CCR Practice of Translational Oncology:

Understanding the Biology of Bone Metastases: Key to the Effective Treatment of Prostate Cancer

Christopher J. Logothetis, Nora M. Navone, and Sue-Hwa Lin
Clin Cancer Res 2008 14: 1599-1602 doi: 10.1158/1078-0432.CCR-07-4603 [Abstract] [Full Text] [PDF]  

Molecular Pathways:

Capitalizing on the Immunogenicity of Dying Tumor Cells

Catia Fonseca and Glenn Dranoff
Clin Cancer Res 2008 14: 1603-1608 doi: 10.1158/1078-0432.CCR-07-2245 [Abstract] [Full Text] [PDF]  

Focus Section:

Newer Cytotoxic Agents: Attacking Cancer Broadly

Beverly A. Teicher
Clin Cancer Res 2008 14: 1610-1617 doi: 10.1158/1078-0432.CCR-07-2249 [Abstract] [Full Text] [PDF]  

The Epothilones: Translating from the Laboratory to the Clinic

James J. Lee and Sandra M. Swain
Clin Cancer Res 2008 14: 1618-1624 doi: 10.1158/1078-0432.CCR-07-2201 [Abstract] [Full Text] [PDF]  

Vinflunine: A New Microtubule Inhibitor Agent

Jaafar Bennouna, Jean-Pierre Delord, Mario Campone, and Laurent Nguyen
Clin Cancer Res 2008 14: 1625-1632 doi: 10.1158/1078-0432.CCR-07-2219 [Abstract] [Full Text] [PDF]  

Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue

Hak Choy, Clinton Park, and Min Yao
Clin Cancer Res 2008 14: 1633-1638 doi: 10.1158/1078-0432.CCR-07-2176 [Abstract] [Full Text] [PDF]  

Aurora Kinases as Anticancer Drug Targets

Oliver Gautschi, Jim Heighway, Philip C. Mack, Phillip R. Purnell, Primo N. Lara, Jr., and David R. Gandara
Clin Cancer Res 2008 14: 1639-1648 doi: 10.1158/1078-0432.CCR-07-2179 [Abstract] [Full Text] [PDF]  

Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

Robert Z. Orlowski and Deborah J. Kuhn
Clin Cancer Res 2008 14: 1649-1657 doi: 10.1158/1078-0432.CCR-07-2218 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Small Molecular Weight Variants of p53 Are Expressed in Human Melanoma Cells and Are Induced by the DNA-Damaging Agent Cisplatin

Kelly A. Avery-Kiejda, Xu Dong Zhang, Luke J. Adams, Rodney J. Scott, Borivoj Vojtesek, David P. Lane, and Peter Hersey
Clin Cancer Res 2008 14: 1659-1668 Published Online First February 29, 2008. doi: 10.1158/1078-0432.CCR-07-1422 [Abstract] [Full Text] [PDF] Supplementary Data  

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

Wilko Weichert, Annika Röske, Silvia Niesporek, Aurelia Noske, Ann-Christin Buckendahl, Manfred Dietel, Volker Gekeler, Markus Boehm, Thomas Beckers, and Carsten Denkert
Clin Cancer Res 2008 14: 1669-1677 doi: 10.1158/1078-0432.CCR-07-0990 [Abstract] [Full Text] [PDF] Supplementary Data  

Endothelial Differentiation of Hematopoietic Stem and Progenitor Cells from Patients with Multiple Myeloma

Roberto Ria, Claudia Piccoli, Teresa Cirulli, Franca Falzetti, Giuseppe Mangialardi, Diego Guidolin, Antonio Tabilio, Nicola Di Renzo, Attilio Guarini, Domenico Ribatti, Franco Dammacco, and Angelo Vacca
Clin Cancer Res 2008 14: 1678-1685 doi: 10.1158/1078-0432.CCR-07-4071 [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of the Bric-a-Brac Tramtrack Broad Complex Protein NAC-1 in Cervical Carcinomas Seems to Correlate with Poorer Prognosis

Shamima Yeasmin, Kentaro Nakayama, Masako Ishibashi, Atsuko Katagiri, Kouji Iida, Indri Nuryani Purwana, Naomi Nakayama, and Kohji Miyazaki
Clin Cancer Res 2008 14: 1686-1691 doi: 10.1158/1078-0432.CCR-07-4085 [Abstract] [Full Text] [PDF] Supplementary Data  

Imaging, Diagnosis, Prognosis:

Molecular, Pathologic, and Clinical Features of Early-Onset Endometrial Cancer: Identifying Presumptive Lynch Syndrome Patients

Michael D. Walsh, Margaret C. Cummings, Daniel D. Buchanan, Wendy M. Dambacher, Sven Arnold, Diane McKeone, Rebecca Byrnes, Melissa A. Barker, Barbara A. Leggett, Michael Gattas, Jeremy R. Jass, Amanda B. Spurdle, Joanne Young, and Andreas Obermair
Clin Cancer Res 2008 14: 1692-1700 Published Online First February 29, 2008. doi: 10.1158/1078-0432.CCR-07-1849 [Abstract] [Full Text] [PDF]  

IMP3 Predicts Aggressive Superficial Urothelial Carcinoma of the Bladder

Lioudmila Sitnikova, Gary Mendese, Qin Liu, Bruce A. Woda, Di Lu, Karen Dresser, Sambit Mohanty, Kenneth L. Rock, and Zhong Jiang
Clin Cancer Res 2008 14: 1701-1706 doi: 10.1158/1078-0432.CCR-07-2039 [Abstract] [Full Text] [PDF]  

Pfetin as a Prognostic Biomarker of Gastrointestinal Stromal Tumors Revealed by Proteomics

Yoshiyuki Suehara, Tadashi Kondo, Kunihiko Seki, Tatsuhiro Shibata, Kiyonaga Fujii, Masahiro Gotoh, Tadashi Hasegawa, Yasuhiro Shimada, Mitsuru Sasako, Tadakazu Shimoda, Hisashi Kurosawa, Yasuo Beppu, Akira Kawai, and Setsuo Hirohashi
Clin Cancer Res 2008 14: 1707-1717 doi: 10.1158/1078-0432.CCR-07-1478 [Abstract] [Full Text] [PDF]  

Prognostic Value of Body Mass Index in Locally Advanced Breast Cancer

Shaheenah Dawood, Kristine Broglio, Ana M. Gonzalez-Angulo, Shu-Wan Kau, Rabiul Islam, Gabriel N. Hortobagyi, and Massimo Cristofanilli
Clin Cancer Res 2008 14: 1718-1725 doi: 10.1158/1078-0432.CCR-07-1479 [Abstract] [Full Text] [PDF]  

Subcellular Localization of Activated Leukocyte Cell Adhesion Molecule Is a Molecular Predictor of Survival in Ovarian Carcinoma Patients

Delia Mezzanzanica, Marina Fabbi, Marina Bagnoli, Samantha Staurengo, Marco Losa, Emanuela Balladore, Paola Alberti, Lara Lusa, Antonino Ditto, Silvano Ferrini, Marco A. Pierotti, Mattia Barbareschi, Silvana Pilotti, and Silvana Canevari
Clin Cancer Res 2008 14: 1726-1733 doi: 10.1158/1078-0432.CCR-07-0428 [Abstract] [Full Text] [PDF]  

Identification of Prognostic Biomarkers for Prostate Cancer

Farhad Kosari, Jan Marie A. Munz, C. Dilara Savci-Heijink, Craig Spiro, Eric W. Klee, Dagmar Marie Kube, Lori Tillmans, Jeff Slezak, R. Jeffrey Karnes, John C. Cheville, and George Vasmatzis
Clin Cancer Res 2008 14: 1734-1743 doi: 10.1158/1078-0432.CCR-07-1494 [Abstract] [Full Text] [PDF] Supplementary Data  

A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer

Maïa Chanrion, Vincent Negre, Hélène Fontaine, Nicolas Salvetat, Frédéric Bibeau, Gaëtan Mac Grogan, Louis Mauriac, Dionyssios Katsaros, Franck Molina, Charles Theillet, and Jean-Marie Darbon
Clin Cancer Res 2008 14: 1744-1752 doi: 10.1158/1078-0432.CCR-07-1833 [Abstract] [Full Text] [PDF] Supplementary Data  

Overall and Relapse-Free Survival in Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma Are Associated with Genotypes of T393C Polymorphism of the GNAS1 Gene

Goetz F. Lehnerdt, Peter Franz, Anwar Zaqoul, Klaus J. Schmitz, Sara Grehl, Stephan Lang, Kurt W. Schmid, Winfried Siffert, Klaus Jahnke, and Ulrich H. Frey
Clin Cancer Res 2008 14: 1753-1758 doi: 10.1158/1078-0432.CCR-07-1605 [Abstract] [Full Text] [PDF]  

Topoisomerase II Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma

Ipatia A. Doussis-Anagnostopoulou, Theodoros P. Vassilakopoulos, Irini Thymara, Penelope Korkolopoulou, Maria K. Angelopoulou, Marina P. Siakantaris, Styliani I. Kokoris, Evangelia M. Dimitriadou, Christina Kalpadakis, Marina Matzouranis, Loukas Kaklamanis, Panayiotis Panayiotidis, Marie-Christine Kyrtsonis, Athina Androulaki, Efstratios Patsouris, Christos Kittas, and Gerassimos A. Pangalis
Clin Cancer Res 2008 14: 1759-1766 doi: 10.1158/1078-0432.CCR-07-1395 [Abstract] [Full Text] [PDF]  

Cyclin D1 Expression in Breast Cancer Patients Receiving Adjuvant Tamoxifen-Based Therapy

Margaretha Rudas, Martina Lehnert, Anh Huynh, Raimund Jakesz, Christian Singer, Sigurd Lax, Walter Schippinger, Otto Dietze, Richard Greil, Wolfgang Stiglbauer, Werner Kwasny, Renate Grill, Michael Stierer, Michael F.X. Gnant, Martin Filipits for the Austrian Breast and Colorectal Cancer Study Group
Clin Cancer Res 2008 14: 1767-1774 doi: 10.1158/1078-0432.CCR-07-4122 [Abstract] [Full Text] [PDF]  

Prognostic Factors in Renal Cell Carcinoma: Association of Preoperative Sodium Concentration with Survival

Naveen S. Vasudev, Janet E. Brown, Sarah R. Brown, Rumana Rafiq, Ruth Morgan, Poulam M. Patel, Dearbhaile O'Donnell, Patricia Harnden, Mark Rogers, Kim Cocks, Kirsty Anderson, Alan Paul, Ian Eardley, Peter J. Selby, and Rosamonde E. Banks
Clin Cancer Res 2008 14: 1775-1781 doi: 10.1158/1078-0432.CCR-07-1721 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Improving the Quality of Abstract Reporting for Phase I Cancer Trials

Elizabeth L. Strevel, Nicole G. Chau, Gregory R. Pond, Anthony J. Murgo, Percy S. Ivy, and Lillian L. Siu
Clin Cancer Res 2008 14: 1782-1787 doi: 10.1158/1078-0432.CCR-07-4886 [Abstract] [Full Text] [PDF]  

Irinotecan Pharmacogenetics: Influence of Pharmacodynamic Genes

Janelle M. Hoskins, Eugenio Marcuello, Albert Altes, Sharon Marsh, Taylor Maxwell, Derek J. Van Booven, Laia Paré, Robert Culverhouse, Howard L. McLeod, and Montserrat Baiget
Clin Cancer Res 2008 14: 1788-1796 doi: 10.1158/1078-0432.CCR-07-1472 [Abstract] [Full Text] [PDF] Supplementary Data  

Correlation of CDA, ERCC1, and XPD Polymorphisms with Response and Survival in Gemcitabine/Cisplatin–Treated Advanced Non–Small Cell Lung Cancer Patients

Carmelo Tibaldi, Elisa Giovannetti, Enrico Vasile, Valentina Mey, Adrie C. Laan, Sara Nannizzi, Roberta Di Marsico, Andrea Antonuzzo, Cinzia Orlandini, Simona Ricciardi, Mario Del Tacca, Godefridus J. Peters, Alfredo Falcone, and Romano Danesi
Clin Cancer Res 2008 14: 1797-1803 doi: 10.1158/1078-0432.CCR-07-1364 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Targeting Hyaluronan Interactions in Malignant Gliomas and Their Drug-Resistant Multipotent Progenitors

Anne G. Gilg, Sandra L. Tye, Lauren B. Tolliver, William G. Wheeler, Richard P. Visconti, James D. Duncan, Felina V. Kostova, Letitia N. Bolds, Bryan P. Toole, and Bernard L. Maria
Clin Cancer Res 2008 14: 1804-1813 doi: 10.1158/1078-0432.CCR-07-1228 [Abstract] [Full Text] [PDF]  

Antimyeloma Effects of a Sesquiterpene Lactone Parthenolide

Attaya Suvannasankha, Colin D. Crean, Rajasubramaniam Shanmugam, Sherif S. Farag, Rafat Abonour, H. Scott Boswell, and Harikrishna Nakshatri
Clin Cancer Res 2008 14: 1814-1822 doi: 10.1158/1078-0432.CCR-07-1359 [Abstract] [Full Text] [PDF]  

Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer

Yi-Hung Tan, Kung-Hsueh Lee, Topp Lin, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Hsueh-Fen Juan, and Yi-Ching Wang
Clin Cancer Res 2008 14: 1823-1830 doi: 10.1158/1078-0432.CCR-07-1806 [Abstract] [Full Text] [PDF]  

Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor

Xianhua Cao, Mark Bloomston, Tao Zhang, Wendy L. Frankel, Guang Jia, Bing Wang, Nathan C. Hall, Regina M. Koch, Hao Cheng, Michael V. Knopp, and Duxin Sun
Clin Cancer Res 2008 14: 1831-1839 doi: 10.1158/1078-0432.CCR-07-1607 [Abstract] [Full Text] [PDF]  

Vitamin E Succinate Induces Ceramide-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma In vitro and In vivo

Xinbin Gu, Xiaodong Song, Yongheng Dong, Hui Cai, Eric Walters, Renshu Zhang, Xiaowu Pang, Tianpei Xie, Yinhan Guo, Rajagopalan Sridhar, and Joseph A. Califano
Clin Cancer Res 2008 14: 1840-1848 doi: 10.1158/1078-0432.CCR-07-1811 [Abstract] [Full Text] [PDF]  

Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström's Macroglobulinemia

Aldo M. Roccaro, Xavier Leleu, Antonio Sacco, Anne-Sophie Moreau, Evdoxia Hatjiharissi, Xiaoying Jia, Lian Xu, Bryan Ciccarelli, Christopher J. Patterson, Hai T. Ngo, Domenico Russo, Angelo Vacca, Franco Dammacco, Kenneth C. Anderson, Irene M. Ghobrial, and Steven P. Treon
Clin Cancer Res 2008 14: 1849-1858 doi: 10.1158/1078-0432.CCR-07-1750 [Abstract] [Full Text] [PDF]  

Radiation Enhances Adenoviral Gene Therapy in Pancreatic Cancer via Activation of Cytomegalovirus Promoter and Increased Adenovirus Uptake

Takuya Egami, Kenoki Ohuchida, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Shoko Nishio, Eishi Nagai, Kunio Matsumoto, Toshikazu Nakamura, and Masao Tanaka
Clin Cancer Res 2008 14: 1859-1867 doi: 10.1158/1078-0432.CCR-07-0933 [Abstract] [Full Text] [PDF]  

Inhibition of the Tumor Necrosis Factor- Pathway Is Radioprotective for the Lung

Ming Zhang, Jun Qian, Xianying Xing, Feng-Ming Kong, Lujun Zhao, Ming Chen, and Theodore S. Lawrence
Clin Cancer Res 2008 14: 1868-1876 doi: 10.1158/1078-0432.CCR-07-1894 [Abstract] [Full Text] [PDF]  

Ataxia Telangiectasia Mutated and p21^CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

Elvira Crescenzi, Giuseppe Palumbo, Jasper de Boer, and Hugh J.M. Brady
Clin Cancer Res 2008 14: 1877-1887 doi: 10.1158/1078-0432.CCR-07-4298 [Abstract] [Full Text] [PDF] Supplementary Data  

Novel Delivery of SN38 Markedly Inhibits Tumor Growth in Xenografts, Including a Camptothecin-11–Refractory Model

Puja Sapra, Hong Zhao, Mary Mehlig, Jennifer Malaby, Patricia Kraft, Clifford Longley, Lee M. Greenberger, and Ivan D. Horak
Clin Cancer Res 2008 14: 1888-1896 doi: 10.1158/1078-0432.CCR-07-4456 [Abstract] [Full Text] [PDF]  

Sensitivity of Squamous Cell Carcinoma Lymph Node Metastases to Herpes Oncolytic Therapy

Zhenkun Yu, Sen Li, Yu-Yao Huang, Shu-Fu Lin, Yuman Fong, and Richard J. Wong
Clin Cancer Res 2008 14: 1897-1904 doi: 10.1158/1078-0432.CCR-07-4615 [Abstract] [Full Text] [PDF]  

Toll-like Receptor 4 Mediates an Antitumor Host Response Induced by Salmonella choleraesuis

Che-Hsin Lee, Chao-Liang Wu, and Ai-Li Shiau
Clin Cancer Res 2008 14: 1905-1912 doi: 10.1158/1078-0432.CCR-07-2050 [Abstract] [Full Text] [PDF]  

Cancer Susceptibility and Prevention:

Molecular Alterations in Spontaneous Sputum of Cancer-Free Heavy Smokers: Results from a Large Screening Program

Ekaterina Baryshnikova, Annarita Destro, Maurizio Valentino Infante, Silvio Cavuto, Umberto Cariboni, Marco Alloisio, Giovanni Luca Ceresoli, Romano Lutman, Giorgio Brambilla, Giuseppe Chiesa, Gianni Ravasi, and Massimo Roncalli
Clin Cancer Res 2008 14: 1913-1919 doi: 10.1158/1078-0432.CCR-07-1741 [Abstract] [Full Text] [PDF] Supplementary Data  

Letters to the Editor:

Does Erythropoietin Promote Tumor Growth?

Donghoon Yoon, Neeraj Agarwal, and Josef T. Prchal
Clin Cancer Res 2008 14: 1920 doi: 10.1158/1078-0432.CCR-07-4612 [Full Text] [PDF]  

Does Erythropoietin Promote Tumor Growth?

Pierre Saintigny, Benjamin Besse, Jean-Charles Soria, Jean-François Bernaudin, and Patrice Callard
Clin Cancer Res 2008 14: 1920-1921 doi: 10.1158/1078-0432.CCR-07-4884 [Full Text] [PDF]  

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