Editor's Note:

Introducing Statistics in Clinical Cancer Research

Steven Piantadosi
Clin Cancer Res 2008 14: 4357 doi: 10.1158/1078-0432.CCR-14-14-ED [Full Text] [PDF]  

Statistics in Clinical Cancer Research:

Randomized Phase III Clinical Trial Designs for Targeted Agents

Antje Hoering, Mike LeBlanc, and John J. Crowley
Clin Cancer Res 2008 14: 4358-4367 doi: 10.1158/1078-0432.CCR-08-0288 [Abstract] [Full Text] [PDF]  

Multi-Arm Clinical Trials of New Agents: Some Design Considerations

Boris Freidlin, Edward L. Korn, Robert Gray, and Alison Martin
Clin Cancer Res 2008 14: 4368-4371 doi: 10.1158/1078-0432.CCR-08-0325 [Abstract] [Full Text] [PDF]  

Molecular Pathways:

RLIP76 and Cancer

Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung-Hee Woo, C. Casey Cunningham, and Arthur E. Frankel
Clin Cancer Res 2008 14: 4372-4377 doi: 10.1158/1078-0432.CCR-08-0145 [Abstract] [Full Text] [PDF]  

Report from the FDA:

Ixabepilone in Combination with Capecitabine and as Monotherapy for Treatment of Advanced Breast Cancer Refractory to Previous Chemotherapies

Robert J. Lechleider, Edvardas Kaminskas, Xiaoping Jiang, Robeena Aziz, Julie Bullock, Ravindra Kasliwal, Ravi Harapanhalli, Sarah Pope, Rajeshwari Sridhara, John Leighton, Brian Booth, Ramzi Dagher, Robert Justice, and Richard Pazdur
Clin Cancer Res 2008 14: 4378-4384 doi: 10.1158/1078-0432.CCR-08-0015 [Abstract] [Full Text] [PDF]  

Perspective:

Targeted Therapies to Improve Tumor Immunotherapy

Jonathan Begley and Antoni Ribas
Clin Cancer Res 2008 14: 4385-4391 doi: 10.1158/1078-0432.CCR-07-4804 [Abstract] [Full Text] [PDF]  

Reviews:

Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia

Alfonso Quintás-Cardama and Jorge Cortes
Clin Cancer Res 2008 14: 4392-4399 doi: 10.1158/1078-0432.CCR-08-0117 [Abstract] [Full Text] [PDF]  

Comparison of Nomograms With Other Methods for Predicting Outcomes in Prostate Cancer: A Critical Analysis of the Literature

Shahrokh F. Shariat, Pierre I. Karakiewicz, Nazareno Suardi, and Michael W. Kattan
Clin Cancer Res 2008 14: 4400-4407 doi: 10.1158/1078-0432.CCR-07-4713 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer

Noboru Konishi, Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Ichiro Ota, Nobumichi Tanaka, and Kiyohide Fujimoto
Clin Cancer Res 2008 14: 4408-4416 doi: 10.1158/1078-0432.CCR-07-4120 [Abstract] [Full Text] [PDF]  

Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma

Hiromichi Niikawa, Takashi Suzuki, Yasuhiro Miki, Satoshi Suzuki, Shuji Nagasaki, Junichi Akahira, Seijiro Honma, Dean B. Evans, Shin-ichi Hayashi, Takashi Kondo, and Hironobu Sasano
Clin Cancer Res 2008 14: 4417-4426 Published Online First June 25, 2008. doi: 10.1158/1078-0432.CCR-07-1950 [Abstract] [Full Text] [PDF]  

Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells

Archana Thakur, Yuan Sun, Aliccia Bollig, Jack Wu, Hector Biliran, Sanjeev Banerjee, Fazlul H. Sarkar, and D. Joshua Liao
Clin Cancer Res 2008 14: 4427-4436 doi: 10.1158/1078-0432.CCR-08-0458 [Abstract] [Full Text] [PDF]  

Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591

Sridhar Vempati, Carola Reindl, Ulla Wolf, Ruth Kern, Konstantin Petropoulos, Vegi M. Naidu, Christian Buske, Wolfgang Hiddemann, Tobias M. Kohl, and Karsten Spiekermann
Clin Cancer Res 2008 14: 4437-4445 doi: 10.1158/1078-0432.CCR-07-1873 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

Genomic Differences Between Pure Ductal Carcinoma In Situ of the Breast and that Associated with Invasive Disease: a Calibrated aCGH Study

Vladimir V. Iakovlev, Nona C.R. Arneson, Vietty Wong, Chunjie Wang, Stephanie Leung, Gaiane Iakovleva, Keisha Warren, Melania Pintilie, and Susan J. Done
Clin Cancer Res 2008 14: 4446-4454 doi: 10.1158/1078-0432.CCR-07-4960 [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer

Yasmine Nadler, Robert L. Camp, Candice Schwartz, David L. Rimm, Harriet M. Kluger, and Yuval Kluger
Clin Cancer Res 2008 14: 4455-4462 doi: 10.1158/1078-0432.CCR-07-5268 [Abstract] [Full Text] [PDF] Supplementary Data  

Analysis and Reproducibility of 3'-Deoxy-3'-[¹⁸F]Fluorothymidine Positron Emission Tomography Imaging in Patients with Non–Small Cell Lung Cancer

Anthony F. Shields, Jawana M. Lawhorn-Crews, David A. Briston, Sajad Zalzala, Shirish Gadgeel, Kirk A. Douglas, Thomas J. Mangner, Lance K. Heilbrun, and Otto Muzik
Clin Cancer Res 2008 14: 4463-4468 doi: 10.1158/1078-0432.CCR-07-5243 [Abstract] [Full Text] [PDF]  

Visualization of Circulating Melanoma Cells in Peripheral Blood of Patients with Primary Uveal Melanoma

Anja Ulmer, Julia Beutel, Daniela Süsskind, Ralf-Dieter Hilgers, Focke Ziemssen, Matthias Lüke, Martin Röcken, Martin Rohrbach, Gerhard Fierlbeck, Karl-Ulrich Bartz-Schmidt, and Salvatore Grisanti
Clin Cancer Res 2008 14: 4469-4474 doi: 10.1158/1078-0432.CCR-08-0012 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Irradiance-Dependent Photobleaching and Pain in -Aminolevulinic Acid-Photodynamic Therapy of Superficial Basal Cell Carcinomas

William J. Cottrell, Anne D. Paquette, Kenneth R. Keymel, Thomas H. Foster, and Allan R. Oseroff
Clin Cancer Res 2008 14: 4475-4483 doi: 10.1158/1078-0432.CCR-07-5199 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Lapatinib in Combination with Letrozole in Patients with Advanced Cancer

Quincy S.C. Chu, Mary E. Cianfrocca, Lori J. Goldstein, Meg Gale, Nicholas Murray, Jill Loftiss, Nikita Arya, Kevin M. Koch, Lini Pandite, Ronald A. Fleming, Elaine Paul, and Eric K. Rowinsky
Clin Cancer Res 2008 14: 4484-4490 doi: 10.1158/1078-0432.CCR-07-4417 [Abstract] [Full Text] [PDF]  

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

Navneet Dhillon, Bharat B. Aggarwal, Robert A. Newman, Robert A. Wolff, Ajaikumar B. Kunnumakkara, James L. Abbruzzese, Chaan S. Ng, Vladimir Badmaev, and Razelle Kurzrock
Clin Cancer Res 2008 14: 4491-4499 doi: 10.1158/1078-0432.CCR-08-0024 [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma

Leigh Ellis, Yan Pan, Gordon K. Smyth, Daniel J. George, Chris McCormack, Roxanne Williams-Truax, Monica Mita, Joachim Beck, Howard Burris, Gail Ryan, Peter Atadja, Dale Butterfoss, Margaret Dugan, Kenneth Culver, Ricky W. Johnstone, and H. Miles Prince
Clin Cancer Res 2008 14: 4500-4510 doi: 10.1158/1078-0432.CCR-07-4262 [Abstract] [Full Text] [PDF] Supplementary Data  

Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel

Carlos M. Galmarini, Isabelle Treilleux, Fatima Cardoso, Chantal Bernard-Marty, Virginie Durbecq, David Gancberg, Marie-Christine Bissery, Marianne Paesmans, Denis Larsimont, Martine J. Piccart, Angelo Di Leo, and Charles Dumontet
Clin Cancer Res 2008 14: 4511-4516 doi: 10.1158/1078-0432.CCR-07-4741 [Abstract] [Full Text] [PDF] Supplementary Data  

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

Lia Gore, Mace L. Rothenberg, Cindy L. O'Bryant, Mary Kay Schultz, Alan B. Sandler, Denise Coffin, Candice McCoy, Astrid Schott, Catherine Scholz, and S. Gail Eckhardt
Clin Cancer Res 2008 14: 4517-4525 Published Online First June 25, 2008. doi: 10.1158/1078-0432.CCR-07-1461 [Abstract] [Full Text] [PDF]  

Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy

Ravi A. Madan, James L. Gulley, Jeffrey Schlom, Seth M. Steinberg, David J. Liewehr, William L. Dahut, and Philip M. Arlen
Clin Cancer Res 2008 14: 4526-4531 doi: 10.1158/1078-0432.CCR-07-5048 [Abstract] [Full Text] [PDF]  

Local Administration of PF-3512676 CpG-B Instigates Tumor-Specific CD8⁺ T-Cell Reactivity in Melanoma Patients

Barbara G. Molenkamp, Berbel J.R. Sluijter, Paul A.M. van Leeuwen, Saskia J.A.M. Santegoets, Sybren Meijer, Pepijn G.J.T.B. Wijnands, John B.A.G. Haanen, Alfons J.M. van den Eertwegh, Rik J. Scheper, and Tanja D. de Gruijl
Clin Cancer Res 2008 14: 4532-4542 doi: 10.1158/1078-0432.CCR-07-4711 [Abstract] [Full Text] [PDF]  

ABCB1 Genetic Variation Influences the Toxicity and Clinical Outcome of Patients with Androgen-Independent Prostate Cancer Treated with Docetaxel

Tristan M. Sissung, Caitlin E. Baum, John Deeken, Douglas K. Price, Jeanny Aragon-Ching, Seth M. Steinberg, William Dahut, Alex Sparreboom, and William D. Figg
Clin Cancer Res 2008 14: 4543-4549 doi: 10.1158/1078-0432.CCR-07-4230 [Abstract] [Full Text] [PDF]  

Therapeutic Consequences from Molecular Biology for Gastrointestinal Stromal Tumor Patients Affected by Neurofibromatosis Type 1

Chiara Mussi, Hans-Ulrich Schildhaus, Alessandro Gronchi, Eva Wardelmann, and Peter Hohenberger
Clin Cancer Res 2008 14: 4550-4555 doi: 10.1158/1078-0432.CCR-08-0086 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268

Karen Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, William W. Lamph, Nicola Vannini, Ilaria Sogno, Adriana Albini, and Michael B. Sporn
Clin Cancer Res 2008 14: 4556-4563 doi: 10.1158/1078-0432.CCR-08-0040 [Abstract] [Full Text] [PDF]  

Expression of t-DARPP Mediates Trastuzumab Resistance in Breast Cancer Cells

Abbes Belkhiri, Altaf A. Dar, Dun Fa Peng, Mohammad H. Razvi, Cammie Rinehart, Carlos L. Arteaga, and Wael El-Rifai
Clin Cancer Res 2008 14: 4564-4571 Published Online First June 25, 2008. doi: 10.1158/1078-0432.CCR-08-0121 [Abstract] [Full Text] [PDF]  

Molecular Characterization of the Pediatric Preclinical Testing Panel

Geoffrey Neale, Xiaoping Su, Christopher L. Morton, Doris Phelps, Richard Gorlick, Richard B. Lock, C. Patrick Reynolds, John M. Maris, Henry S. Friedman, Jeffrey Dome, Joseph Khoury, Timothy J. Triche, Robert C. Seeger, Richard Gilbertson, Javed Khan, Malcolm A. Smith, and Peter J. Houghton
Clin Cancer Res 2008 14: 4572-4583 doi: 10.1158/1078-0432.CCR-07-5090 [Abstract] [Full Text] [PDF] Supplementary Data  

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

Elinborg Ostermann, Pilar Garin-Chesa, Karl Heinz Heider, Milena Kalat, Herbert Lamche, Christina Puri, Dontscho Kerjaschki, Wolfgang J. Rettig, and Guenther R. Adolf
Clin Cancer Res 2008 14: 4584-4592 doi: 10.1158/1078-0432.CCR-07-5211 [Abstract] [Full Text] [PDF]  

KML001 Cytotoxic Activity Is Associated with Its Binding to Telomeric Sequences and Telomere Erosion in Prostate Cancer Cells

Pornima Phatak, Fangping Dai, Melody Butler, M.P. Nandakumar, Peter L. Gutierrez, Martin J. Edelman, Hans Hendriks, and Angelika M. Burger
Clin Cancer Res 2008 14: 4593-4602 doi: 10.1158/1078-0432.CCR-07-4572 [Abstract] [Full Text] [PDF] Supplementary Data  

Paclitaxel Encapsulated in Cationic Liposomes Increases Tumor Microvessel Leakiness and Improves Therapeutic Efficacy in Combination with Cisplatin

Sebastian Strieth, Martin E. Eichhorn, Alexander Werner, Birgitta Sauer, Michael Teifel, Uwe Michaelis, Alexander Berghaus, and Marc Dellian
Clin Cancer Res 2008 14: 4603-4611 doi: 10.1158/1078-0432.CCR-07-4738 [Abstract] [Full Text] [PDF]  

A Novel Recombinant Soluble Splice Variant of Met Is a Potent Antagonist of the Hepatocyte Growth Factor/Scatter Factor-Met Pathway

Zohar Tiran, Anat Oren, Chen Hermesh, Galit Rotman, Zurit Levine, Hagit Amitai, Tal Handelsman, Merav Beiman, Aviva Chen, Dalit Landesman-Milo, Liat Dassa, Yair Peres, Cynthia Koifman, Sarit Glezer, Rinat Vidal-Finkelstein, Kobi Bahat, Tania Pergam, Cylia Israel, Judith Horev, Ilan Tsarfaty, and Michal Ayalon-Soffer
Clin Cancer Res 2008 14: 4612-4621 doi: 10.1158/1078-0432.CCR-08-0108 [Abstract] [Full Text] [PDF] Supplementary Data  

Slug (SNAI2) Down-Regulation by RNA Interference Facilitates Apoptosis and Inhibits Invasive Growth in Neuroblastoma Preclinical Models

Roberta Vitali, Camillo Mancini, Vincenzo Cesi, Barbara Tanno, Mariateresa Mancuso, Gianluca Bossi, Ying Zhang, Robert V. Martinez, Bruno Calabretta, Carlo Dominici, and Giuseppe Raschellà
Clin Cancer Res 2008 14: 4622-4630 doi: 10.1158/1078-0432.CCR-07-5210 [Abstract] [Full Text] [PDF]  

Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo

Nobuyuki Watanabe, Munenori Takaoka, Kazufumi Sakurama, Yasuko Tomono, Shinji Hatakeyama, Osamu Ohmori, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, David G. Beer, Hitoshi Nagatsuka, Noriaki Tanaka, and Yoshio Naomoto
Clin Cancer Res 2008 14: 4631-4639 doi: 10.1158/1078-0432.CCR-07-4755 [Abstract] [Full Text] [PDF] Supplementary Data  

Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma

Jennifer Woodard, Antonella Sassano, Nissim Hay, and Leonidas C. Platanias
Clin Cancer Res 2008 14: 4640-4649 doi: 10.1158/1078-0432.CCR-07-5232 [Abstract] [Full Text] [PDF]  

Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20⁺ Tumor Cells

Lei Wu, Mary Adams, Troy Carter, Roger Chen, George Muller, David Stirling, Peter Schafer, and J. Blake Bartlett
Clin Cancer Res 2008 14: 4650-4657 doi: 10.1158/1078-0432.CCR-07-4405 [Abstract] [Full Text] [PDF]  

Differential Effect of Doxorubicin and Zoledronic Acid on Intraosseous versus Extraosseous Breast Tumor Growth In vivo

Penelope D. Ottewell, Blandine Deux, Hannu Mönkkönen, Simon Cross, Robert E. Coleman, Philippe Clezardin, and Ingunn Holen
Clin Cancer Res 2008 14: 4658-4666 doi: 10.1158/1078-0432.CCR-07-1545 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Penetrance Analysis of the PALB2 c.1592delT Founder Mutation

Hannele Erkko, James G. Dowty, Jenni Nikkilä, Kirsi Syrjäkoski, Arto Mannermaa, Katri Pylkäs, Melissa C. Southey, Kaija Holli, Anne Kallioniemi, Arja Jukkola-Vuorinen, Vesa Kataja, Veli-Matti Kosma, Bing Xia, David M. Livingston, Robert Winqvist, and John L. Hopper
Clin Cancer Res 2008 14: 4667-4671 doi: 10.1158/1078-0432.CCR-08-0210 [Abstract] [Full Text] [PDF]  

A Novel Breast Cancer–Associated BRIP1 (FANCJ/BACH1) Germ-line Mutation Impairs Protein Stability and Function

Arcangela De Nicolo, Mariella Tancredi, Grazia Lombardi, Cristina Chantal Flemma, Serena Barbuti, Claudio Di Cristofano, Bijan Sobhian, Generoso Bevilacqua, Ronny Drapkin, and Maria Adelaide Caligo
Clin Cancer Res 2008 14: 4672-4680 doi: 10.1158/1078-0432.CCR-08-0087 [Abstract] [Full Text] [PDF] Supplementary Data  

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