Editorials:

"PIKing" the Winner for Phosphatidylinositol 3-Kinase Inhibitors in ErbB2-Positive Breast Cancer: Let's Not "PTENed" It's Easy!

Matthew J. Ellis and Robert Crowder
Clin Cancer Res 2007 13: 5661-5662 doi: 10.1158/1078-0432.CCR-07-1698 [Full Text] [PDF]  

The Biology Behind:

NF-B Gene Signatures and p53 Mutations in Head and Neck Squamous Cell Carcinoma

Robert L. Ferris and Jennifer R. Grandis
Clin Cancer Res 2007 13: 5663 -5664 doi: 10.1158/1078-0432.CCR-07-1544 [Full Text] [PDF]  

Molecular Pathways:

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer Therapy

Doris Germain and David A. Frank
Clin Cancer Res 2007 13: 5665-5669 doi: 10.1158/1078-0432.CCR-06-2491 [Abstract] [Full Text] [PDF]  

Hypoxia Inducible Factor-1–Independent Pathways in Tumor Angiogenesis

Yusuke Mizukami, Yutaka Kohgo, and Daniel C. Chung
Clin Cancer Res 2007 13: 5670-5674 doi: 10.1158/1078-0432.CCR-07-0111 [Abstract] [Full Text] [PDF]  

Perspective:

Universal and Stemness-Related Tumor Antigens: Potential Use in Cancer Immunotherapy

Giorgio Parmiani, Vincenzo Russo, Andrea Marrari, Gianluca Cutolo, Chiara Casati, Lorenzo Pilla, Cristina Maccalli, Licia Rivoltini, and Chiara Castelli
Clin Cancer Res 2007 13: 5675-5679 doi: 10.1158/1078-0432.CCR-07-0879 [Full Text] [PDF]  

Human Cancer Biology:

A Novel Nuclear Factor-B Gene Signature Is Differentially Expressed in Head and Neck Squamous Cell Carcinomas in Association with TP53 Status

Tin Lap Lee, Xin Ping Yang, Bin Yan, Jay Friedman, Praveen Duggal, Lorena Bagain, Gang Dong, Ning T. Yeh, Jie Wang, Jian Zhou, Abdel Elkahloun, Carter Van Waes, and Zhong Chen
Clin Cancer Res 2007 13: 5680-5691 doi: 10.1158/1078-0432.CCR-07-0670 [Abstract] [Full Text] [PDF]  

Smad3 Is Overexpressed in Advanced Human Prostate Cancer and Necessary for Progressive Growth of Prostate Cancer Cells in Nude Mice

Shan Lu, Juwon Lee, Monica Revelo, Xiaohong Wang, Shan Lu, and Zhongyun Dong
Clin Cancer Res 2007 13: 5692-5702 doi: 10.1158/1078-0432.CCR-07-1078 [Abstract] [Full Text] [PDF]  

Identification of Toll-Like Receptor 3 as a Potential Therapeutic Target in Clear Cell Renal Cell Carcinoma

Teppei Morikawa, Akira Sugiyama, Haruki Kume, Satoshi Ota, Takeshi Kashima, Kyoichi Tomita, Tadaichi Kitamura, Tatsuhiko Kodama, Masashi Fukayama, and Hiroyuki Aburatani
Clin Cancer Res 2007 13: 5703-5709 doi: 10.1158/1078-0432.CCR-07-0603 [Abstract] [Full Text] [PDF]  

The Proangiogenic Phenotype of Tumor-Derived Endothelial Cells is Reverted by the Overexpression of Platelet-Activating Factor Acetylhydrolase

Sophie Doublier, Monica Ceretto, Enrico Lupia, Stefania Bravo, Benedetta Bussolati, and Giovanni Camussi
Clin Cancer Res 2007 13: 5710-5718 doi: 10.1158/1078-0432.CCR-07-0412 [Abstract] [Full Text] [PDF]  

Eotaxin-2 and Colorectal Cancer: A Potential Target for Immune Therapy

Eleanor J. Cheadle, Kallingal Riyad, Daren Subar, Dominic G. Rothwell, Garry Ashton, Hayley Batha, David J. Sherlock, Robert E. Hawkins, and David E. Gilham
Clin Cancer Res 2007 13: 5719-5728 doi: 10.1158/1078-0432.CCR-07-1145 [Abstract] [Full Text] [PDF]  

Molecular Analysis of Colorectal Cancer Tumors from Patients with Mismatch Repair–Proficient Hereditary Nonpolyposis Colorectal Cancer Suggests Novel Carcinogenic Pathways

Ana Sánchez-de-Abajo, Miguel de la Hoya, Marjo van Puijenbroek, Alicia Tosar, J.A. López-Asenjo, Eduardo Díaz-Rubio, Hans Morreau, and Trinidad Caldes
Clin Cancer Res 2007 13: 5729-5735 doi: 10.1158/1078-0432.CCR-06-2996 [Abstract] [Full Text] [PDF]  

Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer

Ralph S. Freedman, Ena Wang, Sonia Voiculescu, Rebecca Patenia, Roland L. Bassett, Jr., Michael Deavers, Francesco M. Marincola, Peiying Yang, and Robert A. Newman
Clin Cancer Res 2007 13: 5736-5744 doi: 10.1158/1078-0432.CCR-07-0583 [Abstract] [Full Text] [PDF]  

Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer

Yinghui Guan, Wen-Lin Kuo, Jackie L. Stilwell, Hirokuni Takano, Anna V. Lapuk, Jane Fridlyand, Jian-Hua Mao, Mamie Yu, Melinda A. Miller, Jennifer L. Santos, Steve E. Kalloger, Joseph W. Carlson, David G. Ginzinger, Susan E. Celniker, Gordon B. Mills, David G. Huntsman, and Joe W. Gray
Clin Cancer Res 2007 13: 5745-5755 doi: 10.1158/1078-0432.CCR-06-2882 [Abstract] [Full Text] [PDF] Supplementary Data  

CMTM5 Exhibits Tumor Suppressor Activities and Is Frequently Silenced by Methylation in Carcinoma Cell Lines

Luning Shao, Yan Cui, Hongyu Li, Yanan Liu, Hongshan Zhao, Yu Wang, Yingmei Zhang, Ka Man Ng, Wenling Han, Dalong Ma, and Qian Tao
Clin Cancer Res 2007 13: 5756-5762 doi: 10.1158/1078-0432.CCR-06-3082 [Abstract] [Full Text] [PDF]  

The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non–small Cell Lung Cancer

Shinichi Toyooka, Keitaro Matsuo, Hisayuki Shigematsu, Takayuki Kosaka, Masaki Tokumo, Yasushi Yatabe, Syuji Ichihara, Michio Inukai, Hiroshi Suehisa, Junichi Soh, Katsuyuki Kiura, Kwun M. Fong, Huei Lee, Ignacio I. Wistuba, Adi F. Gazdar, Tetsuya Mitsudomi, and Hiroshi Date
Clin Cancer Res 2007 13: 5763-5768 doi: 10.1158/1078-0432.CCR-07-0216 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Phosphorylation of Estrogen Receptor- at Ser¹⁶⁷ Is Indicative of Longer Disease-Free and Overall Survival in Breast Cancer Patients

Jie Jiang, Naveed Sarwar, David Peston, Elena Kulinskaya, Sami Shousha, R. Charles Coombes, and Simak Ali
Clin Cancer Res 2007 13: 5769-5776 doi: 10.1158/1078-0432.CCR-07-0822 [Abstract] [Full Text] [PDF]  

Short Telomeres: A Novel Potential Predictor of Relapse in Ewing Sarcoma

Smadar Avigad, Inna Naumov, Anat Ohali, Marta Jeison, Gili Halevy Berco, Jacques Mardoukh, Batia Stark, Shifra Ash, Ian J. Cohen, Isaac Meller, Yehuda Kollender, Josephine Issakov, and Isaac Yaniv
Clin Cancer Res 2007 13: 5777-5783 doi: 10.1158/1078-0432.CCR-07-0308 [Abstract] [Full Text] [PDF]  

A High Tumor-Associated Macrophage Content Predicts Favorable Outcome in Follicular Lymphoma Patients Treated with Rituximab and Cyclophosphamide-Doxorubicin-Vincristine-Prednisone

Minna Taskinen, Marja-Liisa Karjalainen-Lindsberg, Heidi Nyman, Leena-Maija Eerola, and Sirpa Leppä
Clin Cancer Res 2007 13: 5784-5789 doi: 10.1158/1078-0432.CCR-07-0778 [Abstract] [Full Text] [PDF]  

The AA Genotype of the Regulatory BCL2 Promoter Polymorphism (–938C>A) Is Associated with a Favorable Outcome in Lymph Node–Negative Invasive Breast Cancer Patients

Hagen S. Bachmann, Friedrich Otterbach, Rainer Callies, Holger Nückel, Maja Bau, Kurt W. Schmid, Winfried Siffert, and Rainer Kimmig
Clin Cancer Res 2007 13: 5790-5797 doi: 10.1158/1078-0432.CCR-06-2673 [Abstract] [Full Text] [PDF]  

p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer

Steven R. Grossman, Stephen Lyle, Murray B. Resnick, Edmond Sabo, Rosina T. Lis, Elizabeth Rosinha, Qin Liu, Chung-Cheng Hsieh, Gajanan Bhat, A. Raymond Frackelton, Jr., and Laurie J. Hafer
Clin Cancer Res 2007 13: 5798-5804 doi: 10.1158/1078-0432.CCR-07-0073 [Abstract] [Full Text] [PDF]  

Measurement of Cyclin E Genomic Copy Number and Strand Length in Cell-Free DNA Distinguish Malignant versus Benign Effusions

Ritu Salani, Ben Davidson, Michael Fiegl, Christian Marth, Elisabeth Müller-Holzner, Guenther Gastl, Han-Yao Huang, Jui-Chi Hsiao, Her-Sheng Lin, Tian-Li Wang, Bai-Ling Lin, and Ie-Ming Shih
Clin Cancer Res 2007 13: 5805-5809 doi: 10.1158/1078-0432.CCR-07-0853 [Abstract] [Full Text] [PDF]  

Caspase-3 Activity Predicts Local Recurrence in Rectal Cancer

Pieter de Heer, Elza C. de Bruin, Elma Klein-Kranenbarg, Remco I.J.M. Aalbers, Corrie A.M. Marijnen, Hein Putter, Hans J. de Bont, J. Fred Nagelkerke, J. Han J.M. van Krieken, Hein W. Verspaget, Cornelis J.H. van de Velde, Peter J.K. Kuppen for the Dutch Colorectal Cancer Group
Clin Cancer Res 2007 13: 5810-5815 doi: 10.1158/1078-0432.CCR-07-0343 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Platelet-Derived Growth Factor Receptor Inhibition and Chemotherapy for Castration-Resistant Prostate Cancer with Bone Metastases

Paul Mathew, Peter F. Thall, Corazon D. Bucana, William K. Oh, Michael J. Morris, Donnah M. Jones, Marcella M. Johnson, Sijin Wen, Lance C. Pagliaro, Nizar M. Tannir, Shi-Ming Tu, Anthony A. Meluch, Lon Smith, Lorenzo Cohen, Sun-Jin Kim, Patricia Troncoso, Isaiah J. Fidler, and Christopher J. Logothetis
Clin Cancer Res 2007 13: 5816-5824 doi: 10.1158/1078-0432.CCR-07-1269 [Abstract] [Full Text] [PDF]  

Molecular Alterations in Prostate Carcinomas that Associate with In vivo Exposure to Chemotherapy: Identification of a Cytoprotective Mechanism Involving Growth Differentiation Factor 15

Chung-Ying Huang, Tomasz M. Beer, Celestia S. Higano, Lawrence D. True, Robert Vessella, Paul H. Lange, Mark Garzotto, and Peter S. Nelson
Clin Cancer Res 2007 13: 5825-5833 doi: 10.1158/1078-0432.CCR-07-1037 [Abstract] [Full Text] [PDF]  

Phase I Dose Escalation Study of the Anti–Insulin-Like Growth Factor-I Receptor Monoclonal Antibody CP-751,871 in Patients with Refractory Solid Tumors

Paul Haluska, Heather M. Shaw, Gretchen N. Batzel, Donghua Yin, Julian R. Molina, L. Rhoda Molife, Timothy A. Yap, M. Luisa Roberts, Amarnath Sharma, Antonio Gualberto, Alex A. Adjei, and Johann S. de Bono
Clin Cancer Res 2007 13: 5834-5840 doi: 10.1158/1078-0432.CCR-07-1118 [Abstract] [Full Text] [PDF]  

Phase I Dose-Finding Study of Weekly Docetaxel Followed by Flavopiridol for Patients with Advanced Solid Tumors

M.N. Fornier, D. Rathkopf, M. Shah, S. Patil, E. O'Reilly, A.N. Tse, C. Hudis, R. Lefkowitz, D.P. Kelsen, and G.K. Schwartz
Clin Cancer Res 2007 13: 5841-5846 doi: 10.1158/1078-0432.CCR-07-1218 [Abstract] [Full Text] [PDF]  

Adjuvant Adenovirus-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Administration Improves Outcome of Liver Transplantation in Patients with Advanced Hepatocellular Carcinoma

Ning Li, Jianfeng Zhou, Danhui Weng, Chenghua Zhang, Lixin Li, Beibei Wang, Yang Song, Qiang He, Dongdong Lin, Dazhi Chen, Gang Chen, Qinglei Gao, Shixuan Wang, Gang Xu, Li Meng, YunPing Lu, and Ding Ma
Clin Cancer Res 2007 13: 5847-5854 doi: 10.1158/1078-0432.CCR-07-0499 [Abstract] [Full Text] [PDF]  

Phase I Trial of Poly-L-Glutamate Camptothecin (CT-2106) Administered Weekly in Patients with Advanced Solid Malignancies

Jade Homsi, George R. Simon, Chris R. Garrett, Gregory Springett, Ronald De Conti, Alberto A. Chiappori, Pamela N. Munster, Michelle K. Burton, Scott Stromatt, Claudia Allievi, Patrizia Angiuli, Amy Eisenfeld, Daniel M. Sullivan, and Adil I. Daud
Clin Cancer Res 2007 13: 5855-5861 doi: 10.1158/1078-0432.CCR-06-2821 [Abstract] [Full Text] [PDF]  

Inflammatory Breast Cancer as a Model Disease to Study Tumor Angiogenesis: Results of a Phase IB Trial of Combination SU5416 and Doxorubicin

Beth Overmoyer, Pingfu Fu, Charles Hoppel, Tomas Radivoyevitch, Robert Shenk, Marjie Persons, Paula Silverman, Kelly Robertson, Nicholas P. Ziats, Jay K. Wasman, Fadi W. Abdul-Karim, John A. Jesberger, Jeffrey Duerk, Paul Hartman, Shelli Hanks, Jonathan Lewin, Afshin Dowlati, Keith McCrae, Percy Ivy, and Scot C. Remick
Clin Cancer Res 2007 13: 5862-5868 doi: 10.1158/1078-0432.CCR-07-0688 [Abstract] [Full Text] [PDF]  

A Phase II Study of Gefitinib Monotherapy in Advanced Esophageal Adenocarcinoma: Evidence of Gene Expression, Cellular, and Clinical Response

David R. Ferry, Mark Anderson, Kate Beddard, Simon Tomlinson, Paul Atherfold, Jolanta Obszynska, Rebecca Harrison, and Janusz Jankowski
Clin Cancer Res 2007 13: 5869-5875 doi: 10.1158/1078-0432.CCR-06-1970 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors

Yaqoob Ali, Yong Lin, Mecide M. Gharibo, Murugesan K. Gounder, Mark N. Stein, Theodore F. Lagattuta, Merrill J. Egorin, Eric H. Rubin, and Elizabeth A. Poplin
Clin Cancer Res 2007 13: 5876-5882 doi: 10.1158/1078-0432.CCR-07-0883 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Preclinical Testing of Clinically Applicable Strategies for Overcoming Trastuzumab Resistance Caused by PTEN Deficiency

Chien-Hsing Lu, Shannon L. Wyszomierski, Ling-Ming Tseng, Meng-Hong Sun, Keng-Hsueh Lan, Christopher L. Neal, Gordon B. Mills, Gabriel N. Hortobagyi, Francisco J. Esteva, and Dihua Yu
Clin Cancer Res 2007 13: 5883-5888 doi: 10.1158/1078-0432.CCR-06-2837 [Abstract] [Full Text] [PDF]  

Characterization of a Putative Ovarian Oncogene, Elongation Factor 1, Isolated by Panning a Synthetic Phage Display Single-Chain Variable Fragment Library with Cultured Human Ovarian Cancer Cells

Sameer Sharma, Jonathan Tammela, Xinhui Wang, Hilal Arnouk, Deborah Driscoll, Paulette Mhawech-Fauceglia, Shashikant Lele, A. Latif Kazim, and Kunle Odunsi
Clin Cancer Res 2007 13: 5889-5896 doi: 10.1158/1078-0432.CCR-07-0703 [Abstract] [Full Text] [PDF]  

Herpes Simplex Virus Us3(–) Mutant as Oncolytic Strategy and Synergizes with Phosphatidylinositol 3-Kinase-Akt–Targeting Molecular Therapeutics

Ta-Chiang Liu, Hiroaki Wakimoto, Robert L. Martuza, and Samuel D. Rabkin
Clin Cancer Res 2007 13: 5897-5902 doi: 10.1158/1078-0432.CCR-07-1013 [Abstract] [Full Text] [PDF]  

Neutralizing B-Cell–Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model

Paola Neri, Shaji Kumar, Maria Teresa Fulciniti, Sonia Vallet, Shweta Chhetri, Sidhartha Mukherjee, YuTzu Tai, Dharminder Chauhan, Pierfrancesco Tassone, Salvatore Venuta, Nikhil C. Munshi, Teru Hideshima, Kenneth C. Anderson, and Noopur Raje
Clin Cancer Res 2007 13: 5903-5909 doi: 10.1158/1078-0432.CCR-07-0753 [Abstract] [Full Text] [PDF]  

Inhibition of Jun NH₂-Terminal Kinases Suppresses the Growth of Experimental Head and Neck Squamous Cell Carcinoma

Neil D. Gross, Jay O. Boyle, Baoheng Du, Vikram D. Kekatpure, Agnieszka Lantowski, Howard T. Thaler, Babette B. Weksler, Kotha Subbaramaiah, and Andrew J. Dannenberg
Clin Cancer Res 2007 13: 5910-5917 doi: 10.1158/1078-0432.CCR-07-0352 [Abstract] [Full Text] [PDF]  

The Therapeutic Efficacy of Anti–Vascular Endothelial Growth Factor Antibody, Bevacizumab, and Pemetrexed against Orthotopically Implanted Human Pleural Mesothelioma Cells in Severe Combined Immunodeficient Mice

Qi Li, Seiji Yano, Hirokazu Ogino, Wei Wang, Hisanori Uehara, Yasuhiko Nishioka, and Saburo Sone
Clin Cancer Res 2007 13: 5918-5925 doi: 10.1158/1078-0432.CCR-07-0501 [Abstract] [Full Text] [PDF]  

Anthrax Lethal Toxin Inhibits Growth of and Vascular Endothelial Growth Factor Release from Endothelial Cells Expressing the Human Herpes Virus 8 Viral G Protein–Coupled Receptor

Philippe Depeille, John J. Young, Elissa A. Boguslawski, Bree D. Berghuis, Eric J. Kort, James H. Resau, Arthur E. Frankel, and Nicholas S. Duesbery
Clin Cancer Res 2007 13: 5926-5934 doi: 10.1158/1078-0432.CCR-07-0732 [Abstract] [Full Text] [PDF]  

Imaging and Modulating Antisense Microdistribution in Solid Human Xenograft Tumor Models

Joseph D. Mocanu, Kenneth W. Yip, Julia Skliarenko, Wei Shi, Pierre Busson, Kwok-Wai Lo, Carlo Bastianutto, and Fei-Fei Liu
Clin Cancer Res 2007 13: 5935-5941 doi: 10.1158/1078-0432.CCR-06-3085 [Abstract] [Full Text] [PDF]  

Bortezomib Inhibits Nuclear Factor-B–Dependent Survival and Has Potent In vivo Activity in Mesothelioma

Andrea Sartore-Bianchi, Fabio Gasparri, Arturo Galvani, Linda Nici, James W. Darnowski, Dario Barbone, Dean A. Fennell, Giovanni Gaudino, Camillo Porta, and Luciano Mutti
Clin Cancer Res 2007 13: 5942-5951 doi: 10.1158/1078-0432.CCR-07-0536 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

N-Acetylcysteine Protects Melanocytes against Oxidative Stress/Damage and Delays Onset of Ultraviolet-Induced Melanoma in Mice

Murray A. Cotter, Joshua Thomas, Pamela Cassidy, Kyle Robinette, Noah Jenkins, Scott R. Florell, Sancy Leachman, Wolfram E. Samlowski, and Douglas Grossman
Clin Cancer Res 2007 13: 5952-5958 doi: 10.1158/1078-0432.CCR-07-1187 [Abstract] [Full Text] [PDF]  

Association of RNASEL Variants with Prostate Cancer Risk in Hispanic Caucasians and African Americans

Stacie J. Shook, Joke Beuten, Kathleen C. Torkko, Teresa L. Johnson-Pais, Dean A. Troyer, Ian M. Thompson, and Robin J. Leach
Clin Cancer Res 2007 13: 5959-5964 doi: 10.1158/1078-0432.CCR-07-0702 [Abstract] [Full Text] [PDF]  

Exisulind in Combination with Celecoxib Modulates Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Cyclin D1 against Prostate Carcinogenesis: In vivo Evidence

Bhagavathi A. Narayanan, Bandaru S. Reddy, Maarten C. Bosland, Dominick Nargi, Lori Horton, Carla Randolph, and Narayanan K. Narayanan
Clin Cancer Res 2007 13: 5965-5973 doi: 10.1158/1078-0432.CCR-07-0744 [Abstract] [Full Text] [PDF]  

Genetic Variants in Cell Cycle Control Pathway Confer Susceptibility to Lung Cancer

Wei Wang, Margaret R. Spitz, Hushan Yang, Charles Lu, David J. Stewart, and Xifeng Wu
Clin Cancer Res 2007 13: 5974-5981 doi: 10.1158/1078-0432.CCR-07-0113 [Abstract] [Full Text] [PDF]  

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