A histologic section of a MEN 1 pituitary tumor following administration of an anti-VEGF-A antibody. Treatment with anti-VEGF-A resulted in a 3.7-fold inhibition of the pituitary tumor growth and increased mean tumor doubling-free survival compared with mice treated with a control antibody. Vessel density was reduced by anti-VEGF-A treatment to 46% that of control IgG-treated tumors.For further details, please see the article by Korsisaari and associates on page 249 of this issue.

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