Editorials:

Editorial

John Mendelsohn
Clin Cancer Res 1999 5: 1 [Full Text] [PDF]  

Topotecan: What Dose, What Schedule, What Route?

Seamus O’Reilly
Clin Cancer Res 1999 5: 3 [Full Text] [PDF]  

Doxorubicin-Polymer Conjugates: Further Demonstration of the Concept of Enhanced Permeability and Retention

Franco M. Muggia
Clin Cancer Res 1999 5: 7 [Full Text] [PDF]  

Advances in Brief:

Immunological Effects of Interleukin 12 Administered by Bolus Intravenous Injection to Patients with Cancer

Michael J. Robertson, Christine Cameron, Michael B. Atkins, Michael S. Gordon, Michael T. Lotze, Matthew L. Sherman, and Jerome Ritz
Clin Cancer Res 1999 5: 9 [Abstract] [Full Text] [PDF]  

Deletions of Chromosome 4 at Multiple Sites Are Frequent in Malignant Mesothelioma and Small Cell Lung Carcinoma

Narayan Shivapurkar, Arvind K. Virmani, Ignacio I. Wistuba, Sara Milchgrub, Bruce Mackay, John D. Minna, and Adi F. Gazdar
Clin Cancer Res 1999 5: 17 [Abstract] [Full Text] [PDF]  

Relative Expression of E-Cadherin and Type IV Collagenase Genes Predicts Disease Outcome in Patients with Resectable Pancreatic Carcinoma

Hiroki Kuniyasu, Lee M. Ellis, Douglas B. Evans, James L. Abbruzzese, Claudia J. Fenoglio, Corazon D. Bucana, Karen R. Cleary, Eiichi Tahara, and Isaiah J. Fidler
Clin Cancer Res 1999 5: 25 [Abstract] [Full Text] [PDF]  

Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) and TGF/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis

Peter Nørgaard, Brian Law, Heather Joseph, David L. Page, Yu Shyr, Debbie Mays, Jennifer A. Pietenpol, Nancy E. Kohl, Allen Oliff, Robert J. Coffey, Jr., Hans Skovgaard Poulsen, and Harold L. Moses
Clin Cancer Res 1999 5: 35 [Abstract] [Full Text] [PDF]  

Interleukin-6 Modulated Conditionally Replicative Adenovirus as an Antitumor/Cytotoxic Agent for Cancer Therapy

Claudine Rancourt, Alain Piché, Jesús Gomez-Navarro, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Gerald M. Fuller, Simon A. Jones, and David T. Curiel
Clin Cancer Res 1999 5: 43 [Abstract] [Full Text] [PDF]  

Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors

Jason L. Hornick, Leslie A. Khawli, Peisheng Hu, Jahangir Sharifi, Chand Khanna, and Alan L. Epstein
Clin Cancer Res 1999 5: 51 [Abstract] [Full Text] [PDF]  

Cyclic-AMP Induction of Gap Junctional Intercellular Communication Increases Bystander Effect in Suicide Gene Therapy

George D. Carystinos, Maha M. Katabi, Dale W. Laird, Jacques Galipeau, Helen Chan, Moulay A. Alaoui-Jamali, and Gerald Batist
Clin Cancer Res 1999 5: 61 [Abstract] [Full Text] [PDF]  

Clinical Trials:

A Comparison of Clinical Pharmacodynamics of Different Administration Schedules of Oral Topotecan (Hycamtin)

Cees J. H. Gerrits, Jan H. M. Schellens, Howard Burris, John R. Eckardt, Andre S. T. Planting, Maria E. L. van der Burg, Gail I. Rodriguez, Walter J. Loos, Vera van Beurden, Ian Hudson, Daniel D. Von Hoff, and Jaap Verweij
Clin Cancer Res 1999 5: 69 [Abstract] [Full Text] [PDF]  

Immunization of Melanoma Patients with BEC2-Keyhole Limpet Hemocyanin plus BCG Intradermally Followed by Intravenous Booster Immunizations with BEC2 to Induce Anti-GD3 Ganglioside Antibodies

Tzy-Jyun Yao, Michael Meyers, Philip O. Livingston, Alan N. Houghton, and Paul B. Chapman
Clin Cancer Res 1999 5: 77 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates

Paul A. Vasey, Stan B. Kaye, Rosemary Morrison, Chris Twelves, Peter Wilson, Ruth Duncan, Alison H. Thomson, Lilian S. Murray, Tom E. Hilditch, Tom Murray, Sally Burtles, D. Fraier, E. Frigerio, and Jim Cassidy
Clin Cancer Res 1999 5: 83 [Abstract] [Full Text] [PDF]  

Hepatic Transcatheter Arterial Chemoembolization Alternating with Systemic Protracted Continuous Infusion 5-Fluorouracil for Gastrointestinal Malignancies Metastatic to Liver: A Phase II Trial of the Puget Sound Oncology Consortium (PSOC 1104)

Linda M. Bavisotto, Nilesh H. Patel, Sandra J. Althaus, Douglas M. Coldwell, Hanh V. Nghiem, Tove Thompson, Barry Storer, and Charles R. Thomas, Jr.
Clin Cancer Res 1999 5: 95 [Abstract] [Full Text] [PDF]  

Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days

Andy N. Hughes, Imran Rafi, Melanie J. Griffin, A. Hilary Calvert, David R. Newell, Joanne A. Calvete, Amanda Johnston, Neil Clendeninn, and Alan V. Boddy
Clin Cancer Res 1999 5: 111 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

The Nuclear Factor-B RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells

Weixin Wang, James L. Abbruzzese, Douglas B. Evans, Lillie Larry, Karen R. Cleary, and Paul J. Chiao
Clin Cancer Res 1999 5: 119 [Abstract] [Full Text] [PDF]  

p53 Codon 72 Polymorphism in Taiwanese Lung Cancer Patients: Association with Lung Cancer Susceptibility and Prognosis

Yi-Ching Wang, Chih-Yi Chen, Shin-Kuang Chen, Yuan-Yen Chang, and Pinpin Lin
Clin Cancer Res 1999 5: 129 [Abstract] [Full Text] [PDF]  

Changes of Angiogenesis and Tumor Cell Apoptosis during Colorectal Carcinogenesis

Toshiharu Aotake, Cai-De Lu, Yukio Chiba, Ryusuke Muraok, and Nobuhiko Tanigawa
Clin Cancer Res 1999 5: 135 [Abstract] [Full Text] [PDF]  

Overexpression of Ornithine Decarboxylase in Prostate Cancer and Prostatic Fluid in Humans

Rajiv R. Mohan, Anjana Challa, Sanjay Gupta, David G. Bostwick, Nihal Ahmad, Rajesh Agarwal, Susan R. Marengo, Saeid B. Amini, Francisco Paras, Gregory T. MacLennan, Martin I. Resnick, and Hasan Mukhtar
Clin Cancer Res 1999 5: 143 [Abstract] [Full Text] [PDF]  

Elevated Levels of Circulating Plasma Matrix Metalloproteinase 9 in Non-Small Cell Lung Cancer Patients

Toshihiko Iizasa, Takehiko Fujisawa, Makoto Suzuki, Shin-ichirou Motohashi, Kazuhiro Yasufuku, Tomohisa Yasukawa, Masayuki Baba, and Mitsutoshi Shiba
Clin Cancer Res 1999 5: 149 [Abstract] [Full Text] [PDF]  

Thrombospondins I and II Messenger RNA Expression in Lung Carcinoma: Relationship with p53 Alterations, Angiogenic Growth Factors, and Vascular Density

Gabriella Fontanini, Laura Boldrini, Alessandra Calcinai, Silvana Chinè, Marco Lucchi, Alfredo Mussi, Carlo Alberto Angeletti, Fulvio Basolo, and Generoso Bevilacqua
Clin Cancer Res 1999 5: 155 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Simultaneous Protection of G156A Methylguanine DNA Methyltransferase Gene-transduced Hematopoietic Progenitors and Sensitization of Tumor Cells Using O⁶-Benzylguanine and Temozolomide

Jane S. Reese, Brian M. Davis, Lili Liu, and Stanton L. Gerson
Clin Cancer Res 1999 5: 163 [Abstract] [Full Text] [PDF]  

Without Prior Stimulation, Tumor-associated Lymphocytes from Malignant Effusions Lyse Autologous Tumor Cells in the Presence of Bispecific Antibody HEA125xOKT3

Gudrun Strauß, Brigitte Gückel, Diethelm Wallwiener, and Gerhard Moldenhauer
Clin Cancer Res 1999 5: 171 [Abstract] [Full Text] [PDF]  

Antiangiogenic Effects of Camptothecin Analogues 9-Amino-20(S)-camptothecin, Topotecan, and CPT-11 Studied in the Mouse Cornea Model

James J. O’Leary, Richard L. Shapiro, Chris J. Ren, Neal Chuang, Henry W. Cohen, and Milan Potmesil
Clin Cancer Res 1999 5: 181 [Abstract] [Full Text] [PDF]  

Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-induced Angiogenesis: IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion

Mark E. Stearns, Johng Rhim, and Min Wang
Clin Cancer Res 1999 5: 189 [Abstract] [Full Text] [PDF]  

Attenuation of WAF1/Cip1 Expression by an Antisense Adenovirus Expression Vector Sensitizes Glioblastoma Cells to Apoptosis Induced by Chemotherapeutic Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin

Sanbao Ruan, M. Fatih Okcu, Rey-Chen Pong, Michael Andreeff, Victor Levin, Jer-Tsong Hsieh, and Wei Zhang
Clin Cancer Res 1999 5: 197 [Abstract] [Full Text] [PDF]  

Selective Modulation of Collagenase 1 Gene Expression by the Chemotherapeutic Agent Doxorubicin

Ulrike Benbow, Rangan Maitra, Joshua W. Hamilton, and Constance E. Brinckerhoff
Clin Cancer Res 1999 5: 203 [Abstract] [Full Text] [PDF]  

Lack of Evidence for a Polymorphism at Codon 160 of Human O⁶-Alkylguanine-DNA Alkyltransferase Gene in Normal Tissue and Cancer

Michael H. Wu, Karen E. Lohrbach, Olufunmilayo I. Olopade, Demetrius M. Kokkinakis, Henry S. Friedman, and M. Eileen Dolan
Clin Cancer Res 1999 5: 209 [Abstract] [Full Text] [PDF]  

Synergistic Interaction between Paclitaxel and 8-Chloro-adenosine 3',5'-Monophosphate in Human Ovarian Carcinoma Cell Lines

Hayley M. McDaid and Patrick G. Johnston
Clin Cancer Res 1999 5: 215 [Abstract] [Full Text] [PDF]  

Errata:

Errata

Clin Cancer Res 1999 5: 222 [Full Text] [PDF]  

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