Editorials:

Oral Cancer Chemotherapy: The Promise and the Pitfalls

Howard L. McLeod and William E. Evans
Clin Cancer Res 1999 5: 2669 [Full Text] [PDF]  

Dihydropyrimidine Dehydrogenase: Its Role in 5-Fluorouracil Clinical Toxicity and Tumor Resistance

Robert B. Diasio and Martin R. Johnson
Clin Cancer Res 1999 5: 2672 [Full Text] [PDF]  

Advances in Brief:

Prostate-specific Membrane Antigen Is Produced in Tumor-associated Neovasculature

Sam S. Chang, Denise S. O’Keefe, Dean J. Bacich, Victor E. Reuter, Warren D. W. Heston, and Paul B. Gaudin
Clin Cancer Res 1999 5: 2674 [Abstract] [Full Text] [PDF]  

Differences in Ki67 and c-erbB2 Expression between Screen-detected and True Interval Breast Cancers

Moira Crosier, David Scott, Ronald G. Wilson, Clive D. M. Griffiths, Felicity E. B. May, and Bruce R. Westley
Clin Cancer Res 1999 5: 2682 [Abstract] [Full Text] [PDF]  

Detection of Microsatellite Alterations in Plasma DNA of Non-Small Cell Lung Cancer Patients: A Prospect for Early Diagnosis

Gabriella Sozzi, Katia Musso, Cathy Ratcliffe, Peter Goldstraw, Marco A. Pierotti, and Ugo Pastorino
Clin Cancer Res 1999 5: 2689 [Abstract] [Full Text] [PDF]  

Myeloma Cells Release Soluble Interleukin-6R in Relation to Disease Progression by Two Distinct Mechanisms: Alternative Splicing and Proteolytic Cleavage

Wilfrid Thabard, Sophie Barillé, Madeleine Collette, Jean-Luc Harousseau, Marie-Josée Rapp, Régis Bataille, and Martine Amiot
Clin Cancer Res 1999 5: 2693 [Abstract] [Full Text] [PDF]  

Association between Keratin and Vimentin Expression, Malignant Phenotype, and Survival in Postmenopausal Breast Cancer Patients

Patricia A. Thomas, Dawn A. Kirschmann, James R. Cerhan, Robert Folberg, Elisabeth A. Seftor, Thomas A. Sellers, and Mary J. C. Hendrix
Clin Cancer Res 1999 5: 2698 [Abstract] [Full Text] [PDF]  

Mechanisms of Inactivation of p14^ARF, p15^INK4b, and p16^INK4a Genes in Human Esophageal Squamous Cell Carcinoma

Eric Poe Xing, Yan Nie, Yunlong Song, Guang-Yu Yang, Yuyang Christine Cai, Li-Dong Wang, and Chung S. Yang
Clin Cancer Res 1999 5: 2704 [Abstract] [Full Text] [PDF]  

Sensitization of Tumor Cells to Ribotoxic Stress-induced Apoptotic Cell Death: A New Therapeutic Strategy

Stephan Rüller, Christian Stahl, Gotje Köhler, Bodo Eickhoff, Jörg Breder, Max Schlaak, and Jürgen van der Bosch
Clin Cancer Res 1999 5: 2714 [Abstract] [Full Text] [PDF]  

Interferon--mediated Down-Regulation of Angiogenesis-related Genes and Therapy of Bladder Cancer Are Dependent on Optimization of Biological Dose and Schedule

Joel W. Slaton, Paul Perrotte, Keiji Inoue, Colin P. N. Dinney, and Isaiah J. Fidler
Clin Cancer Res 1999 5: 2726 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Selective in Vivo Mobilization with Granulocyte Macrophage Colony-stimulating Factor (GM-CSF)/Granulocyte-CSF ascompared to G-CSF Alone of Dendritic Cell Progenitors from Peripheral Blood Progenitor Cells in Patients with Advanced Breast Cancer Undergoing Autologous Transplantation

David Avigan, Zekui Wu, Jianlin Gong, Robin Joyce, James Levine, Anthony Elias, Paul Richardson, Joya Milano, Leslie Kennedy, Kenneth Anderson, and Donald Kufe
Clin Cancer Res 1999 5: 2735 [Abstract] [Full Text] [PDF]  

Inter- and Intrapatient Variability in Etoposide Kinetics with Oral and Intravenous Drug Administration

Kenneth Hande, Mark Messenger, Judy Wagner, Mary Krozely, and Sanjeev Kaul
Clin Cancer Res 1999 5: 2742 [Abstract] [Full Text] [PDF]  

A Phase I Trial of Humanized Monoclonal Antibody HuM195 (anti-CD33) with Low-Dose Interleukin 2 in Acute Myelogenous Leukemia

S. E. Kossman, D. A. Scheinberg, J. G. Jurcic, J. Jimenez, and P. C. Caron
Clin Cancer Res 1999 5: 2748 [Abstract] [Full Text] [PDF]  

Phase I Trial of a MART-1 Peptide Vaccine with Incomplete Freund’s Adjuvant for Resected High-Risk Melanoma

Flora Wang, Elizabeth Bade, Catherine Kuniyoshi, Lucy Spears, Georgia Jeffery, Verna Marty, Susan Groshen, and Jeffrey Weber
Clin Cancer Res 1999 5: 2756 [Abstract] [Full Text] [PDF]  

Phase I Study of Direct Intralesional Gene Transfer of HLA-B7 into Metastatic Renal Carcinoma Lesions

Brian I. Rini, Linda M. Selk, and Nicholas J. Vogelzang
Clin Cancer Res 1999 5: 2766 [Abstract] [Full Text] [PDF]  

Immunogenicity of a Fucosyl-GM1-Keyhole Limpet Hemocyanin Conjugate Vaccine in Patients with Small Cell Lung Cancer

Maura N. Dickler, Govindaswami Ragupathi, Nancy X. Liu, Cristina Musselli, Damian J. Martino, Vincent A. Miller, Mark G. Kris, Fred-Thomas Brezicka, Philip O. Livingston, and Stefan C. Grant
Clin Cancer Res 1999 5: 2773 [Abstract] [Full Text] [PDF]  

Interferon- and CXC Chemokine Induction by Interleukin 12 in Renal Cell Carcinoma

Ronald M. Bukowski, Patricia Rayman, Luis Molto, Charles S. Tannenbaum, Thomas Olencki, David Peereboom, Raymond Tubbs, Denise McLain, G. Thomas Budd, Thomas Griffin, Andrew Novick, Thomas A. Hamilton, and James Finke
Clin Cancer Res 1999 5: 2780 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Comparison of Telomerase and CD44 Expression as Diagnostic Tumor Markers in Lesions of the Thyroid

Kenjiro Aogi, Kenji Kitahara, Virginia Urquidi, David Tarin, and Steve Goodison
Clin Cancer Res 1999 5: 2790 [Abstract] [Full Text] [PDF]  

Drug Resistance-associated Markers P-Glycoprotein, Multidrug Resistance-associated Protein 1, Multidrug Resistance-associated Protein 2, and Lung Resistance Protein as Prognostic Factors in Ovarian Carcinoma

Henriette J. G. Arts, Dionyssios Katsaros, Elisabeth G. E. de Vries, Marco Massobrio, Franco Genta, Silvio Danese, Riccardo Arisio, Rick J. Scheper, Marcel Kool, George L. Scheffer, Pax H. B. Willemse, Ate G. J. van der Zee, and Albert J. H. Suurmeijer
Clin Cancer Res 1999 5: 2798 [Abstract] [Full Text] [PDF]  

Serum Concentrations of Vascular Endothelial Growth Factor in Vulvar Cancer

Lukas Hefler, Clemens Tempfer, Andreas Obermair, Katrin Frischmuth, Gerhard Sliutz, Alexander Reinthaller, Sepp Leodolter, and Christian Kainz
Clin Cancer Res 1999 5: 2806 [Abstract] [Full Text] [PDF]  

Cyclin D1 and p16^INK4A Expression Predict Reduced Survival in Carcinoma of the Anterior Tongue

Ronaldo J. Bova, David I. Quinn, Jane S. Nankervis, Ian E. Cole, Brian F. Sheridan, Michael J. Jensen, Gary J. Morgan, Christopher J. Hughes, and Robert L. Sutherland
Clin Cancer Res 1999 5: 2810 [Abstract] [Full Text] [PDF]  

Cell Proliferation in Prostate Cancer Patients with Lymph Node Metastasis: A Marker for Progression

Liang Cheng, Thomas M. Pisansky, Thomas J. Sebo, Bradley C. Leibovich, Dharamdas M. Ramnani, Amy L. Weaver, Beth G. Scherer, Michael L. Blute, Horst Zincke, and David G. Bostwick
Clin Cancer Res 1999 5: 2820 [Abstract] [Full Text] [PDF]  

Relative Expression of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in Mouse Renal Cell Carcinoma Cells Regulates Their Metastatic Potential

Hideaki Miyake, Isao Hara, Kazuo Gohji, Kazuki Yamanaka, Shoji Hara, Soichi Arakawa, Motowo Nakajima, and Sadao Kamidono
Clin Cancer Res 1999 5: 2824 [Abstract] [Full Text] [PDF]  

Prognostic Relevance of p53 Alterations and Mib-1 Proliferation Index in Subgroups of Primary Liposarcomas

Regine Schneider-Stock, Anke Ziegeler, Carsten Haeckel, Dagmar-S. Franke, Janusz Rys, and Albert Roessner
Clin Cancer Res 1999 5: 2830 [Abstract] [Full Text] [PDF]  

Relationship between Intratumoral Dihydropyrimidine Dehydrogenase Activity and Gene Expression in Human Colorectal Cancer

Hiroyuki Uetake, Wataru Ichikawa, Teiji Takechi, Masakazu Fukushima, Zenro Nihei, and Kenichi Sugihara
Clin Cancer Res 1999 5: 2836 [Abstract] [Full Text] [PDF]  

Characterization of Cytokeratin 20 Expression in Pancreatic and Colorectal Cancer

Stefan Wildi, Jörg Kleeff, Haruhisa Maruyama, Christoph A. Maurer, Helmut Friess, Markus W. Büchler, Arthur D. Lander, and Murray Korc
Clin Cancer Res 1999 5: 2840 [Abstract] [Full Text] [PDF]  

Lack of Independent Prognostic Significance of p21 and p27 Expression in Advanced Ovarian Cancer: An Immunohistochemical Study

Mark Baekelandt, Ruth Holm, Claes G. Tropé, Jahn M. Nesland, and Gunnar B. Kristensen
Clin Cancer Res 1999 5: 2848 [Abstract] [Full Text] [PDF]  

Measurement of Neovascularization Is an Independent Prognosticator of Survival in Node-negative Breast Cancer Patients with Long-Term Follow-Up

Sabino De Placido, Chiara Carlomagno, Fortunato Ciardiello, Michelino De Laurentiis, Stefano Pepe, Angela Ruggiero, Giampaolo Tortora, Luigi Panico, Antonio D’Antonio, Guido Pettinato, Giuseppe Petrella, and A. Raffaele Bianco
Clin Cancer Res 1999 5: 2854 [Abstract] [Full Text] [PDF]  

Bcl-2, Bcl-X, Bax, and Bak Expression in Short- and Long-Lived Patients with Diffuse Large B-Cell Lymphomas

Osnat Bairey, Yael Zimra, Mati Shaklai, Elimelech Okon, and Esther Rabizadeh
Clin Cancer Res 1999 5: 2860 [Abstract] [Full Text] [PDF]  

Angiogenic Growth Factors in Preinvasive Breast Disease

Sue C. Heffelfinger, Mary Ann Miller, Rawia Yassin, and Robin Gear
Clin Cancer Res 1999 5: 2867 [Abstract] [Full Text] [PDF]  

Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 Growth Factor Receptors and Their Ligands, Neuregulin-1 , Neuregulin-1 , and Betacellulin, in Normal Endometrium and Endometrial Cancer

Radhika Srinivasan, Eleanor Benton, Frances McCormick, Hillary Thomas, and William J. Gullick
Clin Cancer Res 1999 5: 2877 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Inverse Relationship between Epidermal Growth Factor Receptor Expression and Radiocurability of Murine Carcinomas

Tetsuo Akimoto, Nancy R. Hunter, Lara Buchmiller, Kathy Mason, K. Kian Ang, and Luka Milas
Clin Cancer Res 1999 5: 2884 [Abstract] [Full Text] [PDF]  

Progression to Androgen Independence Is Delayed by Adjuvant Treatment with Antisense Bcl-2 Oligodeoxynucleotides after Castration in the LNCaP Prostate Tumor Model

Martin Gleave, Anthony Tolcher, Hideaki Miyake, Colleen Nelson, Bob Brown, Eliana Beraldi, and James Goldie
Clin Cancer Res 1999 5: 2891 [Abstract] [Full Text] [PDF]  

Inhibitors of Topoisomerase II as pH-dependent Modulators of Etoposide-mediated Cytotoxicity

Seppo W. Langer, Günther Schmidt, Morten Sørensen, Maxwell Sehested, and Peter Buhl Jensen
Clin Cancer Res 1999 5: 2899 [Abstract] [Full Text] [PDF]  

Pharmacologic Disruption of Base Excision Repair Sensitizes Mismatch Repair-deficient and -proficient Colon Cancer Cells to Methylating Agents

Lili Liu, Pietro Taverna, Cecilia M. Whitacre, Satadal Chatterjee, and Stanton L. Gerson
Clin Cancer Res 1999 5: 2908 [Abstract] [Full Text] [PDF]  

Rapid Esterase-sensitive Breakdown of Polysorbate 80 and Its Impact on the Plasma Pharmacokinetics of Docetaxel and Metabolites in Mice

Olaf van Tellingen, Jos H. Beijnen, Jaap Verweij, Esther J. Scherrenburg, Willem J. Nooijen, and Alex Sparreboom
Clin Cancer Res 1999 5: 2918 [Abstract] [Full Text] [PDF]  

Flavopiridol Induces Cell Cycle Arrest and p53-independent Apoptosis in Non-Small Cell Lung Cancer Cell Lines

Geoffrey I. Shapiro, Darlene A. Koestner, Christian B. Matranga, and Barrett J. Rollins
Clin Cancer Res 1999 5: 2925 [Abstract] [Full Text] [PDF]  

Doxorubicin Encapsulated in Sterically Stabilized Liposomes Exhibits Renal and Biliary Clearance Properties That Are Independent of Valspodar (PSC 833) under Conditions That Significantly Inhibit Nonencapsulated Drug Excretion

Rajesh Krishna, Natashia McIntosh, K. Wayne Riggs, and Lawrence D. Mayer
Clin Cancer Res 1999 5: 2939 [Abstract] [Full Text] [PDF]  

X-Ray Irradiation Induces Thymidine Phosphorylase and Enhances the Efficacy of Capecitabine (Xeloda) in Human Cancer Xenografts

Noriaki Sawada, Tohru Ishikawa, Fumiko Sekiguchi, Yutaka Tanaka, and Hideo Ishitsuka
Clin Cancer Res 1999 5: 2948 [Abstract] [Full Text] [PDF]  

In Vivo Toxicity and Pharmacokinetic Features of the Janus Kinase 3 Inhibitor WHI-P131 [4-(4'Hydroxyphenyl)-Amino-6,7-Dimethoxyquinazoline]

Fatih M. Uckun, Onur Ek, Xin-Ping Liu, and Chun-Lin Chen
Clin Cancer Res 1999 5: 2954 [Abstract] [Full Text] [PDF]  

Antibodies to Vascular Endothelial Growth Factor Enhance the Efficacy of Cancer Immunotherapy by Improving Endogenous Dendritic Cell Function

Dmitry I. Gabrilovich, Tadao Ishida, Sorena Nadaf, Joyce E. Ohm, and David P. Carbone
Clin Cancer Res 1999 5: 2963 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Tamoxifen-induced Apoptosis in Breast Cancer Cells Relates to Down-Regulation of bcl-2, but not bax and bcl-X_L, without Alteration of p53 Protein Levels

Guo-Jun Zhang, Izo Kimijima, Masamitsu Onda, Masahiko Kanno, Hisayoshi Sato, Takanori Watanabe, Atsuo Tsuchiya, Rikiya Abe, and Seiichi Takenoshita
Clin Cancer Res 1999 5: 2971 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: P. Salven et al., Leukocytes and Platelets of Patients with Cancer Contain High Levels of Vascular Endothelial Growth Factor. Clin. Cancer Res., 5: 487–491, 1999.

Eberhard Gunsilius, Andreas L. Petzer, Guenther Gastl, and Petri Salven
Clin Cancer Res 1999 5: 2978 [Full Text] [PDF]  

Errata:

Errata

Clin Cancer Res 1999 5: 2980 [Full Text] [PDF]  

Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer:

Introduction to the Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

David M. Goldenberg
Clin Cancer Res 1999 5: 2991s [PDF]  

Tribute to David A. Goodwin and Claude F. Meares, Recipients of the Immunomedics Science Award

Gerald L. DeNardo
Clin Cancer Res 1999 5: 2992s-2993s [PDF]  

Session I: Radiochemistry of Antibodies:

Biodistribution Study of ¹⁸⁸Re-Labeled Trisuccin-HuCC49 and Trisuccin-HuCC49CH2 Conjugates in Athymic Nude Mice Bearing Intraperitoneal Colon Cancer Xenografts

Ahmad Safavy, M. B. Khazaeli, Kamellia Safavy, Matthew S. Mayo, and Donald J. Buchsbaum
Clin Cancer Res 1999 5: 2994s-3000s [Abstract] [PDF]  

Radiolabeling of an Anti-Carcinoembryonic Antigen Antibody Fab' Fragment (CEA-Scan) with the Positron-emitting Radionuclide Tc-94m

Gary L. Griffiths, David M. Goldenberg, Frank Roesch, and Hans J. Hansen
Clin Cancer Res 1999 5: 3001s-3003s [Abstract] [PDF]  

I-131 Anti-B1 Therapy/Tracer Uptake Ratio Using a New Procedure for Fusion of Tracer Images to Computed Tomography Images

Kenneth F. Koral, Jia Li, Yuni Dewaraja, Carla L. Barrett, Denise D. Regan, Kenneth R. Zasadny, Stephen G. Rommelfanger, Isaac R. Francis, Mark S. Kaminski, and Richard L. Wahl
Clin Cancer Res 1999 5: 3004s-3009s [Abstract] [PDF]  

Session II: Radiation Biology, Physics and Dosimetry:

Effect of ⁶⁷Cu-2IT-BAT-Lym-1 Therapy on BCL-2 Gene and Protein Expression in a Lymphoma Mouse Model

Linda A. Kroger, Sally J. DeNardo, Gerald L. DeNardo, Cheng Yi Xiong, Michelle D. Winthrop, and Paul H. Gumerlock
Clin Cancer Res 1999 5: 3010s-3014s [Abstract] [PDF]  

A Method for Patient-specific Absorbed Dose Estimation for Internal β Emitters

Lawrence E. Williams, An Liu, Andrew A. Raubitschek, and Jeffrey Y. C. Wong
Clin Cancer Res 1999 5: 3015s-3019s [Abstract] [PDF]  

Validation of an Analytical Expression for the Absorbed Dose from a Spherical β Source Geometry and Its Application to Micrometastatic Radionuclide Therapy

Mehrdad Sarfaraz and Barry W. Wessels
Clin Cancer Res 1999 5: 3020s-3023s [Abstract] [PDF]  

Can Current Models Explain the Lack of Liver Complications in Y-90 Microsphere Therapy?

Ellen D. Yorke, Andrew Jackson, Richard A. Fox, Barry W. Wessels, and Bruce N. Gray
Clin Cancer Res 1999 5: 3024s-3030s [Abstract] [PDF]  

Studies on the Red Marrow Dosimetry in Radioimmunotherapy: An Experimental Investigation of Factors Influencing the Radiation-induced Myelotoxicity in Therapy with β-, Auger/Conversion Electron-, or -Emitters

Thomas M. Behr, George Sgouros, Michael G. Stabin, Martin Béhé, Christa Angerstein, Rosalyn D. Blumenthal, Christos Apostolidis, Roger Molinet, Robert M. Sharkey, Lothar Koch, David M. Goldenberg, and Wolfgang Becker
Clin Cancer Res 1999 5: 3031s-3043s [Abstract] [PDF]  

A Strategy to Reduce Red Marrow Dose for Intraperitoneal Radioimmunotherapy

Daniel J. Macey and R. F. Meredith
Clin Cancer Res 1999 5: 3044s-3047s [Abstract] [PDF]  

Session III: Experimental Studies of Antibody Targeting:

Targeting Strategies for Cancer Radiotherapy

Donald J. Buchsbaum, Buck E. Rogers, M. B. Khazaeli, Matthew S. Mayo, Diane E. Milenic, S. V. S. Kashmiri, Carolyn J. Anderson, Lara L. Chappell, Martin W. Brechbiel, and David T. Curiel
Clin Cancer Res 1999 5: 3048s-3055s [Abstract] [PDF]  

Ion Exchange Tumor Targeting: A New Approach

Anders R. Holmberg, Meir Wilchek, Marcela Márquez, Jan-Erik Westlin, Jin Du, and Sten Nilsson
Clin Cancer Res 1999 5: 3056s-3058s [Abstract] [PDF]  

Comparison of ¹²⁵I- and ¹¹¹In-labeled Monoclonal Antibody BR96 for Tumor Targeting in Combination with Extracorporeal Immunoadsorption

Michael Garkavij, Jan Tennvall, Tomas Ohlsson, Lars Lindgren, Cecilia Hindorf, Hans-Olov Sjögren, and Sven-Erik Strand
Clin Cancer Res 1999 5: 3059s-3064s [Abstract] [PDF]  

Epithelial Mucin-1 (MUC1) Expression and MA5 Anti-MUC1 Monoclonal Antibody Targeting in Multiple Myeloma

J. Burton, D. Mishina, T. Cardillo, K. Lew, A. Rubin, D. M. Goldenberg, and D. V. Gold
Clin Cancer Res 1999 5: 3065s-3072s [Abstract] [PDF]  

Idiotypic-Anti-idiotypic Antibody Interactions in Experimental Radioimmunotargeting

Per Sandström, Amanda Johansson, Anders Ullén, Sandra Rathsman, Katrine Riklund-Åhlström, and Torgny Stigbrand
Clin Cancer Res 1999 5: 3073s-3078s [Abstract] [PDF]  

Targeting Human Cancer Xenografts with Monoclonal Antibodies Labeled Using Radioiodinated, Diethylenetriaminepentaacetic Acid-appended Peptides

Rhona Stein, Serengulam V. Govindan, M. Jules Mattes, Lisa B. Shih, Gary L. Griffiths, Hans J. Hansen, and David M. Goldenberg
Clin Cancer Res 1999 5: 3079s-3087s [Abstract] [PDF]  

Session IV: New Approaches to Improved Radiopharmaceuticals and Targeting:

Development of a Hyperimmune Anti-MUC-1 Single Chain Antibody Fragments Phage Display Library for Targeting Breast Cancer

Michelle D. Winthrop, Sally J. DeNardo, and Gerald L. DeNardo
Clin Cancer Res 1999 5: 3088s-3094s [Abstract] [PDF]  

Humanization of Immu31, an -Fetoprotein-specific Antibody

Zhengxing Qu, Michele J. Losman, Kristian C. Eliassen, Hans J. Hansen, David M. Goldenberg, and Shui-on Leung
Clin Cancer Res 1999 5: 3095s-3100s [Abstract] [PDF]  

Generation and Monitoring of Cell Lines Producing Humanized Antibodies

Michele J. Losman, Zhengxing Qu, Indira S. Krishnan, Jingrong Wang, Hans J. Hansen, David M. Goldenberg, and Shui-on Leung
Clin Cancer Res 1999 5: 3101s-3105s [Abstract] [PDF]  

The Effects of Domain Deletion, Glycosylation, and Long IgG₃ Hinge on the Biodistribution and Serum Stability Properties of a Humanized IgG₁ Immunoglobulin, hLL2, and Its Fragments

Shui-on Leung, Zhengxing Qu, Hans J. Hansen, Lisa B. Shih, Jingrong Wang, Michele J. Losman, David M. Goldenberg, and Robert M. Sharkey
Clin Cancer Res 1999 5: 3106s-3117s [Abstract] [PDF]  

Generation and Characterization of a Single Gene-encoded Single-Chain-Tetravalent Antitumor Antibody

Ameurfina D. Santos, S. V. S. Kashmiri, Patricia Horan Hand, Jeffrey Schlom, and Eduardo A. Padlan
Clin Cancer Res 1999 5: 3118s-3123s [Abstract] [PDF]  

Cholecystokinin-B/Gastrin Receptor Binding Peptides: Preclinical Development and Evaluation of Their Diagnostic and Therapeutic Potential

Thomas M. Behr, Martin Béhé, Christa Angerstein, Stefan Gratz, Roland Mach, Lars Hagemann, Niels Jenner, Maik Stiehler, Karin Frank-Raue, Friedhelm Raue, and Wolfgang Becker
Clin Cancer Res 1999 5: 3124s-3138s [Abstract] [PDF]  

The Effect of Various Therapeutic Solutions including Colloidal Chromic ³²P via an Intratumoral Injection on the Tumor Physiological Parameters of AsPC-1 Human Pancreatic Tumor Xenografts in Nude Mice

Intae Lee and Young H. Lee
Clin Cancer Res 1999 5: 3139s-3142s [Abstract] [PDF]  

Retargeting Interleukin 13 for Radioimmunodetection and Radioimmunotherapy of Human High-grade Gliomas

Waldemar Debinski and Jeffrey P. Thompson
Clin Cancer Res 1999 5: 3143s-3147s [Abstract] [PDF]  

Internal Radionuclide Therapy of Primary Osteosarcoma in Dogs, Using ¹⁵³Sm-Ethylene-diamino-tetramethylene-phosphonate (EDTMP)

Magne Aas, Lars Moe, Hans Gamlem, Arne Skretting, Nina Ottesen, and Øyvind S. Bruland
Clin Cancer Res 1999 5: 3148s-3152s [Abstract] [PDF]  

Session V: Experimental Radioimmunotherapy, Including Pre-Targeting:

Comparison of Multiple Bolus and Continuous Injections of ¹³¹I-labeled CC49 for Therapy in a Colon Cancer Xenograft Model

Donald J. Buchsbaum, M. B. Khazaeli, Matthew S. Mayo, and Peter L. Roberson
Clin Cancer Res 1999 5: 3153s-3159s [Abstract] [PDF]  

Radioimmunotherapy Using Vascular Targeted ²¹³Bi: The Role of Tumor Necrosis Factor in the Development of Pulmonary Fibrosis

Ila A. Davis and Stephen J. Kennel
Clin Cancer Res 1999 5: 3160s-3164s [Abstract] [PDF]  

Validation of ²¹³Bi- Radioimmunotherapy for Multiple Myeloma

Olivier Couturier, Alain Faivre-Chauvet, Igor V. Filippovich, Philippe Thédrez, Catherine Saï-Maurel, Manuel Bardiès, Anil K. Mishra, Magali Gauvrit, Guy Blain, Christos Apostolidis, Roger Molinet, Jean-Charles Abbe, Regis Bataille, John Wijdenes, Jean-François Chatal, and Michel Chérel
Clin Cancer Res 1999 5: 3165s-3170s [Abstract] [PDF]  

Growth and Characterization of LNCaP Prostate Cancer Cell Spheroids

Åse M. Ballangrud, Wei-Hong Yang, Ann Dnistrian, Nina M. Lampen, and George Sgouros
Clin Cancer Res 1999 5: 3171s-3176s [Abstract] [PDF]  

Immunohistology of Carcinoembryonic Antigen (CEA)-expressing Tumors Grafted in Nude Mice after Radioimmunotherapy with ¹³¹I-labeled Bivalent Hapten and Anti-CEA x Antihapten Bispecific Antibody

Emmanuel Gautherot, Françoise Kraeber-Bodéré, Laurent Daniel, Maryse Fiche, Éric Rouvier, Catherine Saï-Maurel, Philippe Thedrez, Jean-François Chatal, and Jacques Barbet
Clin Cancer Res 1999 5: 3177s-3182s [Abstract] [PDF]  

Toxicity and Efficacy of Radioimmunotherapy in Carcinoembryonic Antigen-producing Medullary Thyroid Cancer Xenograft: Comparison of Iodine 131-labeled F(ab')₂ and Pretargeted Bivalent Hapten and Evaluation of Repeated Injections

Françoise Kraeber-Bodéré, Alain Faivre-Chauvet, Catherine Saï-Maurel, Loïc Campion, Maryse Fiche, Emmanuel Gautherot, Jean Le Boterff, Jacques Barbet, Jean-François Chatal, and Philippe Thédrez
Clin Cancer Res 1999 5: 3183s-3189s [Abstract] [PDF]  

Radioimmunotherapy in Medullary Thyroid Cancer Using Bispecific Antibody and Iodine 131-labeled Bivalent Hapten: Preliminary Results of a Phase I/II Clinical Trial

Françoise Kraeber-Bodéré, Stephane Bardet, Cornelis A. Hoefnagel, Maria R. Vieira, Jean-Philippe Vuillez, Arnaud Murat, Theresa C. Ferreira, Manuel Bardiès, Ludovic Ferrer, Isabelle Resche, Emmanuel Gautherot, Eric Rouvier, Jacques Barbet, and Jean-François Chatal
Clin Cancer Res 1999 5: 3190s-3198s [Abstract] [PDF]  

Assessment of Combined Radioimmunotherapy and Chemotherapy for Treatment of Medullary Thyroid Cancer

Rhona Stein, Malik Juweid, Cun-Hui Zhang, and David M. Goldenberg
Clin Cancer Res 1999 5: 3199s-3206s [Abstract] [PDF]  

Maximum Tolerated Dose and Large Tumor Radioimmunotherapy Studies of ⁶⁴Cu-labeled Monoclonal Antibody 1A3 in a Colon Cancer Model

Judith M. Connett, Thomas L. Buettner, and Carolyn J. Anderson
Clin Cancer Res 1999 5: 3207s-3212s [Abstract] [PDF]  

Antibody Phage Libraries for the Next Generation of Tumor Targeting Radioimmunotherapeutics

Sally J. DeNardo, Gerald L. DeNardo, David G. DeNardo, Cheng-Yi Xiong, Xu-Bao Shi, Michelle D. Winthrop, Linda A. Kroger, and Paul Carter
Clin Cancer Res 1999 5: 3213s-3218s [Abstract] [PDF]  

Session VI: Clinical Radioimmunotherapy: Solid Tumors:

Strategies for Developing Effective Radioimmunotherapy for Solid Tumors

Gerald L. DeNardo, Robert T. O'Donnell, Linda A. Kroger, Carol M. Richman, Desiree S. Goldstein, Sui Shen, and Sally J. DeNardo
Clin Cancer Res 1999 5: 3219s-3223s [Abstract] [PDF]  

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer

Jeffrey Y. C. Wong, George Somlo, Tamara Odom-Maryon, Lawrence E. Williams, An Liu, Dave Yamauchi, Anna M. Wu, Paul Yazaki, Sharon Wilczynski, John E. Shively, Stephen Forman, James H. Doroshow, and Andrew A. Raubitschek
Clin Cancer Res 1999 5: 3224s-3231s [Abstract] [PDF]  

Radioimmunotherapy of Small Volume Disease of Colorectal Cancer Metastatic to the Liver: Preclinical Evaluation in Comparison to Standard Chemotherapy and Initial Results of a Phase I Clinical Study

Thomas M. Behr, Alexandra L. Salib, Torsten Liersch, Martin Béhé, Christa Angerstein, Rosalyn D. Blumenthal, Afshin Fayyazi, Robert M. Sharkey, Bernhard Ringe, Heinz Becker, Bernhard Wörmann, Wolfgang Hiddemann, David M. Goldenberg, and Wolfgang Becker
Clin Cancer Res 1999 5: 3232s-3242s [Abstract] [PDF]  

Dosimetry-based Therapy in Metastatic Breast Cancer Patients Using ⁹⁰Y Monoclonal Antibody 170H.82 with Autologous Stem Cell Support and Cyclosporin A

Carol M. Richman, Sally J. DeNardo, Robert T. O'Donnell, Desiree S. Goldstein, Sui Shen, David L. Kukis, Linda A. Kroger, Aina Yuan, Graeme R. Boniface, Irwin J. Griffith, and Gerald L. DeNardo
Clin Cancer Res 1999 5: 3243s-3448s [Abstract] [PDF]  

A Phase II Study of Intraperitoneal Radioimmunotherapy with Iodine-131-labeled Monoclonal Antibody OC-125 in Patients with Residual Ovarian Carcinoma

Marc-André Mahé, Pierre Fumoleau, Michel Fabbro, Jean-Paul Guastalla, Patrick Faurous, Pierre Chauvot, Lucienne Chetanoud, Jean-Marc Classe, Philippe Rouanet, and Jean-François Chatal
Clin Cancer Res 1999 5: 3249s-3253s [Abstract] [PDF]  

Phase II Study of Interferon-enhanced ¹³¹I-Labeled High Affinity CC49 Monoclonal Antibody Therapy in Patients with Metastatic Prostate Cancer

Ruby F. Meredith, M. B. Khazaeli, Daniel J. Macey, William E. Grizzle, Matthew Mayo, Jeffrey Schlom, Charles D. Russell, and Albert F. LoBuglio
Clin Cancer Res 1999 5: 3254s-3258s [Abstract] [PDF]  

Radioimmunotherapy of Small Cell Lung Carcinoma with the Two-Step Method Using a Bispecific Anti-Carcinoembryonic Antigen/Anti-Diethylenetriaminepentaacetic Acid (DTPA) Antibody and Iodine-131 Di-DTPA Hapten: Results of a Phase I/II Trial

Jean-Philippe Vuillez, Françoise Kraeber-Bodéré, Denis Moro, Manuel Bardiès, Jean-Yves Douillard, Emmanuel Gautherot, Eric Rouvier, Jacques Barbet, Frederic Garban, Philippe Moreau, and Jean-François Chatal
Clin Cancer Res 1999 5: 3259s-3567s [Abstract] [PDF]  

Phase I Radioimmunotherapy of Metastatic Renal Cell Carcinoma with ¹³¹I-labeled Chimeric Monoclonal Antibody G250

Martijn G. Steffens, Otto C. Boerman, Pieter H. M. de Mulder, Wim J. G. Oyen, Wil C. A. M. Buijs, J. Alfred Witjes, Wim J. M. van den Broek, Jeannette C. Oosterwijk-Wakka, Frans M. J. Debruyne, Frans H. M. Corstens, and Egbert Oosterwijk
Clin Cancer Res 1999 5: 3268s-3274s [Abstract] [PDF]  

Loco-Regional Radioimmunotherapy of High-Grade Malignant Gliomas Using Specific Monoclonal Antibodies Labeled with ⁹⁰Y: A Phase I Study

Pietro Riva, Giancarlo Franceschi, Massimo Frattarelli, Simonetta Lazzari, Nada Riva, Giuliano Giuliani, Michela Casi, Gabriella Sarti, Giuliano Guiducci, Gianluigi Giorgetti, Rossella Gentile, Monica Santimaria, Eduard Jermann, and Helmut R. Maeke
Clin Cancer Res 1999 5: 3275s-3280s [Abstract] [PDF]  

Session VII: Clinical Radioimmunotherapy: Lymphomas:

Radioimmunotherapy of Relapsed Non-Hodgkin's Lymphoma with Zevalin, a ⁹⁰Y-labeled Anti-CD20 Monoclonal Antibody

Gregory A. Wiseman, Christine A. White, Thomas E. Witzig, Leo I. Gordon, Christos Emmanouilides, Andrew Raubitschek, Nalini Janakiraman, John Gutheil, Russell J. Schilder, Stewart Spies, Daniel H. S. Silverman, and Antonio J. Grillo-López
Clin Cancer Res 1999 5: 3281s-3286s [Abstract] [PDF]  

Radioimmunotherapy Using ¹³¹I-labeled Anti-CD22 Monoclonal Antibody (LL2) in Patients with Previously Treated B-cell Lymphomas

Ola Lindén, Jan Tennvall, Eva Cavallin-Ståhl, Lennart Darte, Michael Garkavij, Karl-Johan Lindner, Michael Ljungberg, Tomas Ohlsson, Katarina Sjögreen, Karin Wingårdh, and Sven-Erik Strand
Clin Cancer Res 1999 5: 3287s-3291s [Abstract] [PDF]  

Pharmacokinetics, Dosimetry, and Initial Therapeutic Results with ¹³¹I- and ¹¹¹In-⁹⁰Y-Labeled Humanized LL2 Anti-CD22 Monoclonal Antibody in Patients with Relapsed, Refractory Non-Hodgkin's Lymphoma

Malik E. Juweid, Edward Stadtmauer, George Hajjar, Robert M. Sharkey, Samer Suleiman, Selina Luger, Lawrence C. Swayne, Abass Alavi, and David M. Goldenberg
Clin Cancer Res 1999 5: 3292s-3303s [Abstract] [PDF]  

Low- versus High-Dose Radioimmunotherapy with Humanized Anti-CD22 or Chimeric Anti-CD20 Antibodies in a Broad Spectrum of B Cell-associated Malignancies

Thomas M. Behr, Bernhard Wörmann, Martin Gramatzki, Joachim Riggert, Stefan Gratz, Martin Béhé, Frank Griesinger, Robert M. Sharkey, Hans-J. Kolb, Wolfgang Hiddemann, David M. Goldenberg, and Wolfgang Becker
Clin Cancer Res 1999 5: 3304s-3314s [Abstract] [PDF]  

Pharmacokinetics of Radiolabeled Polyclonal Antiferritin in Patients with Hodgkin's Disease

Jing Lai, Syed M. Quadri, Paul E. Borchardt, Leigh Harris, Robin Wucher, Eileen Askew, Louis Schweichler, and Huibert M. Vriesendorp
Clin Cancer Res 1999 5: 3315s-3323s [Abstract] [PDF]  

Fractionated Radiolabeled Antiferritin Therapy for Patients with Recurrent Hodgkin's Disease

Huibert M. Vriesendorp, Syed M. Quadri, Cynthia T. Wyllie, Jing Lai, Paul E. Borchardt, Leigh Harris, Robin Wucher, Eileen Askew, and Louis Schweichler
Clin Cancer Res 1999 5: 3324s-3329s [Abstract] [PDF]  

⁶⁷Copper-2-Iminothiolane-6-[p-(Bromoacetamido)benzyl]-TETA-Lym-1 for Radioimmunotherapy of Non-Hodgkin's Lymphoma

Robert T. O'Donnell, Gerald L. DeNardo, David L. Kukis, Kathleen R. Lamborn, Sui Shen, Aina Yuan, Desiree S. Goldstein, Gary R. Mirick, and Sally J. DeNardo
Clin Cancer Res 1999 5: 3330s-3336s [Abstract] [PDF]  

Importance of Timing of Radioimmunotherapy after Granulocyte Colony-Stimulating Factor Administration for Peripheral Blood Stem Cell Harvest

Malik E. Juweid, Rosalyn D. Blumenthal, Walter Lew, George Hajjar, Arnold D. Rubin, and David M. Goldenberg
Clin Cancer Res 1999 5: 3337s-3342s [Abstract] [PDF]  

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