Editorials:

Phase II Cancer Trials: Out of Control?

Bruce Chabner
Clin Cancer Res 2007 13: 2307-2308 doi: 10.1158/1078-0432.CCR-07-0163 [Full Text] [PDF]  

The Biology Behind:

The Use of Epigenetic Biomarkers for Preclinical Detection of Hepatocellular Carcinoma: Potential for Noninvasive Screening of High-Risk Populations

Ashley G. Rivenbark and William B. Coleman
Clin Cancer Res 2007 13: 2309 -2312 doi: 10.1158/1078-0432.CCR-07-0086 [Full Text] [PDF]  

Molecular Pathways:

Targeting TRAIL Agonistic Receptors for Cancer Therapy

Carmelo Carlo-Stella, Cristiana Lavazza, Alberta Locatelli, Lucia Viganò, Alessandro M. Gianni, and Luca Gianni
Clin Cancer Res 2007 13: 2313-2317 doi: 10.1158/1078-0432.CCR-06-2774 [Abstract] [Full Text] [PDF]  

Report from the FDA:

Vorinostat for Treatment of Cutaneous Manifestations of Advanced Primary Cutaneous T-Cell Lymphoma

Bhupinder S. Mann, John R. Johnson, Kun He, Rajeshwari Sridhara, Sophia Abraham, Brian P. Booth, Leigh Verbois, David E. Morse, Josephine M. Jee, Sarah Pope, Ravi S. Harapanhalli, Ramzi Dagher, Ann Farrell, Robert Justice, and Richard Pazdur
Clin Cancer Res 2007 13: 2318-2322 doi: 10.1158/1078-0432.CCR-06-2672 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Higher Frequency of Diploidy in Young-Onset Microsatellite-Stable Colorectal Cancer

Lisa A. Boardman, Ruth A. Johnson, Gloria M. Petersen, Ann L. Oberg, Brian F. Kabat, Joshua P. Slusser, Liang Wang, Bruce W. Morlan, Amy J. French, Thomas C. Smyrk, Noralane M. Lindor, and Stephen N. Thibodeau
Clin Cancer Res 2007 13: 2323-2328 doi: 10.1158/1078-0432.CCR-06-2739 [Abstract] [Full Text] [PDF]  

The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes

Lisa A. Carey, E. Claire Dees, Lynda Sawyer, Lisa Gatti, Dominic T. Moore, Frances Collichio, David W. Ollila, Carolyn I. Sartor, Mark L. Graham, and Charles M. Perou
Clin Cancer Res 2007 13: 2329-2334 doi: 10.1158/1078-0432.CCR-06-1109 [Abstract] [Full Text] [PDF]  

ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression

Patricia M. McGowan, Bríd M. Ryan, Arnold D.K. Hill, Enda McDermott, Niall O'Higgins, and Michael J. Duffy
Clin Cancer Res 2007 13: 2335-2343 doi: 10.1158/1078-0432.CCR-06-2092 [Abstract] [Full Text] [PDF]  

Reciprocal Regulation of SOCS 1 and SOCS3 Enhances Resistance to Ionizing Radiation in Glioblastoma Multiforme

Hong Zhou, Rika Miki, Mervi Eeva, Francesca M. Fike, David Seligson, Lu Yang, Akihiko Yoshimura, Michael A. Teitell, Christina A.M. Jamieson, and Nicholas A. Cacalano
Clin Cancer Res 2007 13: 2344-2353 doi: 10.1158/1078-0432.CCR-06-2303 [Abstract] [Full Text] [PDF]  

Down-Regulation of CD9 Expression during Prostate Carcinoma Progression Is Associated with CD9 mRNA Modifications

Jia-Chi Wang, Louis R. Bégin, Nathalie G. Bérubé, Simone Chevalier, Armen G. Aprikian, Henriette Gourdeau, and Mario Chevrette
Clin Cancer Res 2007 13: 2354-2361 Published Online First April 3, 2007. doi: 10.1158/1078-0432.CCR-06-1692 [Abstract] [Full Text] [PDF]  

Role of CD14 Promoter Polymorphisms in Helicobacter pylori Infection–Related Gastric Carcinoma

Dan Zhao, Tong Sun, Xuemei Zhang, Yongli Guo, Dianke Yu, Ming Yang, Wen Tan, Guiqi Wang, and Dongxin Lin
Clin Cancer Res 2007 13: 2362-2368 doi: 10.1158/1078-0432.CCR-06-2612 [Abstract] [Full Text] [PDF]  

c-Kit/PDGFRA Gene Status Alterations Possibly Related to Primary Imatinib Resistance in Gastrointestinal Stromal Tumors

Francesca="C"> Miselli, Paola Casieri, Tiziana Negri, Marta Orsenigo, M. Stefania Lagonigro, Alessandro Gronchi, Marco Fiore, Paolo G. Casali, Rossella Bertulli, Antonino Carbone, Marco A. Pierotti, Elena Tamborini, and Silvana Pilotti
Clin Cancer Res 2007 13: 2369-2377 doi: 10.1158/1078-0432.CCR-06-1745 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA

Yu-Jing Zhang, Hui-Chen Wu, Jing Shen, Habibul Ahsan, Wei Yann Tsai, Hwai-I Yang, Li-Yu Wang, Shu-Yuan Chen, Chien-Jen Chen, and Regina M. Santella
Clin Cancer Res 2007 13: 2378-2384 doi: 10.1158/1078-0432.CCR-06-1900 [Abstract] [Full Text] [PDF]  

Serum Cytokine Profiling as a Diagnostic and Prognostic Tool in Ovarian Cancer: A Potential Role for Interleukin 7

Annechien J.A. Lambeck, Anne P.G. Crijns, Ninke Leffers, Wim J. Sluiter, Klaske A. ten Hoor, Mike Braid, Ate G.J. van der Zee, Toos Daemen, Hans W. Nijman, and W. Martin Kast
Clin Cancer Res 2007 13: 2385-2391 doi: 10.1158/1078-0432.CCR-06-1828 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Systemic Interleukin-2 and Adoptive Transfer of Lymphokine-Activated Killer Cells Improves Antibody-Dependent Cellular Cytotoxicity in Patients with Relapsed B-Cell Lymphoma Treated with Rituximab

Jesús G. Berdeja, Allan Hess, David M. Lucas, Paul O'Donnell, Richard F. Ambinder, Louis F. Diehl, Denise Carter-Brookins, Susan Newton, and Ian W. Flinn
Clin Cancer Res 2007 13: 2392-2399 doi: 10.1158/1078-0432.CCR-06-1860 [Abstract] [Full Text] [PDF]  

Phase II Trials Published in 2002: A Cross-Specialty Comparison Showing Significant Design Differences between Oncology Trials and Other Medical Specialties

Laura C. Michaelis and Mark J. Ratain
Clin Cancer Res 2007 13: 2400-2405 doi: 10.1158/1078-0432.CCR-06-1488 [Abstract] [Full Text] [PDF]  

Multiple Molecular Markers as Predictors of Colorectal Cancer in Patients with Normal Perioperative Serum Carcinoembryonic Antigen Levels

Jaw-Yuan Wang, Shiu-Ru Lin, Deng-Chyang Wu, Chien-Yu Lu, Fang-Jung Yu, Jan-Sing Hsieh, Tian-Lu Cheng, Lok-Beng Koay, and Yih-Huei Uen
Clin Cancer Res 2007 13: 2406-2413 Published Online First April 3, 2007. doi: 10.1158/1078-0432.CCR-06-2054 [Abstract] [Full Text] [PDF]  

Phase I Study of Aerosolized SLIT Cisplatin in the Treatment of Patients with Carcinoma of the Lung

Bart P.H. Wittgen, Peter W.A. Kunst, Kasper van der Born, Atie W. van Wijk, Walter Perkins, Frank G. Pilkiewicz, Roman Perez-Soler, Susan Nicholson, Godefridus J. Peters, and Pieter E. Postmus
Clin Cancer Res 2007 13: 2414-2421 doi: 10.1158/1078-0432.CCR-06-1480 [Abstract] [Full Text] [PDF]  

Multiplex Analysis of Serum Cytokines in Melanoma Patients Treated with Interferon-2b

Zoya R. Yurkovetsky, John M. Kirkwood, Howard D. Edington, Adele M. Marrangoni, Lyudmila Velikokhatnaya, Matthew T. Winans, Elieser Gorelik, and Anna E. Lokshin
Clin Cancer Res 2007 13: 2422-2428 doi: 10.1158/1078-0432.CCR-06-1805 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Cholecystokinin Down-Regulation by RNA Interference Impairs Ewing Tumor Growth

Jaime Carrillo, Eva García-Aragoncillo, Daniel Azorín, Noelia Agra, Ana Sastre, Imelda González-Mediero, Purificación García-Miguel, Ángel Pestaña, Soledad Gallego, Dolores Segura, and Javier Alonso
Clin Cancer Res 2007 13: 2429-2440 doi: 10.1158/1078-0432.CCR-06-1762 [Abstract] [Full Text] [PDF]  

Silencing of Hypoxia Inducible Factor-1 by RNA Interference Attenuates Human Glioma Cell Growth In vivo

David L. Gillespie, Kum Whang, Brian T. Ragel, Jeannette R. Flynn, David A. Kelly, and Randy L. Jensen
Clin Cancer Res 2007 13: 2441-2448 doi: 10.1158/1078-0432.CCR-06-2692 [Abstract] [Full Text] [PDF]  

In vivo Imaging of Oral Mucositis in an Animal Model Using Optical Coherence Tomography and Optical Doppler Tomography

Petra Wilder-Smith, Marie J. Hammer-Wilson, Jun Zhang, Qiang Wang, Kathryn Osann, Zhongping Chen, Harvey Wigdor, Joel Schwartz, and Joel Epstein
Clin Cancer Res 2007 13: 2449-2454 doi: 10.1158/1078-0432.CCR-06-2234 [Abstract] [Full Text] [PDF]  

A Novel Chromogranin-A Promoter-Driven Oncolytic Adenovirus for Midgut Carcinoid Therapy

Justyna Leja, Helena Dzojic, Elisabet Gustafson, Kjell Öberg, Valeria Giandomenico, and Magnus Essand
Clin Cancer Res 2007 13: 2455-2462 doi: 10.1158/1078-0432.CCR-06-2532 [Abstract] [Full Text] [PDF]  

The Tyrosine Kinase Inhibitor Imatinib Mesylate Enhances the Efficacy of Photodynamic Therapy by Inhibiting ABCG2

Weiguo Liu, Maria R. Baer, Mary Jo Bowman, Paula Pera, Xiang Zheng, Janet Morgan, Ravindra A. Pandey, and Allan R. Oseroff
Clin Cancer Res 2007 13: 2463-2470 doi: 10.1158/1078-0432.CCR-06-1599 [Abstract] [Full Text] [PDF]  

The Human T-Box Mesodermal Transcription Factor Brachyury Is a Candidate Target for T-Cell–Mediated Cancer Immunotherapy

Claudia Palena, Dmitry E. Polev, Kwong Y. Tsang, Romaine I. Fernando, Mary Litzinger, Larisa L. Krukovskaya, Ancha V. Baranova, Andrei P. Kozlov, and Jeffrey Schlom
Clin Cancer Res 2007 13: 2471-2478 doi: 10.1158/1078-0432.CCR-06-2353 [Abstract] [Full Text] [PDF]  

HLA-DQB1*02–Restricted HPV-16 E7 Peptide–Specific CD4⁺ T-Cell Immune Responses Correlate with Regression of HPV-16–Associated High-Grade Squamous Intraepithelial Lesions

Shiwen Peng, Cornelia Trimble, Lee Wu, Drew Pardoll, Richard Roden, Chien-Fu Hung, and T.-C. Wu
Clin Cancer Res 2007 13: 2479-2487 doi: 10.1158/1078-0432.CCR-06-2916 [Abstract] [Full Text] [PDF] Supplementary Data, Peng, et al.  

Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs

Hongwei Wang, Haiyan Huang, Hao Li, Denise G. Teotico, Michael Sinz, Sharyn D. Baker, Jeffrey Staudinger, Ganjam Kalpana, Matthew R. Redinbo, and Sridhar Mani
Clin Cancer Res 2007 13: 2488-2495 doi: 10.1158/1078-0432.CCR-06-1592 [Abstract] [Full Text] [PDF]  

Proteomics of Canine Lymphoma Identifies Potential Cancer-Specific Protein Markers

Dudley L. McCaw, Arvan S. Chan, Andrew L. Stegner, Brian Mooney, Jeffrey N. Bryan, Susan E. Turnquist, Carolyn J. Henry, Hannah Alexander, and Stephen Alexander
Clin Cancer Res 2007 13: 2496-2503 doi: 10.1158/1078-0432.CCR-06-2699 [Abstract] [Full Text] [PDF]  

Characterization and Magnetic Resonance Imaging of a Rat Model of Human B-Cell Central Nervous System Lymphoma

Carole Soussain, Leslie L. Muldoon, Csanad Varallyay, Kristoph Jahnke, Luciana DePaula, and Edward A. Neuwelt
Clin Cancer Res 2007 13: 2504-2511 doi: 10.1158/1078-0432.CCR-06-2379 [Abstract] [Full Text] [PDF]  

Effect of Epidermal Growth Factor Receptor Inhibitor Class in the Treatment of Head and Neck Cancer with Concurrent Radiochemotherapy In vivo

Felix Y. Feng, Carlos A. Lopez, Daniel P. Normolle, Sooryanarayana Varambally, Xiaoxin Li, Patrick Y. Chun, Mary A. Davis, Theodore S. Lawrence, and Mukesh K. Nyati
Clin Cancer Res 2007 13: 2512-2518 doi: 10.1158/1078-0432.CCR-06-2582 [Abstract] [Full Text] [PDF] Supplementary Data, Feng, et al.  

Cancer Prevention:

Ursodeoxycholic Acid versus Sulfasalazine in Colitis-Related Colon Carcinogenesis in Mice

Hiroyuki Kohno, Rikako Suzuki, Yumiko Yasui, Shingo Miyamoto, Keiji Wakabayashi, and Takuji Tanaka
Clin Cancer Res 2007 13: 2519-2525 doi: 10.1158/1078-0432.CCR-06-2727 [Abstract] [Full Text] [PDF]  

Polymorphisms of MTHFD, Plasma Homocysteine Levels, and Risk of Gastric Cancer in a High-Risk Chinese Population

Lina Wang, Qiao Ke, Wensen Chen, Jianming Wang, Yongfei Tan, Yan Zhou, Zhaolai Hua, Weiliang Ding, Juying Niu, Jing Shen, Zuofeng Zhang, Xinru Wang, Yaochu Xu, and Hongbing Shen
Clin Cancer Res 2007 13: 2526-2532 doi: 10.1158/1078-0432.CCR-06-2293 [Abstract] [Full Text] [PDF]  

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