Editorials:

Kenneth C. Anderson
Clin Cancer Res 2008 14: 1 Published Online First December 13, 2007. doi: 10.1158/1078-0432.CCR-14-1G [Full Text] [PDF]  

Another Negative Chemoprevention Trial: What Can We Learn?

Frank L. Meyskens, Jr.
Clin Cancer Res 2008 14: 2-3 doi: 10.1158/1078-0432.CCR-07-2215 [Full Text] [PDF]  

Perspectives:

The Immunogenicity of the hTERT540-548 Peptide in Cancer

Lynn Wenandy, Rikke Bæk Sørensen, Lisa Sengeløv, Inge Marie Svane, Per thor Straten, and Mads Hald Andersen
Clin Cancer Res 2008 14: 4-7 doi: 10.1158/1078-0432.CCR-07-4590 [Abstract] [Full Text] [PDF]  

Reviews:

Can Inhibiting Dihydropyrimidine Dehydrogenase Limit Hand-Foot Syndrome Caused by Fluoropyrimidines?

Jane L. Yen-Revollo, Richard M. Goldberg, and Howard L. McLeod
Clin Cancer Res 2008 14: 8-13 doi: 10.1158/1078-0432.CCR-07-1225 [Abstract] [Full Text] [PDF]  

Cardiac Toxicity in Breast Cancer Survivors: Review of Potential Cardiac Problems

Brian R.J. Healey Bird and Sandra M. Swain
Clin Cancer Res 2008 14: 14-24 doi: 10.1158/1078-0432.CCR-07-1033 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Two Distinct Local Relapse Subtypes in Invasive Breast Cancer: Effect on their Prognostic Impact

Patrizia Casalini, Maria Luisa Carcangiu, Raija Tammi, Päivi Auvinen, Veli-Matti Kosma, Pinuccia Valagussa, Marco Greco, Andrea Balsari, Sylvie Ménard, and Elda Tagliabue
Clin Cancer Res 2008 14: 25-31 doi: 10.1158/1078-0432.CCR-07-0450 [Abstract] [Full Text] [PDF]  

Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress

Ken Yamaguchi, Masaki Mandai, Shinya Toyokuni, Junzo Hamanishi, Toshihiro Higuchi, Kenji Takakura, and Shingo Fujii
Clin Cancer Res 2008 14: 32-40 doi: 10.1158/1078-0432.CCR-07-1614 [Abstract] [Full Text] [PDF]  

Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer

Ludmila Prudkin, Carmen Behrens, Diane D. Liu, Xian Zhou, Natalie C. Ozburn, B. Nebiyou Bekele, John D. Minna, Cesar Moran, Jack A. Roth, Lin Ji, and Ignacio I. Wistuba
Clin Cancer Res 2008 14: 41-47 doi: 10.1158/1078-0432.CCR-07-1252 [Abstract] [Full Text] [PDF] Supplementary Data  

Aberrant Crypt Foci as Precursors of the Dysplasia-Carcinoma Sequence in Patients with Ulcerative Colitis

Takehiro Kukitsu, Tetsuji Takayama, Koji Miyanishi, Atsushi Nobuoka, Shinichi Katsuki, Yasushi Sato, Rishu Takimoto, Takuya Matsunaga, Junji Kato, Tomoko Sonoda, Sumio Sakamaki, and Yoshiro Niitsu
Clin Cancer Res 2008 14: 48-54 doi: 10.1158/1078-0432.CCR-07-1835 [Abstract] [Full Text] [PDF]  

WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/β-Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer

Jianming Ying, Hongyu Li, Jun Yu, Ka Man Ng, Fan Fong Poon, Sze Chuen Cesar Wong, Anthony T.C. Chan, Joseph J.Y. Sung, and Qian Tao
Clin Cancer Res 2008 14: 55-61 doi: 10.1158/1078-0432.CCR-07-1644 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer

Jong Gwang Kim, Yee Soo Chae, Sang Kyun Sohn, Yoon Young Cho, Joon Ho Moon, Jae Yong Park, Seoung Woo Jeon, In Taek Lee, Gyu Seog Choi, and Soo-Han Jun
Clin Cancer Res 2008 14: 62-66 doi: 10.1158/1078-0432.CCR-07-1537 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Cyclooxygenase-2 Overexpression in Glottic Cancer

Melanie K. Sackett, Isabelle Bairati, François Meyer, Édith Jobin, Sébastien Lussier, André Fortin, Michel Gélinas, Abdenour Nabid, François Brochet, and Bernard Têtu
Clin Cancer Res 2008 14: 67-73 doi: 10.1158/1078-0432.CCR-07-2028 [Abstract] [Full Text] [PDF]  

Identification of Matrix Metalloproteinase 11 as a Predictive Tumor Marker in Serum Based on Gene Expression Profiling

Yan-Hong Yang, Hua Deng, Wen-Mei Li, Qing-Yun Zhang, Xiao-Ting Hu, Bai Xiao, Hai-Hong Zhu, Pai-Li Geng, and You-Yong Lu
Clin Cancer Res 2008 14: 74-81 doi: 10.1158/1078-0432.CCR-07-1179 [Abstract] [Full Text] [PDF] Supplementary Data  

Impact of E2F-1 Expression on Clinical Outcome of Gastric Adenocarcinoma Patients with Adjuvant Chemoradiation Therapy

Jeeyun Lee, Cheol Keun Park, Joon Oh Park, Taekyu Lim, Young Suk Park, Ho Yeong Lim, Inkyoung Lee, Tae Sung Sohn, Jae Hyung Noh, Jin Seok Heo, Sung Kim, Do Hoon Lim, Kyoung-Mee Kim, and Won Ki Kang
Clin Cancer Res 2008 14: 82-88 doi: 10.1158/1078-0432.CCR-07-0612 [Abstract] [Full Text] [PDF]  

Both Germ Line and Somatic Genetics of the p53 Pathway Affect Ovarian Cancer Incidence and Survival

Frank Bartel, Juliane Jung, Anja Böhnke, Elise Gradhand, Katharina Zeng, Christoph Thomssen, and Steffen Hauptmann
Clin Cancer Res 2008 14: 89-96 doi: 10.1158/1078-0432.CCR-07-1192 [Abstract] [Full Text] [PDF]  

Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma

André Lopes Carvalho, Carmen Jeronimo, Michael M. Kim, Rui Henrique, Zhe Zhang, Mohammad O. Hoque, Steve Chang, Mariana Brait, Chetan S. Nayak, Wei-Wen Jiang, Quia Claybourne, Yutaka Tokumaru, Juna Lee, David Goldenberg, Elizabeth Garrett-Mayer, Steven Goodman, Chul-so Moon, Wayne Koch, William H. Westra, David Sidransky, and Joseph A. Califano
Clin Cancer Res 2008 14: 97-107 doi: 10.1158/1078-0432.CCR-07-0722 [Abstract] [Full Text] [PDF] Supplementary Data  

How Large a Training Set is Needed to Develop a Classifier for Microarray Data?

Kevin K. Dobbin, Yingdong Zhao, and Richard M. Simon
Clin Cancer Res 2008 14: 108-114 doi: 10.1158/1078-0432.CCR-07-0443 [Abstract] [Full Text] [PDF] Supplementary Data  

Integrative Genomic Analysis of Aneuploidy in Uveal Melanoma

Justis P. Ehlers, Lori Worley, Michael D. Onken, and J. William Harbour
Clin Cancer Res 2008 14: 115-122 doi: 10.1158/1078-0432.CCR-07-1825 [Abstract] [Full Text] [PDF] Supplementary Data  

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

Felix Zeppernick, Rezvan Ahmadi, Benito Campos, Christine Dictus, Burkhard M. Helmke, Natalia Becker, Peter Lichter, Andreas Unterberg, Bernhard Radlwimmer, and Christel C. Herold-Mende
Clin Cancer Res 2008 14: 123-129 doi: 10.1158/1078-0432.CCR-07-0932 [Abstract] [Full Text] [PDF]  

Axl and Growth Arrest–Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

Markus Hutterer, Pjotr Knyazev, Ariane Abate, Markus Reschke, Hans Maier, Nadia Stefanova, Tatjana Knyazeva, Verena Barbieri, Markus Reindl, Armin Muigg, Herwig Kostron, Guenther Stockhammer, and Axel Ullrich
Clin Cancer Res 2008 14: 130-138 doi: 10.1158/1078-0432.CCR-07-0862 [Abstract] [Full Text] [PDF]  

Identification of Patients with (Atypical) MUTYH-Associated Polyposis by KRAS2 c.34G > T Prescreening Followed by MUTYH Hotspot Analysis in Formalin-Fixed Paraffin-Embedded Tissue

Marjo van Puijenbroek, Maartje Nielsen, Carli M.J. Tops, Hans Halfwerk, Hans F.A. Vasen, Marjan M. Weiss, Tom van Wezel, Frederik J. Hes, and Hans Morreau
Clin Cancer Res 2008 14: 139-142 doi: 10.1158/1078-0432.CCR-07-1705 [Abstract] [Full Text] [PDF]  

Node-Negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression

Inti Zlobec, Kristi Baker, Parham Minoo, Jeremy R. Jass, Luigi Terracciano, and Alessandro Lugli
Clin Cancer Res 2008 14: 143-148 doi: 10.1158/1078-0432.CCR-07-1380 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Bronchopulmonary Carcinoid: Phenotype and Long-term Outcome in a Single-Institution Series of Italian Patients

Massimo Rugge, Matteo Fassan, Roberto Clemente, Giovanna Rizzardi, Luciano Giacomelli, Gianmaria Pennelli, Claudia Mescoli, Daniela Segat, and Federico Rea
Clin Cancer Res 2008 14: 149-154 doi: 10.1158/1078-0432.CCR-07-1631 [Abstract] [Full Text] [PDF]  

Fludarabine, Cyclophosphamide, and Mitoxantrone as Initial Therapy of Chronic Lymphocytic Leukemia: High Response Rate and Disease Eradication

Francesc Bosch, Ana Ferrer, Neus Villamor, Marcos González, Javier Briones, Eva González-Barca, Eugenia Abella, Santiago Gardella, Lourdes Escoda, Elena Pérez-Ceballos, Antoni Asensi, Ma José Sayas, Llorenç Font, Albert Altés, Ana Muntañola, Paola Bertazzoni, María Rozman, Marta Aymerich, Eva Giné, and Emili Montserrat
Clin Cancer Res 2008 14: 155-161 doi: 10.1158/1078-0432.CCR-07-1371 [Abstract] [Full Text] [PDF]  

Radiotherapy in Lung Adenocarcinoma with Brain Metastases: Effects of Activating Epidermal Growth Factor Receptor Mutations on Clinical Response

Chien-Hung Gow, Chun-Ru Chien, Yih-Leong Chang, Yueh-Hsia Chiu, Sung-Hsin Kuo, Jin-Yuan Shih, Yeun-Chung Chang, Chong-Jen Yu, Chih-Hsin Yang, and Pan-Chyr Yang
Clin Cancer Res 2008 14: 162-168 doi: 10.1158/1078-0432.CCR-07-1468 [Abstract] [Full Text] [PDF]  

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

Gemma G. Kenter, Marij J.P. Welters, A.Rob P.M. Valentijn, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Annelies P.G. Vloon, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg, and Cornelis J.M. Melief
Clin Cancer Res 2008 14: 169-177 doi: 10.1158/1078-0432.CCR-07-1881 [Abstract] [Full Text] [PDF]  

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

Marij J.P. Welters, Gemma G. Kenter, Sytse J. Piersma, Annelies P.G. Vloon, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Jan W. Drijfhout, A. Rob P.M. Valentijn, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Cornelis J.M. Melief, and Sjoerd H. van der Burg
Clin Cancer Res 2008 14: 178-187 doi: 10.1158/1078-0432.CCR-07-1880 [Abstract] [Full Text] [PDF]  

Clinical and Molecular Responses in Lung Cancer Patients Receiving Romidepsin

David S. Schrump, Maria R. Fischette, Dao M. Nguyen, Ming Zhao, Xinmin Li, Tricia F. Kunst, Ana Hancox, Julie A. Hong, G. Aaron Chen, Evgeny Kruchin, John J. Wright, Douglas R. Rosing, Alex Sparreboom, William D. Figg, and Seth M. Steinberg
Clin Cancer Res 2008 14: 188-198 doi: 10.1158/1078-0432.CCR-07-0135 [Abstract] [Full Text] [PDF]  

Interleukin-13 Receptor 2, EphA2, and Fos-Related Antigen 1 as Molecular Denominators of High-Grade Astrocytomas and Specific Targets for Combinatorial Therapy

Jill Wykosky, Denise M. Gibo, Constance Stanton, and Waldemar Debinski
Clin Cancer Res 2008 14: 199-208 doi: 10.1158/1078-0432.CCR-07-1990 [Abstract] [Full Text] [PDF]  

A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer

William L. Dahut, Charity Scripture, Edwin Posadas, Lokesh Jain, James L. Gulley, Philip M. Arlen, John J. Wright, Yunkai Yu, Liang Cao, Seth M. Steinberg, Jeanny B. Aragon-Ching, Jürgen Venitz, Elizabeth Jones, Clara C. Chen, and William D. Figg
Clin Cancer Res 2008 14: 209-214 doi: 10.1158/1078-0432.CCR-07-1355 [Abstract] [Full Text] [PDF]  

Phase I Pharmacokinetic/Pharmacodynamic Study of EKB-569, an Irreversible Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Combination with Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in First-Line Treatment of Patients with Metastatic Colorectal Cancer

Gunnar Folprecht, Josep Tabernero, Claus-Henning Köhne, Charles Zacharchuk, Luis Paz-Ares, Federico Rojo, Susan Quinn, Esther Casado, Ramon Salazar, Richat Abbas, Chantal Lejeune, Irene Marimón, Jordi Andreu, Ulrike Ubbelohde, Hernan Cortes-Funes, and Jose Baselga
Clin Cancer Res 2008 14: 215-223 doi: 10.1158/1078-0432.CCR-07-1053 [Abstract] [Full Text] [PDF]  

Phase III Prevention Trial of Fenretinide in Patients with Resected Non–Muscle-Invasive Bladder Cancer

Anita L. Sabichi, Seth P. Lerner, E. Neely Atkinson, H. Barton Grossman, Nancy P. Caraway, Colin P. Dinney, David F. Penson, Surena Matin, Ashish Kamat, Louis L. Pisters, Daniel W. Lin, Ruth L. Katz, Dean E. Brenner, George P. Hemstreet, III, Mary Wargo, Archie Bleyer, William H. Sanders, John L. Clifford, Howard L. Parnes, and Scott M. Lippman
Clin Cancer Res 2008 14: 224-229 doi: 10.1158/1078-0432.CCR-07-0733 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

Nikolas K. Haass, Katrin Sproesser, Thiennga K. Nguyen, Rooha Contractor, C. Angelica Medina, Katherine L. Nathanson, Meenhard Herlyn, and Keiran S.M. Smalley
Clin Cancer Res 2008 14: 230-239 doi: 10.1158/1078-0432.CCR-07-1440 [Abstract] [Full Text] [PDF] Supplementary Data  

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

Sarat Chandarlapaty, Ayana Sawai, Qing Ye, Anisa Scott, Melanie Silinski, Ken Huang, Pat Fadden, Jeff Partdrige, Steven Hall, Paul Steed, Larry Norton, Neal Rosen, and David B. Solit
Clin Cancer Res 2008 14: 240-248 doi: 10.1158/1078-0432.CCR-07-1667 [Abstract] [Full Text] [PDF]  

Blocking Vascular Endothelial Growth Factor-A Inhibits the Growth of Pituitary Adenomas and Lowers Serum Prolactin Level in a Mouse Model of Multiple Endocrine Neoplasia Type 1

Nina Korsisaari, Jed Ross, Xiumin Wu, Marcin Kowanetz, Navneet Pal, Linda Hall, Jeffrey Eastham-Anderson, William F. Forrest, Nicholas Van Bruggen, Franklin V. Peale, and Napoleone Ferrara
Clin Cancer Res 2008 14: 249-258 doi: 10.1158/1078-0432.CCR-07-1552 [Abstract] [Full Text] [PDF] Supplementary Data  

Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus

Jian Qiao, Hongxun Wang, Timothy Kottke, Christine White, Katie Twigger, Rosa Maria Diaz, Jill Thompson, Peter Selby, Johann de Bono, Alan Melcher, Hardev Pandha, Matt Coffey, Richard Vile, and Kevin Harrington
Clin Cancer Res 2008 14: 259-269 doi: 10.1158/1078-0432.CCR-07-1510 [Abstract] [Full Text] [PDF]  

Combining Agents that Target the Tumor Microenvironment Improves the Efficacy of Anticancer Therapy

Joseph A. Blansfield, Diana Caragacianu, H. Richard Alexander, III, Michael A. Tangrea, Shane Y. Morita, Dominique Lorang, Peter Schafer, George Muller, David Stirling, Richard E. Royal, and Steven K. Libutti
Clin Cancer Res 2008 14: 270-280 doi: 10.1158/1078-0432.CCR-07-1562 [Abstract] [Full Text] [PDF]  

Antitumor Effects of Systemically Delivered Adenovirus Harboring Trans-Splicing Ribozyme in Intrahepatic Colon Cancer Mouse Model

Jin-Sook Jeong, Seong-Wook Lee, Seung-Hee Hong, Yoon-Jong Lee, Haeng-Im Jung, Kyung-Sook Cho, Hye-Hyun Seo, Sang-Jin Lee, Sohee Park, Min-Sun Song, Chang-Min Kim, and In-Hoo Kim
Clin Cancer Res 2008 14: 281-290 doi: 10.1158/1078-0432.CCR-07-1524 [Abstract] [Full Text] [PDF]  

Prostate-Restricted Replicative Adenovirus Expressing Human Endostatin-Angiostatin Fusion Gene Exhibiting Dramatic Antitumor Efficacy

Xiong Li, You-Hong Liu, Sang-Jin Lee, Thomas A. Gardner, Meei-Huey Jeng, and Chinghai Kao
Clin Cancer Res 2008 14: 291-299 doi: 10.1158/1078-0432.CCR-07-0867 [Abstract] [Full Text] [PDF]  

Oral Silibinin Inhibits In vivo Human Bladder Tumor Xenograft Growth Involving Down-Regulation of Survivin

Rana P. Singh, Alpna Tyagi, Girish Sharma, Sarumathi Mohan, and Rajesh Agarwal
Clin Cancer Res 2008 14: 300-308 doi: 10.1158/1078-0432.CCR-07-1565 [Abstract] [Full Text] [PDF]  

Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents

Lorenzo M. Leoni, Brandi Bailey, Jack Reifert, Heather H. Bendall, Robert W. Zeller, Jacques Corbeil, Gary Elliott, and Christina C. Niemeyer
Clin Cancer Res 2008 14: 309-317 doi: 10.1158/1078-0432.CCR-07-1061 [Abstract] [Full Text] [PDF]  

Using Pharmacokinetic and Pharmacodynamic Modeling and Simulation to Evaluate Importance of Schedule in Topotecan Therapy for Pediatric Neuroblastoma

John C. Panetta, Paula Schaiquevich, Victor M. Santana, and Clinton F. Stewart
Clin Cancer Res 2008 14: 318-325 doi: 10.1158/1078-0432.CCR-07-1243 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on Human Glioma Cell Growth

Clin Cancer Res 2008 14: 326 doi: 10.1158/1078-0432.CCR-14-1-COR [Full Text] [PDF]  

Acknowledgment to Reviewers:

Clin Cancer Res 2008 14: 327-336 doi: 10.1158/1078-0432.CCR-14-1-ACK [Full Text] [PDF]  

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