Editorials:

Metabolic Jeopardy with High-Dose Cyclophosphamide?—Not So Fast

William P. Petros and O. Michael Colvin
Clin Cancer Res 1999 5: 723 [Full Text] [PDF]  

Advances in Brief:

Sensitive Detection of Squamous Cells in Bone Marrow and Blood of Head and Neck Cancer Patients by E48 Reverse Transcriptase-Polymerase Chain Reaction

Ruud H. Brakenhoff, Joep G. W. Stroomer, Corlinda ten Brink, Remco de Bree, Sjerp M. Weima, Gordon B. Snow, and Guus A. M. S. van Dongen
Clin Cancer Res 1999 5: 725 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase I Trial of Docetaxel with Filgrastim Support in Pediatric Patients with Refractory Solid Tumors: A Collaborative Pediatric Oncology Branch, National Cancer Institute and Children‘s Cancer Group Trial

Nita L. Seibel, Susan M. Blaney, Michelle O‘Brien, Mark Krailo, Ray Hutchinson, Revonda B. Mosher, Frank M. Balis, and Gregory H. Reaman
Clin Cancer Res 1999 5: 733 [Abstract] [Full Text] [PDF]  

A Phase I Single-Dose Trial of Gadolinium Texaphyrin (Gd-Tex), a Tumor Selective Radiation Sensitizer Detectable by Magnetic Resonance Imaging

David I. Rosenthal, Pamela Nurenberg, Carlos R. Becerra, Eugene P. Frenkel, David P. Carbone, Bert L. Lum, Richard Miller, Julie Engel, Stuart Young, Dale Miles, and Markus F. Renschler
Clin Cancer Res 1999 5: 739 [Abstract] [Full Text] [PDF]  

Nonpredictable Pharmacokinetic Behavior of High-Dose Cyclophosphamide in Combination with Cisplatin and 1,3-Bis(2-chloroethyl)-1-nitrosourea

Yago Nieto, Xuesheng Xu, Pablo J. Cagnoni, Steve Matthes, Elizabeth J. Shpall, Scott I. Bearman, James Murphy, and Roy B. Jones
Clin Cancer Res 1999 5: 747 [Abstract] [Full Text] [PDF]  

Phase I Trial of Methotrexate-Albumin in a Weekly Intravenous Bolus Regimen in Cancer Patients

Gernot Hartung, Gerd Stehle, Hannsjörg Sinn, Andreas Wunder, Hans Hermann Schrenk, Steffen Heeger, Marion Kränzle, Lutz Edler, Eva Frei, Heinz Herbert Fiebig, Dieter Ludwig Heene, Wolfgang Maier-Borst, and Wolfgang Queisser
Clin Cancer Res 1999 5: 753 [Abstract] [Full Text] [PDF]  

Oxaliplatin Pharmacokinetics during a Four-Hour Infusion

Wolfgang Kern, Jan Braess, Bettina Böttger, Cornelia Christine Kaufmann, Wolfgang Hiddemann, and Eberhard Schleyer
Clin Cancer Res 1999 5: 761 [Abstract] [Full Text] [PDF]  

Paclitaxel Steady-State Plasma Concentration as a Determinant of Disease Outcome and Toxicity in Lung Cancer Patients Treated with Paclitaxel and Cisplatin

Eric K. Rowinsky, Micheal Jiroutek, Philip Bonomi, David Johnson, and Sharyn D. Baker
Clin Cancer Res 1999 5: 767 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Vascular Endothelial Growth Factor Is a Marker of Tumor Invasion and Metastasis in Squamous Cell Carcinomas of the Head and Neck

Edward R. Sauter, Mark Nesbit, James C. Watson, Andres Klein-Szanto, Samuel Litwin, and Meenhard Herlyn
Clin Cancer Res 1999 5: 775 [Abstract] [Full Text] [PDF]  

Highly Metastatic Human Prostate Cancer Growing within the Prostate of Athymic Mice Overexpresses Vascular Endothelial Growth Factor

M. Derya Balbay, Curtis A. Pettaway, Hiroki Kuniyasu, Keiji Inoue, Edilberto Ramirez, Emily Li, Isaiah J. Fidler, and Colin P. N. Dinney
Clin Cancer Res 1999 5: 783 [Abstract] [Full Text] [PDF]  

Correlation of Abnormal RB, p16^ink4a, and p53 Expression with 3p Loss of Heterozygosity, Other Genetic Abnormalities, and Clinical Features in 103 Primary Non-Small Cell Lung Cancers

Joseph Geradts, Kwun M. Fong, Paul V. Zimmerman, Robert Maynard, and John D. Minna
Clin Cancer Res 1999 5: 791 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Clinical Parameters and Biological Markers in Patients with Squamous Cell Carcinoma of the Head and Neck Treated with Concurrent Chemoradiotherapy

Akihiro Homma, Yasushi Furuta, Nobuhiko Oridate, Yuko Nakano, Gen Kohashi, Katsunori Yagi, Tatsumi Nagahashi, Satoshi Fukuda, Kazuaki Inoue, and Yukio Inuyama
Clin Cancer Res 1999 5: 801 [Abstract] [Full Text] [PDF]  

O⁶-Methylguanine-DNA Methyltransferase-deficient Phenotype in Human Gliomas: Frequency and Time to Tumor Progression after Alkylating Agent-based Chemotherapy

John R. Silber, A. Blank, Michael S. Bobola, Saadi Ghatan, Douglas D. Kolstoe, and Mitchel S. Berger
Clin Cancer Res 1999 5: 807 [Abstract] [Full Text] [PDF]  

Predictive Value of c-erbB-2 and Cathepsin-D for Greek Breast Cancer Patients Using Univariate and Multivariate Analysis

Andreas Scorilas, Julia Yotis, Charilaos Pateras, Theoni Trangas, and Maroulio Talieri
Clin Cancer Res 1999 5: 815 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Levels in Ovarian Cyst Fluid Correlate with Malignancy

Darcie Hazelton, Roberto F. Nicosia, and Santo V. Nicosia
Clin Cancer Res 1999 5: 823 [Abstract] [Full Text] [PDF]  

A Prognostic Score for Hormone-Refractory Prostate Cancer: Analysis of Two Cancer and Leukemia Group B Studies

Robin T. Vollmer, Philip W. Kantoff, Nancy A. Dawson, and Nicholas J. Vogelzang
Clin Cancer Res 1999 5: 831 [Abstract] [Full Text] [PDF]  

Microsatellite Instability Is Uncommon in Breast Cancer

Ramaswamy Anbazhagan, Hiroaki Fujii, and Edward Gabrielson
Clin Cancer Res 1999 5: 839 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Marked Inhibition of Tumor Growth in a Malignant Glioma Tumor Model by a Novel Synthetic Matrix MetalloproteinaseInhibitor AG3340

Angela Price, Qiao Shi, Donald Morris, M. Elizabeth Wilcox, Penny M. A. Brasher, N. Barry Rewcastle, David Shalinsky, Helen Zou, Krzysztof Appelt, Randall N. Johnston, V. Wee Yong, Dylan Edwards, and Peter Forsyth
Clin Cancer Res 1999 5: 845 [Abstract] [Full Text] [PDF]  

Evaluation of 5-Aminosalicylic Acid (5-ASA) for Cancer Chemoprevention: Lack of Efficacy against Nascent Adenomatous Polyps in the Apc^Min Mouse

Steve R. Ritland, Jonathan A. Leighton, Rhoda Elison Hirsch, Jason D. Morrow, Amy L. Weaver, and Sandra J. Gendler
Clin Cancer Res 1999 5: 855 [Abstract] [Full Text] [PDF]  

Recombinant Immunotoxins Directed against the c-erb-2/HER2/neu Oncogene Product: In Vitro Cytotoxicity, Pharmacokinetics, and in Vivo Efficacy Studies in Xenograft Models

Michael G. Rosenblum, Laura K. Shawver, John W. Marks, Jody Brink, Lawrence Cheung, and Beatrice Langton-Webster
Clin Cancer Res 1999 5: 865 [Abstract] [Full Text] [PDF]  

Cooperative Inhibitory Effect of Novel Mixed Backbone Oligonucleotide Targeting Protein Kinase A in Combination with Docetaxel and Anti-Epidermal Growth Factor-Receptor Antibody on Human Breast Cancer Cell Growth

Giampaolo Tortora, Rosa Caputo, Grazia Pomatico, Stefano Pepe, A. Raffaele Bianco, Sudhir Agrawal, John Mendelsohn, and Fortunato Ciardiello
Clin Cancer Res 1999 5: 875 [Abstract] [Full Text] [PDF]  

Dihydropyrimidine Dehydrogenase Activity and Messenger RNA Level May Be Related to the Antitumor Effect of 5-Fluorouracil on Human Tumor Xenografts in Nude Mice

Yoichiro Ishikawa, Tetsuro Kubota, Yoshihide Otani, Masahiko Watanabe, Tatsuo Teramoto, Koichiro Kumai, Masaki Kitajima, Teiji Takechi, Hiroyuki Okabe, and Masakazu Fukushima
Clin Cancer Res 1999 5: 883 [Abstract] [Full Text] [PDF]  

Antitumor Activity of Poly(L-glutamic acid)-Paclitaxel on Syngeneic and Xenografted Tumors

Chun Li, Janet E. Price, Luka Milas, Nancy R. Hunter, Shi Ke, Dong-Fang Yu, Chusilp Charnsangavej, and Sidney Wallace
Clin Cancer Res 1999 5: 891 [Abstract] [Full Text] [PDF]  

Molecular Modeling and Preclinical Evaluation of the Humanized NR-LU-13 Antibody

Scott S. Graves, Stephen C. Goshorn, Diane M. Stone, Don B. Axworthy, John M. Reno, Becky Bottino, Stephen Searle, Andrew Henry, Jan Pedersen, Anthony R. Rees, and Randell T. Libby
Clin Cancer Res 1999 5: 899 [Abstract] [Full Text] [PDF]  

Antitumor Activity of Sequential Treatment with Topotecan and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225

Fortunato Ciardiello, Roberto Bianco, Vincenzo Damiano, Sonya De Lorenzo, Stefano Pepe, Sabino De Placido, Zhen Fan, John Mendelsohn, A. Raffaele Bianco, and Giampaolo Tortora
Clin Cancer Res 1999 5: 909 [Abstract] [Full Text] [PDF]  

Comparison of Activation of CPT-11 by Rabbit and Human Carboxylesterases for Use in Enzyme/Prodrug Therapy

Mary K. Danks, Christopher L. Morton, Erik J. Krull, Pamela J. Cheshire, Lois B. Richmond, Clayton W. Naeve, Cynthia A. Pawlik, Peter J. Houghton, and Philip M. Potter
Clin Cancer Res 1999 5: 917 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Isolation of Human Tumor-specific Antibodies by Selection of an Antibody Phage Library on Melanoma Cells

Jörg-Michael Kupsch, Nick Harold Tidman, Norbert V. Kang, Hazel Truman, Stephen Hamilton, Nimesha Patel, Julia A. Newton Bishop, Irene May Leigh, and James Scott Crowe
Clin Cancer Res 1999 5: 925 [Abstract] [Full Text] [PDF]  

Loss of HLA Haplotype in Lung Cancer Cell Lines: Implications for Immunosurveillance of Altered HLA Class I/II Phenotypes in Lung Cancer

Akio Hiraki, Toshihiko Kaneshige, Katsuyuki Kiura, Hiroshi Ueoka, Hiromichi Yamane, Motoyuki Tanaka, and Mine Harada
Clin Cancer Res 1999 5: 933 [Abstract] [Full Text] [PDF]  

Cooperation between p53 and hMLH1 in a Human Colocarcinoma Cell Line in Response to DNA Damage

Faina Vikhanskaya, Gennaro Colella, Monica Valenti, Silvio Parodi, Maurizio D’Incalci, and Massimo Broggini
Clin Cancer Res 1999 5: 937 [Abstract] [Full Text] [PDF]  

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