Editorials:

A Patient Perspective on Brain Metastases in Breast Cancer

Musa Mayer
Clin Cancer Res 2007 13: 1623-1624 doi: 10.1158/1078-0432.CCR-06-2842 [Full Text] [PDF]  

The Biology Behind:

Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells

Wanping Xu and Len Neckers
Clin Cancer Res 2007 13: 1625 -1629 doi: 10.1158/1078-0432.CCR-06-2966 [Full Text] [PDF]  

CCR Practice of Translational Oncology:

Chromosomes, Hypoxia, Angiogenesis, and Trial Design: A Brief History of Renal Cancer Drug Development

Walter Stadler
Clin Cancer Res 2007 13: 1630-1633 doi: 10.1158/1078-0432.CCR-06-2721 [Full Text] [PDF]  

Molecular Pathways:

DNA Methylation as a Therapeutic Target in Cancer

Jean-Pierre J. Issa
Clin Cancer Res 2007 13: 1634-1637 doi: 10.1158/1078-0432.CCR-06-2076 [Abstract] [Full Text] [PDF]  

From mRNA Metabolism to Cancer Therapy: Chronic Myelogenous Leukemia Shows the Way

Danilo Perrotti and Paolo Neviani
Clin Cancer Res 2007 13: 1638-1642 doi: 10.1158/1078-0432.CCR-06-2320 [Abstract] [Full Text] [PDF]  

CCR Focus:

CNS Metastasis: An Old Problem in a New Guise

Jeanny B. Aragon-Ching and Jo Anne Zujewski
Clin Cancer Res 2007 13: 1644-1647 doi: 10.1158/1078-0432.CCR-07-0096 [Abstract] [Full Text] [PDF]  

Brain Metastases: The HER2 Paradigm

Nancy U. Lin and Eric P. Winer
Clin Cancer Res 2007 13: 1648-1655 doi: 10.1158/1078-0432.CCR-06-2478 [Abstract] [Full Text] [PDF]  

The Biology of Metastasis to a Sanctuary Site

Diane Palmieri, Ann F. Chambers, Brunhilde Felding-Habermann, Suyun Huang, and Patricia S. Steeg
Clin Cancer Res 2007 13: 1656-1662 doi: 10.1158/1078-0432.CCR-06-2659 [Abstract] [Full Text] [PDF]  

The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses

John F. Deeken and Wolfgang Löscher
Clin Cancer Res 2007 13: 1663-1674 doi: 10.1158/1078-0432.CCR-06-2854 [Abstract] [Full Text] [PDF]  

Targeted Therapy for Brain Metastases: Improving the Therapeutic Ratio

Rakesh R. Patel and Minesh P. Mehta
Clin Cancer Res 2007 13: 1675-1683 doi: 10.1158/1078-0432.CCR-06-2489 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Identification and Prognostic Significance of an Epithelial-Mesenchymal Transition Expression Profile in Human Bladder Tumors

Egbert Baumgart, Michael S. Cohen, Brasil Silva Neto, Micah A. Jacobs, Chad Wotkowicz, Kimberly M. Rieger-Christ, Andreia Biolo, Ron Zeheb, Massimo Loda, John A. Libertino, and Ian C. Summerhayes
Clin Cancer Res 2007 13: 1685-1694 doi: 10.1158/1078-0432.CCR-06-2330 [Abstract] [Full Text] [PDF]  

Relaxin Promotes Prostate Cancer Progression

Shu Feng, Irina U. Agoulnik, Natalia V. Bogatcheva, Aparna A. Kamat, Bernard Kwabi-Addo, Rile Li, Gustavo Ayala, Michael M. Ittmann, and Alexander I. Agoulnik
Clin Cancer Res 2007 13: 1695-1702 doi: 10.1158/1078-0432.CCR-06-2492 [Abstract] [Full Text] [PDF]  

Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers

Yuesheng Jin, Ylva Stewénius, David Lindgren, Attila Frigyesi, Olga Calcagnile, Tord Jonson, Anna Edqvist, Nina Larsson, Lena Maria Lundberg, Gunilla Chebil, Fredrik Liedberg, Sigurdur Gudjonsson, Wiking Månsson, Mattias Höglund, and David Gisselsson
Clin Cancer Res 2007 13: 1703-1712 doi: 10.1158/1078-0432.CCR-06-2705 [Abstract] [Full Text] [PDF] Supplementary Data, Jin, et al.  

Global Expression Analysis of Cancer/Testis Genes in Uterine Cancers Reveals a High Incidence of BORIS Expression

John Ian Risinger, Gadisetti V.R. Chandramouli, G. Larry Maxwell, Mary Custer, Svetlana Pack, Dmitri Loukinov, Olga Aprelikova, Tracy Litzi, David S. Schrump, Susan K. Murphy, Andrew Berchuck, Victor Lobanenkov, and J. Carl Barrett
Clin Cancer Res 2007 13: 1713-1719 doi: 10.1158/1078-0432.CCR-05-2569 [Abstract] [Full Text] [PDF] Supplementary Data, Risinger, et al.  

Molecular Detection of Localized Prostate Cancer Using Quantitative Methylation-Specific PCR on Urinary Cells Obtained Following Prostate Massage

Morgan Rouprêt, Vincent Hupertan, David R. Yates, James W.F. Catto, Ishtiaq Rehman, Mark Meuth, Sylvie Ricci, Roger Lacave, Géraldine Cancel-Tassin, Alexandre de la Taille, François Rozet, Xavier Cathelineau, Guy Vallancien, Freddie C. Hamdy, and Olivier Cussenot
Clin Cancer Res 2007 13: 1720-1725 doi: 10.1158/1078-0432.CCR-06-2467 [Abstract] [Full Text] [PDF]  

The Identification of (ETV6)/RUNX1-Regulated Genes in Lymphopoiesis Using Histone Deacetylase Inhibitors in ETV6/RUNX1-Positive Lymphoid Leukemic Cells

Julia Starkova, Jozef Madzo, Gunnar Cario, Tomas Kalina, Anthony Ford, Marketa Zaliova, Ondrej Hrusak, and Jan Trka
Clin Cancer Res 2007 13: 1726-1735 Published Online First February 26, 2007. doi: 10.1158/1078-0432.CCR-06-2569 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer

Leonard R. Henry, Hyung-Ok Lee, John S. Lee, Andres Klein-Szanto, Perry Watts, Eric A. Ross, Wen-Tien Chen, and Jonathan D. Cheng
Clin Cancer Res 2007 13: 1736-1741 doi: 10.1158/1078-0432.CCR-06-1746 [Abstract] [Full Text] [PDF]  

Primary Tumor Levels of Human Tissue Kallikreins Affect Surgical Success and Survival in Ovarian Cancer Patients

Julia Dorn, Manfred Schmitt, Ronald Kates, Barbara Schmalfeldt, Marion Kiechle, Andreas Scorilas, Eleftherios P. Diamandis, and Nadia Harbeck
Clin Cancer Res 2007 13: 1742-1748 doi: 10.1158/1078-0432.CCR-06-2482 [Abstract] [Full Text] [PDF]  

Survivin and B7-H1 Are Collaborative Predictors of Survival and Represent Potential Therapeutic Targets for Patients with Renal Cell Carcinoma

Amy E. Krambeck, Haidong Dong, R. Houston Thompson, Susan M. Kuntz, Christine M. Lohse, Bradley C. Leibovich, Michael L. Blute, Thomas J. Sebo, John C. Cheville, Alexander S. Parker, and Eugene D. Kwon
Clin Cancer Res 2007 13: 1749-1756 doi: 10.1158/1078-0432.CCR-06-2129 [Abstract] [Full Text] [PDF]  

PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma

R. Houston Thompson, Haidong Dong, Christine M. Lohse, Bradley C. Leibovich, Michael L. Blute, John C. Cheville, and Eugene D. Kwon
Clin Cancer Res 2007 13: 1757-1761 doi: 10.1158/1078-0432.CCR-06-2599 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Phase I/II Study of Arsenic Trioxide/Bortezomib/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma

James R. Berenson, Jeffrey Matous, Regina A. Swift, Russell Mapes, Blake Morrison, and Howard S. Yeh
Clin Cancer Res 2007 13: 1762-1768 doi: 10.1158/1078-0432.CCR-06-1812 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients with Refractory Advanced Cancers

Ramesh K. Ramanathan, Merrill J. Egorin, Julie L. Eiseman, Suresh Ramalingam, David Friedland, Sanjiv S. Agarwala, S. Percy Ivy, Douglas M. Potter, Gurkamal Chatta, Eleanor G. Zuhowski, Ronald G. Stoller, Cynthia Naret, Jianxia Guo, and Chandra P. Belani
Clin Cancer Res 2007 13: 1769-1774 doi: 10.1158/1078-0432.CCR-06-2233 [Abstract] [Full Text] [PDF]  

Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Advanced Cancer

David B. Solit, S. Percy Ivy, Catherine Kopil, Rachel Sikorski, Michael J. Morris, Susan F. Slovin, W. Kevin Kelly, Anthony DeLaCruz, Tracy Curley, Glenn Heller, Steven Larson, Lawrence Schwartz, Merrill J. Egorin, Neal Rosen, and Howard I. Scher
Clin Cancer Res 2007 13: 1775-1782 doi: 10.1158/1078-0432.CCR-06-1863 [Abstract] [Full Text] [PDF]  

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-N-Allylamino-17-Demethoxygeldanamycin in Pediatric Patients with Recurrent or Refractory Solid Tumors: A Pediatric Oncology Experimental Therapeutics Investigators Consortium Study

Rochelle Bagatell, Lia Gore, Merrill J. Egorin, Richard Ho, Glenn Heller, Nichole Boucher, Eleanor G. Zuhowski, James A. Whitlock, Stephen P. Hunger, Aru Narendran, Howard M. Katzenstein, Robert J. Arceci, Jessica Boklan, Cynthia E. Herzog, Luke Whitesell, S. Percy Ivy, and Tanya M. Trippett
Clin Cancer Res 2007 13: 1783-1788 doi: 10.1158/1078-0432.CCR-06-1892 [Abstract] [Full Text] [PDF]  

A Phase I Study of 17-Allylaminogeldanamycin in Relapsed/Refractory Pediatric Patients with Solid Tumors: A Children's Oncology Group Study

Brenda J. Weigel, Susan M. Blaney, Joel M. Reid, Stephanie L. Safgren, Rochelle Bagatell, John Kersey, Joseph P. Neglia, S. Percy Ivy, Ashish M. Ingle, Luke Whitesell, Richard J. Gilbertson, Mark Krailo, Matthew Ames, and Peter C. Adamson
Clin Cancer Res 2007 13: 1789-1793 doi: 10.1158/1078-0432.CCR-06-2270 [Abstract] [Full Text] [PDF]  

A Proof-of-Principle Clinical Trial of Bexarotene in Patients with Non–Small Cell Lung Cancer

Konstantin H. Dragnev, W. Jeffrey Petty, Sumit J. Shah, Lionel D. Lewis, Candice C. Black, Vincent Memoli, William C. Nugent, Thomas Hermann, Andres Negro-Vilar, James R. Rigas, and Ethan Dmitrovsky
Clin Cancer Res 2007 13: 1794-1800 doi: 10.1158/1078-0432.CCR-06-1836 [Abstract] [Full Text] [PDF] Supplementary Data, Dragnev, et al.  

Phase I Trial of Sorafenib in Combination with IFN -2a in Patients with Unresectable and/or Metastatic Renal Cell Carcinoma or Malignant Melanoma

Bernard Escudier, Nathalie Lassau, Eric Angevin, Jean Charles Soria, Linda Chami, Michele Lamuraglia, Eric Zafarana, Veronique Landreau, Brian Schwartz, Eric Brendel, Jean-Pierre Armand, and Caroline Robert
Clin Cancer Res 2007 13: 1801-1809 doi: 10.1158/1078-0432.CCR-06-1432 [Abstract] [Full Text] [PDF]  

A Pilot Trial of CTLA-4 Blockade with Human Anti-CTLA-4 in Patients with Hormone-Refractory Prostate Cancer

Eric J. Small, N. Simon Tchekmedyian, Brian I. Rini, Lawrence Fong, Israel Lowy, and James P. Allison
Clin Cancer Res 2007 13: 1810-1815 doi: 10.1158/1078-0432.CCR-06-2318 [Abstract] [Full Text] [PDF]  

A Randomized Phase II Pharmacokinetic and Pharmacodynamic Study of Indisulam as Second-Line Therapy in Patients with Advanced Non–Small Cell Lung Cancer

Denis C. Talbot, Joachim von Pawel, Emma Cattell, S. Murray Yule, Claire Johnston, Anthe S. Zandvliet, Alwin D.R. Huitema, Chris J. Norbury, Paul Ellis, Leon Bosquee, and Martin Reck
Clin Cancer Res 2007 13: 1816-1822 doi: 10.1158/1078-0432.CCR-06-0249 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Soluble PD-1 Facilitates 4-1BBL–Triggered Antitumor Immunity against Murine H22 Hepatocarcinoma In vivo

Han Xiao, Bo Huang, Ye Yuan, Dong Li, Ling-Fei Han, Yi Liu, Wei Gong, Feng-Hua Wu, Gui-Mei Zhang, and Zuo-Hua Feng
Clin Cancer Res 2007 13: 1823-1830 Published Online First February 26, 2007. doi: 10.1158/1078-0432.CCR-06-2154 [Abstract] [Full Text] [PDF]  

Monoclonal Antibody 4C5 Immunostains Human Melanomas and Inhibits Melanoma Cell Invasion and Metastasis

Dimitris Stellas, Andreas Karameris, and Evangelia Patsavoudi
Clin Cancer Res 2007 13: 1831-1838 doi: 10.1158/1078-0432.CCR-06-1585 [Abstract] [Full Text] [PDF]  

Noninvasive Molecular Imaging Sheds Light on the Synergy between 5-Fluorouracil and TRAIL/Apo2L for Cancer Therapy

Kuei C. Lee, Daniel A. Hamstra, Mahaveer S. Bhojani, Amjad P. Khan, Brian D. Ross, and Alnawaz Rehemtulla
Clin Cancer Res 2007 13: 1839-1846 doi: 10.1158/1078-0432.CCR-06-1657 [Abstract] [Full Text] [PDF]  

Garlic-Derived S-allylmercaptocysteine Is a Novel In vivo Antimetastatic Agent for Androgen-Independent Prostate Cancer

Edward W. Howard, Ming-Tat Ling, Chee Wai Chua, Hiu Wing Cheung, Xianghong Wang, and Yong Chuan Wong
Clin Cancer Res 2007 13: 1847-1856 doi: 10.1158/1078-0432.CCR-06-2074 [Abstract] [Full Text] [PDF]  

Long-Lived Antitumor CD8⁺ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-Presenting Cell

Marcus O. Butler, Jeng-Shin Lee, Sascha Ansén, Donna Neuberg, F. Stephen Hodi, Andrew P. Murray, Linda Drury, Alla Berezovskaya, Richard C. Mulligan, Lee M. Nadler, and Naoto Hirano
Clin Cancer Res 2007 13: 1857-1867 doi: 10.1158/1078-0432.CCR-06-1905 [Abstract] [Full Text] [PDF]  

130-nm Albumin–Bound Paclitaxel Enhances Tumor Radiocurability and Therapeutic Gain

Nicole Wiedenmann, David Valdecanas, Nancy Hunter, Stephen Hyde, Thomas A. Buchholz, Luka Milas, and Kathryn A. Mason
Clin Cancer Res 2007 13: 1868-1874 doi: 10.1158/1078-0432.CCR-06-2534 [Abstract] [Full Text] [PDF]  

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Eiji Suzuki, Rinpei Niwa, Shigehira Saji, Mariko Muta, Makiko Hirose, Shigeru Iida, Yukimasa Shiotsu, Mitsuo Satoh, Kenya Shitara, Masahide Kondo, and Masakazu Toi
Clin Cancer Res 2007 13: 1875-1882 doi: 10.1158/1078-0432.CCR-06-1335 [Abstract] [Full Text] [PDF]  

Tumor Antigen–Specific T-Cell Expansion Is Greatly Facilitated by In vivo Priming

Yushe Dang, Keith L. Knutson, Vivian Goodell, Corazon dela Rosa, Lupe G. Salazar, Doreen Higgins, Jennifer Childs, and Mary L. Disis
Clin Cancer Res 2007 13: 1883-1891 doi: 10.1158/1078-0432.CCR-06-2083 [Abstract] [Full Text] [PDF]  

Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer

Jordan S. Fridman, Eian Caulder, Michael Hansbury, Xiangdong Liu, Genjie Yang, Qian Wang, Yvonne Lo, Bin-Bing Zhou, Maxwell Pan, Sufi M. Thomas, Jennifer R. Grandis, Jincong Zhuo, Wenqing Yao, Robert C. Newton, Steven M. Friedman, Peggy A. Scherle, and Kris Vaddi
Clin Cancer Res 2007 13: 1892-1902 doi: 10.1158/1078-0432.CCR-06-2116 [Abstract] [Full Text] [PDF]  

Combining Radioimmunotherapy with Antihypoxia Therapy 2-Deoxy-D-Glucose Results in Reduction of Therapeutic Efficacy

Jason L.J. Dearling, Uzma Qureshi, Richard H.J. Begent, and R. Barbara Pedley
Clin Cancer Res 2007 13: 1903-1910 doi: 10.1158/1078-0432.CCR-06-2094 [Abstract] [Full Text] [PDF]  

The Efficacy of Epidermal Growth Factor Receptor–Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

Terrance G. Johns, Rushika M. Perera, Sonja C. Vernes, Angela A. Vitali, Diana X. Cao, Webster K. Cavenee, Andrew M. Scott, and Frank B. Furnari
Clin Cancer Res 2007 13: 1911-1925 doi: 10.1158/1078-0432.CCR-06-1453 [Abstract] [Full Text] [PDF]  

Potentiation of High-LET Radiation by Gemcitabine: Targeting HER2 with Trastuzumab to Treat Disseminated Peritoneal Disease

Diane E. Milenic, Kayhan Garmestani, Erik D. Brady, Paul S. Albert, Alia Abdulla, Joseph Flynn, and Martin W. Brechbiel
Clin Cancer Res 2007 13: 1926-1935 doi: 10.1158/1078-0432.CCR-06-2300 [Abstract] [Full Text] [PDF]  

Combination Therapy of an Orthotopic Renal Cell Carcinoma Model Using Intratumoral Vector-Mediated Costimulation and Systemic Interleukin-2

Chie Kudo-Saito, Elizabeth K. Wansley, M. Eilene Gruys, Robert Wiltrout, Jeffrey Schlom, and James W. Hodge
Clin Cancer Res 2007 13: 1936-1946 doi: 10.1158/1078-0432.CCR-06-2398 [Abstract] [Full Text] [PDF]  

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