The Biology Behind:

Rexinoids and Breast Cancer Prevention

Louise R. Howe
Clin Cancer Res 2007 13: 5983 -5987 doi: 10.1158/1078-0432.CCR-07-1065 [Full Text] [PDF]  

The Clinical Connection:

Phosphatidylinositol 3-Kinase in Breast Cancer: Where from Here?

Paradiso Angelo, Mangia Anita, Azzariti Amalia, and Tommasi Stefania
Clin Cancer Res 2007 13: 5988-5990 doi: 10.1158/1078-0432.CCR-07-1106 [Full Text] [PDF]  

Molecular Pathways:

The Universal Character of the Tumor-Associated Antigen Survivin

Mads Hald Andersen, Inge Marie Svane, Jürgen C. Becker, and Per thor Straten
Clin Cancer Res 2007 13: 5991-5994 doi: 10.1158/1078-0432.CCR-07-0686 [Abstract] [Full Text] [PDF]  

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

Domagoj Vucic and Wayne J. Fairbrother
Clin Cancer Res 2007 13: 5995-6000 doi: 10.1158/1078-0432.CCR-07-0729 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

De novo Identification of MIZ-1 (ZBTB17) Encoding a MYC-Interacting Zinc-Finger Protein as a New Favorable Neuroblastoma Gene

Naohiko Ikegaki, Takahiro Gotoh, Bing Kung, Justin S. Riceberg, David Y. Kim, Huaqing Zhao, Eric F. Rappaport, Sakeenah L. Hicks, Robert C. Seeger, and Xao X. Tang
Clin Cancer Res 2007 13: 6001-6009 doi: 10.1158/1078-0432.CCR-07-0071 [Abstract] [Full Text] [PDF]  

Canonical Nuclear Factor B Pathway Inhibition Blocks Myeloma Cell Growth and Induces Apoptosis in Strong Synergy with TRAIL

Mathilde Romagnoli, Grégoire Desplanques, Sophie Maïga, Steven Legouill, Michel Dreano, Régis Bataille, and Sophie Barillé-Nion
Clin Cancer Res 2007 13: 6010-6018 doi: 10.1158/1078-0432.CCR-07-0140 [Abstract] [Full Text] [PDF]  

Genome-Wide Allelotypes of Familial Pancreatic Adenocarcinomas and Familial and Sporadic Intraductal Papillary Mucinous Neoplasms

Tadayoshi Abe, Noriyoshi Fukushima, Kieran Brune, Corinne Boehm, Norihiro Sato, Hiroyuki Matsubayashi, Marcia Canto, Gloria M. Petersen, Ralph H. Hruban, and Michael Goggins
Clin Cancer Res 2007 13: 6019-6025 doi: 10.1158/1078-0432.CCR-07-0471 [Abstract] [Full Text] [PDF]  

Hyperdiploidy Is a Common Finding in Monoclonal Gammopathy of Undetermined Significance and Monosomy 13 Is Restricted to These Hyperdiploid Patients

Maud Brousseau, Xavier Leleu, Jérémie Gerard, Thomas Gastinne, Alban Godon, Franck Genevieve, Mamoun Dib, Jean-Luc Lai, Thierry Facon, Marc Zandecki for the Intergroupe Francophone du Myélome
Clin Cancer Res 2007 13: 6026-6031 doi: 10.1158/1078-0432.CCR-07-0031 [Abstract] [Full Text] [PDF]  

The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor B and Akt Activation

Urs von Holzen, Abujiang Pataer, Uma Raju, Dora Bocangel, Stephan A. Vorburger, Yanna Liu, Xiaolin Lu, Jack A. Roth, Bharat B. Aggarwal, Glen N. Barber, Khandan Keyomarsi, Kelly K. Hunt, and Stephen G. Swisher
Clin Cancer Res 2007 13: 6032-6039 doi: 10.1158/1078-0432.CCR-06-2932 [Abstract] [Full Text] [PDF]  

PrLZ Is Expressed in Normal Prostate Development and in Human Prostate Cancer Progression

Ruoxiang Wang, Jianchun Xu, Nicola Mabjeesh, Guodong Zhu, Jianguang Zhou, Mahul Amin, Dalin He, Fray F. Marshall, Haiyen E. Zhau, and Leland W.K. Chung
Clin Cancer Res 2007 13: 6040-6048 doi: 10.1158/1078-0432.CCR-07-0640 [Abstract] [Full Text] [PDF]  

Identification of a Met-Binding Peptide from a Phage Display Library

Ping Zhao, Tessa Grabinski, Chongfeng Gao, R. Scot Skinner, Troy Giambernardi, Yanli Su, Eric Hudson, James Resau, Milton Gross, George F. Vande Woude, Rick Hay, and Brian Cao
Clin Cancer Res 2007 13: 6049-6055 doi: 10.1158/1078-0432.CCR-07-0035 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Expression of X-Linked Inhibitor of Apoptosis Protein Is a Strong Predictor of Human Prostate Cancer Recurrence

David B. Seligson, Fumiya Hongo, Sara Huerta-Yepez, Yoichi Mizutani, Tsuneharu Miki, Hong Yu, Steve Horvath, David Chia, Lee Goodglick, and Benjamin Bonavida
Clin Cancer Res 2007 13: 6056-6063 doi: 10.1158/1078-0432.CCR-07-0960 [Abstract] [Full Text] [PDF]  

Different Prognostic Roles of Mutations in the Helical and Kinase Domains of the PIK3CA Gene in Breast Carcinomas

Mattia Barbareschi, Fiamma Buttitta, Lara Felicioni, Sabrina Cotrupi, Fabio Barassi, Maela Del Grammastro, Antonella Ferro, Paolo Dalla Palma, Enzo Galligioni, and Antonio Marchetti
Clin Cancer Res 2007 13: 6064-6069 doi: 10.1158/1078-0432.CCR-07-0266 [Abstract] [Full Text] [PDF]  

Evaluation of an ¹¹¹In-Radiolabeled Peptide as a Targeting and Imaging Agent for ErbB-2 Receptor–Expressing Breast Carcinomas

Senthil R. Kumar, Thomas P. Quinn, and Susan L. Deutscher
Clin Cancer Res 2007 13: 6070-6079 doi: 10.1158/1078-0432.CCR-07-0160 [Abstract] [Full Text] [PDF]  

Pharmacogenomic Predictor Discovery in Phase II Clinical Trials for Breast Cancer

Lajos Pusztai, Keith Anderson, and Kenneth R. Hess
Clin Cancer Res 2007 13: 6080-6086 doi: 10.1158/1078-0432.CCR-07-0809 [Abstract] [Full Text] [PDF]  

Synchronous Alterations of Wnt and Epidermal Growth Factor Receptor Signaling Pathways through Aberrant Methylation and Mutation in Non–Small Cell Lung Cancer

Makoto Suzuki, Hisayuki Shigematsu, Takahiro Nakajima, Rieko Kubo, Shinichiro Motohashi, Yasuo Sekine, Kiyoshi Shibuya, Toshihiko Iizasa, Kenzo Hiroshima, Yukio Nakatani, Adi F. Gazdar, and Takehiko Fujisawa
Clin Cancer Res 2007 13: 6087-6092 doi: 10.1158/1078-0432.CCR-07-0591 [Abstract] [Full Text] [PDF]  

Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

Lanlan Shen, Paul J. Catalano, Al B. Benson, III, Peter O'Dwyer, Stanley R. Hamilton, and Jean-Pierre J. Issa
Clin Cancer Res 2007 13: 6093-6098 doi: 10.1158/1078-0432.CCR-07-1011 [Abstract] [Full Text] [PDF]  

p53 Mutations in Deep Tissues Are More Strongly Associated with Recurrence than Mutation-Positive Mucosal Margins

Xiaohong Huang, Stelios Pateromichelakis, Allison Hills, Martyn Sherriff, Andrew Lyons, John Langdon, Edward Odell, Peter Morgan, John Harrison, and Max Partridge
Clin Cancer Res 2007 13: 6099-6106 doi: 10.1158/1078-0432.CCR-07-1369 [Abstract] [Full Text] [PDF]  

High Levels of B-Cell Activating Factor in Patients with Active Chronic Graft-Versus-Host Disease

Stefanie Sarantopoulos, Kristen E. Stevenson, Haesook T. Kim, Nazmim S. Bhuiya, Corey S. Cutler, Robert J. Soiffer, Joseph H. Antin, and Jerome Ritz
Clin Cancer Res 2007 13: 6107-6114 doi: 10.1158/1078-0432.CCR-07-1290 [Abstract] [Full Text] [PDF]  

Wwox and Ap2 Expression Levels Predict Tamoxifen Response

Gulnur Guler, Dimitrios Iliopoulos, Nilufer Guler, Cigdem Himmetoglu, Mutlu Hayran, and Kay Huebner
Clin Cancer Res 2007 13: 6115-6121 doi: 10.1158/1078-0432.CCR-07-1282 [Abstract] [Full Text] [PDF]  

High Promoter Methylation Levels of APC Predict Poor Prognosis in Sextant Biopsies from Prostate Cancer Patients

Rui Henrique, Franclim R. Ribeiro, Daniel Fonseca, Mohammad O. Hoque, André L. Carvalho, Vera L. Costa, Mafalda Pinto, Jorge Oliveira, Manuel R. Teixeira, David Sidransky, and Carmen Jerónimo
Clin Cancer Res 2007 13: 6122-6129 doi: 10.1158/1078-0432.CCR-07-1042 [Abstract] [Full Text] [PDF]  

Enhancing Fraction Predicts Clinical Outcome following First-Line Chemotherapy in Patients with Epithelial Ovarian Carcinoma

James P.B. O'Connor, Gordon C. Jayson, Alan Jackson, Dana Ghiorghiu, Bernadette M. Carrington, Chris J. Rose, Samantha J. Mills, Ric Swindell, Caleb Roberts, Claire L. Mitchell, and Geoffrey J.M. Parker
Clin Cancer Res 2007 13: 6130-6135 doi: 10.1158/1078-0432.CCR-07-0331 [Abstract] [Full Text] [PDF]  

A Half-Log Increase in BCR-ABL RNA Predicts a Higher Risk of Relapse in Patients with Chronic Myeloid Leukemia with an Imatinib-Induced Complete Cytogenetic Response

Richard D. Press, Chad Galderisi, Rui Yang, Carole Rempfer, Stephanie G. Willis, Michael J. Mauro, Brian J. Druker, and Michael W.N. Deininger
Clin Cancer Res 2007 13: 6136-6143 doi: 10.1158/1078-0432.CCR-07-1112 [Abstract] [Full Text] [PDF]  

Magnetic Resonance Imaging of the Breast Improves Detection of Invasive Cancer, Preinvasive Cancer, and Premalignant Lesions during Surveillance of Women at High Risk for Breast Cancer

Christopher C. Riedl, Lothar Ponhold, Daniel Flöry, Michael Weber, Regina Kroiss, Teresa Wagner, Michael Fuchsjäger, and Thomas H. Helbich
Clin Cancer Res 2007 13: 6144-6152 doi: 10.1158/1078-0432.CCR-07-1270 [Abstract] [Full Text] [PDF]  

DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma

Anjana A. Kulkarni, Marco Loddo, Elisabetta Leo, Mohammed Rashid, Kathryn L. Eward, Thomas R. Fanshawe, Jessica Butcher, Alison Frost, Jonathan A. Ledermann, Gareth H. Williams, and Kai Stoeber
Clin Cancer Res 2007 13: 6153-6161 doi: 10.1158/1078-0432.CCR-07-0671 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Novel Therapy with 2-Methoxyestradiol for the Treatment of Relapsed and Plateau Phase Multiple Myeloma

S. Vincent Rajkumar, Paul G. Richardson, Martha Q. Lacy, Angela Dispenzieri, Philip R. Greipp, Thomas E. Witzig, Robert Schlossman, Carolyn F. Sidor, Kenneth C. Anderson, and Morie A. Gertz
Clin Cancer Res 2007 13: 6162-6167 doi: 10.1158/1078-0432.CCR-07-0807 [Abstract] [Full Text] [PDF]  

Phase I Trial of Toll-Like Receptor 9 Agonist PF-3512676 with and Following Rituximab in Patients with Recurrent Indolent and Aggressive Non–Hodgkin's Lymphoma

John P. Leonard, Brian K. Link, Christos Emmanouilides, Stephanie A. Gregory, Daniel Weisdorf, Jeffrey Andrey, John Hainsworth, Joseph A. Sparano, Donald E. Tsai, Sandra Horning, Arthur M. Krieg, and George J. Weiner
Clin Cancer Res 2007 13: 6168-6174 doi: 10.1158/1078-0432.CCR-07-0815 [Abstract] [Full Text] [PDF]  

Efficacy and Safety of Single-Agent Pertuzumab, a Human Epidermal Receptor Dimerization Inhibitor, in Patients with Non–Small Cell Lung Cancer

Roy S. Herbst, Angela M. Davies, Ronald B. Natale, Thao P. Dang, Joan H. Schiller, Linda L. Garland, Vincent A. Miller, David Mendelson, Annick D. Van den Abbeele, Yulia Melenevsky, Daniel J. de Vries, David A. Eberhard, Benjamin Lyons, Stuart G. Lutzker, and Bruce E. Johnson
Clin Cancer Res 2007 13: 6175-6181 doi: 10.1158/1078-0432.CCR-07-0460 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacologic Study of Belotecan in Combination with Cisplatin in Patients with Previously Untreated Extensive-Stage Disease Small Cell Lung Cancer

Dae Ho Lee, Sang-We Kim, Kyun-Seop Bae, Jeong-Sook Hong, Cheolwon Suh, Yoon-Koo Kang, and Jung-Shin Lee
Clin Cancer Res 2007 13: 6182-6186 doi: 10.1158/1078-0432.CCR-07-0534 [Abstract] [Full Text] [PDF]  

Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

Ruth Plummer, Gerhardt Attard, Simon Pacey, Louise Li, Albiruni Razak, Rebecca Perrett, Mary Barrett, Ian Judson, Stan Kaye, Norma Lynn Fox, Wendy Halpern, Alfred Corey, Hilary Calvert, and Johann de Bono
Clin Cancer Res 2007 13: 6187-6194 doi: 10.1158/1078-0432.CCR-07-0950 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Antibody and CD8⁺ T Cell Responses against HER2/neu Required for Tumor Eradication after DNA Immunization with a Flt-3 Ligand Fusion Vaccine

Francesca Orlandi, Franco M. Venanzi, Antonio Concetti, Hanako Yamauchi, Shakuntala Tiwari, Larry Norton, Jedd D. Wolchok, Alan N. Houghton, and Polly D. Gregor
Clin Cancer Res 2007 13: 6195-6203 doi: 10.1158/1078-0432.CCR-07-0258 [Abstract] [Full Text] [PDF]  

Combination Treatment of Prostate Cancer Cell Lines with Bioactive Soy Isoflavones and Perifosine Causes Increased Growth Arrest and/or Apoptosis

Ruth L. Vinall, Kimberley Hwa, Paramita Ghosh, Chong-Xian Pan, Primo N. Lara, Jr., and Ralph W. de Vere White
Clin Cancer Res 2007 13: 6204-6216 doi: 10.1158/1078-0432.CCR-07-0600 [Abstract] [Full Text] [PDF]  

Adenovirally Delivered Tumor Necrosis Factor- Improves the Antiglioma Efficacy of Concomitant Radiation and Temozolomide Therapy

Bakhtiar Yamini, Xiaohong Yu, Peter Pytel, Nicholas Galanopoulos, Vinay Rawlani, Jula Veerapong, Kai Bickenbach, and Ralph R. Weichselbaum
Clin Cancer Res 2007 13: 6217-6223 doi: 10.1158/1078-0432.CCR-07-1421 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice

Yuxin Li, Yun Zhang, Jamal Hill, Qiang Shen, Hee-Tae Kim, Xiaochun Xu, Susan G. Hilsenbeck, Reid P. Bissonnette, William W. Lamph, and Powel H. Brown
Clin Cancer Res 2007 13: 6224-6231 doi: 10.1158/1078-0432.CCR-06-2681 [Abstract] [Full Text] [PDF]  

Telomere Shortening and Chromosomal Abnormalities in Intestinal Metaplasia of the Urinary Bladder

Michael J. Morton, Shaobo Zhang, Antonio Lopez-Beltran, Gregory T. MacLennan, John N. Eble, Rodolfo Montironi, Ming-Tse Sung, Puay-Hoon Tan, Suqin Zheng, Honghong Zhou, and Liang Cheng
Clin Cancer Res 2007 13: 6232-6236 doi: 10.1158/1078-0432.CCR-07-0121 [Abstract] [Full Text] [PDF]  

A New Rexinoid, NRX194204, Prevents Carcinogenesis in Both the Lung and Mammary Gland

Karen Liby, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Matthew D. Wood, Roshantha A. Chandraratna, and Michael B. Sporn
Clin Cancer Res 2007 13: 6237-6243 doi: 10.1158/1078-0432.CCR-07-1342 [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Potential Biomarkers in Metastatic Gastrointestinal Stromal Tumors

Michiel H. Strijbos, Jaco Kraan, Stefan Sleijfer, and Jan W. Gratama
Clin Cancer Res 2007 13: 6244 doi: 10.1158/1078-0432.CCR-07-1142 [Full Text] [PDF]  

Corrections:

Correction: Article on Pharmacokinetic Study of Vorinostat

Clin Cancer Res 2007 13: 6245 doi: 10.1158/1078-0432.CCR-13-20-COR1 [Full Text] [PDF]  

Correction: Article on La Autoantigen

Clin Cancer Res 2007 13: 6245 doi: 10.1158/1078-0432.CCR-13-20-COR2 [Full Text] [PDF]  

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