Editorials:

BRCA-1 in Sporadic Epithelial Ovarian Cancer: Lessons Learned from the Genetics of Hereditary Disease

Stephen A. Cannistra
Clin Cancer Res 2007 13: 7225-7227 doi: 10.1158/1078-0432.CCR-07-2222 [Full Text] [PDF]  

The Clinical Connection:

The Requirements for CTL-Mediated Rejection of Cancer in Humans: NKG2D and Its Role in the Immune Responsiveness of Melanoma

Ena Wang, Silvia Selleri, and Francesco M. Marincola
Clin Cancer Res 2007 13: 7228-7231 doi: 10.1158/1078-0432.CCR-07-2150 [Full Text] [PDF]  

CCR Practice of Translational Oncology:

Src Continues Aging: Current and Future Clinical Directions

Scott Kopetz, Ami N. Shah, and Gary E. Gallick
Clin Cancer Res 2007 13: 7232-7236 doi: 10.1158/1078-0432.CCR-07-1902 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Pathways:

Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications

Valeria R. Fantin and Victoria M. Richon
Clin Cancer Res 2007 13: 7237-7242 doi: 10.1158/1078-0432.CCR-07-2114 [Abstract] [Full Text] [PDF]  

Delta-like 4/Notch Signaling and Its Therapeutic Implications

Minhong Yan and Greg D. Plowman
Clin Cancer Res 2007 13: 7243-7246 doi: 10.1158/1078-0432.CCR-07-1393 [Abstract] [Full Text] [PDF]  

CCR Focus:

Dedication

Edward J. Benz, Jr. and David G. Nathan
Clin Cancer Res 2007 13: 7248-7249 doi: 10.1158/1078-0432.CCR-07-2227 [Full Text] [PDF]  

Targeting the Cell Death-Survival Equation

Edward J. Benz, Jr., David G. Nathan, Ravi K. Amaravadi, and Nika N. Danial
Clin Cancer Res 2007 13: 7250-7253 doi: 10.1158/1078-0432.CCR-07-2221 [Full Text] [PDF]  

BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death

Nika N. Danial
Clin Cancer Res 2007 13: 7254-7263 doi: 10.1158/1078-0432.CCR-07-1598 [Abstract] [Full Text] [PDF]  

The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

Gregory L. Verdine and Loren D. Walensky
Clin Cancer Res 2007 13: 7264-7270 doi: 10.1158/1078-0432.CCR-07-2184 [Abstract] [Full Text] [PDF]  

The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment

Ravi K. Amaravadi and Craig B. Thompson
Clin Cancer Res 2007 13: 7271-7279 doi: 10.1158/1078-0432.CCR-07-1595 [Abstract] [Full Text] [PDF]  

Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient?

Olivier Rixe and Tito Fojo
Clin Cancer Res 2007 13: 7280-7287 doi: 10.1158/1078-0432.CCR-07-2141 [Abstract] [Full Text] [PDF]  

Review:

Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications

Karène Mahtouk, Dirk Hose, John De Vos, Jérôme Moreaux, Michel Jourdan, Jean François Rossi, Thierry Rème, Harmut Goldschmidt, and Bernard Klein
Clin Cancer Res 2007 13: 7289-7295 doi: 10.1158/1078-0432.CCR-07-1758 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

A Novel Set of DNA Methylation Markers in Urine Sediments for Sensitive/Specific Detection of Bladder Cancer

Jian Yu, Tongyu Zhu, Zhirou Wang, Hongyu Zhang, Ziliang Qian, Huili Xu, Baomei Gao, Wei Wang, Lianping Gu, Jun Meng, Jina Wang, Xu Feng, Yixue Li, Xuebiao Yao, and Jingde Zhu
Clin Cancer Res 2007 13: 7296-7304 doi: 10.1158/1078-0432.CCR-07-0861 [Abstract] [Full Text] [PDF] Supplementary Data  

Estrogen Receptor Status Could Modulate the Genomic Pattern in Familial and Sporadic Breast Cancer

Lorenzo Melchor, Emiliano Honrado, Jia Huang, Sara Álvarez, Tara L. Naylor, María J. García, Ana Osorio, David Blesa, Michael R. Stratton, Barbara L. Weber, Juan C. Cigudosa, Nazneen Rahman, Katherine L. Nathanson, and Javier Benítez
Clin Cancer Res 2007 13: 7305-7313 doi: 10.1158/1078-0432.CCR-07-0711 [Abstract] [Full Text] [PDF] Supplementary Data  

Angiogenesis-Promoting Gene Patterns in Alveolar Soft Part Sarcoma

Alexander J.F. Lazar, Parimal Das, Daniel Tuvin, Borys Korchin, Quansheng Zhu, Zeming Jin, Carla L. Warneke, Peter S. Zhang, Vivian Hernandez, Dolores Lopez-Terrada, Peter W. Pisters, Raphael E. Pollock, and Dina Lev
Clin Cancer Res 2007 13: 7314-7321 doi: 10.1158/1078-0432.CCR-07-0174 [Abstract] [Full Text] [PDF]  

EWSR1-CREB1 and EWSR1-ATF1 Fusion Genes in Angiomatoid Fibrous Histiocytoma

Sabrina Rossi, Kàroly Szuhai, Marije Ijszenga, Hans J. Tanke, Lucia Zanatta, Raf Sciot, Christopher D.M. Fletcher, Angelo P. Dei Tos, and Pancras C.W. Hogendoorn
Clin Cancer Res 2007 13: 7322-7328 doi: 10.1158/1078-0432.CCR-07-1744 [Abstract] [Full Text] [PDF]  

HLA Tetramer–Based Artificial Antigen-Presenting Cells Efficiently Stimulate CTLs Specific for Malignant Glioma

Xiaobing Jiang, Xiaoling Lu, Ruen Liu, Fangcheng Zhang, and Hongyang Zhao
Clin Cancer Res 2007 13: 7329-7334 doi: 10.1158/1078-0432.CCR-07-1025 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Mitochondrial Resequencing Arrays Detect Tumor-Specific Mutations in Salivary Rinses of Patients with Head and Neck Cancer

Suhail K. Mithani, Ian M. Smith, Shaoyu Zhou, Andrew Gray, Wayne M. Koch, Anirban Maitra, and Joseph A. Califano
Clin Cancer Res 2007 13: 7335-7340 doi: 10.1158/1078-0432.CCR-07-0220 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression-Based Molecular Diagnostic System for Malignant Gliomas Is Superior to Histological Diagnosis

Mitsuaki Shirahata, Kyoko Iwao-Koizumi, Sakae Saito, Noriko Ueno, Masashi Oda, Nobuo Hashimoto, Jun A. Takahashi, and Kikuya Kato
Clin Cancer Res 2007 13: 7341-7356 doi: 10.1158/1078-0432.CCR-06-2789 [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials

Madeleine M.A. Tilanus-Linthorst, Inge-Marie Obdeijn, Wim C.J. Hop, Petrina A. Causer, Martin O. Leach, Ellen Warner, Linda Pointon, Kimberley Hill, Jan G.M. Klijn, Ruth M.L. Warren, and Fiona J. Gilbert
Clin Cancer Res 2007 13: 7357-7362 doi: 10.1158/1078-0432.CCR-07-0689 [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity at D8S298 Is a Predictor for Long-term Survival of Patients with Tumor-Node-Metastasis Stage I of Hepatocellular Carcinoma

Jin-Zhong Pang, Lun-Xiu Qin, Ning Ren, Zhen-Yu Hei, Qing-Hai Ye, Wei-Dong Jia, Bing-Sheng Sun, Guo-Ling Lin, Dao-Yong Liu, Yin-Kun Liu, and Zhao-You Tang
Clin Cancer Res 2007 13: 7363-7369 doi: 10.1158/1078-0432.CCR-07-0593 [Abstract] [Full Text] [PDF]  

Proteomic Profiling Identifies Afamin as a Potential Biomarker for Ovarian Cancer

David Jackson, Rachel A. Craven, Richard C. Hutson, Ina Graze, Paul Lueth, Robert P. Tonge, Joanne L. Hartley, Janice A. Nickson, Steve J. Rayner, Colin Johnston, Benjamin Dieplinger, Michael Hubalek, Nafisa Wilkinson, Timothy J. Perren, Sean Kehoe, Geoffrey D. Hall, Guenter Daxenbichler, Hans Dieplinger, Peter J. Selby, and Rosamonde E. Banks
Clin Cancer Res 2007 13: 7370-7379 doi: 10.1158/1078-0432.CCR-07-0747 [Abstract] [Full Text] [PDF]  

PAM4-Reactive MUC1 Is a Biomarker for Early Pancreatic Adenocarcinoma

David V. Gold, Zarir Karanjawala, David E. Modrak, David M. Goldenberg, and Ralph H. Hruban
Clin Cancer Res 2007 13: 7380-7387 doi: 10.1158/1078-0432.CCR-07-1488 [Abstract] [Full Text] [PDF]  

Hypoxia-Inducible Factor 1 in Clear Cell Renal Cell Carcinoma

Tobias Klatte, David B. Seligson, Stephen B. Riggs, John T. Leppert, Maria K. Berkman, Mark D. Kleid, Hong Yu, Fairooz F. Kabbinavar, Allan J. Pantuck, and Arie S. Belldegrun
Clin Cancer Res 2007 13: 7388-7393 doi: 10.1158/1078-0432.CCR-07-0411 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib

Nielka P. van Erp, Hans Gelderblom, Mats O. Karlsson, Jing Li, Ming Zhao, Jan Ouwerkerk, Johan W. Nortier, Henk-Jan Guchelaar, Sharyn D. Baker, and Alex Sparreboom
Clin Cancer Res 2007 13: 7394-7400 doi: 10.1158/1078-0432.CCR-07-0346 [Abstract] [Full Text] [PDF]  

Pharmacokinetic and Tumor Distribution Characteristics of Temsirolimus in Patients with Recurrent Malignant Glioma

John G. Kuhn, Susan M. Chang, Patrick Y. Wen, Timothy F. Cloughesy, Harry Greenberg, David Schiff, Charles Conrad, Karen L. Fink, H. Ian Robins, Minesh Mehta, Lisa DeAngelis, Jeffrey Raizer, Kenneth Hess, Kathleen R. Lamborn, Janet Dancey, Michael D. Prados for the North American Brain Tumor Consortium and the National Cancer Institute
Clin Cancer Res 2007 13: 7401-7406 doi: 10.1158/1078-0432.CCR-07-0781 [Abstract] [Full Text] [PDF]  

L-Arginine Reduces Cell Proliferation and Ornithine Decarboxylase Activity in Patients with Colorectal Adenoma and Adenocarcinoma

Qingyong Ma, Yunjian Wang, Xiaopeng Gao, Zhenhua Ma, and Zhengjun Song
Clin Cancer Res 2007 13: 7407-7412 doi: 10.1158/1078-0432.CCR-07-0751 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy

Jennifer E. Quinn, Colin R. James, Gail E. Stewart, Jude M. Mulligan, Patricia White, Gary K.F. Chang, Paul B. Mullan, Patrick G. Johnston, Richard H. Wilson, and D. Paul Harkin
Clin Cancer Res 2007 13: 7413-7420 doi: 10.1158/1078-0432.CCR-07-1083 [Abstract] [Full Text] [PDF]  

Pharmacodynamic Markers of Perifosine Efficacy

Bryan T. Hennessy, Yiling Lu, Enrique Poradosu, Qianghua Yu, Shuangxing Yu, Hassan Hall, Mark S. Carey, Murali Ravoori, Ana Maria Gonzalez-Angulo, Robert Birch, I. Craig Henderson, Vikas Kundra, and Gordon B. Mills
Clin Cancer Res 2007 13: 7421-7431 doi: 10.1158/1078-0432.CCR-07-0760 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumors Established with Cell Lines Selected for Oxaliplatin Resistance Respond to Oxaliplatin if Combined with Cetuximab

Marie Prewett, Dhanvanthri S. Deevi, Rajiv Bassi, Fan Fan, Lee M. Ellis, Daniel J. Hicklin, and James R. Tonra
Clin Cancer Res 2007 13: 7432-7440 doi: 10.1158/1078-0432.CCR-07-1768 [Abstract] [Full Text] [PDF]  

Modulation of Reactive Oxygen Species in Pancreatic Cancer

Melissa L.T. Teoh, Wenqing Sun, Brian J. Smith, Larry W. Oberley, and Joseph J. Cullen
Clin Cancer Res 2007 13: 7441-7450 doi: 10.1158/1078-0432.CCR-07-0851 [Abstract] [Full Text] [PDF]  

Differential Effects of Combined Ad5-24RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma

Martine L.M. Lamfers, Sander Idema, Lisette Bosscher, Stan Heukelom, Sharif Moeniralm, Ida H. van der Meulen-Muileman, Renée M. Overmeer, Paul van der Valk, Victor W. van Beusechem, Winald R. Gerritsen, W. Peter Vandertop, and Clemens M.F. Dirven
Clin Cancer Res 2007 13: 7451-7458 doi: 10.1158/1078-0432.CCR-07-1265 [Abstract] [Full Text] [PDF]  

NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients

Cristina Maccalli, Daisuke Nonaka, Adriano Piris, Daniela Pende, Licia Rivoltini, Chiara Castelli, and Giorgio Parmiani
Clin Cancer Res 2007 13: 7459-7468 doi: 10.1158/1078-0432.CCR-07-1166 [Abstract] [Full Text] [PDF] Supplementary Data  

Allogeneic MHC Gene Transfer Enhances an Effective Antitumor Immunity in the Early Period of Autologous Hematopoietic Stem Cell Transplantation

Akihiko Kobayashi, Hidehiko Hara, Masaki Ohashi, Takeshi Nishimoto, Kimiko Yoshida, Nobuhiro Ohkohchi, Teruhiko Yoshida, and Kazunori Aoki
Clin Cancer Res 2007 13: 7469-7479 doi: 10.1158/1078-0432.CCR-07-1163 [Abstract] [Full Text] [PDF] Supplementary Data  

Evidence for Microtubule Target Engagement in Tumors of Patients Receiving Ixabepilone

Sen H. Zhuang, Y. Elizabeth Hung, Laura Hung, Robert W. Robey, Dan L. Sackett, W. Marston Linehan, Susan E. Bates, Tito Fojo, and Marianne S. Poruchynsky
Clin Cancer Res 2007 13: 7480-7486 doi: 10.1158/1078-0432.CCR-06-2883 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer

Aparna A. Kamat, William M. Merritt, Donna Coffey, Yvonne G. Lin, Pooja R. Patel, Russell Broaddus, Elizabeth Nugent, Liz Y. Han, Charles N. Landen, Jr., Whitney A. Spannuth, Chunhua Lu, Robert L. Coleman, David M. Gershenson, and Anil K. Sood
Clin Cancer Res 2007 13: 7487-7495 doi: 10.1158/1078-0432.CCR-07-1017 [Abstract] [Full Text] [PDF]  

Fractionated versus Standard Continuous Light Delivery in Interstitial Photodynamic Therapy of Dunning Prostate Carcinomas

Zhengwen Xiao, Steve Halls, Dwayne Dickey, John Tulip, and Ronald B. Moore
Clin Cancer Res 2007 13: 7496-7505 doi: 10.1158/1078-0432.CCR-07-1561 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk

Matjaz Rokavec, Christina Justenhoven, Werner Schroth, Monica Adina Istrate, Susanne Haas, Hans-Peter Fischer, Caren Vollmert, Thomas Illig, Ute Hamann, Yon-Dschun Ko, Damjan Glavac, and Hiltrud Brauch
Clin Cancer Res 2007 13: 7506-7514 doi: 10.1158/1078-0432.CCR-07-0457 [Abstract] [Full Text] [PDF] Supplementary Data  

Analysis of hMLH1 Missense Mutations in East Asian Patients with Suspected Hereditary Nonpolyposis Colorectal Cancer

Yimei Fan, Wei Wang, Ming Zhu, Jiji Zhou, Jingyuan Peng, Lizhi Xu, Zichun Hua, Xiang Gao, and Yaping Wang
Clin Cancer Res 2007 13: 7515-7521 doi: 10.1158/1078-0432.CCR-07-1028 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

[¹¹C]Docetaxel and Positron Emission Tomography for Noninvasive Measurements of Docetaxel Kinetics

Astrid A.M. van der Veldt, Adriaan A. Lammertsma, and N. Harry Hendrikse
Clin Cancer Res 2007 13: 7522 doi: 10.1158/1078-0432.CCR-07-1626 [Full Text] [PDF]  

Daniel L. Gustafson, S. Gail Eckhardt, and Erica L. Bradshaw-Pierce
Clin Cancer Res 2007 13: 7522 doi: 10.1158/1078-0432.CCR-07-1946 [Full Text] [PDF]  

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