Editorials:

Biomarkers in Phase I Oncology Trials: Signal, Noise, or Expensive Distraction?

Mark J. Ratain and Robert H. Glassman
Clin Cancer Res 2007 13: 6545-6548 doi: 10.1158/1078-0432.CCR-07-2133 [Full Text] [PDF]  

Molecular Pathways:

Therapeutic Implications of Leukemic Stem Cell Pathways

Saranya Chumsri, William Matsui, and Angelika M. Burger
Clin Cancer Res 2007 13: 6549-6554 doi: 10.1158/1078-0432.CCR-07-1088 [Abstract] [Full Text] [PDF]  

The Epidermal Growth Factor Receptor: A Role in Repair of Radiation-Induced DNA Damage

David J. Chen and Chaitanya S. Nirodi
Clin Cancer Res 2007 13: 6555-6560 doi: 10.1158/1078-0432.CCR-07-1610 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Defining Cancer Cachexia in Head and Neck Squamous Cell Carcinoma

Luke M. Richey, Jonathan R. George, Marion E. Couch, Brian K. Kanapkey, Xiaoying Yin, Trinitia Cannon, Paul W. Stewart, Mark C. Weissler, and Carol G. Shores
Clin Cancer Res 2007 13: 6561-6567 doi: 10.1158/1078-0432.CCR-07-0116 [Abstract] [Full Text] [PDF]  

Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

Jay Friedman, Liesl Nottingham, Praveen Duggal, Francisco G. Pernas, Bin Yan, Xin Ping Yang, Zhong Chen, and Carter Van Waes
Clin Cancer Res 2007 13: 6568-6578 doi: 10.1158/1078-0432.CCR-07-1591 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer

Thorsten Schlomm, Patrick Kirstein, Liv Iwers, Birte Daniel, Thomas Steuber, Jochen Walz, Felix H.K. Chun, Alexander Haese, Jens Kollermann, Markus Graefen, Hartwig Huland, Guido Sauter, Ronald Simon, and Andreas Erbersdobler
Clin Cancer Res 2007 13: 6579-6584 doi: 10.1158/1078-0432.CCR-07-1257 [Abstract] [Full Text] [PDF]  

BAG-4/SODD and Associated Antiapoptotic Proteins Are Linked to Aggressiveness of Epithelial Ovarian Cancer

Christina M. Annunziata, Lilach Kleinberg, Ben Davidson, Aasmund Berner, David Gius, Nana Tchabo, Seth M. Steinberg, and Elise C. Kohn
Clin Cancer Res 2007 13: 6585-6592 doi: 10.1158/1078-0432.CCR-07-0327 [Abstract] [Full Text] [PDF]  

Defective Chromosome Segregation and Telomere Dysfunction in Aggressive Wilms' Tumors

Ylva Stewénius, Yuesheng Jin, Ingrid Øra, Jan de Kraker, Johannes Bras, Attila Frigyesi, Jan Alumets, Bengt Sandstedt, Alan K. Meeker, and David Gisselsson
Clin Cancer Res 2007 13: 6593-6602 doi: 10.1158/1078-0432.CCR-07-1081 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Phosphorylated Pak1 Level in the Cytoplasm Correlates with Shorter Survival Time in Patients with Glioblastoma

Hiroshi Aoki, Tomohisa Yokoyama, Keishi Fujiwara, Ana M. Tari, Raymond Sawaya, Dima Suki, Kenneth R. Hess, Kenneth D. Aldape, Seiji Kondo, Rakesh Kumar, and Yasuko Kondo
Clin Cancer Res 2007 13: 6603-6609 doi: 10.1158/1078-0432.CCR-07-0145 [Abstract] [Full Text] [PDF]  

[¹⁸F]Galacto-RGD Positron Emission Tomography for Imaging of vß3 Expression on the Neovasculature in Patients with Squamous Cell Carcinoma of the Head and Neck

Ambros J. Beer, Anca-Ligia Grosu, Janette Carlsen, Andreas Kolk, Mario Sarbia, Isabelle Stangier, Petra Watzlowik, Hans-Jürgen Wester, Roland Haubner, and Markus Schwaiger
Clin Cancer Res 2007 13: 6610-6616 doi: 10.1158/1078-0432.CCR-07-0528 [Abstract] [Full Text] [PDF]  

Circumferential Margin Involvement Is the Crucial Prognostic Factor after Multimodality Treatment in Patients with Locally Advanced Rectal Carcinoma

Marleen J.E.M. Gosens, René A. Klaassen, Ivonne Tan-Go, Harm J.T. Rutten, Hendrik Martijn, Adriaan J.C. van den Brule, Grard A.P. Nieuwenhuijzen, J. Han J.M. van Krieken, and Iris D. Nagtegaal
Clin Cancer Res 2007 13: 6617-6623 doi: 10.1158/1078-0432.CCR-07-1197 [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of KIF4A as a Prognostic Biomarker and Therapeutic Target for Lung Cancer

Masaya Taniwaki, Atsushi Takano, Nobuhisa Ishikawa, Wataru Yasui, Kouki Inai, Hitoshi Nishimura, Eiju Tsuchiya, Nobuoki Kohno, Yusuke Nakamura, and Yataro Daigo
Clin Cancer Res 2007 13: 6624-6631 doi: 10.1158/1078-0432.CCR-07-1328 [Abstract] [Full Text] [PDF] Supplementary Data  

Prognostic Significance of p53 and X-ray Repair Cross-complementing Group 1 Polymorphisms on Prostate-Specific Antigen Recurrence in Prostate Cancer Post–Radical Prostatectomy

Shu-Pin Huang, Chao-Yuan Huang, Jyh-Seng Wang, Chia-Chu Liu, Yeong-Shiau Pu, Hong-Jeng Yu, Chia-Cheng Yu, Tony T. Wu, Chun-Hsiung Huang, Wen-Jeng Wu, Yii-Her Chou, and Ming-Tsang Wu
Clin Cancer Res 2007 13: 6632-6638 doi: 10.1158/1078-0432.CCR-07-1437 [Abstract] [Full Text] [PDF]  

In vivo Diagnosis of Epidermal Growth Factor Receptor Expression using Molecular Imaging with a Cocktail of Optically Labeled Monoclonal Antibodies

Tristan Barrett, Yoshinori Koyama, Yukihiro Hama, Gregory Ravizzini, In Soo Shin, Beom-Su Jang, Chang H. Paik, Yasuteru Urano, Peter L. Choyke, and Hisataka Kobayashi
Clin Cancer Res 2007 13: 6639-6648 Published Online First November 2, 2007. doi: 10.1158/1078-0432.CCR-07-1119 [Abstract] [Full Text] [PDF] Supplementary Data  

Inverse Prognostic Impact of Angiogenic Marker Expression in Tumor Cells versus Stromal Cells in Non–Small Cell Lung Cancer

Tom Donnem, Samer Al-Saad, Khalid Al-Shibli, Marit P. Delghandi, Magnus Persson, Marit N. Nilsen, Lill-Tove Busund, and Roy M. Bremnes
Clin Cancer Res 2007 13: 6649-6657 doi: 10.1158/1078-0432.CCR-07-0414 [Abstract] [Full Text] [PDF]  

A Promoter Methylation Pattern in the N-Methyl-D-Aspartate Receptor 2B Gene Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma

Myoung Sook Kim, Keishi Yamashita, Young Kwang Chae, Yutaka Tokumaru, Xiaofei Chang, Marianna Zahurak, Motonobu Osada, Hannah Lui Park, Alice Chuang, Joseph A. Califano, and David Sidransky
Clin Cancer Res 2007 13: 6658-6665 doi: 10.1158/1078-0432.CCR-07-1178 [Abstract] [Full Text] [PDF] Supplementary Data  

Distribution Patterns of Dendritic Cells and T Cells in Diffuse Large B-Cell Lymphomas Correlate with Prognoses

Kung-Chao Chang, Guan-Cheng Huang, Dan Jones, and Ya-Hui Lin
Clin Cancer Res 2007 13: 6666-6672 doi: 10.1158/1078-0432.CCR-07-0504 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase Single-Nucleotide Polymorphisms and Haplotypes Predict Breast Cancer Progression

Simon Hughes, Olorunsola Agbaje, Rebecca L. Bowen, Deborah L. Holliday, Jacqueline A. Shaw, Stephen Duffy, and J. Louise Jones
Clin Cancer Res 2007 13: 6673-6680 doi: 10.1158/1078-0432.CCR-07-0884 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Prognostic Factors Related to Clinical Response in Patients with Metastatic Melanoma Treated by CTL-Associated Antigen-4 Blockade

Stephanie G. Downey, Jacob A. Klapper, Franz O. Smith, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, Marybeth S. Hughes, Tamika E. Allen, Catherine L. Levy, Michael Yellin, Geoffrey Nichol, Donald E. White, Seth M. Steinberg, and Steven A. Rosenberg
Clin Cancer Res 2007 13: 6681-6688 Published Online First November 2, 2007. doi: 10.1158/1078-0432.CCR-07-0187 [Abstract] [Full Text] [PDF]  

Phase 2 Study of ABT-510 in Patients with Previously Untreated Advanced Renal Cell Carcinoma

Scot Ebbinghaus, Maha Hussain, Nizar Tannir, Michael Gordon, Apurva A. Desai, Raymond A. Knight, Rod A. Humerickhouse, Jiang Qian, Gary B. Gordon, and Robert Figlin
Clin Cancer Res 2007 13: 6689-6695 doi: 10.1158/1078-0432.CCR-07-1477 [Abstract] [Full Text] [PDF]  

Response to [⁹⁰Yttrium-DOTA]-TOC Treatment is Associated with Long-term Survival Benefit in Metastasized Medullary Thyroid Cancer: A Phase II Clinical Trial

Fabienne Iten, Beat Müller, Christian Schindler, Christoph Rochlitz, Daniel Oertli, Helmut R. Mäcke, Jan Müller-Brand, and Martin A. Walter
Clin Cancer Res 2007 13: 6696-6702 doi: 10.1158/1078-0432.CCR-07-0935 [Abstract] [Full Text] [PDF]  

Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer Patients

Paula Schaiquevich, John C. Panetta, Lisa C. Iacono, Burgess B. Freeman, III, Victor M. Santana, Amar Gajjar, and Clinton F. Stewart
Clin Cancer Res 2007 13: 6703-6711 doi: 10.1158/1078-0432.CCR-07-1376 [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I Trial of Single-Dose Temozolomide and Continuous Administration of O⁶-Benzylguanine in Children with Brain Tumors: a Pediatric Brain Tumor Consortium Report

Alberto Broniscer, Sridharan Gururangan, Tobey J. MacDonald, Stewart Goldman, Roger J. Packer, Clinton F. Stewart, Dana Wallace, Mary K. Danks, Henry S. Friedman, Tina Y. Poussaint, Larry E. Kun, James M. Boyett, Amar Gajjar for the Pediatric Brain Tumor Consortium
Clin Cancer Res 2007 13: 6712-6718 doi: 10.1158/1078-0432.CCR-07-1016 [Abstract] [Full Text] [PDF] Supplementary Data  

Trends in the Use and Role of Biomarkers in Phase I Oncology Trials

Bernardo H.L. Goulart, Jeffrey W. Clark, Homer H. Pien, Thomas G. Roberts, Stan N. Finkelstein, and Bruce A. Chabner
Clin Cancer Res 2007 13: 6719-6726 doi: 10.1158/1078-0432.CCR-06-2860 [Abstract] [Full Text] [PDF]  

Association of Intratumoral Vascular Endothelial Growth Factor Expression and Clinical Outcome for Patients with Gastrointestinal Stromal Tumors Treated with Imatinib Mesylate

John C. McAuliffe, Alexander J.F. Lazar, Dan Yang, Dejka M. Steinert, Wei Qiao, Peter F. Thall, A. Kevin Raymond, Robert S. Benjamin, and Jonathan C. Trent
Clin Cancer Res 2007 13: 6727-6734 doi: 10.1158/1078-0432.CCR-07-0895 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Preclinical:

AMG 102, A Fully Human Anti-Hepatocyte Growth Factor/Scatter Factor Neutralizing Antibody, Enhances the Efficacy of Temozolomide or Docetaxel in U-87 MG Cells and Xenografts

H. Toni Jun, Jan Sun, Karen Rex, Robert Radinsky, Richard Kendall, Angela Coxon, and Teresa L. Burgess
Clin Cancer Res 2007 13: 6735-6742 doi: 10.1158/1078-0432.CCR-06-2969 [Abstract] [Full Text] [PDF]  

1,1-Bis(3'-Indolyl)-1-(p-Substitutedphenyl)methanes Induce Apoptosis and Inhibit Renal Cell Carcinoma Growth

Melissa York, Maen Abdelrahim, Sudhakar Chintharlapalli, Salina D. Lucero, and Stephen Safe
Clin Cancer Res 2007 13: 6743-6752 doi: 10.1158/1078-0432.CCR-07-0967 [Abstract] [Full Text] [PDF]  

Schisandrin B Prevents Doxorubicin-Induced Cardiotoxicity via Enhancing Glutathione Redox Cycling

Ling Li, Qiangrong Pan, Weidong Han, Zhen Liu, Ling Li, and Xun Hu
Clin Cancer Res 2007 13: 6753-6760 doi: 10.1158/1078-0432.CCR-07-1579 [Abstract] [Full Text] [PDF]  

Normal Brain Cells Contribute to the Bystander Effect in Suicide Gene Therapy of Malignant Glioma

Hrvoje Miletic, Yvonne Heidemarie Fischer, Tsanan Giroglou, Maria Adele Rueger, Alexandra Winkeler, Huongfeng Li, Uwe Himmelreich, Werner Stenzel, Andreas H. Jacobs, and Dorothee von Laer
Clin Cancer Res 2007 13: 6761-6768 doi: 10.1158/1078-0432.CCR-07-1240 [Abstract] [Full Text] [PDF]  

Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma

Sabiha Abbas, Anindita Bhoumik, Russell Dahl, Stefan Vasile, Stan Krajewski, Nicholas D.P. Cosford, and Ze'ev A. Ronai
Clin Cancer Res 2007 13: 6769-6778 doi: 10.1158/1078-0432.CCR-07-1536 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunity against Tumor Angiogenesis Induced by a Fusion Vaccine with Murine ß-Defensin 2 and mFlk-1

Yong-sheng Wang, Guo-qing Wang, Yan-jun Wen, Lian Wang, Xian-cheng Chen, Ping Chen, Bin Kan, Jiong Li, Canhua Huang, You Lu, Qin Zhou, Ning Xu, Dan Li, Ling-yu Fan, Tao Yi, Hong-bo Wu, and Yu-quan Wei
Clin Cancer Res 2007 13: 6779-6787 doi: 10.1158/1078-0432.CCR-07-1587 [Abstract] [Full Text] [PDF]  

Relationship of EGFR Mutations, Expression, Amplification, and Polymorphisms to Epidermal Growth Factor Receptor Inhibitors in the NCI60 Cell Lines

Wanqing Liu, Xiaolin Wu, Wei Zhang, Raquel C. Montenegro, Donna Lee Fackenthal, Jared A. Spitz, Lyn Mickley Huff, Federico Innocenti, Soma Das, Edwin H. Cook,, Jr., Nancy J. Cox, Susan E. Bates, and Mark J. Ratain
Clin Cancer Res 2007 13: 6788-6795 doi: 10.1158/1078-0432.CCR-07-0547 [Abstract] [Full Text] [PDF]  

A Mycoplasma Peptide Elicits Heteroclitic CD4⁺ T Cell Responses against Tumor Antigen MAGE-A6

Lazar Vujanovic, Maja Mandic, Walter C. Olson, John M. Kirkwood, and Walter J. Storkus
Clin Cancer Res 2007 13: 6796-6806 doi: 10.1158/1078-0432.CCR-07-1909 [Abstract] [Full Text] [PDF]  

Gene Expression Analysis Proposes Alternative Pathways for the Mechanism by Which Celecoxib Selectively Inhibits the Growth of Transformed but not Normal Enterocytes

Eyal Sagiv, Uri Rozovski, Diana Kazanov, Eliezer Liberman, and Nadir Arber
Clin Cancer Res 2007 13: 6807-6815 doi: 10.1158/1078-0432.CCR-07-1091 [Abstract] [Full Text] [PDF]  

Radiosensitization by the Histone Deacetylase Inhibitor PCI-24781

Carmen A. Banuelos, Judit P. Banáth, Susan H. MacPhail, Jin Zhao, Tarren Reitsema, and Peggy L. Olive
Clin Cancer Res 2007 13: 6816-6826 doi: 10.1158/1078-0432.CCR-07-1126 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Protein Kinase Cß by Enzastaurin Enhances Radiation Cytotoxicity in Pancreatic Cancer

Aaron C. Spalding, Richard Watson, Mary E. Davis, Alex C. Kim, Theodore S. Lawrence, and Edgar Ben-Josef
Clin Cancer Res 2007 13: 6827-6833 doi: 10.1158/1078-0432.CCR-07-0454 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Susceptibility and Prevention:

Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF

Gregory R. Bean, Andrew D. Bryson, Patrick G. Pilie, Vanessa Goldenberg, Joseph C. Baker, Jr., Catherine Ibarra, Danielle M.U. Brander, Carolyn Paisie, Natalie R. Case, Mona Gauthier, Paul A. Reynolds, Eric Dietze, Julie Ostrander, Victoria Scott, Lee G. Wilke, Lisa Yee, Bruce F. Kimler, Carol J. Fabian, Carola M. Zalles, Gloria Broadwater, Thea D. Tlsty, and Victoria L. Seewaldt
Clin Cancer Res 2007 13: 6834-6841 doi: 10.1158/1078-0432.CCR-07-0407 [Abstract] [Full Text] [PDF]  

Annexin XI Is Associated with Cisplatin Resistance and Related to Tumor Recurrence in Ovarian Cancer Patients

Jin Song, Ie-ming Shih, Ritu Salani, Daniel W. Chan, and Zhen Zhang
Clin Cancer Res 2007 13: 6842-6849 Published Online First November 2, 2007. doi: 10.1158/1078-0432.CCR-07-0569 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Zoledronic Acid and Angiogenesis

Gianluigi Ferretti, Alessandra Fabi, Paolo Carlini, Paola Papaldo, Alessandra Felici, Silverio Tomao, and Francesco Cognetti
Clin Cancer Res 2007 13: 6850 doi: 10.1158/1078-0432.CCR-07-4036 [Full Text] [PDF]  

Zoledronic Acid and Angiogenesis

Daniele Santini, Bruno Vincenzi, and Giuseppe Tonini
Clin Cancer Res 2007 13: 6850-6851 doi: 10.1158/1078-0432.CCR-07-4408 [Full Text] [PDF]  

New Approaches to Assessing and Treating Early-Stage Colon and Rectal Cancers:

New Approaches to Assessing and Treating Early-Stage Colon and Rectal Cancer: Summary Statement from 2007 Santa Monica Conference

Lee S. Rosen, Anton J. Bilchik, Robert W. Beart, Jr., Al B. Benson, III, Kenneth J. Chang, Carolyn C. Compton, Axel Grothey, Daniel G. Haller, Clifford Y. Ko, Patrick M. Lynch, Heidi Nelson, Michael J. Stamos, Roderick R. Turner, and Christopher G. Willett
Clin Cancer Res 2007 13: 6853s-6856s doi: 10.1158/1078-0432.CCR-07-1629 [Abstract] [Full Text] [PDF]  

New Issues in Genetic Counseling of Hereditary Colon Cancer

Patrick M. Lynch
Clin Cancer Res 2007 13: 6857s-6861s doi: 10.1158/1078-0432.CCR-07-1124 [Abstract] [Full Text] [PDF]  

Optimal Pathologic Staging: Defining Stage II Disease

Carolyn C. Compton
Clin Cancer Res 2007 13: 6862s-6870s doi: 10.1158/1078-0432.CCR-07-1398 [Abstract] [Full Text] [PDF]  

Newer Pathologic Assessment Techniques for Colorectal Carcinoma

Roderick R. Turner, Carolyn Li, and Carolyn C. Compton
Clin Cancer Res 2007 13: 6871s-6876s doi: 10.1158/1078-0432.CCR-07-1151 [Abstract] [Full Text] [PDF]  

Optimal Methods for Staging Rectal Cancer

V. Raman Muthusamy and Kenneth J. Chang
Clin Cancer Res 2007 13: 6877s-6884s doi: 10.1158/1078-0432.CCR-07-1137 [Abstract] [Full Text] [PDF]  

Management of Early Rectal T1 and T2 Cancers

Michael J. Stamos and Zuri Murrell
Clin Cancer Res 2007 13: 6885s-6889s doi: 10.1158/1078-0432.CCR-07-1150 [Abstract] [Full Text] [PDF]  

Multidisciplinary Management of Patients with Advanced Rectal Cancer

Robert W. Beart, Jr.
Clin Cancer Res 2007 13: 6890s-6893s doi: 10.1158/1078-0432.CCR-07-1135 [Abstract] [Full Text] [PDF]  

Colon and Rectal Cancer: Laparoscopic or Open?

Anne-Marie Boller and Heidi Nelson
Clin Cancer Res 2007 13: 6894s-6896s doi: 10.1158/1078-0432.CCR-07-1138 [Abstract] [Full Text] [PDF]  

Quality of Care Issues in Colorectal Cancer

Michael J. Leonardi, Marcia L. McGory, and Clifford Y. Ko
Clin Cancer Res 2007 13: 6897s-6902s doi: 10.1158/1078-0432.CCR-07-1123 [Abstract] [Full Text] [PDF]  

Radiation Therapy in Stage II and III Rectal Cancer

Christopher G. Willett, Brian G. Czito, and Johanna C. Bendell
Clin Cancer Res 2007 13: 6903s-6908s doi: 10.1158/1078-0432.CCR-07-1158 [Abstract] [Full Text] [PDF]  

Biological Therapy and Other Novel Therapies in Early-Stage Disease: Are They Appropriate?

Axel Grothey
Clin Cancer Res 2007 13: 6909s-6912s doi: 10.1158/1078-0432.CCR-07-1125 [Abstract] [Full Text] [PDF]  

New Approaches to Assessing and Treating Early-Stage Colon and Rectal Cancers: Cooperative Group Strategies for Assessing Optimal Approaches in Early-Stage Disease

Al B. Benson, III
Clin Cancer Res 2007 13: 6913s-6920s doi: 10.1158/1078-0432.CCR-07-1188 [Abstract] [Full Text] [PDF]  

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