FISH analysis of EGFR (red signals) and centromere 7 (green signals) copy numbers in a highly amplified prostate cancer with more than 20 EGFR signals per cell. EGFR amplification was heterogeneous in this cancer and could only be found in about 30% of the tumor volume. The remaining cancer had 2-4 centromere 7 and 2-4 EGFR copies per cell. For further details, please see the article by Schlomm and associates on page 6579 of this issue.

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