Editorials:

p53 Prognostication: Paradigm or Paradox?

Jack A. Roth
Clin Cancer Res 1999 5: 3345 [Full Text] [PDF]  

Drug Resistance: Still on the Learning Curve

Susan E. Bates
Clin Cancer Res 1999 5: 3346 [Full Text] [PDF]  

Intrathecal Depot Cytarabine Therapy: A Welcome Addition to a Limited Armamentarium

W. Archie Bleyer
Clin Cancer Res 1999 5: 3349 [Full Text] [PDF]  

Advances in Brief:

Rapid Activation of MDR1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin

Amir Abolhoda, Amy E. Wilson, Howard Ross, Peter V. Danenberg, Michael Burt, and Kathleen W. Scotto
Clin Cancer Res 1999 5: 3352 [Abstract] [Full Text] [PDF]  

Phase I Study of an Antisense Oligonucleotide to Protein Kinase C- (ISIS 3521/CGP 64128A ) in Patients with Cancer

Alan R. Yuen, Joanne Halsey, George A. Fisher, Jon T. Holmlund, Richard S. Geary, T. Jesse Kwoh, Andrew Dorr, and Branimir I. Sikic
Clin Cancer Res 1999 5: 3357 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Levels and Induction of Permeability in Malignant Pleural Effusions

Brian K. Zebrowski, Seiji Yano, Wenbiao Liu, Raymond M. Shaheen, Daniel J. Hicklin, Joe B. Putnam, Jr., and Lee M. Ellis
Clin Cancer Res 1999 5: 3364 [Abstract] [Full Text] [PDF]  

Clinical Trials:

A Phase I and Pharmacological Study of Protracted Infusions of Crisnatol Mesylate in Patients with Solid Malignancies

Miguel A. Villalona-Calero, Thierry Petit, John Kuhn, Patrick Cobb, Maura Kraynak, S. Gail Eckhardt, Ronald Drengler, Cecelia Simmons, Pedro Santabarbara, Daniel D. Von Hoff, and Eric K. Rowinsky
Clin Cancer Res 1999 5: 3369 [Abstract] [Full Text] [PDF]  

Coadministration of Oral Cyclosporin A Enables Oral Therapy with Paclitaxel

Jetske M. Meerum Terwogt, Mirte M. Malingré, Jos H. Beijnen, Wim W. ten Bokkel Huinink, Hilde Rosing, Franciska J. Koopman, Olaf van Tellingen, Martha Swart, and Jan H. M. Schellens
Clin Cancer Res 1999 5: 3379 [Abstract] [Full Text] [PDF]  

Phase I and Imaging Trial of a Monoclonal Antibody Directed against Gastrin-releasing Peptide in Patients with Lung Cancer

Arvind Chaudhry, Jorge A. Carrasquillo, Ingalill L. Avis, Noriyuki Shuke, James C. Reynolds, Richard Bartholomew, Steven M. Larson, Frank Cuttitta, Bruce E. Johnson, and James L. Mulshine
Clin Cancer Res 1999 5: 3385 [Abstract] [Full Text] [PDF]  

A Randomized Controlled Trial Comparing Intrathecal Sustained-release Cytarabine (DepoCyt) to Intrathecal Methotrexate in Patients with Neoplastic Meningitis from Solid Tumors

Michael J. Glantz, Kurt A. Jaeckle, Marc C. Chamberlain, Surasak Phuphanich, Lawrence Recht, Lode J. Swinnen, Bernard Maria, Susan LaFollette, G. Berry Schumann, Bernard F. Cole, and Stephen B. Howell
Clin Cancer Res 1999 5: 3394 [Abstract] [Full Text] [PDF]  

Classification and Regression Tree Analysis of 1000 Consecutive Patients with Unknown Primary Carcinoma

Kenneth R. Hess, Marie C. Abbruzzese, Renato Lenzi, Martin N. Raber, and James L. Abbruzzese
Clin Cancer Res 1999 5: 3403 [Abstract] [Full Text] [PDF]  

A Feasibility Study of Multiple Cycle Therapy with Melphalan, Thiotepa, and Paclitaxel followed by Mitoxantrone, Thiotepa, and Paclitaxel with Autologous Hematopoietic Cell Support for Metastatic Breast Cancer

Wendy W. Hu, Gwynn D. Long, Keith E. Stockerl-Goldstein, Laura J. Johnston, Nelson J. Chao, Robert S. Negrin, and Karl G. Blume
Clin Cancer Res 1999 5: 3411 [Abstract] [Full Text] [PDF]  

A Phase I Study of Paclitaxel, Etoposide, and Cisplatin in Extensive Stage Small Cell Lung Cancer

Karen Kelly, Zhaoxing Pan, Marie E. Wood, James Murphy, and Paul A. Bunn, Jr.
Clin Cancer Res 1999 5: 3419 [Abstract] [Full Text] [PDF]  

A Predictive Model for Relapse in High-Risk Primary Breast Cancer Patients Treated with High-Dose Chemotherapy and Autologous Stem-Cell Transplant

Yago Nieto, Pablo J. Cagnoni, Elizabeth J. Shpall, Xuesheng Xu, James Murphy, James Vredenburgh, Nelson J. Chao, Scott I. Bearman, and Roy B. Jones
Clin Cancer Res 1999 5: 3425 [Abstract] [Full Text] [PDF]  

AIDS-related Kaposi’s Sarcoma: A Phase II Study of Liposomal Doxorubicin

Tony W. Cheung, Scot C. Remick, Nozar Azarnia, Jo Ann Proper, Jose R. Barrueco, and Bruce J. Dezube
Clin Cancer Res 1999 5: 3432 [Abstract] [Full Text] [PDF]  

-Difluoromethylornithine as Treatment for Metastatic Breast Cancer Patients

Joyce A. O’Shaughnessy, Laurence M. Demers, Stephen E. Jones, James Arseneau, Pankaj Khandelwal, Timothy George, Robert Gersh, David Mauger, and Andrea Manni
Clin Cancer Res 1999 5: 3438 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Discovery of Differentially Expressed Genes Associated with Paclitaxel Resistance Using cDNA Array Technology: Analysis of Interleukin (IL) 6, IL-8, and Monocyte Chemotactic Protein 1 in the Paclitaxel-resistant Phenotype

Zhenfeng Duan, Aynn J. Feller, Richard T. Penson, Bruce. A. Chabner, and Michael V. Seiden
Clin Cancer Res 1999 5: 3445 [Abstract] [Full Text] [PDF]  

Prospective Assessment of Allelic Losses at 4p14–16 in Colorectal Cancer: Two Mutational Patterns and a Locus Associated with Poorer Survival

Rosa Arribas, Maria Ribas, Rosa-Ana Risques, Laia Masramon, Silvia Tórtola, Eugenio Marcuello, Gemma Aiza, Rosa Miró, Gabriel Capellà, and Miguel A. Peinado
Clin Cancer Res 1999 5: 3454 [Abstract] [Full Text] [PDF]  

Expression of Nuclear Receptor Interacting Proteins TIF-1, SUG-1, Receptor Interacting Protein 140, and Corepressor SMRT in Tamoxifen-resistant Breast Cancer

Christina M. W. Chan, Anne E. Lykkesfeldt, Malcolm G. Parker, and Mitchell Dowsett
Clin Cancer Res 1999 5: 3460 [Abstract] [Full Text] [PDF]  

Aberrant Fragile Histidine Triad Gene Transcripts in Primary Hepatocellular Carcinoma and Liver Cirrhosis

Laura Gramantieri, Pasquale Chieco, Maddalena Di Tomaso, Livia Masi, Fabio Piscaglia, Stefano Brillanti, Stefano Gaiani, Marco Valgimigli, Alighieri Mazziotti, and Luigi Bolondi
Clin Cancer Res 1999 5: 3468 [Abstract] [Full Text] [PDF]  

Allelic Loss in Esophageal Squamous Cell Carcinoma Patients with and without Family History of Upper Gastrointestinal Tract Cancer

Nan Hu, Mark J. Roth, Michael R. Emmert-Buck, Ze-Zhong Tang, Mihael Polymeropolous, Quan-Hong Wang, Alisa M. Goldstein, Xiao-You Han, Sanford M. Dawsey, Ti Ding, Carol Giffen, and Philip R. Taylor
Clin Cancer Res 1999 5: 3476 [Abstract] [Full Text] [PDF]  

Immunohistochemical Expression of Somatostatin Type 2A Receptor in Neuroendocrine Tumors

Noriko Kimura, Monika Pilichowska, Fumiko Date, Itaru Kimura, and Marcus Schindler
Clin Cancer Res 1999 5: 3483 [Abstract] [Full Text] [PDF]  

Human Ovarian Cancer, Cell Lines, and Primary Ascites Cells Express the Human Mullerian Inhibiting Substance (MIS) Type II Receptor, Bind, and Are Responsive to MIS

Peter T. Masiakos, David T. MacLaughlin, Shyamala Maheswaran, Jose Teixeira, Arlan F. Fuller, Jr., Paresh C. Shah, David J. Kehas, Mary K. Kenneally, David M. Dombkowski, Thanh U. Ha, Frederic I. Preffer, and Patricia K. Donahoe
Clin Cancer Res 1999 5: 3488 [Abstract] [Full Text] [PDF]  

TP53 Accumulation Predicts Improved Survival in Patients Resistant to Systemic Cisplatin-based Chemotherapy forMuscle-invasive Bladder Cancer

K. N. Qureshi, T. R. L. Griffiths, M. C. Robinson, C. Marsh, J. T. Roberts, R. R. Hall, J. Lunec, and D. E. Neal
Clin Cancer Res 1999 5: 3500 [Abstract] [Full Text] [PDF]  

Apoptosis and Expression of Apoptosis Regulating Proteins bcl-2, mcl-1, bcl-X, and bax in Malignant Mesothelioma

Ylermi Soini, Vuokko Kinnula, Riitta Kaarteenaho-Wiik, Esko Kurttila, Kaija Linnainmaa, and Paavo Pääkkö
Clin Cancer Res 1999 5: 3508 [Abstract] [Full Text] [PDF]  

Different Patterns of Angiogenesis in Sarcomas and Carcinomas

James Tomlinson, Sanford H. Barsky, Scott Nelson, Samuel Singer, Behnaz Pezeshki, Maggie C. Lee, Frederick Eilber, and Mai Nguyen
Clin Cancer Res 1999 5: 3516 [Abstract] [Full Text] [PDF]  

Characterization of p53 Mutations in Colorectal Liver Metastases and Correlation with Clinical Parameters

Appolonia Tullo, Anna M. D’Erchia, Kazuo Honda, Ragai R. Mitry, Michael D. Kelly, Nagy A. Habib, Cecilia Saccone, and Elisabetta Sbisà
Clin Cancer Res 1999 5: 3523 [Abstract] [Full Text] [PDF]  

Circulating Soluble Fas Concentration in Breast Cancer Patients

Takayuki Ueno, Masakazu Toi, and Takeshi Tominaga
Clin Cancer Res 1999 5: 3529 [Abstract] [Full Text] [PDF]  

Evaluation of Soluble CD44v6 as a Potential Serum Marker for Head and Neck Squamous Cell Carcinoma

Nicole L. W. Van Hal, Guus A. M. S. Van Dongen, Corlinda B. M. Ten Brink, Karl-Heinz Heider, Irene Rech-Weichselbraun, Gordon B. Snow, and Ruud H. Brakenhoff
Clin Cancer Res 1999 5: 3534 [Abstract] [Full Text] [PDF]  

Importance of Nuclear Morphology in Breast Cancer Prognosis

William H. Wolberg, W. Nick Street, and Olvi L. Mangasarian
Clin Cancer Res 1999 5: 3542 [Abstract] [Full Text] [PDF]  

Genetically Fluorescent Melanoma Bone and Organ Metastasis Models

Meng Yang, Ping Jiang, Zili An, Eugene Baranov, Lingna Li, Satoshi Hasegawa, Maraya Al-Tuwaijri, Takashi Chishima, Hiroshi Shimada, A. R. Moossa, and Robert M. Hoffman
Clin Cancer Res 1999 5: 3549 [Abstract] [Full Text] [PDF]  

Five Novel Immunogenic Antigens in Meningioma: Cloning, Expression Analysis, and Chromosomal Mapping

Nicole Comtesse, Dirk Heckel, Alexander Rácz, Nicole Brass, Brenda Glass, and Eckart Meese
Clin Cancer Res 1999 5: 3560 [Abstract] [Full Text] [PDF]  

Deletion of Chromosome 1p and Loss of Expression of Alkaline Phosphatase Indicate Progression of Meningiomas

Patrick Müller, Wolfram Henn, Isolde Niedermayer, Ralf Ketter, Wolfgang Feiden, Wolf-Ingo Steudel, Klaus D. Zang, and Heike Steilen-Gimbel
Clin Cancer Res 1999 5: 3569 [Abstract] [Full Text] [PDF]  

Androgen Receptor Gene Alterations and Chromosomal Gains and Losses in Prostate Carcinomas Appearing During Finasteride Treatment for Benign Prostatic Hyperplasia

Pasi A. Koivisto, Johanna Schleutker, Heikki Helin, Conny Ehren-van Eekelen, Olli-Pekka Kallioniemi, and Jan Trapman
Clin Cancer Res 1999 5: 3578 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

A Human Prolactin Antagonist, hPRL-G129R, Inhibits Breast Cancer Cell Proliferation through Induction of Apoptosis

Wen Y. Chen, Preveen Ramamoorthy, Nian-yi Chen, Robert Sticca, and Thomas E. Wagner
Clin Cancer Res 1999 5: 3583 [Abstract] [Full Text] [PDF]  

Antitumor Activity of CEP-751 (KT-6587) on Human Neuroblastoma and Medulloblastoma Xenografts

Audrey E. Evans, Kristin D. Kisselbach, Darrell J. Yamashiro, Naohiko Ikegaki, Anna Marie Camoratto, Craig A. Dionne, and Garrett M. Brodeur
Clin Cancer Res 1999 5: 3594 [Abstract] [Full Text] [PDF]  

BAY 12-9566, A Novel Inhibitor of Matrix Metalloproteinases with Antiangiogenic Activity

Carmen Gatto, Monica Rieppi, Patrizia Borsotti, Silvia Innocenti, Roberta Ceruti, Teresa Drudis, Eugenio Scanziani, Anna M. Casazza, Giulia Taraboletti, and Raffaella Giavazzi
Clin Cancer Res 1999 5: 3603 [Abstract] [Full Text] [PDF]  

Radiotherapy and Dosimetry of ⁶⁴Cu-TETA-Tyr³-Octreotate in a Somatostatin Receptor-positive, Tumor-bearing Rat Model

Jason S. Lewis, Michael R. Lewis, P. Duffy Cutler, Ananth Srinivasan, Michelle A. Schmidt, Sally W. Schwarz, Margaret M. Morris, J. Philip Miller, and Carolyn J. Anderson
Clin Cancer Res 1999 5: 3608 [Abstract] [Full Text] [PDF]  

Synergy of Topotecan in Combination with Vincristine for Treatment of Pediatric Solid Tumor Xenografts

Joyce Thompson, E. Olusegun George, Catherine A. Poquette, Pamela J. Cheshire, Lois B. Richmond, Siebold S. N. de Graaf, Margaret Ma, Clinton F. Stewart, and Peter J. Houghton
Clin Cancer Res 1999 5: 3617 [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Activity of Paclitaxel in Combination with the Anticarcinoma Immunoconjugate BR96-Doxorubicin

Pamela A. Trail, David Willner, Albert B. Bianchi, Arris J. Henderson, Mark D. TrailSmith, Emel Girit, Shirley Lasch, Ingegerd Hellström, and Karl Erik Hellström
Clin Cancer Res 1999 5: 3632 [Abstract] [Full Text] [PDF]  

A Cell Type-specific and Gap Junction-independent Mechanism for the Herpes Simplex Virus-1 Thymidine Kinase Gene/Ganciclovir-mediated Bystander Effect

Frédéric Princen, Pierre Robe, Chantal Lechanteur, Marc Mesnil, Jean-Michel Rigo, Jacques Gielen, Marie-Paule Merville, and Vincent Bours
Clin Cancer Res 1999 5: 3639 [Abstract] [Full Text] [PDF]  

Direct Comparison of Liposomal Doxorubicin with or without Polyethylene Glycol Coating in C-26 Tumor-bearing Mice: Is Surface Coating with Polyethylene Glycol Beneficial?

Ruey-Long Hong, Chang-Jen Huang, Yun-Long Tseng, Victor Fei Pang, Shui-Tsung Chen, Jun-Jen Liu, and Fu-Hsiung Chang
Clin Cancer Res 1999 5: 3645 [Abstract] [Full Text] [PDF]  

The Outcome of Heregulin-induced Activation of Ovarian Cancer Cells Depends on the Relative Levels of HER-2 and HER-3 Expression

Fengji Xu, Yinhua Yu, Xiao-Feng Le, Cinda Boyer, Gordon B. Mills, and Robert C. Bast, Jr.
Clin Cancer Res 1999 5: 3653 [Abstract] [Full Text] [PDF]  

Expression of Bisecting GlcNAc in Pediatric Brain Tumors and Its Association with Tumor Cell Response to Vinblastine

Abdelhadi Rebbaa, Pauline M. Chou, Ivica Vucic, Bernard L. Mirkin, Tadanori Tomita, and Eric G. Bremer
Clin Cancer Res 1999 5: 3661 [Abstract] [Full Text] [PDF]  

The Antiangiogenic Agent Linomide Inhibits the Growth Rate of von Hippel-Lindau Paraganglioma Xenografts to Mice

David J. Gross, Israel Reibstein, Lola Weiss, Shimon Slavin, Ilan Stein, Michal Neeman, Rinat Abramovitch, and Laura E. Benjamin
Clin Cancer Res 1999 5: 3669 [Abstract] [Full Text] [PDF]  

Eradication of Human Medulloblastoma Tumor Xenografts with a Combination of O⁶-Benzyl-2'-deoxyguanosine and 1,3-Bis(2-chloroethyl)-1-nitrosourea

Demetrius M. Kokkinakis, Robert C. Moschel, Anthony E. Pegg, and S. Clifford Schold
Clin Cancer Res 1999 5: 3676 [Abstract] [Full Text] [PDF]  

Pharmacokinetics of PK1 and Doxorubicin in Experimental Colon Tumor Models with Differing Responses to PK1

Paul M. Loadman, Mike C. Bibby, John A. Double, Waleed M. Al-Shakhaa, and Ruth Duncan
Clin Cancer Res 1999 5: 3682 [Abstract] [Full Text] [PDF]  

Simplified Production of a Recombinant Human Angiostatin Derivative That Suppresses Intracerebral Glial Tumor Growth

Patricio I. Meneses, Lauren E. Abrey, Katherine A. Hajjar, S. Humayun Gultekin, Robert M. Duvoisin, Kenneth I. Berns, and Myrna R. Rosenfeld
Clin Cancer Res 1999 5: 3689 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Antagonistic Effect of NK4, a Novel Hepatocyte Growth Factor Variant, on in Vitro Angiogenesis of Human Vascular Endothelial Cells

Wen G. Jiang, Steve E. Hiscox, Christian Parr, Tracey A. Martin, Kunio Matsumoto, Toshikazu Nakamura, and Robert E. Mansel
Clin Cancer Res 1999 5: 3695 [Abstract] [Full Text] [PDF]  

Lysophosphatidic Acid Induces Urokinase Secretion by Ovarian Cancer Cells

Terri B. Pustilnik, Veronica Estrella, Jon R. Wiener, Muling Mao, Astrid Eder, Mary-Anne V. Watt, Robert C. Bast, Jr., and Gordon B. Mills
Clin Cancer Res 1999 5: 3704 [Abstract] [Full Text] [PDF]  

Constitutive and Inducible Interleukin 8 Expression by Hypoxia and Acidosis Renders Human Pancreatic Cancer Cells More Tumorigenic and Metastatic

Qian Shi, James L. Abbruzzese, Suyun Huang, Isaiah J. Fidler, Qinghua Xiong, and Keping Xie
Clin Cancer Res 1999 5: 3711 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: S. Shimoyama et al., Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression. Clin. Cancer Res., 5: 1125–1130, 1999.

Sagrario Montero, Belén Lloveras, Hernán Cortés-Funes, and Ramon Colomer
Clin Cancer Res 1999 5: 3722 [Full Text] [PDF]  

Correspondence re: G. Tallini et al., RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotype. Clin. Cancer Res., 4:287–294, 1998.

Paula Soares, Manuel Sobrinho-Simões, Giovanni Tallini, M. L. Carcangiu, Massimo Santoro, and Alfredo Fusco
Clin Cancer Res 1999 5: 3724 [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.