The Clinical Connections:

Comparisons of Metastases in Different Organs: Biological and Clinical Implications

David Tarin
Clin Cancer Res 2008 14: 1923-1925 doi: 10.1158/1078-0432.CCR-07-5259 [Full Text] [PDF]  

Molecular Pathways:

Regulation of Hematopoietic Stem Cells by the Steel Factor/KIT Signaling Pathway

David Kent, Michael Copley, Claudia Benz, Brad Dykstra, Michelle Bowie, and Connie Eaves
Clin Cancer Res 2008 14: 1926-1930 doi: 10.1158/1078-0432.CCR-07-5134 [Abstract] [Full Text] [PDF]  

Review:

Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy

Nikolaos A. Dallas, Shaija Samuel, Ling Xia, Fan Fan, Michael J. Gray, Sherry J. Lim, and Lee M. Ellis
Clin Cancer Res 2008 14: 1931-1937 doi: 10.1158/1078-0432.CCR-07-4478 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Heterogeneity of Breast Cancer Metastases: Comparison of Therapeutic Target Expression and Promoter Methylation Between Primary Tumors and Their Multifocal Metastases

Julie M. Wu, Mary Jo Fackler, Marc K. Halushka, Diana W. Molavi, M. Evangeline Taylor, Wei Wen Teo, Constance Griffin, John Fetting, Nancy E. Davidson, Angelo M. De Marzo, Jessica L. Hicks, Dhananjay Chitale, Marc Ladanyi, Saraswati Sukumar, and Pedram Argani
Clin Cancer Res 2008 14: 1938-1946 doi: 10.1158/1078-0432.CCR-07-4082 [Abstract] [Full Text] [PDF] Supplementary Data  

Histogenesis of Clear Cell Adenocarcinoma in the Urinary Tract: Evidence of Urothelial Origin

Ming-Tse Sung, Shaobo Zhang, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi, Mingsheng Wang, Puay-Hoon Tan, and Liang Cheng
Clin Cancer Res 2008 14: 1947-1955 doi: 10.1158/1078-0432.CCR-07-4147 [Abstract] [Full Text] [PDF]  

Integrated Genomic and Transcriptomic Analysis of Ductal Carcinoma In situ of the Breast

Anne Vincent-Salomon, Carlo Lucchesi, Nadège Gruel, Virginie Raynal, Gaëlle Pierron, Rémi Goudefroye, Fabien Reyal, François Radvanyi, Rémy Salmon, Jean-Paul Thiery, Xavier Sastre-Garau, Brigitte Sigal-Zafrani, Alain Fourquet, Olivier Delattre for the breast cancer study group of the Institut Curie
Clin Cancer Res 2008 14: 1956-1965 doi: 10.1158/1078-0432.CCR-07-1465 [Abstract] [Full Text] [PDF] Supplementary Data  

Dissection of the APC^Cdh1-Skp2 Cascade in Breast Cancer

Takeo Fujita, Weijun Liu, Hiroyoshi Doihara, Hiroshi Date, and Yong Wan
Clin Cancer Res 2008 14: 1966-1975 doi: 10.1158/1078-0432.CCR-07-1585 [Abstract] [Full Text] [PDF]  

Familial Breast Cancers without Mutations in BRCA1 or BRCA2 Have Low Cyclin E and High Cyclin D1 in Contrast to Cancers in BRCA Mutation Carriers

Kirsimari Aaltonen, Carl Blomqvist, Rose-Marie Amini, Hannaleena Eerola, Kristiina Aittomäki, Päivi Heikkilä, and Heli Nevanlinna
Clin Cancer Res 2008 14: 1976-1983 doi: 10.1158/1078-0432.CCR-07-4100 [Abstract] [Full Text] [PDF]  

Fibroblast Growth Factor 2 and Estrogen Control the Balance of Histone 3 Modifications Targeting MAGE-A3 in Pituitary Neoplasia

Xuegong Zhu, Sylvia L. Asa, and Shereen Ezzat
Clin Cancer Res 2008 14: 1984-1996 doi: 10.1158/1078-0432.CCR-07-2003 [Abstract] [Full Text] [PDF]  

Tissue Transglutaminase Regulates Focal Adhesion Kinase/AKT Activation by Modulating PTEN Expression in Pancreatic Cancer Cells

Amit Verma, Sushovan Guha, Huamin Wang, Jansina Y. Fok, Dimpy Koul, James Abbruzzese, and Kapil Mehta
Clin Cancer Res 2008 14: 1997-2005 doi: 10.1158/1078-0432.CCR-07-1533 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions

Stephen Lam, Beau Standish, Corisande Baldwin, Annette McWilliams, Jean leRiche, Adi Gazdar, Alex I. Vitkin, Victor Yang, Norihiko Ikeda, and Calum MacAulay
Clin Cancer Res 2008 14: 2006-2011 doi: 10.1158/1078-0432.CCR-07-4418 [Abstract] [Full Text] [PDF]  

Early Metabolic Response Evaluation by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Allows In vivo Testing of Chemosensitivity in Gastric Cancer: Long-term Results of a Prospective Study

Katja Ott, Ken Herrmann, Florian Lordick, Hinrich Wieder, Wolfgang A. Weber, Karen Becker, Andreas K. Buck, Martin Dobritz, Ulrich Fink, Kurt Ulm, Tibor Schuster, Markus Schwaiger, Jörg-Rüdiger Siewert, and Bernd J. Krause
Clin Cancer Res 2008 14: 2012-2018 doi: 10.1158/1078-0432.CCR-07-0934 [Abstract] [Full Text] [PDF]  

New Pansomatostatin Ligands and Their Chelated Versions: Affinity Profile, Agonist Activity, Internalization, and Tumor Targeting

Mihaela Ginj, Hanwen Zhang, Klaus-Peter Eisenwiener, Damian Wild, Stefan Schulz, Hans Rink, Renzo Cescato, Jean Claude Reubi, and Helmut R. Maecke
Clin Cancer Res 2008 14: 2019-2027 doi: 10.1158/1078-0432.CCR-07-1687 [Abstract] [Full Text] [PDF]  

Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8⁺/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

Ekaterina S. Jordanova, Arko Gorter, Ouissam Ayachi, Frans Prins, Lindy G. Durrant, Gemma G. Kenter, Sjoerd H. van der Burg, and Gert Jan Fleuren
Clin Cancer Res 2008 14: 2028-2035 doi: 10.1158/1078-0432.CCR-07-4554 [Abstract] [Full Text] [PDF]  

¹⁸F-Fluoro-2-Deoxy-Glucose Uptake Predicts Clinical Outcome in Patients with Gefitinib-Treated Non–Small Cell Lung Cancer

Im Il Na, Byung Hyun Byun, Hye Jin Kang, Gi Jeong Cheon, Jae Soo Koh, Cheol Hyeon Kim, Du Hwan Choe, Baek-Yeol Ryoo, Jae Cheol Lee, Sang Moo Lim, and Sung Hyun Yang
Clin Cancer Res 2008 14: 2036-2041 doi: 10.1158/1078-0432.CCR-07-4074 [Abstract] [Full Text] [PDF]  

Single-Nucleotide Polymorphisms of DNA Damage Response Genes Are Associated with Overall Survival in Patients with Pancreatic Cancer

Taro Okazaki, Li Jiao, Ping Chang, Douglas B. Evans, James L. Abbruzzese, and Donghui Li
Clin Cancer Res 2008 14: 2042-2048 doi: 10.1158/1078-0432.CCR-07-1520 [Abstract] [Full Text] [PDF]  

Glioma Proliferation as Assessed by 3‘-Fluoro-3’-Deoxy-L-Thymidine Positron Emission Tomography in Patients with Newly Diagnosed High-Grade Glioma

Roland Ullrich, Heiko Backes, Hongfeng Li, Lutz Kracht, Hrvoje Miletic, Kristina Kesper, Bernd Neumaier, Wolf-Dieter Heiss, Klaus Wienhard, and Andreas H. Jacobs
Clin Cancer Res 2008 14: 2049-2055 doi: 10.1158/1078-0432.CCR-07-1553 [Abstract] [Full Text] [PDF]  

Gene Expression–Based Recurrence Prediction of Hepatitis B Virus–Related Human Hepatocellular Carcinoma

Hyun Goo Woo, Eun Sung Park, Jae Hee Cheon, Ju Han Kim, Ju-Seog Lee, Bum Joon Park, Won Kim, Su Cheol Park, Young Jin Chung, Byeong Gwan Kim, Jung-Hwan Yoon, Hyo-Suk Lee, Chung Yong Kim, Nam-Joon Yi, Kyung-Suk Suh, Kuhn Uk Lee, In-Sun Chu, Tania Roskams, Snorri S. Thorgeirsson, and Yoon Jun Kim
Clin Cancer Res 2008 14: 2056-2064 doi: 10.1158/1078-0432.CCR-07-1473 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Clinical:

Neoadjuvant Treatment of Colorectal Cancer with Bevacizumab: The Perioperative Angiogenic Balance Is Sensitive to Systemic Thrombospondin-1 Levels

Christine Brostjan, Kristina Gebhardt, Birgit Gruenberger, Verena Steinrueck, Halina Zommer, Harald Freudenthaler, Sebastian Roka, and Thomas Gruenberger
Clin Cancer Res 2008 14: 2065-2074 doi: 10.1158/1078-0432.CCR-07-4081 [Abstract] [Full Text] [PDF] Supplementary Data  

A Phase I Pharmacokinetic and Pharmacodynamic Study of TKI258, an Oral, Multitargeted Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Debashis Sarker, Rhoda Molife, T.R. Jeffrey Evans, Maryon Hardie, Cheryl Marriott, Priska Butzberger-Zimmerli, Rosemary Morrison, Judith A. Fox, Carla Heise, Sharianne Louie, Natasha Aziz, Felix Garzon, Glenn Michelson, Ian R. Judson, Dalal Jadayel, Edgar Braendle, and Johann S. de Bono
Clin Cancer Res 2008 14: 2075-2081 doi: 10.1158/1078-0432.CCR-07-1466 [Abstract] [Full Text] [PDF]  

Anemia Is a Significant Prognostic Factor in Local Relapse-Free Survival of Premenopausal Primary Breast Cancer Patients Receiving Adjuvant Cyclophosphamide/Methotrexate/5-Fluorouracil Chemotherapy

Peter Dubsky, Paul Sevelda, Raimund Jakesz, Hubert Hausmaninger, Hellmut Samonigg, Michael Seifert, Ursula Denison, Brigitte Mlineritsch, Günther Steger, Werner Kwasny, Herbert Stöger, Rupert Bartsch, Michael Stierer, Susanne Taucher, Michael Fridrik, Walter Schippinger, Richard Greil, Richard Pötter, Michael Gnant for the Austrian Breast and Colorectal Cancer Study Group
Clin Cancer Res 2008 14: 2082-2087 doi: 10.1158/1078-0432.CCR-07-2068 [Abstract] [Full Text] [PDF]  

The Potential Predictive Value of Cyclooxygenase-2 Expression and Increased Risk of Gastrointestinal Hemorrhage in Advanced Non–Small Cell Lung Cancer Patients Treated with Erlotinib and Celecoxib

Mary J. Fidler, Athanassios Argiris, Jyoti D. Patel, David H. Johnson, Alan Sandler, Victoria M. Villaflor, John Coon, IV, Lela Buckingham, Kelly Kaiser, Sanjib Basu, and Philip Bonomi
Clin Cancer Res 2008 14: 2088-2094 doi: 10.1158/1078-0432.CCR-07-4013 [Abstract] [Full Text] [PDF]  

Pilot Randomized Phase II Study of Celecoxib in Oral Premalignant Lesions

Vassiliki A. Papadimitrakopoulou, William N. William, Jr., Andrew J. Dannenberg, Scott M. Lippman, J. Jack Lee, Frank G. Ondrey, Douglas E. Peterson, Lei Feng, Anthea Atwell, Adel K. El-Naggar, Cherie-Ann Nathan, Joseph I. Helman, Baoheng Du, Bevan Yueh, and Jay O. Boyle
Clin Cancer Res 2008 14: 2095-2101 doi: 10.1158/1078-0432.CCR-07-4024 [Abstract] [Full Text] [PDF]  

Population Pharmacokinetic-Pharmacodynamic Model of the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid in Cancer Patients

Jing Li, Michael B. Jameson, Bruce C. Baguley, Roberto Pili, and Sharyn D. Baker
Clin Cancer Res 2008 14: 2102-2110 doi: 10.1158/1078-0432.CCR-07-1475 [Abstract] [Full Text] [PDF]  

Stress, Immunity, and Cervical Cancer: Biobehavioral Outcomes of a Randomized Clinical Trail

Edward L. Nelson, Lari B. Wenzel, Kathryn Osann, Aysun Dogan-Ates, Nissa Chantana, Astrid Reina-Patton, Amanda K. Laust, Kevin P. Nishimoto, Alexandra Chicz-DeMet, Nefertiti du Pont, and Bradley J. Monk
Clin Cancer Res 2008 14: 2111-2118 doi: 10.1158/1078-0432.CCR-07-1632 [Abstract] [Full Text] [PDF] Supplementary Data  

Cancer Therapy: Preclinical:

Lupeol Inhibits Growth of Highly Aggressive Human Metastatic Melanoma Cells In vitro and In vivo by Inducing Apoptosis

Mohammad Saleem, Nityanand Maddodi, Mohammad Abu Zaid, Naghma Khan, Bilal bin Hafeez, Mohammad Asim, Yewseok Suh, Jung-Mi Yun, Vijayasaradhi Setaluri, and Hasan Mukhtar
Clin Cancer Res 2008 14: 2119-2127 doi: 10.1158/1078-0432.CCR-07-4413 [Abstract] [Full Text] [PDF]  

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to -Radiation by Targeting Nuclear Factor-B–Regulated Gene Products

Ajaikumar B. Kunnumakkara, Parmeswaran Diagaradjane, Sushovan Guha, Amit Deorukhkar, Shujun Shentu, Bharat B. Aggarwal, and Sunil Krishnan
Clin Cancer Res 2008 14: 2128-2136 doi: 10.1158/1078-0432.CCR-07-4722 [Abstract] [Full Text] [PDF]  

Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH₂): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth

Fernando Doñate, Graham C. Parry, Yuval Shaked, Harvey Hensley, Xiaojun Guan, Ivy Beck, Ziva Tel-Tsur, Marian L. Plunkett, Mari Manuia, David E. Shaw, Robert S. Kerbel, and Andrew P. Mazar
Clin Cancer Res 2008 14: 2137-2144 doi: 10.1158/1078-0432.CCR-07-4530 [Abstract] [Full Text] [PDF]  

DTS-108, A Novel Peptidic Prodrug of SN38: In vivo Efficacy and Toxicokinetic Studies

Florence Meyer-Losic, Céline Nicolazzi, Jérôme Quinonero, Fabien Ribes, Matthieu Michel, Vincent Dubois, Catherine de Coupade, Matthieu Boukaissi, Anne-Sophie Chéné, Isabelle Tranchant, Valérie Arranz, Imane Zoubaa, Jean-Sébastien Fruchart, Denis Ravel, and Jonathan Kearsey
Clin Cancer Res 2008 14: 2145-2153 doi: 10.1158/1078-0432.CCR-07-4580 [Abstract] [Full Text] [PDF]  

A Severe Combined Immunodeficient–hu In vivo Mouse Model of Human Primary Mantle Cell Lymphoma

Michael Wang, Liang Zhang, Xiaohong Han, Jing Yang, Jianfei Qian, Sungyoul Hong, Pei Lin, Yuankai Shi, Jorge Romaguera, Larry W. Kwak, and Qing Yi
Clin Cancer Res 2008 14: 2154-2160 doi: 10.1158/1078-0432.CCR-07-4409 [Abstract] [Full Text] [PDF]  

Evaluation of D-Methionine as a Novel Oral Radiation Protector for Prevention of Mucositis

Saleha B. Vuyyuri, Daniel A. Hamstra, Divya Khanna, Christin A. Hamilton, Sonja M. Markwart, Kathleen C.M. Campbell, Prasad Sunkara, Brian D. Ross, and Alnawaz Rehemtulla
Clin Cancer Res 2008 14: 2161-2170 doi: 10.1158/1078-0432.CCR-07-1954 [Abstract] [Full Text] [PDF] Supplementary Data  

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

Jennifer H.E. Baker, Kirstin E. Lindquist, Lynsey A. Huxham, Alastair H. Kyle, Jonathan T. Sy, and Andrew I. Minchinton
Clin Cancer Res 2008 14: 2171-2179 doi: 10.1158/1078-0432.CCR-07-4465 [Abstract] [Full Text] [PDF]  

Treatment of Human Colon Cancer Xenografts with TRA-8 Anti-death Receptor 5 Antibody Alone or in Combination with CPT-11

Patsy G. Oliver, Albert F. LoBuglio, Kurt R. Zinn, Hyunki Kim, Li Nan, Tong Zhou, Wenquan Wang, and Donald J. Buchsbaum
Clin Cancer Res 2008 14: 2180-2189 doi: 10.1158/1078-0432.CCR-07-1392 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo

Kathleen F. Pirollo, Antonina Rait, Qi Zhou, Xin-qiao Zhang, Jain Zhou, Chang-Soo Kim, William F. Benedict, and Esther H. Chang
Clin Cancer Res 2008 14: 2190-2198 doi: 10.1158/1078-0432.CCR-07-1951 [Abstract] [Full Text] [PDF]  

Loss of Retinoblastoma Tumor Suppressor Protein Makes Human Breast Cancer Cells More Sensitive to Antimetabolite Exposure

Massimo Derenzini, Giulio Donati, Giuliano Mazzini, Lorenzo Montanaro, Manuela Vici, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, and Davide Treré
Clin Cancer Res 2008 14: 2199-2209 doi: 10.1158/1078-0432.CCR-07-2065 [Abstract] [Full Text] [PDF]  

Combination of Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor Inhibition Markedly Improves Radiation Tumor Therapy

Carmen Timke, Heike Zieher, Alexandra Roth, Kai Hauser, Kenneth E. Lipson, Klaus J. Weber, Jürgen Debus, Amir Abdollahi, and Peter E. Huber
Clin Cancer Res 2008 14: 2210-2219 doi: 10.1158/1078-0432.CCR-07-1893 [Abstract] [Full Text] [PDF]  

An In vivo Model of Met-Driven Lymphoma as a Tool to Explore the Therapeutic Potential of Met Inhibitors

Paolo Accornero, Giuseppe Lattanzio, Tony Mangano, Roberto Chiarle, Riccardo Taulli, Francesca Bersani, Paolo E. Forni, Silvia Miretti, Claudio Scuoppo, Walter Dastrù, James G. Christensen, Tiziana Crepaldi, and Carola Ponzetto
Clin Cancer Res 2008 14: 2220-2226 doi: 10.1158/1078-0432.CCR-07-2064 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

Toxigenic Helicobacter pylori Infection Precedes Gastric Hypochlorhydria in Cancer Relatives, and H. pylori Virulence Evolves in These Families

Richard H. Argent, Rachael J. Thomas, Francisco Aviles-Jimenez, Darren P. Letley, Marie C. Limb, Emad M. El-Omar, and John C. Atherton
Clin Cancer Res 2008 14: 2227-2235 doi: 10.1158/1078-0432.CCR-07-2022 [Abstract] [Full Text] [PDF] Supplementary Data  

Profiling of Genetic Variations in Inflammation Pathway Genes in Relation to Bladder Cancer Predisposition

Hushan Yang, Jian Gu, Xin Lin, H. Barton Grossman, Yuanqing Ye, Colin P. Dinney, and Xifeng Wu
Clin Cancer Res 2008 14: 2236-2244 doi: 10.1158/1078-0432.CCR-07-1670 [Abstract] [Full Text] [PDF] Supplementary Data  

Letters to the Editor:

Re: Wieland BM, et al. Is There a Human Homologue to the Murine Proteolysis–Inducing Factor?

Michael J. Tisdale
Clin Cancer Res 2008 14: 2245 doi: 10.1158/1078-0432.CCR-07-4769 [Full Text] [PDF]  

Reply to Letter to the Editor: a Response to the Letter of M. Tisdale

Vickie E. Baracos
Clin Cancer Res 2008 14: 2245 doi: 10.1158/1078-0432.CCR-08-0021 [Full Text] [PDF]  

Corrections:

Correction: Article on Immunohistochemical Analysis of Phosphotyrosine STAT3 and EGFR Autocrine Signaling Pathways

Clin Cancer Res 2008 14: 2247 doi: 10.1158/1078-0432.CCR-14-7-COR [Full Text] [PDF]  

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