The Biology Behind:

CCR9 Homes Metastatic Melanoma Cells to the Small Bowel

Ann Richmond
Clin Cancer Res 2008 14: 621 -623 doi: 10.1158/1078-0432.CCR-07-2235 [Full Text] [PDF]  

The Clinical Connection:

Follistatin as an Inhibitor of Experimental Metastasis

James E. Talmadge
Clin Cancer Res 2008 14: 624-626 doi: 10.1158/1078-0432.CCR-07-2216 [Full Text] [PDF]  

Molecular Pathways:

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

J. Thomas Parsons, Jill Slack-Davis, Robert Tilghman, and W. Gregory Roberts
Clin Cancer Res 2008 14: 627-632 doi: 10.1158/1078-0432.CCR-07-2220 [Abstract] [Full Text] [PDF]  

Review:

Association between Phosphatidylinositol 3-Kinase Regulatory Subunit p85 Met326Ile Genetic Polymorphism and Colon Cancer Risk

Li Li, Sarah J. Plummer, Cheryl L. Thompson, Thomas C. Tucker, and Graham Casey
Clin Cancer Res 2008 14: 633-637 doi: 10.1158/1078-0432.CCR-07-1211 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Activation of CCR9/CCL25 in Cutaneous Melanoma Mediates Preferential Metastasis to the Small Intestine

Farin F. Amersi, Alicia M. Terando, Yasufumi Goto, Richard A. Scolyer, John F. Thompson, Andy N. Tran, Mark B. Faries, Donald L. Morton, and Dave S.B. Hoon
Clin Cancer Res 2008 14: 638-645 doi: 10.1158/1078-0432.CCR-07-2025 [Abstract] [Full Text] [PDF] Supplementary Data  

Immune Function Abnormalities in Peripheral Blood Mononuclear Cell Cytokine Expression Differentiates Stages of Cutaneous T-Cell Lymphoma/Mycosis Fungoides

Benjamin F. Chong, Adam J. Wilson, Heather M. Gibson, Mikehl S. Hafner, Yu Luo, Carrie J. Hedgcock, and Henry K. Wong
Clin Cancer Res 2008 14: 646-653 doi: 10.1158/1078-0432.CCR-07-0610 [Abstract] [Full Text] [PDF] Supplementary Data  

Effect of Melanoma on Immune Function in the Regional Lymph Node Basin

Benjamin Negin, David Panka, Wei Wang, Mustaqueem Siddiqui, Nicholas Tawa, John Mullen, Steven Tahan, Lucy Mandato, Adam Polivy, James Mier, and Michael Atkins
Clin Cancer Res 2008 14: 654-659 doi: 10.1158/1078-0432.CCR-07-1577 [Abstract] [Full Text] [PDF]  

Follistatin Suppresses the Production of Experimental Multiple-Organ Metastasis by Small Cell Lung Cancer Cells in Natural Killer Cell–Depleted SCID Mice

Hirokazu Ogino, Seiji Yano, Soji Kakiuchi, Hiroaki Muguruma, Kenji Ikuta, Masaki Hanibuchi, Hisanori Uehara, Kunihiro Tsuchida, Hiromu Sugino, and Saburo Sone
Clin Cancer Res 2008 14: 660-667 doi: 10.1158/1078-0432.CCR-07-1221 [Abstract] [Full Text] [PDF]  

Function of Heparanase in Prostate Tumorigenesis: Potential for Therapy

Immanuel Lerner, Leah Baraz, Eli Pikarsky, Amichay Meirovitz, Evgeny Edovitsky, Tamar Peretz, Israel Vlodavsky, and Michael Elkin
Clin Cancer Res 2008 14: 668-676 Published Online First January 22, 2008. doi: 10.1158/1078-0432.CCR-07-1866 [Abstract] [Full Text] [PDF] Supplementary Data  

Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer

Koji Ezumi, Hirofumi Yamamoto, Kohei Murata, Masahiko Higashiyama, Bazarragchaa Damdinsuren, Yurika Nakamura, Naganori Kyo, Jiro Okami, Chew Yee Ngan, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Hiroshi Nojima, and Morito Monden
Clin Cancer Res 2008 14: 677-684 doi: 10.1158/1078-0432.CCR-07-1184 [Abstract] [Full Text] [PDF]  

Tumor-Infiltrated Immune Response Correlates with Alterations in the Apoptotic and Cell Cycle Pathways in Hodgkin and Reed-Sternberg Cells

Tomás Álvaro, Marylène Lejeune, Juan F. García, Ma. Teresa Salvadó, Carlos López, Ramón Bosch, Joaquín Jaén, Patricia Escrivá, and Lluis E. Pons
Clin Cancer Res 2008 14: 685-691 doi: 10.1158/1078-0432.CCR-07-1246 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

T Cell Receptor Genotyping and HOXA/TLX1 Expression Define Three T Lymphoblastic Lymphoma Subsets which Might Affect Clinical Outcome

Frederic Baleydier, Anne-Valerie Decouvelaere, Julie Bergeron, Philippe Gaulard, Danielle Canioni, Yves Bertrand, Stephane Lepretre, Barbara Petit, Herve Dombret, Kheira Beldjord, Thierry Molina, Vahid Asnafi, and Elizabeth Macintyre
Clin Cancer Res 2008 14: 692-700 doi: 10.1158/1078-0432.CCR-07-1927 [Abstract] [Full Text] [PDF] Supplementary Data  

Prognostic Value of CCN3 in Osteosarcoma

Bernard Perbal, Monia Zuntini, Diana Zambelli, Massimo Serra, Marika Sciandra, Lara Cantiani, Enrico Lucarelli, Piero Picci, and Katia Scotlandi
Clin Cancer Res 2008 14: 701-709 doi: 10.1158/1078-0432.CCR-07-0806 [Abstract] [Full Text] [PDF] Supplementary Data  

Serum C-Reactive Protein as Independent Prognostic Variable in Patients with Ovarian Cancer

Lukas A. Hefler, Nicole Concin, Gerda Hofstetter, Christian Marth, Alexander Mustea, Jalid Sehouli, Robert Zeillinger, Heinz Leipold, Harald Lass, Christoph Grimm, Clemens B. Tempfer, and Alexander Reinthaller
Clin Cancer Res 2008 14: 710-714 doi: 10.1158/1078-0432.CCR-07-1044 [Abstract] [Full Text] [PDF]  

Reduction of Glucose Metabolic Activity Is More Accurate than Change in Size at Predicting Histopathologic Response to Neoadjuvant Therapy in High-Grade Soft-Tissue Sarcomas

Vladimir Evilevitch, Wolfgang A. Weber, William D. Tap, Martin Allen-Auerbach, Kira Chow, Scott D. Nelson, Fredrick R. Eilber, Jeffery J. Eckardt, Robert M. Elashoff, Michael E. Phelps, Johannes Czernin, and Fritz C. Eilber
Clin Cancer Res 2008 14: 715-720 doi: 10.1158/1078-0432.CCR-07-1762 [Abstract] [Full Text] [PDF]  

The Prognostic Significance of Serum β₂ Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients

Apostolia-Maria Tsimberidou, Hagop M. Kantarjian, Sijin Wen, Susan O'Brien, Jorge Cortes, William G. Wierda, Charles Koller, Sherry Pierce, Mark Brandt, Emil J. Freireich, Michael J. Keating, and Elihu H. Estey
Clin Cancer Res 2008 14: 721-730 doi: 10.1158/1078-0432.CCR-07-2063 [Abstract] [Full Text] [PDF]  

Imaging Epidermal Growth Factor Receptor Expression In vivo: Pharmacokinetic and Biodistribution Characterization of a Bioconjugated Quantum Dot Nanoprobe

Parmeswaran Diagaradjane, Jacobo M. Orenstein-Cardona, Norman E. Colón-Casasnovas, Amit Deorukhkar, Shujun Shentu, Norihito Kuno, David L. Schwartz, Juri G. Gelovani, and Sunil Krishnan
Clin Cancer Res 2008 14: 731-741 doi: 10.1158/1078-0432.CCR-07-1958 [Abstract] [Full Text] [PDF] Supplementary Data  

Development of a Multiplex RNA Urine Test for the Detection and Stratification of Transitional Cell Carcinoma of the Bladder

Andrew Holyoake, Paul O'Sullivan, Rob Pollock, Terry Best, Jun Watanabe, Yoichiro Kajita, Yoshiyuki Matsui, Masaaki Ito, Hiroyuki Nishiyama, Natalie Kerr, Fernanda da Silva Tatley, Lisa Cambridge, Tumi Toro, Osamu Ogawa, and Parry Guilford
Clin Cancer Res 2008 14: 742-749 doi: 10.1158/1078-0432.CCR-07-1672 [Abstract] [Full Text] [PDF] Supplementary Data  

Polycyclic Aromatic Hydrocarbon–DNA Adducts in Prostate and Biochemical Recurrence after Prostatectomy

Benjamin A. Rybicki, Christine Neslund-Dudas, Cathryn H. Bock, Andrew Rundle, Adnan T. Savera, James J. Yang, Nora L. Nock, and Deliang Tang
Clin Cancer Res 2008 14: 750-757 doi: 10.1158/1078-0432.CCR-07-0986 [Abstract] [Full Text] [PDF]  

Higher Expression of the Androgen-Regulated Gene PSA/HK3 mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival

Joseph R. Sterbis, Chunling Gao, Bungo Furusato, Yongmei Chen, Syed Shaheduzzaman, Lakshmi Ravindranath, David J. Osborn, Inger L. Rosner, Albert Dobi, David G. McLeod, Isabell A. Sesterhenn, Shiv Srivastava, Jennifer Cullen, and Gyorgy Petrovics
Clin Cancer Res 2008 14: 758-763 doi: 10.1158/1078-0432.CCR-07-1356 [Abstract] [Full Text] [PDF] Supplementary Data  

Use of a Combination of Approaches to Identify and Validate Relevant Tumor-Associated Antigens and Their Corresponding Autoantibodies in Ovarian Cancer Patients

Audrey Gagnon, Jae-Hoon Kim, John O. Schorge, Bin Ye, Brian Liu, Kathleen Hasselblatt, William R. Welch, Christina A. Bandera, and Samuel C. Mok
Clin Cancer Res 2008 14: 764-771 doi: 10.1158/1078-0432.CCR-07-0856 [Abstract] [Full Text] [PDF]  

Progression and Tumor Heterogeneity Analysis in Early Rectal Cancer

Esther H. Lips, Ronald van Eijk, Eelco J.R. de Graaf, Pascal G. Doornebosch, Noel F.C.C. de Miranda, Jan Oosting, Tom Karsten, Paul H.C. Eilers, Rob A.E.M. Tollenaar, Tom van Wezel, and Hans Morreau
Clin Cancer Res 2008 14: 772-781 doi: 10.1158/1078-0432.CCR-07-2052 [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic and Epigenetic Alterations in the von Hippel-Lindau Gene: the Influence on Renal Cancer Prognosis

Kim M. Smits, Leo J. Schouten, Boukje A.C. van Dijk, Christina A. Hulsbergen-van de Kaa, Kim A.D. Wouters, Egbert Oosterwijk, Manon van Engeland, and Piet A. van den Brandt
Clin Cancer Res 2008 14: 782-787 doi: 10.1158/1078-0432.CCR-07-1753 [Abstract] [Full Text] [PDF]  

WP1066, a Novel JAK2 Inhibitor, Suppresses Proliferation and Induces Apoptosis in Erythroid Human Cells Carrying the JAK2 V617F Mutation

Srdan Verstovsek, Taghi Manshouri, Alfonso Quintás-Cardama, David Harris, Jorge Cortes, Francis J. Giles, Hagop Kantarjian, Waldemar Priebe, and Zeev Estrov
Clin Cancer Res 2008 14: 788-796 doi: 10.1158/1078-0432.CCR-07-0524 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Combined Clinical Trial Results of a HER2/neu (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02

George E. Peoples, Jarrod P. Holmes, Matthew T. Hueman, Elizabeth A. Mittendorf, Asna Amin, Steven Khoo, Zia A. Dehqanzada, Jennifer M. Gurney, Michael M. Woll, Gayle B. Ryan, Catherine E. Storrer, Dianna Craig, Constantin G. Ioannides, and Sathibalan Ponniah
Clin Cancer Res 2008 14: 797-803 doi: 10.1158/1078-0432.CCR-07-1448 [Abstract] [Full Text] [PDF]  

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors

Nicola L. Steele, Jane A. Plumb, Laura Vidal, Jette Tjørnelund, Poul Knoblauch, Annie Rasmussen, Chean Eng Ooi, Peter Buhl-Jensen, Robert Brown, T.R. Jeffry Evans, and Johann S. DeBono
Clin Cancer Res 2008 14: 804-810 doi: 10.1158/1078-0432.CCR-07-1786 [Abstract] [Full Text] [PDF]  

A Single-Nucleotide Polymorphism in the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor Letrozole in Advanced Breast Carcinoma

Ramon Colomer, Mariano Monzo, Ignasi Tusquets, Juli Rifa, José M. Baena, Agusti Barnadas, Lourdes Calvo, Francisco Carabantes, Carmen Crespo, Montserrat Muñoz, Antonio Llombart, Arrate Plazaola, Rosa Artells, Monstsrrat Gilabert, Belen Lloveras, and Emilio Alba
Clin Cancer Res 2008 14: 811-816 doi: 10.1158/1078-0432.CCR-07-1923 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphisms and Toxicity to Capecitabine in Advanced Colorectal Cancer Patients

Rohini Sharma, Janelle M. Hoskins, Laurent P. Rivory, Manuela Zucknick, Rosyln London, Christopher Liddle, and Stephen J. Clarke
Clin Cancer Res 2008 14: 817-825 doi: 10.1158/1078-0432.CCR-07-0425 [Abstract] [Full Text] [PDF]  

Tolerability, Pharmacodynamics, and Pharmacokinetics Studies of Depsipeptide (Romidepsin) in Patients with Acute Myelogenous Leukemia or Advanced Myelodysplastic Syndromes

Virginia M. Klimek, Sophia Fircanis, Peter Maslak, Ilhem Guernah, Michael Baum, Nian Wu, Katherine Panageas, John J. Wright, Pier Paolo Pandolfi, and Stephen D. Nimer
Clin Cancer Res 2008 14: 826-832 doi: 10.1158/1078-0432.CCR-07-0318 [Abstract] [Full Text] [PDF]  

A Phase I Study of OGX-011, a 2'-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer

Kim N. Chi, Lillian L. Siu, Hal Hirte, Sebastien J. Hotte, Jennifer Knox, Christian Kollmansberger, Martin Gleave, Emma Guns, Jean Powers, Wendy Walsh, Dongsheng Tu, and Elizabeth Eisenhauer
Clin Cancer Res 2008 14: 833-839 doi: 10.1158/1078-0432.CCR-07-1310 [Abstract] [Full Text] [PDF]  

Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti–Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non–Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine

Beatriz García, Elia Neninger, Ana de la Torre, Idrissa Leonard, Rocío Martínez, Carmen Viada, Gisela González, Zaima Mazorra, Agustín Lage, and Tania Crombet
Clin Cancer Res 2008 14: 840-846 doi: 10.1158/1078-0432.CCR-07-1050 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Immune Expression and Inhibition of Heat Shock Protein 90 in Uveal Melanoma

Dana Faingold, Jean-Claude Marshall, Emilia Antecka, Sebastian Di Cesare, Alexandre N. Odashiro, Silvin Bakalian, Bruno F. Fernandes, and Miguel N. Burnier, Jr.
Clin Cancer Res 2008 14: 847-855 doi: 10.1158/1078-0432.CCR-07-0926 [Abstract] [Full Text] [PDF]  

An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma

Reinhard Dummer, Axel Hauschild, Juergen C. Becker, Jean-Jacques Grob, Dirk Schadendorf, Veronica Tebbs, Jeannine Skalsky, Katharina C. Kaehler, Stephanie Moosbauer, Ruth Clark, Tze-Chiang Meng, and Mirjana Urosevic
Clin Cancer Res 2008 14: 856-864 doi: 10.1158/1078-0432.CCR-07-1938 [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

Alissa Huston, Xavier Leleu, Xiaoying Jia, Anne-Sophie Moreau, Hai T. Ngo, Judith Runnels, Judy Anderson, Yazan Alsayed, Aldo Roccaro, Sonia Vallet, Evdoxia Hatjiharissi, Yu-Tsu Tai, Peter Sportelli, Nikhil Munshi, Paul Richardson, Teru Hideshima, David G. Roodman, Kenneth C. Anderson, and Irene M. Ghobrial
Clin Cancer Res 2008 14: 865-874 doi: 10.1158/1078-0432.CCR-07-1299 [Abstract] [Full Text] [PDF]  

Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the -Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies

Matthew K. Robinson, Calvin Shaller, Kayhan Garmestani, Paul S. Plascjak, Kathryn M. Hodge, Qing-An Yuan, James D. Marks, Thomas A. Waldmann, Martin W. Brechbiel, and Gregory P. Adams
Clin Cancer Res 2008 14: 875-882 doi: 10.1158/1078-0432.CCR-07-1250 [Abstract] [Full Text] [PDF]  

Molecular Targeting and Treatment of Composite EGFR and EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibodies

Weilian Yang, Gong Wu, Rolf F. Barth, Michele R. Swindall, Achintya K. Bandyopadhyaya, Werner Tjarks, Kevin Tordoff, Melvin Moeschberger, Thomas J. Sferra, Peter J. Binns, Kent J. Riley, Michael J. Ciesielski, Robert A. Fenstermaker, and Carol J. Wikstrand
Clin Cancer Res 2008 14: 883-891 doi: 10.1158/1078-0432.CCR-07-1968 [Abstract] [Full Text] [PDF]  

Antiangiogenic Therapy with Mammalian Target of Rapamycin Inhibitor RAD001 (Everolimus) Increases Radiosensitivity in Solid Cancer

Philipp C. Manegold, Carmen Paringer, Ulrike Kulka, Klaus Krimmel, Martin E. Eichhorn, Ralf Wilkowski, Karl-Walter Jauch, Markus Guba, and Christiane J. Bruns
Clin Cancer Res 2008 14: 892-900 doi: 10.1158/1078-0432.CCR-07-0955 [Abstract] [Full Text] [PDF]  

Inhibition of IB Kinase Subunit 2 in Cutaneous T-Cell Lymphoma Down-Regulates Nuclear Factor-B Constitutive Activation, Induces Cell Death, and Potentiates the Apoptotic Response to Antineoplastic Chemotherapeutic Agents

Aurore Sors, Francette Jean-Louis, Elodie Bégué, Laurent Parmentier, Louis Dubertret, Michel Dreano, Gilles Courtois, Hervé Bachelez, and Laurence Michel
Clin Cancer Res 2008 14: 901-911 doi: 10.1158/1078-0432.CCR-07-1419 [Abstract] [Full Text] [PDF]  

Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and Radiotherapy

Katie Twigger, Laura Vidal, Christine L. White, Johann S. De Bono, Shreerang Bhide, Matt Coffey, Brad Thompson, Richard G. Vile, Lucy Heinemann, Hardev S. Pandha, Fiona Errington, Alan A. Melcher, and Kevin J. Harrington
Clin Cancer Res 2008 14: 912-923 doi: 10.1158/1078-0432.CCR-07-1400 [Abstract] [Full Text] [PDF] Supplementary Data  

Endogenous Vascular Endothelial Growth Factor-C Expression Is Associated with Decreased Drug Responsiveness in Childhood Acute Myeloid Leukemia

Hendrik J.M. de Jonge, Alida C. Weidenaar, Arja ter Elst, H. Marike Boezen, Frank J.G. Scherpen, Jessica C.A. Bouma-ter Steege, Gertjan J.L. Kaspers, Bianca F. Goemans, Ursula Creutzig, Martin Zimmermann, Willem A. Kamps, and Eveline S.J.M. de Bont
Clin Cancer Res 2008 14: 924-930 doi: 10.1158/1078-0432.CCR-07-1821 [Abstract] [Full Text] [PDF]  

In vitro and In vivo Radiosensitization Induced by the DNA Methylating Agent Temozolomide

Whoon Jong Kil, David Cerna, William E. Burgan, Katie Beam, Donna Carter, Patricia S. Steeg, Philip J. Tofilon, and Kevin Camphausen
Clin Cancer Res 2008 14: 931-938 doi: 10.1158/1078-0432.CCR-07-1856 [Abstract] [Full Text] [PDF]  

Suppression of Lung Tumor Growth and Metastasis in Mice by Adeno-Associated Virus-Mediated Expression of Vasostatin

Ke Xia Cai, Lai Ying Tse, Carly Leung, Paul K.H. Tam, Ruian Xu, and Mai Har Sham
Clin Cancer Res 2008 14: 939-949 doi: 10.1158/1078-0432.CCR-07-1930 [Abstract] [Full Text] [PDF] Supplementary Data  

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