/1078-0432.CCR-07-0382 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of the (6-Maleimidocaproyl)Hydrazone Derivative of Doxorubicin

Clemens Unger, Brigitte Häring, Michael Medinger, Joachim Drevs, Simone Steinbild, Felix Kratz, and Klaus Mross
Clin Cancer Res 2007 13: 4858-4866 doi: 10.1158/1078-0432.CCR-06-2776 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Suppression of Ewing's Sarcoma Tumor Growth, Tumor Vessel Formation, and Vasculogenesis Following Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy

Zhichao Zhou, Marcela F. Bolontrade, Krishna Reddy, Xiaoping Duan, Hui Guan, Ling Yu, Daniel J. Hicklin, and Eugenie S. Kleinerman
Clin Cancer Res 2007 13: 4867-4873 doi: 10.1158/1078-0432.CCR-07-0133 [Abstract] [Full Text] [PDF]  

Sorafenib Inhibits the Imatinib-Resistant KIT^T670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor

Tianhua Guo, Narasimhan P. Agaram, Grace C. Wong, Glory Hom, David D'Adamo, Robert G. Maki, Gary K. Schwartz, Darren Veach, Bayard D. Clarkson, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, and Cristina R. Antonescu
Clin Cancer Res 2007 13: 4874-4881 doi: 10.1158/1078-0432.CCR-07-0484 [Abstract] [Full Text] [PDF]  

Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor- Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90

Warren Fiskus, Yuan Ren, Alex Mohapatra, Purva Bali, Aditya Mandawat, Rekha Rao, Bryan Herger, Yonghua Yang, Peter Atadja, Jie Wu, and Kapil Bhalla
Clin Cancer Res 2007 13: 4882-4890 doi: 10.1158/1078-0432.CCR-06-3093 [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Effect of Combined Triptolide and Ionizing Radiation

Wei Wang, Shanmin Yang, Ying Su, Zhenyu Xiao, Chunyou Wang, Xinfeng Li, Ling Lin, Bruce M. Fenton, Scott F. Paoni, Ivan Ding, Peter Keng, Paul Okunieff, and Lurong Zhang
Clin Cancer Res 2007 13: 4891-4899 doi: 10.1158/1078-0432.CCR-07-0416 [Abstract] [Full Text] [PDF]  

p53 Aerosol Formulation with Low Toxicity and High Efficiency for Early Lung Cancer Treatment

Yiyu Zou, Carmen Tornos, Xuan Qiu, Marie Lia, and Roman Perez-Soler
Clin Cancer Res 2007 13: 4900-4908 doi: 10.1158/1078-0432.CCR-07-0395 [Abstract] [Full Text] [PDF]  

Human Breast Cancer Cells Selected for Resistance to Trastuzumab In vivo Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network

Christoph A. Ritter, Marianela Perez-Torres, Cammie Rinehart, Marta Guix, Teresa Dugger, Jeffrey A. Engelman, and Carlos L. Arteaga
Clin Cancer Res 2007 13: 4909-4919 doi: 10.1158/1078-0432.CCR-07-0701 [Abstract] [Full Text] [PDF]  

Phosphodiesterase 4 Inhibitors Augment Levels of Glucocorticoid Receptor in B Cell Chronic Lymphocytic Leukemia but Not in Normal Circulating Hematopoietic Cells

John A. Meyers, Josephine Taverna, Jorge Chaves, Anthony Makkinje, and Adam Lerner
Clin Cancer Res 2007 13: 4920-4927 doi: 10.1158/1078-0432.CCR-07-0276 [Abstract] [Full Text] [PDF]  

Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging

Ana P. Cotrim, Fuminori Hyodo, Ken-Ichiro Matsumoto, Anastasia L. Sowers, John A. Cook, Bruce J. Baum, Murali C. Krishna, and James B. Mitchell
Clin Cancer Res 2007 13: 4928-4933 doi: 10.1158/1078-0432.CCR-07-0662 [Abstract] [Full Text] [PDF]  

Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1

Yu Fang Wang, Chen Chen Jiang, Kelly Anne Kiejda, Susan Gillespie, Xu Dong Zhang, and Peter Hersey
Clin Cancer Res 2007 13: 4934-4942 Published Online First July 25, 2007. doi: 10.1158/1078-0432.CCR-07-0665 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Comparison of Ductal Lavage and Random Periareolar Fine Needle Aspiration as Tissue Acquisition Methods in Early Breast Cancer Prevention Trials

Banu Arun, Vicente Valero, Catherine Logan, Kristine Broglio, Edgardo Rivera, Abenaa Brewster, Guosheng Yin, Marjorie Green, Henry Kuerer, Yun Gong, Doris Browne, Gabriel N. Hortobagyi, and Nour Sneige
Clin Cancer Res 2007 13: 4943-4948 doi: 10.1158/1078-0432.CCR-06-2732 [Abstract] [Full Text] [PDF]  

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