The Biology Behind:

Hypoxia and Metastasis

Naz Chaudary and Richard P. Hill
Clin Cancer Res 2007 13: 1947 -1949 doi: 10.1158/1078-0432.CCR-06-2971 [Full Text] [PDF]  

Molecular Pathways:

Unraveling the Mechanisms of Endocrine Resistance in Breast Cancer: New Therapeutic Opportunities

Suleiman Massarweh and Rachel Schiff
Clin Cancer Res 2007 13: 1950-1954 doi: 10.1158/1078-0432.CCR-06-2540 [Abstract] [Full Text] [PDF]  

Targeting Checkpoint Kinase 1 in Cancer Therapeutics

Archie N. Tse, Richard Carvajal, and Gary K. Schwartz
Clin Cancer Res 2007 13: 1955-1960 doi: 10.1158/1078-0432.CCR-06-2793 [Abstract] [Full Text] [PDF]  

Review:

The Potential of Antiangiogenic Therapy in Non–Small Cell Lung Cancer

Giuseppe Giaccone
Clin Cancer Res 2007 13: 1961-1970 doi: 10.1158/1078-0432.CCR-06-2186 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis

Einar K. Rofstad, Kanthi Galappathi, Berit Mathiesen, and Else-Beate M. Ruud
Clin Cancer Res 2007 13: 1971-1978 Published Online First March 14, 2007. doi: 10.1158/1078-0432.CCR-06-1967 [Abstract] [Full Text] [PDF]  

ß-2-Microglobulin Is an Androgen-Regulated Secreted Protein Elevated in Serum of Patients with Advanced Prostate Cancer

Mitchell Gross, Irina Top, Isett Laux, Jonathan Katz, John Curran, Charles Tindell, and David Agus
Clin Cancer Res 2007 13: 1979-1986 doi: 10.1158/1078-0432.CCR-06-1156 [Abstract] [Full Text] [PDF]  

Estrogen Receptor ß Expression Is Associated with Tamoxifen Response in ER-Negative Breast Carcinoma

Sofia K. Gruvberger-Saal, Pär-Ola Bendahl, Lao H. Saal, Mervi Laakso, Cecilia Hegardt, Patrik Edén, Carsten Peterson, Per Malmström, Jorma Isola, Åke Borg, and Mårten Fernö
Clin Cancer Res 2007 13: 1987-1994 doi: 10.1158/1078-0432.CCR-06-1823 [Abstract] [Full Text] [PDF] Supplementary Data, Gruverberger-Saal, et al.  

3q26 Amplification and Polysomy of Chromosome 3 in Squamous Cell Lesions of the Lung: A Fluorescence In situ Hybridization Study

Giuseppe Pelosi, Barbara Del Curto, Maurizio Trubia, Andrew G. Nicholson, Michela Manzotti, Giulia Veronesi, Lorenzo Spaggiari, Patrick Maisonneuve, Felice Pasini, Alberto Terzi, Antonio Iannucci, and Giuseppe Viale
Clin Cancer Res 2007 13: 1995-2004 doi: 10.1158/1078-0432.CCR-06-2483 [Abstract] [Full Text] [PDF]  

Molecular Characterization of Waldenstrom's Macroglobulinemia Reveals Frequent Occurrence of Two B-Cell Clones Having Distinct IgH VDJ Sequences

Jitra Kriangkum, Brian J. Taylor, Steven P. Treon, Michael J. Mant, Tony Reiman, Andrew R. Belch, and Linda M. Pilarski
Clin Cancer Res 2007 13: 2005-2013 doi: 10.1158/1078-0432.CCR-06-2788 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Population-Based Molecular Prognosis of Breast Cancer by Transcriptional Profiling

Yan Ma, Yong Qian, Liang Wei, Jame Abraham, Xianglin Shi, Vincent Castranova, E. James Harner, Daniel C. Flynn, and Lan Guo
Clin Cancer Res 2007 13: 2014-2022 doi: 10.1158/1078-0432.CCR-06-2222 [Abstract] [Full Text] [PDF] Supplementary Data, Ma, et al.  

Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer

David R. Shaffer, Margaret A. Leversha, Daniel C. Danila, Oscar Lin, Rita Gonzalez-Espinoza, Bin Gu, Aseem Anand, Katherine Smith, Peter Maslak, Gerald V. Doyle, Leon W.M.M. Terstappen, Hans Lilja, Glenn Heller, Martin Fleisher, and Howard I. Scher
Clin Cancer Res 2007 13: 2023-2029 doi: 10.1158/1078-0432.CCR-06-2701 [Abstract] [Full Text] [PDF]  

Adrenal Androgen Levels as Predictors of Outcome in Prostate Cancer Patients Treated with Ketoconazole Plus Antiandrogen Withdrawal: Results from a Cancer and Leukemia Group B Study

Charles J. Ryan, Susan Halabi, San-San Ou, Nicholas J. Vogelzang, Philip Kantoff, Eric J. Small for the Cancer and Leukemia Group B
Clin Cancer Res 2007 13: 2030-2037 doi: 10.1158/1078-0432.CCR-06-2344 [Abstract] [Full Text] [PDF]  

Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is Associated with Tumor Progression during Temozolomide Treatment

Daniel P. Cahill, Kymberly K. Levine, Rebecca A. Betensky, Patrick J. Codd, Candice A. Romany, Linsey B. Reavie, Tracy T. Batchelor, P. Andrew Futreal, Michael R. Stratton, William T. Curry, A. John Iafrate, and David N. Louis
Clin Cancer Res 2007 13: 2038-2045 doi: 10.1158/1078-0432.CCR-06-2149 [Abstract] [Full Text] [PDF] Supplementary Data, Cahill, et al.  

Promoter Hypermethylation Identifies Progression Risk in Bladder Cancer

David R. Yates, Ishtiaq Rehman, Maysam F. Abbod, Mark Meuth, Simon S. Cross, Derek A. Linkens, Freddie C. Hamdy, and James W.F. Catto
Clin Cancer Res 2007 13: 2046-2053 doi: 10.1158/1078-0432.CCR-06-2476 [Abstract] [Full Text] [PDF] Supplementary Data, Yates, et al.  

Plasma Matrix Metalloproteinase-9 Level Is Better than Serum Matrix Metalloproteinase-9 Level to Predict Gastric Cancer Evolution

Chun-Ying Wu, Ming-Shiang Wu, En-Pei Chiang, Yi-Ju Chen, Chien-Jen Chen, Nai-Hui Chi, Ying-Ting Shih, Gran-Hum Chen, and Jaw-Town Lin
Clin Cancer Res 2007 13: 2054-2060 doi: 10.1158/1078-0432.CCR-06-2299 [Abstract] [Full Text] [PDF]  

Microtubule-Associated Protein-tau is a Bifunctional Predictor of Endocrine Sensitivity and Chemotherapy Resistance in Estrogen Receptor–Positive Breast Cancer

Fabrice Andre, Christos Hatzis, Keith Anderson, Christos Sotiriou, Chafika Mazouni, Jaime Mejia, Bailiang Wang, Gabriel N. Hortobagyi, W. Fraser Symmans, and Lajos Pusztai
Clin Cancer Res 2007 13: 2061-2067 doi: 10.1158/1078-0432.CCR-06-2078 [Abstract] [Full Text] [PDF] Supplementary Data, Andre, et al  

Utility of Circulating B-RAF DNA Mutation in Serum for Monitoring Melanoma Patients Receiving Biochemotherapy

Masaru Shinozaki, Steven J. O'Day, Minoru Kitago, Farin Amersi, Christine Kuo, Joseph Kim, He-Jing Wang, and Dave S.B. Hoon
Clin Cancer Res 2007 13: 2068-2074 doi: 10.1158/1078-0432.CCR-06-2120 [Abstract] [Full Text] [PDF]  

Tumor-Infiltrating Foxp3^–CD4⁺CD25⁺ T Cells Predict Poor Survival in Renal Cell Carcinoma

Sameer A. Siddiqui, Xavier Frigola, Sandra Bonne-Annee, Maria Mercader, Susan M. Kuntz, Amy E. Krambeck, Shomik Sengupta, Haidong Dong, John C. Cheville, Christine M. Lohse, Christopher J. Krco, W. Scott Webster, Bradley C. Leibovich, Michael L. Blute, Keith L. Knutson, and Eugene D. Kwon
Clin Cancer Res 2007 13: 2075-2081 doi: 10.1158/1078-0432.CCR-06-2139 [Abstract] [Full Text] [PDF]  

Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

Tadashi Tsujino, Iwao Seshimo, Hirofumi Yamamoto, Chew Yee Ngan, Koji Ezumi, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, and Morito Monden
Clin Cancer Res 2007 13: 2082-2090 doi: 10.1158/1078-0432.CCR-06-2191 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

A Phase I Pharmacokinetic and Pharmacodynamic Study of S-3304, a Novel Matrix Metalloproteinase Inhibitor, in Patients with Advanced and Refractory Solid Tumors

Alberto A. Chiappori, S. Gail Eckhardt, Ronald Bukowski, Daniel M. Sullivan, Minoru Ikeda, Yoshitaka Yano, Takuko Yamada-Sawada, Yoshikaze Kambayashi, Kazushige Tanaka, Milind M. Javle, Tarek Mekhail, Cindy L. O'Bryant, and Patrick J. Creaven
Clin Cancer Res 2007 13: 2091-2099 doi: 10.1158/1078-0432.CCR-06-1586 [Abstract] [Full Text] [PDF]  

Effects of the Administration of High-Dose Interleukin-2 on Immunoregulatory Cell Subsets in Patients with Advanced Melanoma and Renal Cell Cancer

Hans J.J. van derVliet, Henry B. Koon, Simon C. Yue, Burak Uzunparmak, Virginia Seery, Marc A. Gavin, Alexander Y. Rudensky, Michael B. Atkins, Steven P. Balk, and Mark A. Exley
Clin Cancer Res 2007 13: 2100-2108 doi: 10.1158/1078-0432.CCR-06-1662 [Abstract] [Full Text] [PDF]  

A Phase I Pharmacokinetic and Pharmacodynamic Study of PX-12, a Novel Inhibitor of Thioredoxin-1, in Patients with Advanced Solid Tumors

Ramesh K. Ramanathan, D. Lynn Kirkpatrick, Chandra P. Belani, David Friedland, Sylvan B. Green, H-H. Sherry Chow, Catherine A. Cordova, Steven P. Stratton, Elizabeth R. Sharlow, Amanda Baker, and Tomislav Dragovich
Clin Cancer Res 2007 13: 2109-2114 doi: 10.1158/1078-0432.CCR-06-2250 [Abstract] [Full Text] [PDF]  

Angiopoietin 2 Is a Potential Mediator of High-Dose Interleukin 2–Induced Vascular Leak

Diana C. Gallagher, Rupal S. Bhatt, Samir M. Parikh, Parin Patel, Virginia Seery, David F. McDermott, Michael B. Atkins, and Vikas P. Sukhatme
Clin Cancer Res 2007 13: 2115-2120 doi: 10.1158/1078-0432.CCR-06-2509 [Abstract] [Full Text] [PDF]  

Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors

Julie L. Eiseman, Jianxia Guo, Ramesh K. Ramanathan, Chandra P. Belani, David B. Solit, Howard I. Scher, S. Percy Ivy, Eleanor G. Zuhowski, and Merrill J. Egorin
Clin Cancer Res 2007 13: 2121-2127 doi: 10.1158/1078-0432.CCR-06-2286 [Abstract] [Full Text] [PDF]  

Phase I Evaluation of a Fully Human Anti–_v Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors

Saifee A. Mullamitha, Nhuan C. Ton, Geoff J.M. Parker, Alan Jackson, Peter J. Julyan, Caleb Roberts, Gio A. Buonaccorsi, Yvonne Watson, Karen Davies, Sue Cheung, Lynn Hope, Juan W. Valle, John A. Radford, Jeremy Lawrance, Mark P. Saunders, Mihaela C. Munteanu, Marian T. Nakada, Jeffrey A. Nemeth, Hugh M. Davis, Qun Jiao, Uma Prabhakar, Zhihui Lang, Robert E. Corringham, Robert A. Beckman, Gordon C. Jayson in association with the Biotherapy Development Association
Clin Cancer Res 2007 13: 2128-2135 doi: 10.1158/1078-0432.CCR-06-2779 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

5-Aza-2'-Deoxycytidine Delays Androgen-Independent Disease and Improves Survival in the Transgenic Adenocarcinoma of the Mouse Prostate Mouse Model of Prostate Cancer

Christoph S. Zorn, Kirk J. Wojno, Michael T. McCabe, Rainer Kuefer, Juergen E. Gschwend, and Mark L. Day
Clin Cancer Res 2007 13: 2136-2143 doi: 10.1158/1078-0432.CCR-06-2381 [Abstract] [Full Text] [PDF]  

Mcl-1 Is a Relevant Therapeutic Target in Acute and Chronic Lymphoid Malignancies: Down-Regulation Enhances Rituximab-Mediated Apoptosis and Complement-Dependent Cytotoxicity

Syed-Rehan A. Hussain, Carolyn M. Cheney, Amy J. Johnson, Thomas S. Lin, Michael R. Grever, Michael A. Caligiuri, David M. Lucas, and John C. Byrd
Clin Cancer Res 2007 13: 2144-2150 doi: 10.1158/1078-0432.CCR-06-2294 [Abstract] [Full Text] [PDF]  

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

Takeo Nomi, Masayuki Sho, Takahiro Akahori, Kaoru Hamada, Atsushi Kubo, Hiromichi Kanehiro, Shinji Nakamura, Koji Enomoto, Hideo Yagita, Miyuki Azuma, and Yoshiyuki Nakajima
Clin Cancer Res 2007 13: 2151-2157 doi: 10.1158/1078-0432.CCR-06-2746 [Abstract] [Full Text] [PDF]  

Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4⁺ T Cell Compartment without Affecting Regulatory T-Cell Function

Peter E. Fecci, Hidenobu Ochiai, Duane A. Mitchell, Peter M. Grossi, Alison E. Sweeney, Gary E. Archer, Thomas Cummings, James P. Allison, Darell D. Bigner, and John H. Sampson
Clin Cancer Res 2007 13: 2158-2167 doi: 10.1158/1078-0432.CCR-06-2070 [Abstract] [Full Text] [PDF]  

Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models

Lyuba Varticovski, Melinda G. Hollingshead, Ana I. Robles, Xiaolin Wu, James Cherry, David J. Munroe, Luanne Lukes, Miriam R. Anver, John P. Carter, Suzanne D. Borgel, Howard Stotler, Carrie A. Bonomi, Nomelí P. Nunez, Stephen D. Hursting, Wenhui Qiao, Chuxia X. Deng, Jeff E. Green, Kent W. Hunter, Glenn Merlino, Patricia S. Steeg, Lalage M. Wakefield, and J. Carl Barrett
Clin Cancer Res 2007 13: 2168-2177 doi: 10.1158/1078-0432.CCR-06-0918 [Abstract] [Full Text] [PDF] Supplementary Data, Varticovski, et al.  

Transfection with Anti-p65 Intrabody Suppresses Invasion and Angiogenesis in Glioma Cells by Blocking Nuclear Factor-B Transcriptional Activity

Liang Li, Christopher S. Gondi, Dzung H. Dinh, William C. Olivero, Meena Gujrati, and Jasti S. Rao
Clin Cancer Res 2007 13: 2178-2190 doi: 10.1158/1078-0432.CCR-06-1711 [Abstract] [Full Text] [PDF]  

The Therapeutic Potential of Hepatocyte Growth Factor to Sensitize Ovarian Cancer Cells to Cisplatin and Paclitaxel In vivo

Chiara Bardella, Daniela Dettori, Martina Olivero, Nadia Coltella, Massimiliano Mazzone, and Maria Flavia Di Renzo
Clin Cancer Res 2007 13: 2191-2198 doi: 10.1158/1078-0432.CCR-06-1915 [Abstract] [Full Text] [PDF] Supplementary Data, Bardella, et al.  

Chemosensitization of Cancer In vitro and In vivo by Nitric Oxide Signaling

Lisa J. Frederiksen, Richard Sullivan, Lori R. Maxwell, Shannyn K. Macdonald-Goodfellow, Michael A. Adams, Brian M. Bennett, D. Robert Siemens, and Charles H. Graham
Clin Cancer Res 2007 13: 2199-2206 doi: 10.1158/1078-0432.CCR-06-1807 [Abstract] [Full Text] [PDF]  

Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation In vitro and In vivo

Jeremy D. Heidel, Joanna Yi-Ching Liu, Yun Yen, Bingsen Zhou, Bret S.E. Heale, John J. Rossi, Derek W. Bartlett, and Mark E. Davis
Clin Cancer Res 2007 13: 2207-2215 doi: 10.1158/1078-0432.CCR-06-2218 [Abstract] [Full Text] [PDF] Supplementary Data, Heidel, et al.  

Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer

Alshad S. Lalani, Susan E. Alters, Alvin Wong, Mark R. Albertella, Jeffrey L. Cleland, and William David Henner
Clin Cancer Res 2007 13: 2216-2225 doi: 10.1158/1078-0432.CCR-06-2427 [Abstract] [Full Text] [PDF]  

Preclinical Studies of TW-37, a New Nonpeptidic Small-Molecule Inhibitor of Bcl-2, in Diffuse Large Cell Lymphoma Xenograft Model Reveal Drug Action on Both Bcl-2 and Mcl-1

Ramzi M. Mohammad, Anton Scott Goustin, Amro Aboukameel, Ben Chen, Sanjeev Banerjee, Guoping Wang, Zaneta Nikolovska-Coleska, Shaomeng Wang, and Ayad Al-Katib
Clin Cancer Res 2007 13: 2226-2235 doi: 10.1158/1078-0432.CCR-06-1574 [Abstract] [Full Text] [PDF]  

Menatetrenone, a Vitamin K2 Analogue, Inhibits Hepatocellular Carcinoma Cell Growth by Suppressing Cyclin D1 Expression through Inhibition of Nuclear Factor B Activation

Iwata Ozaki, Hao Zhang, Toshihiko Mizuta, Yasushi Ide, Yuichiro Eguchi, Tsutomu Yasutake, Toshiyuki Sakamaki, Richard G. Pestell, and Kyosuke Yamamoto
Clin Cancer Res 2007 13: 2236-2245 doi: 10.1158/1078-0432.CCR-06-2308 [Abstract] [Full Text] [PDF]  

c-Met Is a Potentially New Therapeutic Target for Treatment of Human Melanoma

Neelu Puri, Salman Ahmed, Varalakshmi Janamanchi, Maria Tretiakova, Osvaldo Zumba, Thomas Krausz, Ramasamy Jagadeeswaran, and Ravi Salgia
Clin Cancer Res 2007 13: 2246-2253 doi: 10.1158/1078-0432.CCR-06-0776 [Abstract] [Full Text] [PDF] Supplementary Data, Puri, et al.  

Identification of Molecular Predictors of Response in a Study of Tipifarnib Treatment in Relapsed and Refractory Acute Myelogenous Leukemia

Mitch Raponi, Jean-Luc Harousseau, Jeffrey E. Lancet, Bob Löwenberg, Richard Stone, Yi Zhang, Wayne Rackoff, Yixin Wang, and David Atkins
Clin Cancer Res 2007 13: 2254-2260 doi: 10.1158/1078-0432.CCR-06-2609 [Abstract] [Full Text] [PDF] Supplementary Data, Raponi, et al.  

Synergism between Arsenic Trioxide and Heat Shock Protein 90 Inhibitors on Signal Transducer and Activator of Transcription Protein 3 Activity—Pharmacodynamic Drug-Drug Interaction Modeling

Meir Wetzler, Justin C. Earp, Michael T. Brady, Michael K. Keng, and William J. Jusko
Clin Cancer Res 2007 13: 2261-2270 doi: 10.1158/1078-0432.CCR-06-2468 [Abstract] [Full Text] [PDF]  

The Therapeutic and Preventive Effect of RRR--Vitamin E Succinate on Prostate Cancer via Induction of Insulin-Like Growth Factor Binding Protein-3

Yi Yin, Jing Ni, Ming Chen, Matthew A. DiMaggio, Yinglu Guo, and Shuyuan Yeh
Clin Cancer Res 2007 13: 2271-2280 doi: 10.1158/1078-0432.CCR-06-1217 [Abstract] [Full Text] [PDF]  

Cancer Prevention:

Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced Murine Lung Tumors

Courtney A. Granville, Noel Warfel, Junji Tsurutani, M. Christine Hollander, Matthew Robertson, Stephen D. Fox, Timothy D. Veenstra, Haleem J. Issaq, R. Ilona Linnoila, and Phillip A. Dennis
Clin Cancer Res 2007 13: 2281-2289 doi: 10.1158/1078-0432.CCR-06-2570 [Abstract] [Full Text] [PDF]  

Morin (3,5,7,2',4'-Pentahydroxyflavone) Abolishes Nuclear Factor-B Activation Induced by Various Carcinogens and Inflammatory Stimuli, Leading to Suppression of Nuclear Factor-B–Regulated Gene Expression and Up-regulation of Apoptosis

Sunil K. Manna, Rishi S. Aggarwal, Gautam Sethi, Bharat B. Aggarwal, and Govindarajan T. Ramesh
Clin Cancer Res 2007 13: 2290-2297 doi: 10.1158/1078-0432.CCR-06-2394 [Abstract] [Full Text] [PDF]  

Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect

Nashi Widodo, Kamaljit Kaur, Bhupal G. Shrestha, Yasuomi Takagi, Tetsuro Ishii, Renu Wadhwa, and Sunil C. Kaul
Clin Cancer Res 2007 13: 2298-2306 doi: 10.1158/1078-0432.CCR-06-0948 [Abstract] [Full Text] [PDF]  

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