A number of different topics were discussed at the 11^th Conference. A new human antibody to the insulin-growth factor I receptor (IGF-IR), which can block downstream MAPK and P13/AKT pathways, was presented (A, Rowinsky et al. on page 5549s in this issue). This antibody shows promising anti-tumor activity in animal models alone and in combination with chemotherapy. Innovative antibody constructs, including selective high affinity ligand (SHAL) antibody mimics targeting HLA-DR10 (B, Balhorn et al. on page 5621s in this issue), and a new platform for preparing multivalent, multifunctional bispecific antibodies using a newly described Dock and Lock procedure (C, Chang et al. on page 5586s in this issue) were presented. Microscopic human colon cancer as small as 0.3 mm were disclosed in the lungs using microPET imaging, and autoradiography illustrated the selective uptake in the metastatic tumors (D, Sharkey et al. on page 5577s in this issue). Multivalent bispecific antibodies prepared by the Dock and Lock procedure were used in a pretargeting setting for targeting radionuclides (E, Sharkey et al. on page 5577s in this issue).

[Table of Contents]