In Memoriam:

Judah Folkman, MD (1933–2008)

Clin Cancer Res 2008 14: 1283 doi: 10.1158/1078-0432.CCR-14-5-OB1 [Full Text] [PDF]  

Editorials:

Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players

Michael P. Kim and Gary E. Gallick
Clin Cancer Res 2008 14: 1284-1285 doi: 10.1158/1078-0432.CCR-07-2247 [Full Text] [PDF]  

CCR Drug Update:

Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin

Brian I. Rini
Clin Cancer Res 2008 14: 1286-1290 doi: 10.1158/1078-0432.CCR-07-4719 [Full Text] [PDF]  

Molecular Pathways:

Platinum Resistance: The Role of DNA Repair Pathways

Lainie P. Martin, Thomas C. Hamilton, and Russell J. Schilder
Clin Cancer Res 2008 14: 1291-1295 doi: 10.1158/1078-0432.CCR-07-2238 [Abstract] [Full Text] [PDF]  

Report From the FDA:

U.S. Food and Drug Administration Approval: Panitumumab for Epidermal Growth Factor Receptor–Expressing Metastatic Colorectal Carcinoma with Progression Following Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Containing Chemotherapy Regimens

Ruthann M. Giusti, Kaushikkumar Shastri, Anne M. Pilaro, Chana Fuchs, Ruth Cordoba-Rodriguez, Kallappa Koti, Mark Rothmann, Angela Yuxin Men, Hong Zhao, Monica Hughes, Patricia Keegan, Karen D. Weiss, and Richard Pazdur
Clin Cancer Res 2008 14: 1296-1302 doi: 10.1158/1078-0432.CCR-07-1354 [Abstract] [Full Text] [PDF]  

Reviews:

Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes

Raja R. Seethala, William E. Gooding, Phoebe N. Handler, Bobby Collins, Qing Zhang, Jill M. Siegfried, and Jennifer R. Grandis
Clin Cancer Res 2008 14: 1303-1309 doi: 10.1158/1078-0432.CCR-07-1543 [Abstract] [Full Text] [PDF]  

Therapeutic Nanoparticles for Drug Delivery in Cancer

Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo (Georgia) Chen, and Dong M. Shin
Clin Cancer Res 2008 14: 1310-1316 doi: 10.1158/1078-0432.CCR-07-1441 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Transcription Factor Signal Transducer and Activator of Transcription 5 Promotes Growth of Human Prostate Cancer Cells In vivo

Ayush Dagvadorj, Robert A. Kirken, Benjamin Leiby, James Karras, and Marja T. Nevalainen
Clin Cancer Res 2008 14: 1317-1324 doi: 10.1158/1078-0432.CCR-07-2024 [Abstract] [Full Text] [PDF]  

Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding

Barbara Belletti, Jayant S. Vaidya, Sara D'Andrea, Frank Entschladen, Mario Roncadin, Francesca Lovat, Stefania Berton, Tiziana Perin, Ezio Candiani, Sonia Reccanello, Andrea Veronesi, Vincenzo Canzonieri, Mauro G. Trovò, Kurt S. Zaenker, Alfonso Colombatti, Gustavo Baldassarre, and Samuele Massarut
Clin Cancer Res 2008 14: 1325-1332 doi: 10.1158/1078-0432.CCR-07-4453 [Abstract] [Full Text] [PDF] Supplementary Data  

Enhanced Expression of RAD51 Associating Protein-1 Is Involved in the Growth of Intrahepatic Cholangiocarcinoma Cells

Kazutaka Obama, Seiji Satoh, Ryuji Hamamoto, Yoshiharu Sakai, Yusuke Nakamura, and Yoichi Furukawa
Clin Cancer Res 2008 14: 1333-1339 doi: 10.1158/1078-0432.CCR-07-1381 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

Carme Camps, Francesca M. Buffa, Stefano Colella, John Moore, Christos Sotiriou, Helen Sheldon, Adrian L. Harris, Jonathan M. Gleadle, and Jiannis Ragoussis
Clin Cancer Res 2008 14: 1340-1348 doi: 10.1158/1078-0432.CCR-07-1755 [Abstract] [Full Text] [PDF] Supplementary Data  

Evaluation of Colon Cancer–Specific Antigen 2 as a Potential Serum Marker for Colorectal Cancer

Eddy S. Leman, Robert E. Schoen, Ahmed Magheli, Lori J. Sokoll, Daniel W. Chan, and Robert H. Getzenberg
Clin Cancer Res 2008 14: 1349-1354 doi: 10.1158/1078-0432.CCR-07-4110 [Abstract] [Full Text] [PDF] Supplementary Data  

A Multiparametric Serum Kallikrein Panel for Diagnosis of Non–Small Cell Lung Carcinoma

Chris Planque, Lin Li, Yingye Zheng, Antoninus Soosaipillai, Karen Reckamp, David Chia, Eleftherios P. Diamandis, and Lee Goodglick
Clin Cancer Res 2008 14: 1355-1362 doi: 10.1158/1078-0432.CCR-07-4117 [Abstract] [Full Text] [PDF] Supplementary Data  

Quantitative Monitoring of Adenocarcinoma Development in Rodents by Magnetic Resonance Imaging

Joel R. Garbow, Min Wang, Yian Wang, Ronald A. Lubet, and Ming You
Clin Cancer Res 2008 14: 1363-1367 doi: 10.1158/1078-0432.CCR-07-1757 [Abstract] [Full Text] [PDF]  

Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype

Maggie C.U. Cheang, David Voduc, Chris Bajdik, Samuel Leung, Steven McKinney, Stephen K. Chia, Charles M. Perou, and Torsten O. Nielsen
Clin Cancer Res 2008 14: 1368-1376 doi: 10.1158/1078-0432.CCR-07-1658 [Abstract] [Full Text] [PDF]  

Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic-Labeled Antibody that Binds Exposed Phosphatidylserine

Marc Jennewein, Matthew A. Lewis, Dawen Zhao, Edward Tsyganov, Nikolai Slavine, Jin He, Linda Watkins, Vikram D. Kodibagkar, Sean O'Kelly, Padmakar Kulkarni, Peter P. Antich, Alex Hermanne, Frank Rösch, Ralph P. Mason, and Philip E. Thorpe
Clin Cancer Res 2008 14: 1377-1385 doi: 10.1158/1078-0432.CCR-07-1516 [Abstract] [Full Text] [PDF]  

Dietary Intake of Lactose as a Strong Predictor for Secretor Status of Nipple Aspirate Fluid in Healthy Premenopausal Nonlactating Women

Yafei Huang, Karl E. Anderson, Manubai Nagamani, James J. Grady, and Lee-Jane W. Lu
Clin Cancer Res 2008 14: 1386-1392 doi: 10.1158/1078-0432.CCR-07-4077 [Abstract] [Full Text] [PDF]  

Germ Cell Origin of Testicular Carcinoid Tumors

Phillip H. Abbosh, Shaobo Zhang, Gregory T. MacLennan, Rodolfo Montironi, Antonio Lopez-Beltran, Joseph P. Rank, Lee Ann Baldridge, and Liang Cheng
Clin Cancer Res 2008 14: 1393-1396 doi: 10.1158/1078-0432.CCR-07-4146 [Abstract] [Full Text] [PDF]  

WDR19 Expression is Increased in Prostate Cancer Compared with Normal Cells, but Low-Intensity Expression in Cancers is Associated with Shorter Time to Biochemical Failures and Local Recurrence

Biaoyang Lin, Angelita G. Utleg, Karsten Gravdal, James T. White, Ole J. Halvorsen, Wei Lu, Lawrence D. True, Robert Vessella, Paul H. Lange, Peter S. Nelson, Leroy Hood, Karl-Henning Kalland, and Lars A. Akslen
Clin Cancer Res 2008 14: 1397-1406 doi: 10.1158/1078-0432.CCR-07-1535 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell Adhesion Molecules, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Patients with Non–Small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab—an Eastern Cooperative Oncology Group Study

Afshin Dowlati, Robert Gray, Alan B. Sandler, Joan H. Schiller, and David H. Johnson
Clin Cancer Res 2008 14: 1407-1412 doi: 10.1158/1078-0432.CCR-07-1154 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor-Infiltrating Lymphocytes and Perforation in Colon Cancer Predict Positive Response to 5-Fluorouracil Chemotherapy

Melinda Morris, Cameron Platell, and Barry Iacopetta
Clin Cancer Res 2008 14: 1413-1417 doi: 10.1158/1078-0432.CCR-07-1994 [Abstract] [Full Text] [PDF]  

Use of Preoperative Plasma Endoglin for Prediction of Lymph Node Metastasis in Patients with Clinically Localized Prostate Cancer

Jose A. Karam, Robert S. Svatek, Pierre I. Karakiewicz, Andrea Gallina, Claus G. Roehrborn, Kevin M. Slawin, and Shahrokh F. Shariat
Clin Cancer Res 2008 14: 1418-1422 doi: 10.1158/1078-0432.CCR-07-0901 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas

Cheng-Han Lee, Inigo Espinosa, Suzan Vrijaldenhoven, Subbaya Subramanian, Kelli D. Montgomery, Shirley Zhu, Robert J. Marinelli, Johannes L. Peterse, Neal Poulin, Torsten O. Nielsen, Rob B. West, C. Blake Gilks, and Matt van de Rijn
Clin Cancer Res 2008 14: 1423-1430 doi: 10.1158/1078-0432.CCR-07-1712 [Abstract] [Full Text] [PDF] Supplementary Data  

Sensitive and Specific New Enzyme-Linked Immunosorbent Assay for N-ERC/Mesothelin Increases its Potential as a Useful Serum Tumor Marker for Mesothelioma

Kazu Shiomi, Yoshiaki Hagiwara, Kouji Sonoue, Tatsuya Segawa, Kazuya Miyashita, Masahiro Maeda, Hiroshi Izumi, Kimihiko Masuda, Masataka Hirabayashi, Takao Moroboshi, Takashi Yoshiyama, Atsuko Ishida, Yuji Natori, Akira Inoue, Masashi Kobayashi, Yukinori Sakao, Hideaki Miyamoto, Kazuhisa Takahashi, and Okio Hino
Clin Cancer Res 2008 14: 1431-1437 doi: 10.1158/1078-0432.CCR-07-1613 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

IFN--2b–Induced Signal Transduction and Gene Regulation in Patient Peripheral Blood Mononuclear Cells Is Not Enhanced by a Dose Increase from 5 to 10 Megaunits/m²

Jason M. Zimmerer, Amy M. Lehman, Amy S. Ruppert, Carl W. Noble, Thomas Olencki, Michael J. Walker, Kari Kendra, and William E. Carson, III
Clin Cancer Res 2008 14: 1438-1445 doi: 10.1158/1078-0432.CCR-07-4178 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of Bortezomib in Combination with Idarubicin and Cytarabine in Patients with Acute Myelogenous Leukemia

Eyal C. Attar, Daniel J. DeAngelo, Jeffrey G. Supko, Ferdinando D'Amato, David Zahrieh, Andres Sirulnik, Martha Wadleigh, Karen K. Ballen, Steve McAfee, Kenneth B. Miller, James Levine, Ilene Galinsky, Elizabeth G. Trehu, David Schenkein, Donna Neuberg, Richard M. Stone, and Philip C. Amrein
Clin Cancer Res 2008 14: 1446-1454 doi: 10.1158/1078-0432.CCR-07-4626 [Abstract] [Full Text] [PDF]  

Allogeneic Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study of Safety, Feasibility, and Immune Activation

Dan Laheru, Eric Lutz, James Burke, Barbara Biedrzycki, Sara Solt, Beth Onners, Irena Tartakovsky, John Nemunaitis, Dung Le, Elizabeth Sugar, Kristen Hege, and Elizabeth Jaffee
Clin Cancer Res 2008 14: 1455-1463 doi: 10.1158/1078-0432.CCR-07-0371 [Abstract] [Full Text] [PDF] Supplementary Data  

Phase I/II Study of Atrasentan, an Endothelin A Receptor Antagonist, in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Advanced Non–Small Cell Lung Cancer

Alberto A. Chiappori, Eric Haura, Francisco A. Rodriguez, David Boulware, Rachna Kapoor, Anthony M. Neuger, Richard Lush, Barbara Padilla, Michelle Burton, Charles Williams, George Simon, Scott Antonia, Daniel M. Sullivan, and Gerold Bepler
Clin Cancer Res 2008 14: 1464-1469 doi: 10.1158/1078-0432.CCR-07-1508 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma

Siong-Seng Liau and Edward Whang
Clin Cancer Res 2008 14: 1470-1477 doi: 10.1158/1078-0432.CCR-07-1450 [Abstract] [Full Text] [PDF]  

Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells

Peter C. Black, Gordon A. Brown, Teruo Inamoto, Marissa Shrader, Ameeta Arora, Arlene O. Siefker-Radtke, Liana Adam, Dan Theodorescu, Xifeng Wu, Mark F. Munsell, Menashe Bar-Eli, David J. McConkey, and Colin P.N. Dinney
Clin Cancer Res 2008 14: 1478-1486 doi: 10.1158/1078-0432.CCR-07-1593 [Abstract] [Full Text] [PDF]  

Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy

Tong-Young Lee, Robert M. Tjin Tham Sjin, Shahla Movahedi, Bissan Ahmed, Elke A. Pravda, Kin-Ming Lo, Stephen D. Gillies, Judah Folkman, and Kashi Javaherian
Clin Cancer Res 2008 14: 1487-1493 doi: 10.1158/1078-0432.CCR-07-1530 [Abstract] [Full Text] [PDF]  

Combining the Antigen Processing Components TAP and Tapasin Elicits Enhanced Tumor-Free Survival

Yuanmei Lou, Genc Basha, Robyn P. Seipp, Bing Cai, Susan S. Chen, Alexander R. Moise, Andrew P. Jeffries, Ray S. Gopaul, Timothy Z. Vitalis, and Wilfred A. Jefferies
Clin Cancer Res 2008 14: 1494-1501 doi: 10.1158/1078-0432.CCR-07-1066 [Abstract] [Full Text] [PDF]  

Evaluation of the Antiangiogenic Potential of AQ4N

Martin O'Rourke, Claire Ward, Jenny Worthington, Julie McKenna, Andrea Valentine, Tracy Robson, David G. Hirst, and Stephanie R. McKeown
Clin Cancer Res 2008 14: 1502-1509 doi: 10.1158/1078-0432.CCR-07-1262 [Abstract] [Full Text] [PDF]  

Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin

Boris A. Hadaschik, Hans Adomat, Ladan Fazli, Yves Fradet, Raymond J. Andersen, Martin E. Gleave, and Alan I. So
Clin Cancer Res 2008 14: 1510-1518 doi: 10.1158/1078-0432.CCR-07-4475 [Abstract] [Full Text] [PDF]  

Synergy of a Herpes Oncolytic Virus and Paclitaxel for Anaplastic Thyroid Cancer

Shu-Fu Lin, Sizhi Paul Gao, Daniel L. Price, Sen Li, Ting-Chao Chou, Paramjeet Singh, Yu-Yao Huang, Yuman Fong, and Richard J. Wong
Clin Cancer Res 2008 14: 1519-1528 doi: 10.1158/1078-0432.CCR-07-4628 [Abstract] [Full Text] [PDF]  

Tumor Escape from Endogenous, Extracellular Matrix–Associated Angiogenesis Inhibitors by Up-Regulation of Multiple Proangiogenic Factors

Namali T. Fernando, Moritz Koch, Courtney Rothrock, Lila K. Gollogly, Patricia A. D'Amore, Sandra Ryeom, and Sam S. Yoon
Clin Cancer Res 2008 14: 1529-1539 doi: 10.1158/1078-0432.CCR-07-4126 [Abstract] [Full Text] [PDF]  

Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide

Qingyu Zhou, Ping Guo, and James M. Gallo
Clin Cancer Res 2008 14: 1540-1549 doi: 10.1158/1078-0432.CCR-07-4544 [Abstract] [Full Text] [PDF]  

Acquired Resistance to Rituximab Is Associated with Chemotherapy Resistance Resulting from Decreased Bax and Bak Expression

Scott H. Olejniczak, Francisco J. Hernandez-Ilizaliturri, James L. Clements, and Myron S. Czuczman
Clin Cancer Res 2008 14: 1550-1560 doi: 10.1158/1078-0432.CCR-07-1255 [Abstract] [Full Text] [PDF] Supplementary Data  

Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels

Myron S. Czuczman, Scott Olejniczak, Aruna Gowda, Adam Kotowski, Arvinder Binder, Harman Kaur, Joy Knight, Petr Starostik, Julie Deans, and Francisco J. Hernandez-Ilizaliturri
Clin Cancer Res 2008 14: 1561-1570 doi: 10.1158/1078-0432.CCR-07-1254 [Abstract] [Full Text] [PDF]  

Oncolytic Herpes Simplex Virus Type-1 Therapy in a Highly Infiltrative Animal Model of Human Glioblastoma

Peter C. Huszthy, Dorota Goplen, Frits Thorsen, Heike Immervoll, Jian Wang, Anja Gutermann, Hrvoje Miletic, and Rolf Bjerkvig
Clin Cancer Res 2008 14: 1571-1580 doi: 10.1158/1078-0432.CCR-07-2000 [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor-I Receptor Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in Survivin Expression

Seung Hyun Oh, Quanri Jin, Edward S. Kim, Fadlo R. Khuri, and Ho-Young Lee
Clin Cancer Res 2008 14: 1581-1589 doi: 10.1158/1078-0432.CCR-07-0952 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Higher Levels of the Anti-inflammatory Protein CC10 Are Associated with Improvement in Bronchial Dysplasia and Sputum Cytometric Assessment in Individuals at High Risk for Lung Cancer

Jiping Chen, Stephen Lam, Aprile Pilon, Annette McWilliams, Calum MacAulay, and Eva Szabo
Clin Cancer Res 2008 14: 1590-1597 doi: 10.1158/1078-0432.CCR-07-4066 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Article on activation of CCR9/CCL25 in Cutaneous Melanoma

Clin Cancer Res 2008 14: 1598 doi: 10.1158/1078-0432.CCR-14-5-COR [Full Text] [PDF]  

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