The Biology Behind:

Idiotype Vaccination Strategies in Myeloma: How to Overcome a Dysfunctional Immune System

Frits van Rhee
Clin Cancer Res 2007 13: 1353 -1355 doi: 10.1158/1078-0432.CCR-06-2650 [Full Text] [PDF]  

Molecular Pathways:

Cancer Cachexia Signaling Pathways Continue to Emerge Yet Much Still Points to the Proteasome

Swarnali Acharyya and Denis C. Guttridge
Clin Cancer Res 2007 13: 1356-1361 doi: 10.1158/1078-0432.CCR-06-2307 [Abstract] [Full Text] [PDF]  

Regulation of Metastases by Signal Transducer and Activator of Transcription 3 Signaling Pathway: Clinical Implications

Suyun Huang
Clin Cancer Res 2007 13: 1362-1366 doi: 10.1158/1078-0432.CCR-06-2313 [Abstract] [Full Text] [PDF]  

Report From the FDA:

Approval Summary: Sunitinib for the Treatment of Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors and Advanced Renal Cell Carcinoma

Vicki L. Goodman, Edwin P. Rock, Ramzi Dagher, Roshni P. Ramchandani, Sophia Abraham, Jogarao V.S. Gobburu, Brian P. Booth, S. Leigh Verbois, David E. Morse, Cheng Yi Liang, Nallaperumal Chidambaram, Janet X. Jiang, Shenghui Tang, Kooros Mahjoob, Robert Justice, and Richard Pazdur
Clin Cancer Res 2007 13: 1367-1373 doi: 10.1158/1078-0432.CCR-06-2328 [Abstract] [Full Text] [PDF]  

Reviews:

Optimization of Radioimmunotherapy of Solid Tumors: Biological Impediments and Their Modulation

Maneesh Jain, Ganesh Venkatraman, and Surinder K. Batra
Clin Cancer Res 2007 13: 1374-1382 Published Online First February 19, 2007. doi: 10.1158/1078-0432.CCR-06-2436 [Abstract] [Full Text] [PDF]  

Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology

Kapila Ratnam and Jennifer A. Low
Clin Cancer Res 2007 13: 1383-1388 doi: 10.1158/1078-0432.CCR-06-2260 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Overexpression of Hedgehog Signaling Molecules and Its Involvement in the Proliferation of Endometrial Carcinoma Cells

Yu-Zhen Feng, Tanri Shiozawa, Tsutomu Miyamoto, Hiroyasu Kashima, Miyuki Kurai, Akihisa Suzuki, Jiang Ying-Song, and Ikuo Konishi
Clin Cancer Res 2007 13: 1389-1398 doi: 10.1158/1078-0432.CCR-06-1407 [Abstract] [Full Text] [PDF]  

Epigenetic Silencing of the Candidate Tumor Suppressor Gene Per1 in Non–Small Cell Lung Cancer

Sigal Gery, Naoki Komatsu, Norihiko Kawamata, Carl W. Miller, Julian Desmond, Renu K. Virk, Alberto Marchevsky, Robert Mckenna, Hirokuni Taguchi, and H. Phillip Koeffler
Clin Cancer Res 2007 13: 1399-1404 doi: 10.1158/1078-0432.CCR-06-1730 [Abstract] [Full Text] [PDF]  

Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor–Positive Tumors of Tamoxifen-Treated Breast Cancer Patients

Tove Kirkegaard, Liane M. McGlynn, Fiona M. Campbell, Sven Müller, Sian M. Tovey, Barbara Dunne, Kirsten V. Nielsen, Timothy G. Cooke, and John M.S. Bartlett
Clin Cancer Res 2007 13: 1405-1411 doi: 10.1158/1078-0432.CCR-06-1933 [Abstract] [Full Text] [PDF]  

Haplotypes, Loss of Heterozygosity, and Expression Levels of Glycine N-Methyltransferase in Prostate Cancer

Yu-Chuen Huang, Cheng-Ming Lee, Marcelo Chen, Ming-Yi Chung, Yen-Hwa Chang, William Ji-Shian Huang, Donald Ming-Tak Ho, Chin-Chen Pan, Tony T. Wu, Stone Yang, Ming-Wei Lin, Jer-Tsong Hsieh, and Yi-Ming Arthur Chen
Clin Cancer Res 2007 13: 1412-1420 doi: 10.1158/1078-0432.CCR-06-1551 [Abstract] [Full Text] [PDF]  

Sperm-Associated Antigen 9, a Novel Cancer Testis Antigen, Is a Potential Target for Immunotherapy in Epithelial Ovarian Cancer

Manoj Garg, Dipak Chaurasiya, Ritu Rana, Nirmala Jagadish, Deepika Kanojia, Namrata Dudha, Neha Kamran, Sudha Salhan, Amar Bhatnagar, Sushma Suri, Anju Gupta, and Anil Suri
Clin Cancer Res 2007 13: 1421-1428 doi: 10.1158/1078-0432.CCR-06-2340 [Abstract] [Full Text] [PDF]  

Longitudinal Assessment of Genetic and Epigenetic Markers in Oligodendrogliomas

Iris Lavon, Daniel Zrihan, Bracha Zelikovitch, Yakov Fellig, Dana Fuchs, Dov Soffer, and Tali Siegal
Clin Cancer Res 2007 13: 1429-1437 doi: 10.1158/1078-0432.CCR-06-2050 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Insulin-like Growth Factor Binding Proteins IGFBP3, IGFBP4, and IGFBP5 Predict Endocrine Responsiveness in Patients with Ovarian Cancer

Graeme Walker, Kenneth MacLeod, Alistair R.W. Williams, David A. Cameron, John F. Smyth, and Simon P. Langdon
Clin Cancer Res 2007 13: 1438-1444 doi: 10.1158/1078-0432.CCR-06-2245 [Abstract] [Full Text] [PDF]  

Retropharyngeal Lymph Node Metastasis in Nasopharyngeal Carcinoma: Prognostic Value and Staging Categories

Jun Ma, Lizhi Liu, Linglong Tang, Jingfeng Zong, Aihua Lin, Taixiang Lu, Nianji Cui, Chunyan Cui, and Li Li
Clin Cancer Res 2007 13: 1445-1452 doi: 10.1158/1078-0432.CCR-06-2059 [Abstract] [Full Text] [PDF]  

Virus-Associated Tumor Imaging by Induction of Viral Gene Expression

De-Xue Fu, Yvette C. Tanhehco, Jianmeng Chen, Catherine A. Foss, James J. Fox, Victor Lemas, Ja-Mun Chong, Richard F. Ambinder, and Martin G. Pomper
Clin Cancer Res 2007 13: 1453-1458 doi: 10.1158/1078-0432.CCR-06-2295 [Abstract] [Full Text] [PDF]  

Translating Expression Profiling into a Clinically Feasible Test to Predict Neuroblastoma Outcome

Alexander Schramm, Jo Vandesompele, Johannes H. Schulte, Sabine Dreesmann, Lars Kaderali, Benedikt Brors, Roland Eils, Frank Speleman, and Angelika Eggert
Clin Cancer Res 2007 13: 1459-1465 doi: 10.1158/1078-0432.CCR-06-2032 [Abstract] [Full Text] [PDF]  

Transcriptomic versus Chromosomal Prognostic Markers and Clinical Outcome in Uveal Melanoma

Lori A. Worley, Michael D. Onken, Erica Person, Diane Robirds, Julie Branson, Devron H. Char, Arie Perry, and J. William Harbour
Clin Cancer Res 2007 13: 1466-1471 doi: 10.1158/1078-0432.CCR-06-2401 [Abstract] [Full Text] [PDF] Supplementary Data, Worley, et al.  

High Macrophage Infiltration along the Tumor Front Correlates with Improved Survival in Colon Cancer

Johan Forssell, Åke Öberg, Maria L. Henriksson, Roger Stenling, Andreas Jung, and Richard Palmqvist
Clin Cancer Res 2007 13: 1472-1479 doi: 10.1158/1078-0432.CCR-06-2073 [Abstract] [Full Text] [PDF]  

Tubedown Expression Correlates with the Differentiation Status and Aggressiveness of Neuroblastic Tumors

Darryl T. Martin, Robert L. Gendron, Jason A. Jarzembowski, Arie Perry, Margaret H. Collins, Chitra Pushpanathan, Ewa Miskiewicz, Valerie P. Castle, and Hélène Paradis
Clin Cancer Res 2007 13: 1480-1487 doi: 10.1158/1078-0432.CCR-06-1716 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

The Association Between Measures of Progression and Survival in Castrate-Metastatic Prostate Cancer

Howard I. Scher, Mary Warren, and Glenn Heller
Clin Cancer Res 2007 13: 1488-1492 doi: 10.1158/1078-0432.CCR-06-1885 [Abstract] [Full Text] [PDF]  

Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer

Nancy J. Nesslinger, Robert A. Sahota, Brad Stone, Kayli Johnson, Navraj Chima, Caitlin King, Devon Rasmussen, Darcy Bishop, Paul S. Rennie, Martin Gleave, Paul Blood, Howard Pai, Charles Ludgate, and Brad H. Nelson
Clin Cancer Res 2007 13: 1493-1502 doi: 10.1158/1078-0432.CCR-06-1772 [Abstract] [Full Text] [PDF]  

Long-term Idiotype Vaccination Combined with Interleukin-12 (IL-12), or IL-12 and Granulocyte Macrophage Colony-Stimulating Factor, in Early-Stage Multiple Myeloma Patients

Lotta Hansson, Amir Osman Abdalla, Ali Moshfegh, Aniruddha Choudhury, Hodjattallah Rabbani, Bo Nilsson, Anders Osterborg, and Håkan Mellstedt
Clin Cancer Res 2007 13: 1503-1510 doi: 10.1158/1078-0432.CCR-06-1603 [Abstract] [Full Text] [PDF]  

Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420

Alberto Broniscer, John C. Panetta, Melinda O'Shaughnessy, Charles Fraga, Feng Bai, Matthew J. Krasin, Amar Gajjar, and Clinton F. Stewart
Clin Cancer Res 2007 13: 1511-1515 doi: 10.1158/1078-0432.CCR-06-2372 [Abstract] [Full Text] [PDF]  

A Phase 1 Study of the Proteasome Inhibitor Bortezomib in Pediatric Patients with Refractory Leukemia: a Children's Oncology Group Study

Terzah M. Horton, Debananda Pati, Sharon E. Plon, Patrick A. Thompson, Lisa R. Bomgaars, Peter C. Adamson, Ashish M. Ingle, John Wright, Adam H. Brockman, Martin Paton, and Susan M. Blaney
Clin Cancer Res 2007 13: 1516-1522 doi: 10.1158/1078-0432.CCR-06-2173 [Abstract] [Full Text] [PDF]  

Modulation of Signal Transducers and Activators of Transcription 1 and 3 Signaling in Melanoma by High-Dose IFN2b

Wenjun Wang, Howard D. Edington, Uma N.M. Rao, Drazen M. Jukic, Stephanie R. Land, Soldano Ferrone, and John M. Kirkwood
Clin Cancer Res 2007 13: 1523-1531 doi: 10.1158/1078-0432.CCR-06-1387 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Combined Treatment with Temozolomide and Methoxyamine: Blocking Apurininc/Pyrimidinic Site Repair Coupled with Targeting Topoisomerase II

Ling Yan, Alina Bulgar, Yanling Miao, Varun Mahajan, Jon R. Donze, Stanton L. Gerson, and Lili Liu
Clin Cancer Res 2007 13: 1532-1539 doi: 10.1158/1078-0432.CCR-06-1595 [Abstract] [Full Text] [PDF]  

Tumor Growth Inhibition with Cetuximab and Chemotherapy in Non–Small Cell Lung Cancer Xenografts Expressing Wild-type and Mutated Epidermal Growth Factor Receptor

Philipp Steiner, Christopher Joynes, Rajiv Bassi, Su Wang, James R. Tonra, Yaron R. Hadari, and Daniel J. Hicklin
Clin Cancer Res 2007 13: 1540-1551 doi: 10.1158/1078-0432.CCR-06-1887 [Abstract] [Full Text] [PDF]  

Antibody-Dependent Cellular Cytotoxicity Mediated by Cetuximab against Lung Cancer Cell Lines

Jun Kurai, Hiroki Chikumi, Kiyoshi Hashimoto, Kosuke Yamaguchi, Akira Yamasaki, Takanori Sako, Hirokazu Touge, Haruhiko Makino, Miyako Takata, Masanori Miyata, Masaki Nakamoto, Naoto Burioka, and Eiji Shimizu
Clin Cancer Res 2007 13: 1552-1561 doi: 10.1158/1078-0432.CCR-06-1726 [Abstract] [Full Text] [PDF]  

Inhibition of CXCR4-Mediated Breast Cancer Metastasis: A Potential Role for Heparinoids?

James R. Harvey, Paul Mellor, Hesham Eldaly, Thomas W.J. Lennard, John A. Kirby, and Simi Ali
Clin Cancer Res 2007 13: 1562-1570 doi: 10.1158/1078-0432.CCR-06-1987 [Abstract] [Full Text] [PDF]  

Mesothelin Expression in Human Lung Cancer

Mitchell Ho, Tapan K. Bera, Mark C. Willingham, Masanori Onda, Raffit Hassan, David FitzGerald, and Ira Pastan
Clin Cancer Res 2007 13: 1571-1575 doi: 10.1158/1078-0432.CCR-06-2161 [Abstract] [Full Text] [PDF]  

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Tammie C. Yeh, Vivienne Marsh, Bryan A. Bernat, Josh Ballard, Heidi Colwell, Ron J. Evans, Janet Parry, Darin Smith, Barbara J. Brandhuber, Stefan Gross, Allison Marlow, Brian Hurley, Joe Lyssikatos, Patrice A. Lee, James D. Winkler, Kevin Koch, and Eli Wallace
Clin Cancer Res 2007 13: 1576-1583 doi: 10.1158/1078-0432.CCR-06-1150 [Abstract] [Full Text] [PDF] Supplementary Data, Yeh, et al.  

NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 Activity and Expression in Bladder and Ovarian Cancer and Lower NRH:Quinone Oxidoreductase 2 Activity Associated with an NQO2 Exon 3 Single-Nucleotide Polymorphism

David Jamieson, Kerrie Wilson, Simon Pridgeon, Jane P. Margetts, Richard J. Edmondson, Hing Y. Leung, Richard Knox, and Alan V. Boddy
Clin Cancer Res 2007 13: 1584-1590 doi: 10.1158/1078-0432.CCR-06-1416 [Abstract] [Full Text] [PDF]  

Synergism between Etoposide and 17-AAG in Leukemia Cells: Critical Roles for Hsp90, FLT3, Topoisomerase II, Chk1, and Rad51

Qing Yao, Brenda Weigel, and John Kersey
Clin Cancer Res 2007 13: 1591-1600 doi: 10.1158/1078-0432.CCR-06-1750 [Abstract] [Full Text] [PDF]  

Oral Lactoferrin Results in T Cell–Dependent Tumor Inhibition of Head and Neck Squamous Cell Carcinoma In vivo

Jeffrey S. Wolf, Guoyan Li, Atul Varadhachary, Karel Petrak, Mark Schneyer, Daqing Li, Julina Ongkasuwan, Xiaoyu Zhang, Rodney J. Taylor, Scott E. Strome, and Bert W. O'Malley, Jr.
Clin Cancer Res 2007 13: 1601-1610 doi: 10.1158/1078-0432.CCR-06-2008 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Combined Inhibitory Effects of Green Tea Polyphenols and Selective Cyclooxygenase-2 Inhibitors on the Growth of Human Prostate Cancer Cells Both In vitro and In vivo

Vaqar Mustafa Adhami, Arshi Malik, Najia Zaman, Sami Sarfaraz, Imtiaz Ahmad Siddiqui, Deeba Nadeem Syed, Farrukh Afaq, Farrukh Sierre Pasha, Mohammad Saleem, and Hasan Mukhtar
Clin Cancer Res 2007 13: 1611-1619 doi: 10.1158/1078-0432.CCR-06-2269 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

CD16^low/negative Tumor-Infiltrating Lymphocyte: Lymphoid or Myeloid in Origin?

Giuseppe Sconocchia, Domenico Del Principe, and A. John Barrett
Clin Cancer Res 2007 13: 1620 doi: 10.1158/1078-0432.CCR-06-2247 [Full Text] [PDF]  

The Complexity of Natural Killer Cells

Elfriede Noessner and Julia S. Schleypen
Clin Cancer Res 2007 13: 1621 doi: 10.1158/1078-0432.CCR-06-2689 [Full Text] [PDF]  

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