The Biology Behind:

The Dynamics of Estrogen Receptor Status in Breast Cancer: Re-shaping the Paradigm

Sara Lopez-Tarruella and Rachel Schiff
Clin Cancer Res 2007 13: 6921 -6925 doi: 10.1158/1078-0432.CCR-07-1399 [Full Text] [PDF]  

Molecular Pathways:

Interleukin-21 Signaling: Functions in Cancer and Autoimmunity

Ian D. Davis, Kresten Skak, Mark J. Smyth, Paul E.G. Kristjansen, Dennis M. Miller, and Pallavur V. Sivakumar
Clin Cancer Res 2007 13: 6926-6932 doi: 10.1158/1078-0432.CCR-07-1238 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker?

The German Glioma Network, Michael Weller, Hilmar Berger, Christian Hartmann, Johannes Schramm, Manfred Westphal, Matthias Simon, Roland Goldbrunner, Dietmar Krex, Joachim P. Steinbach, Christoph B. Ostertag, Markus Loeffler, Torsten Pietsch, and Andreas von Deimling
Clin Cancer Res 2007 13: 6933-6937 doi: 10.1158/1078-0432.CCR-07-0573 [Abstract] [Full Text] [PDF]  

E2F1 Overexpression Correlates with Thymidylate Synthase and Survivin Gene Expressions and Tumor Proliferation in Non–Small-Cell Lung Cancer

Cheng-long Huang, Dage Liu, Jun Nakano, Hiroyasu Yokomise, Masaki Ueno, Kyuichi Kadota, and Hiromi Wada
Clin Cancer Res 2007 13: 6938-6946 doi: 10.1158/1078-0432.CCR-07-1539 [Abstract] [Full Text] [PDF]  

CD8⁺ Foxp3⁺ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

Yukiko Kiniwa, Yoshihiro Miyahara, Helen Y. Wang, Weiyi Peng, Guangyong Peng, Thomas M. Wheeler, Timothy C. Thompson, Lloyd J. Old, and Rong-Fu Wang
Clin Cancer Res 2007 13: 6947-6958 doi: 10.1158/1078-0432.CCR-07-0842 [Abstract] [Full Text] [PDF]  

Prognostic Role of HuR in Hereditary Breast Cancer

Mira Heinonen, Rainer Fagerholm, Kirsimari Aaltonen, Outi Kilpivaara, Kristiina Aittomäki, Carl Blomqvist, Päivi Heikkilä, Caj Haglund, Heli Nevanlinna, and Ari Ristimäki
Clin Cancer Res 2007 13: 6959-6963 doi: 10.1158/1078-0432.CCR-07-1432 [Abstract] [Full Text] [PDF]  

Notch-1 Mutations Are Secondary Events in Some Patients with T-Cell Acute Lymphoblastic Leukemia

Marc R. Mansour, Veronique Duke, Letizia Foroni, Bella Patel, Christopher G. Allen, Phil J. Ancliff, Rosemary E. Gale, and David C. Linch
Clin Cancer Res 2007 13: 6964-6969 doi: 10.1158/1078-0432.CCR-07-1474 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Stem Cell Marker Nestin and c-Jun NH₂-Terminal Kinases in Tumor and Peritumor Areas of Glioblastoma Multiforme: Possible Prognostic Implications

Annunziato Mangiola, Gina Lama, Cecilia Giannitelli, Pasquale De Bonis, Carmelo Anile, Libero Lauriola, Giuseppe La Torre, Giovanni Sabatino, Giulio Maira, Meena Jhanwar-Uniyal, and Gigliola Sica
Clin Cancer Res 2007 13: 6970-6977 doi: 10.1158/1078-0432.CCR-07-1229 [Abstract] [Full Text] [PDF]  

Novel Markers of Subclinical Disease for Ewing Family Tumors from Gene Expression Profiling

Irene Y. Cheung, Yi Feng, Karen Danis, Neerav Shukla, Paul Meyers, Marc Ladanyi, and Nai-Kong V. Cheung
Clin Cancer Res 2007 13: 6978-6983 doi: 10.1158/1078-0432.CCR-07-1417 [Abstract] [Full Text] [PDF]  

A Multiparametric Panel for Ovarian Cancer Diagnosis, Prognosis, and Response to Chemotherapy

Yingye Zheng, Dionyssios Katsaros, Shannon J.C. Shan, Irene Rigault de la Longrais, Mauro Porpiglia, Andreas Scorilas, Nam W. Kim, Robert L. Wolfert, Iris Simon, Lin Li, Ziding Feng, and Eleftherios P. Diamandis
Clin Cancer Res 2007 13: 6984-6992 doi: 10.1158/1078-0432.CCR-07-1409 [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma

Rainer Riesenberg, Christoph Weiler, Oliver Spring, Martin Eder, Alexander Buchner, Tanja Popp, Mirna Castro, Robert Kammerer, Osamu Takikawa, Rudolf A. Hatz, Christian G. Stief, Alfons Hofstetter, and Wolfgang Zimmermann
Clin Cancer Res 2007 13: 6993-7002 doi: 10.1158/1078-0432.CCR-07-0942 [Abstract] [Full Text] [PDF]  

A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer

Karsten Gravdal, Ole J. Halvorsen, Svein A. Haukaas, and Lars A. Akslen
Clin Cancer Res 2007 13: 7003-7011 doi: 10.1158/1078-0432.CCR-07-1263 [Abstract] [Full Text] [PDF]  

Inhibition of the Intrinsic Apoptosis Pathway Downstream of Caspase-9 Activation Causes Chemotherapy Resistance in Diffuse Large B-Cell Lymphoma

Saskia A.G.M. Cillessen, Corine J. Hess, Erik Hooijberg, Kitty C.M. Castricum, Pim Kortman, Fedor Denkers, Wim Vos, Mark A. van de Wiel, Gerrit J. Schuurhuis, Gert J. Ossenkoppele, Chris J.L.M. Meijer, and Joost J. Oudejans
Clin Cancer Res 2007 13: 7012-7021 doi: 10.1158/1078-0432.CCR-06-2891 [Abstract] [Full Text] [PDF]  

Gain of 1q Is a Potential Univariate Negative Prognostic Marker for Survival in Medulloblastoma

Ken C. Lo, Changxing Ma, Brian N. Bundy, Scott L. Pomeroy, Charles G. Eberhart, and John K. Cowell
Clin Cancer Res 2007 13: 7022-7028 doi: 10.1158/1078-0432.CCR-07-1420 [Abstract] [Full Text] [PDF]  

Reversal of the Estrogen Receptor–Negative Phenotype in Breast Cancer and Restoration of Antiestrogen Response

Jill Bayliss, Amy Hilger, Prakash Vishnu, Kathleen Diehl, and Dorraya El-Ashry
Clin Cancer Res 2007 13: 7029-7036 doi: 10.1158/1078-0432.CCR-07-0587 [Abstract] [Full Text] [PDF]  

Telomere DNA Content Predicts Breast Cancer–Free Survival Interval

Christopher M. Heaphy, Kathy B. Baumgartner, Marco Bisoffi, Richard N. Baumgartner, and Jeffrey K. Griffith
Clin Cancer Res 2007 13: 7037-7043 doi: 10.1158/1078-0432.CCR-07-0432 [Abstract] [Full Text] [PDF]  

NOXA and PUMA Expression Add to Clinical Markers in Predicting Biochemical Recurrence of Prostate Cancer Patients in a Survival Tree Model

Jean-Simon Diallo, Abdulhadi Aldejmah, Abdelali Filali Mouhim, Benjamin Péant, Mona Alam Fahmy, Ismaël Hervé Koumakpayi, Kanishka Sircar, Louis R. Bégin, Anne-Marie Mes-Masson, and Fred Saad
Clin Cancer Res 2007 13: 7044-7052 doi: 10.1158/1078-0432.CCR-07-1224 [Abstract] [Full Text] [PDF]  

Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer

Daniel C. Danila, Glenn Heller, Gretchen A. Gignac, Rita Gonzalez-Espinoza, Aseem Anand, Erika Tanaka, Hans Lilja, Lawrence Schwartz, Steven Larson, Martin Fleisher, and Howard I. Scher
Clin Cancer Res 2007 13: 7053-7058 doi: 10.1158/1078-0432.CCR-07-1506 [Abstract] [Full Text] [PDF]  

Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

Claire H. Seedhouse, Martin Grundy, Paul White, Yun Li, Janet Fisher, Darya Yakunina, Anthony V. Moorman, Terence Hoy, Nigel Russell, Alan Burnett, and Monica Pallis
Clin Cancer Res 2007 13: 7059-7066 doi: 10.1158/1078-0432.CCR-07-1484 [Abstract] [Full Text] [PDF] Supplementary Data  

High-risk Human Papillomavirus E7 Oncoprotein Detection in Cervical Squamous Cell Carcinoma

Sigrun Ressler, René Scheiden, Kerstin Dreier, Andreas Laich, Elisabeth Müller-Holzner, Haymo Pircher, Dieter Morandell, Ines Stein, Hans-Peter Viertler, Frédéric R. Santer, Andreas Widschwendter, Jos Even, Pidder Jansen-Dürr, Catherine Capesius, and Werner Zwerschke
Clin Cancer Res 2007 13: 7067-7072 doi: 10.1158/1078-0432.CCR-07-1222 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Benefit of Complete Response in Multiple Myeloma Limited to High-Risk Subgroup Identified by Gene Expression Profiling

Jeffrey Haessler, John D. Shaughnessy, Jr., Fenghuang Zhan, John Crowley, Joshua Epstein, Frits van Rhee, Elias Anaissie, Mauricio Pineda-Roman, Maurizio Zangari, Klaus Hollmig, Abid Mohiuddin, Yazan Alsayed, Antje Hoering, Guido Tricot, and Bart Barlogie
Clin Cancer Res 2007 13: 7073-7079 doi: 10.1158/1078-0432.CCR-07-0527 [Abstract] [Full Text] [PDF] Supplementary Data  

BCR-ABL Messenger RNA Levels Continue to Decline in Patients with Chronic Phase Chronic Myeloid Leukemia Treated with Imatinib for More Than 5 Years and Approximately Half of All First-Line Treated Patients Have Stable Undetectable BCR-ABL Using Strict Sensitivity Criteria

Susan Branford, John F. Seymour, Andrew Grigg, Chris Arthur, Zbigniew Rudzki, Kevin Lynch, and Timothy Hughes
Clin Cancer Res 2007 13: 7080-7085 doi: 10.1158/1078-0432.CCR-07-0844 [Abstract] [Full Text] [PDF]  

Pilot Study of Neoadjuvant Treatment with Erlotinib in Nonmetastatic Head and Neck Squamous Cell Carcinoma

Fabienne Thomas, Philippe Rochaix, Adil Benlyazid, Jérôme Sarini, Michel Rives, Jean Louis Lefebvre, Ben C. Allal, Frédéric Courbon, Etienne Chatelut, and Jean-Pierre Delord
Clin Cancer Res 2007 13: 7086-7092 doi: 10.1158/1078-0432.CCR-07-1370 [Abstract] [Full Text] [PDF]  

Glucocorticoids in the Treatment of Children with Acute Lymphoblastic Leukemia and Hodgkin's Disease: A Pilot Study on the Adverse Psychological Reactions and Possible Associations with Neurobiological, Endocrine, and Genetic Markers

Rosemarie Felder-Puig, Christiane Scherzer, Michaela Baumgartner, Magdalena Ortner, Claudia Aschenbrenner, Christian Bieglmayer, Till Voigtländer, E. Renate Panzer-Grümayer, Wim J.E. Tissing, Jan W. Koper, Karl Steinberger, Christian Nasel, Helmut Gadner, Reinhard Topf, and Michael Dworzak
Clin Cancer Res 2007 13: 7093-7100 doi: 10.1158/1078-0432.CCR-07-0902 [Abstract] [Full Text] [PDF]  

A Phase I Trial of Lenalidomide in Patients with Recurrent Primary Central Nervous System Tumors

Howard A. Fine, Lyndon Kim, Paul S. Albert, J. Paul Duic, Hilary Ma, Wei Zhang, Tanyifor Tohnya, William D. Figg, and Cheryl Royce
Clin Cancer Res 2007 13: 7101-7106 doi: 10.1158/1078-0432.CCR-07-1546 [Abstract] [Full Text] [PDF]  

Negative Effect of DNA Hypermethylation on the Outcome of Intensive Chemotherapy in Older Patients with High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia following Myelodysplastic Syndrome

Michael Grövdal, Rasheed Khan, Anni Aggerholm, Petar Antunovic, Jan Astermark, Per Bernell, Lena-Maria Engström, Lars Kjeldsen, Olle Linder, Lars Nilsson, Anna Olsson, Jonas Wallvik, Jon Magnus Tangen, Gunnar Öberg, Sten Eirik Jacobsen, Peter Hokland, Anna Porwit, and Eva Hellström-Lindberg
Clin Cancer Res 2007 13: 7107-7112 doi: 10.1158/1078-0432.CCR-07-1193 [Abstract] [Full Text] [PDF]  

Phase I Evaluation of CDP791, a PEGylated Di-Fab' Conjugate that Binds Vascular Endothelial Growth Factor Receptor 2

N.C. Ton, G.J.M. Parker, A. Jackson, S. Mullamitha, G.A. Buonaccorsi, C. Roberts, Y. Watson, K. Davies, S. Cheung, L. Hope, F. Power, J. Lawrance, J. Valle, M. Saunders, R. Felix, J.A. Soranson, L. Rolfe, K. Zinkewich-Peotti, and G.C. Jayson
Clin Cancer Res 2007 13: 7113-7118 doi: 10.1158/1078-0432.CCR-07-1550 [Abstract] [Full Text] [PDF]  

First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer

Arkadiusz Z. Dudek, Carla Yunis, Lester I. Harrison, Sandeep Kumar, Ronald Hawkinson, Sarah Cooley, John P. Vasilakos, Kevin S. Gorski, and Jeffrey S. Miller
Clin Cancer Res 2007 13: 7119-7125 doi: 10.1158/1078-0432.CCR-07-1443 [Abstract] [Full Text] [PDF]  

Lack of Association of Single-Nucleotide Polymorphisms in Pregnane X Receptor, Hepatic Nuclear Factor 4, and Constitutive Androstane Receptor with Docetaxel Pharmacokinetics

Lai-San Tham, Nicholas H.G. Holford, Sok-Ying Hor, Theresa Tan, Lingzhi Wang, Rui-Chen Lim, How-Sung Lee, Soo-Chin Lee, and Boon-Cher Goh
Clin Cancer Res 2007 13: 7126-7132 doi: 10.1158/1078-0432.CCR-07-1276 [Abstract] [Full Text] [PDF]  

Phase I Study of Temozolomide and Irinotecan for Recurrent Malignant Gliomas in Patients Receiving Enzyme-Inducing Antiepileptic Drugs: A North American Brain Tumor Consortium Study

Monica E. Loghin, Michael D. Prados, Patrick Wen, Larry Junck, Frank Lieberman, Howard Fine, Karen L. Fink, Minesh Metha, John Kuhn, Kathleen Lamborn, Susan M. Chang, Timothy Cloughesy, Lisa M. DeAngelis, Ian H. Robins, Kenneth D. Aldape, and W.K. Alfred Yung
Clin Cancer Res 2007 13: 7133-7138 doi: 10.1158/1078-0432.CCR-07-0874 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment

Hajime Orita, Jonathan Coulter, Colleen Lemmon, Ellen Tully, Aravinda Vadlamudi, Susan M. Medghalchi, Francis P. Kuhajda, and Edward Gabrielson
Clin Cancer Res 2007 13: 7139-7145 Published Online First December 3, 2007. doi: 10.1158/1078-0432.CCR-07-1186 [Abstract] [Full Text] [PDF]  

Nutritional Modulation of Antitumor Efficacy and Diarrhea Toxicity Related to Irinotecan Chemotherapy in Rats Bearing the Ward Colon Tumor

Hongyu Xue, Michael B. Sawyer, Catherine J. Field, Levinus A. Dieleman, and Vickie E. Baracos
Clin Cancer Res 2007 13: 7146-7154 doi: 10.1158/1078-0432.CCR-07-0823 [Abstract] [Full Text] [PDF]  

Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme

Chunsheng Liu, Jann N. Sarkaria, Cory A. Petell, Georgia Paraskevakou, Paula J. Zollman, Mark Schroeder, Brett Carlson, Paul A. Decker, Wenting Wu, C. David James, Stephen J. Russell, and Evanthia Galanis
Clin Cancer Res 2007 13: 7155-7165 doi: 10.1158/1078-0432.CCR-07-1306 [Abstract] [Full Text] [PDF]  

Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts

Raffit Hassan, V. Courtney Broaddus, Shannon Wilson, David J. Liewehr, and Jingli Zhang
Clin Cancer Res 2007 13: 7166-7171 doi: 10.1158/1078-0432.CCR-07-1592 [Abstract] [Full Text] [PDF]  

CD8⁺ T Cells Induce Complete Regression of Advanced Ovarian Cancers by an Interleukin (IL)-2/IL-15–Dependent Mechanism

Taimei Yang, Erika M. Wall, Katy Milne, Patty Theiss, Peter Watson, and Brad H. Nelson
Clin Cancer Res 2007 13: 7172-7180 doi: 10.1158/1078-0432.CCR-07-1724 [Abstract] [Full Text] [PDF] Supplementary Data  

Low-Dose 12-O-Tetradecanoylphorbol-13-Acetate Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Prostate Cancer Cells

Xiaoping Zhang, Wenhua Li, and Aria F. Olumi
Clin Cancer Res 2007 13: 7181-7190 doi: 10.1158/1078-0432.CCR-07-1133 [Abstract] [Full Text] [PDF] Supplementary Data  

The Bcl-2/Bcl-X_L Family Inhibitor ABT-737 Sensitizes Ovarian Cancer Cells to Carboplatin

James Witham, Melanie R. Valenti, Alexis K. De-Haven-Brandon, Susanne Vidot, Suzanne A. Eccles, Stan B. Kaye, and Alan Richardson
Clin Cancer Res 2007 13: 7191-7198 doi: 10.1158/1078-0432.CCR-07-0362 [Abstract] [Full Text] [PDF]  

Alteration of Cellular and Humoral Immunity by Mutant p53 Protein and Processed Mutant Peptide in Head and Neck Cancer

Marion E. Couch, Robert L. Ferris, Joseph A. Brennan, Wayne M. Koch, Elizabeth M. Jaffee, Michael S. Leibowitz, Gerald T. Nepom, Henry A. Erlich, and David Sidransky
Clin Cancer Res 2007 13: 7199-7206 doi: 10.1158/1078-0432.CCR-07-0682 [Abstract] [Full Text] [PDF]  

Glutathione S-Transferase T1 and M1: Gene Sequence Variation and Functional Genomics

Ann M. Moyer, Oreste E. Salavaggione, Scott J. Hebbring, Irene Moon, Michelle A.T. Hildebrandt, Bruce W. Eckloff, Daniel J. Schaid, Eric D. Wieben, and Richard M. Weinshilboum
Clin Cancer Res 2007 13: 7207-7216 doi: 10.1158/1078-0432.CCR-07-0635 [Abstract] [Full Text] [PDF] Supplementary Data  

Plasma, Tumor, and Tissue Disposition of STEALTH Liposomal CKD-602 (S-CKD602) and Nonliposomal CKD-602 in Mice Bearing A375 Human Melanoma Xenografts

William C. Zamboni, Sandra Strychor, Erin Joseph, Dustin R. Walsh, Beth A. Zamboni, Robert A. Parise, Margaret E. Tonda, Ning Y. Yu, Charles Engbers, and Julie L. Eiseman
Clin Cancer Res 2007 13: 7217-7223 doi: 10.1158/1078-0432.CCR-07-1035 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Letter to the Editor on Bortezomib-Mediated Up-Regulation of TRAIL-R1 and TRAIL-R2

Clin Cancer Res 2007 13: 7224 doi: 10.1158/1078-0432.CCR-13-23-COR [Full Text] [PDF]  

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