Apoptotic cancer cells (bright red) identified by TUNEL staining in orthotopic MDA-MB-435 xenograft tumors. Female nude mice with xenograft tumors were treated with vehicle (upper left panel), TRAIL (upper right panel), aspirin (lower left panel), or the combination of aspirin and TRAIL (lower right panel). Aspirin cooperated with TRAIL to induce apoptosis and reduce tumor burden in this model, supporting the potential therapeutic utility of this combination. For further details, please see Lu and colleagues on page 3168 in this issue.

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