Editorials:

Hearsay Medicine Is Not Evidence-Based Medicine

Robert S. DiPaola and Michael A. Gallo
Clin Cancer Res 2008 14: 337-338 doi: 10.1158/1078-0432.CCR-07-2237 [Full Text] [PDF]  

The Biology Behind:

Is Breast Tumor Progression Really Linear?

Kornelia Polyak
Clin Cancer Res 2008 14: 339 -341 doi: 10.1158/1078-0432.CCR-07-2188 [Full Text] [PDF]  

Molecular Pathways:

Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

Bret B. Friday and Alex A. Adjei
Clin Cancer Res 2008 14: 342-346 doi: 10.1158/1078-0432.CCR-07-4790 [Abstract] [Full Text] [PDF]  

Role of IG20 Splice Variants in TRAIL Resistance

Bellur S. Prabhakar, Nirupama Mulherkar, and Kanteti V. Prasad
Clin Cancer Res 2008 14: 347-351 doi: 10.1158/1078-0432.CCR-07-0493 [Abstract] [Full Text] [PDF]  

Report from the FDA:

Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate

Michael Brave, Vicki Goodman, Edvardas Kaminskas, Ann Farrell, William Timmer, Sarah Pope, Ravi Harapanhalli, Haleh Saber, David Morse, Julie Bullock, Angela Men, Carol Noory, Roshni Ramchandani, Leslie Kenna, Brian Booth, Joga Gobburu, Xiaoping Jiang, Rajeshwari Sridhara, Robert Justice, and Richard Pazdur
Clin Cancer Res 2008 14: 352-359 doi: 10.1158/1078-0432.CCR-07-4175 [Abstract] [Full Text] [PDF]  

Review:

MicroRNAs as Prognostic Indicators and Therapeutic Targets: Potential Effect on Breast Cancer Management

Aoife J. Lowery, Nicola Miller, Roisin E. McNeill, and Michael J. Kerin
Clin Cancer Res 2008 14: 360-365 doi: 10.1158/1078-0432.CCR-07-0992 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck

William H. Westra, Janis M. Taube, M.L. Poeta, Shanaz Begum, David Sidransky, and Wayne M. Koch
Clin Cancer Res 2008 14: 366-369 doi: 10.1158/1078-0432.CCR-07-1402 [Abstract] [Full Text] [PDF]  

Ductal Carcinoma In situ and the Emergence of Diversity during Breast Cancer Evolution

D. Craig Allred, Yun Wu, Sufeng Mao, Iris D. Nagtegaal, Sangjun Lee, Charles M. Perou, Syed K. Mohsin, Peter O'Connell, Anna Tsimelzon, and Dan Medina
Clin Cancer Res 2008 14: 370-378 doi: 10.1158/1078-0432.CCR-07-1127 [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Cellular Iron Import Proteins Is Associated with Malignant Progression of Esophageal Adenocarcinoma

Jessica Boult, Keith Roberts, Matthew J. Brookes, Sharon Hughes, Jonathan P. Bury, Simon S. Cross, Gregory J. Anderson, Robert Spychal, Tariq Iqbal, and Chris Tselepis
Clin Cancer Res 2008 14: 379-387 doi: 10.1158/1078-0432.CCR-07-1054 [Abstract] [Full Text] [PDF]  

Large Deletions of the PRKAR1A Gene in Carney Complex

Anelia Horvath, Ioannis Bossis, Christoforos Giatzakis, Elizabeth Levine, Frank Weinberg, Elise Meoli, Audrey Robinson-White, Jennifer Siegel, Payal Soni, Lionel Groussin, Ludmila Matyakhina, Somya Verma, Elaine Remmers, Maria Nesterova, J. Aidan Carney, Jérôme Bertherat, and Constantine A. Stratakis
Clin Cancer Res 2008 14: 388-395 doi: 10.1158/1078-0432.CCR-07-1155 [Abstract] [Full Text] [PDF]  

Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia

Sivasubramanian Baskar, Ka Yin Kwong, Thomas Hofer, Jessica M. Levy, Michael G. Kennedy, Elinor Lee, Louis M. Staudt, Wyndham H. Wilson, Adrian Wiestner, and Christoph Rader
Clin Cancer Res 2008 14: 396-404 doi: 10.1158/1078-0432.CCR-07-1823 [Abstract] [Full Text] [PDF]  

Carcinoembryonic Antigen Cell Adhesion Molecule 6 Predicts Breast Cancer Recurrence following Adjuvant Tamoxifen

Loaie Maraqa, Michele Cummings, Mark B. Peter, Abeer M. Shaaban, Kieran Horgan, Andrew M. Hanby, and Valerie Speirs
Clin Cancer Res 2008 14: 405-411 doi: 10.1158/1078-0432.CCR-07-1363 [Abstract] [Full Text] [PDF] Supplementary Data  

Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer

Jordan M. Winter, Angela H. Ting, Felip Vilardell, Eike Gallmeier, Steve B. Baylin, Ralph H. Hruban, Scott E. Kern, and Christine A. Iacobuzio-Donahue
Clin Cancer Res 2008 14: 412-418 doi: 10.1158/1078-0432.CCR-07-0487 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

Jinmai Jiang, Yuriy Gusev, Ileana Aderca, Teresa A. Mettler, David M. Nagorney, Daniel J. Brackett, Lewis R. Roberts, and Thomas D. Schmittgen
Clin Cancer Res 2008 14: 419-427 doi: 10.1158/1078-0432.CCR-07-0523 [Abstract] [Full Text] [PDF] Supplementary Data  

Serum Interleukin-6 Level but not Genotype Predicts Survival after Resection in Stages II and III Gastric Carcinoma

Wei-Chih Liao, Jaw-Town Lin, Chun-Ying Wu, Shih-Pei Huang, Ming-Tsan Lin, Ariel Sing-Huei Wu, Yu-Jie Huang, and Ming-Shiang Wu
Clin Cancer Res 2008 14: 428-434 Published Online First January 15, 2008. doi: 10.1158/1078-0432.CCR-07-1032 [Abstract] [Full Text] [PDF]  

Identification of Novel Nasopharyngeal Carcinoma Biomarkers by Laser Capture Microdissection and Proteomic Analysis

Ai-Lan Cheng, Wei-Guo Huang, Zhu-Chu Chen, Fang Peng, Peng-Fei Zhang, Mao-Yu Li, Feng Li, Jian-Ling Li, Cui Li, Hong Yi, Bin Yi, and Zhi-Qiang Xiao
Clin Cancer Res 2008 14: 435-445 doi: 10.1158/1078-0432.CCR-07-1215 [Abstract] [Full Text] [PDF]  

Plasma Stromal Cell–Derived Factor-1: Host Derived Marker Predictive of Distant Metastasis in Breast Cancer

Saima Hassan, Andrea Baccarelli, Ombretta Salvucci, and Mark Basik
Clin Cancer Res 2008 14: 446-454 doi: 10.1158/1078-0432.CCR-07-1189 [Abstract] [Full Text] [PDF]  

Novel Blood-Based, Five-Gene Biomarker Set for the Detection of Colorectal Cancer

Mark Han, Choong Tsek Liew, Hong Wei Zhang, Samuel Chao, Run Zheng, Kok Thye Yip, Zhen-Ya Song, Hiu Ming Li, Xiao Ping Geng, Li Xin Zhu, Jian-Jiang Lin, K. Wayne Marshall, and Choong Chin Liew
Clin Cancer Res 2008 14: 455-460 Published Online First January 18, 2008. doi: 10.1158/1078-0432.CCR-07-1801 [Abstract] [Full Text] [PDF]  

Clinical Validation of a Customized Multiple Signature Microarray for Breast Cancer

Benita K.T. Tan, Lay Keng Tan, Kun Yu, Puay Hoon Tan, Ming Lee, Lang Hiong Sii, Chow Yin Wong, Gay Hui Ho, Allen W.Y. Yeo, Pierce K.H. Chow, Heng Nung Koong, Wei Sean Yong, Dennis T.H. Lim, London L.P.J. Ooi, Khee Chee Soo, and Patrick Tan
Clin Cancer Res 2008 14: 461-469 doi: 10.1158/1078-0432.CCR-07-0999 [Abstract] [Full Text] [PDF] Supplementary Data  

Serum Proteomics and Biomarkers in Hepatocellular Carcinoma and Chronic Liver Disease

Noah T. Zinkin, Franck Grall, Killimangalam Bhaskar, Hasan H. Otu, Dimitrios Spentzos, Brett Kalmowitz, Meghan Wells, Manuel Guerrero, John M. Asara, Towia A. Libermann, and Nezam H. Afdhal
Clin Cancer Res 2008 14: 470-477 doi: 10.1158/1078-0432.CCR-07-0586 [Abstract] [Full Text] [PDF]  

Predicting Outcome in Follicular Lymphoma by Using Interactive Gene Pairs

David LeBrun, Tara Baetz, Cheryl Foster, Patricia Farmer, Roger Sidhu, Hong Guo, Karen Harrison, Roland Somogyi, Larry D. Greller, and Harriet Feilotter
Clin Cancer Res 2008 14: 478-487 doi: 10.1158/1078-0432.CCR-07-1720 [Abstract] [Full Text] [PDF] Supplementary Data  

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

Koji Yoshimoto, Julie Dang, Shaojun Zhu, David Nathanson, Tiffany Huang, Rebecca Dumont, David B. Seligson, William H. Yong, Zhenggang Xiong, Nagesh Rao, Henrik Winther, Arnab Chakravarti, Darell D. Bigner, Ingo K. Mellinghoff, Steve Horvath, Webster K. Cavenee, Timothy F. Cloughesy, and Paul S. Mischel
Clin Cancer Res 2008 14: 488-493 doi: 10.1158/1078-0432.CCR-07-1966 [Abstract] [Full Text] [PDF] Supplementary Data  

EMMPRIN Expression as a Prognostic Factor in Radiotherapy of Cervical Cancer

Xing-Zhu Ju, Jin-Ming Yang, Xiao-Yan Zhou, Zi-Ting Li, and Xiao-Hua Wu
Clin Cancer Res 2008 14: 494-501 doi: 10.1158/1078-0432.CCR-07-1072 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Dose and Schedule Study of Panitumumab Monotherapy in Patients with Advanced Solid Malignancies

Louis M. Weiner, Arie S. Belldegrun, Jeffrey Crawford, Anthony W. Tolcher, Pamela Lockbaum, Rosalin H. Arends, Lynn Navale, Rafael G. Amado, Gisela Schwab, and Robert A. Figlin
Clin Cancer Res 2008 14: 502-508 doi: 10.1158/1078-0432.CCR-07-1509 [Abstract] [Full Text] [PDF]  

Phase I Study of Alternate-Week Administration of Tipifarnib in Patients with Myelodysplastic Syndrome

Razelle Kurzrock, Hagop M. Kantarjian, Michelle A. Blascovich, Cindy Bucher, Srdan Verstovsek, John J. Wright, Susan R. Pilat, Jorge E. Cortes, Elihu H. Estey, Francis J. Giles, Miloslav Beran, and Said M. Sebti
Clin Cancer Res 2008 14: 509-514 doi: 10.1158/1078-0432.CCR-07-1532 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Image-Guided Enzyme/Prodrug Cancer Therapy

Cong Li, Marie-France Penet, Paul Winnard, Jr., Dmitri Artemov, and Zaver M. Bhujwalla
Clin Cancer Res 2008 14: 515-522 doi: 10.1158/1078-0432.CCR-07-1837 [Abstract] [Full Text] [PDF] Supplementary Data  

Rhabdoid Tumor Growth is Inhibited by Flavopiridol

Melissa E. Smith, Velasco Cimica, Srinivasa Chinni, Kavitha Challagulla, Sridhar Mani, and Ganjam V. Kalpana
Clin Cancer Res 2008 14: 523-532 doi: 10.1158/1078-0432.CCR-07-1347 [Abstract] [Full Text] [PDF]  

Sodium Thiosulfate Administered Six Hours after Cisplatin Does Not Compromise Antineuroblastoma Activity

Theresa M. Harned, Ondrej Kalous, Alexander Neuwelt, Jason Loera, Lingyun Ji, Peter Iovine, Richard Sposto, Edward A. Neuwelt, and C. Patrick Reynolds
Clin Cancer Res 2008 14: 533-540 doi: 10.1158/1078-0432.CCR-06-2289 [Abstract] [Full Text] [PDF]  

Imatinib Mesylate Enhances Therapeutic Effects of Gemcitabine in Human Malignant Mesothelioma Xenografts

Pietro Bertino, Federica Piccardi, Camillo Porta, Roberto Favoni, Michele Cilli, Luciano Mutti, and Giovanni Gaudino
Clin Cancer Res 2008 14: 541-548 doi: 10.1158/1078-0432.CCR-07-1388 [Abstract] [Full Text] [PDF]  

Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells

Yun Dai, Shuang Chen, Lora B. Kramer, Vanessa L. Funk, Paul Dent, and Steven Grant
Clin Cancer Res 2008 14: 549-558 doi: 10.1158/1078-0432.CCR-07-1934 [Abstract] [Full Text] [PDF] Supplementary Data  

Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth

Ling Zhang, Lifang Gao, Yang Li, Guimiao Lin, Yueting Shao, Kun Ji, Hao Yu, Jiadi Hu, Dhananjaya V. Kalvakolanu, Dennis J. Kopecko, Xuejian Zhao, and De-Qi Xu
Clin Cancer Res 2008 14: 559-568 doi: 10.1158/1078-0432.CCR-07-1176 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel Raji-Burkitt's Lymphoma Model for Preclinical and Mechanistic Evaluation of CD52-Targeted Immunotherapeutic Agents

Rosa Lapalombella, Xiaobin Zhao, Georgia Triantafillou, Bo Yu, Yan Jin, Gerard Lozanski, Carolyn Cheney, Nyla Heerema, David Jarjoura, Amy Lehman, L. James Lee, Guido Marcucci, Robert J. Lee, Michael A. Caligiuri, Natarajan Muthusamy, and John C. Byrd
Clin Cancer Res 2008 14: 569-578 doi: 10.1158/1078-0432.CCR-07-1006 [Abstract] [Full Text] [PDF]  

Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer

Peisheng Hu, Robyn S. Arias, Rebecca E. Sadun, Yu-Chih Nien, Nan Zhang, Helen Sabzevari, M.E. Christine Lutsiak, Leslie A. Khawli, and Alan L. Epstein
Clin Cancer Res 2008 14: 579-588 doi: 10.1158/1078-0432.CCR-07-0940 [Abstract] [Full Text] [PDF]  

In vivo and Microarray Analysis of Rexinoid-Responsive Anaplastic Thyroid Carcinoma

Joshua P. Klopper, Andrew Berenz, William R. Hays, Vibha Sharma, Umarani Pugazhenthi, Jennifer Janssen, Meenakshi Singh, Reid P. Bissonnette, and Bryan R. Haugen
Clin Cancer Res 2008 14: 589-596 doi: 10.1158/1078-0432.CCR-07-0269 [Abstract] [Full Text] [PDF]  

STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells

Simon P. Newman, Paul A. Foster, Chloe Stengel, Joanna M. Day, Yaik T. Ho, Jean-Gabriel Judde, Myriam Lassalle, Gregoire Prevost, Mathew P. Leese, Barry V.L. Potter, Michael J. Reed, and Atul Purohit
Clin Cancer Res 2008 14: 597-606 doi: 10.1158/1078-0432.CCR-07-1717 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Herbal/Hormonal Dietary Supplement Possibly Associated with Prostate Cancer Progression

Shahrokh F. Shariat, Dolores J. Lamb, Radha G. Iyengar, Claus G. Roehrborn, and Kevin M. Slawin
Clin Cancer Res 2008 14: 607-611 doi: 10.1158/1078-0432.CCR-07-1576 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Genotypes, Haplotypes, Gender, and the Risk of Non–Small Cell Lung Cancer

Rihong Zhai, Geoffrey Liu, Wei Zhou, Li Su, Rebecca Suk Heist, Thomas J. Lynch, John C. Wain, Kofi Asomaning, Xihong Lin, and David C. Christiani
Clin Cancer Res 2008 14: 612-617 doi: 10.1158/1078-0432.CCR-07-1655 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Are Triple-Negative and Basal-Like Breast Cancer Synonymous?

Emad Rakha, Ian Ellis, and Jorge Reis-Filho
Clin Cancer Res 2008 14: 618 doi: 10.1158/1078-0432.CCR-07-1943 [Full Text] [PDF]  

Steven Narod, Rebecca Dent, and Wedad Hanna
Clin Cancer Res 2008 14: 618 doi: 10.1158/1078-0432.CCR-07-2178 [Full Text] [PDF]  

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