Editorials:

Understanding Barriers to Drug Delivery: High Resolution in Vivo Imaging Is Key

Rakesh K. Jain
Clin Cancer Res 1999 5: 1605 [Full Text] [PDF]  

Clinical Trials Involving Multidrug Resistance Transcription Units in Retroviral Vectors

Albert B. Deisseroth
Clin Cancer Res 1999 5: 1607 [Full Text] [PDF]  

Advances in Brief:

Quantitation of the Change in GADD153 Messenger RNA Level as a Molecular Marker of Tumor Response in Head and Neck Cancer

Gerrit Los, Khalid Benbatoul, Dennis P. Gately, Racine Barton, Randolph Christen, K. Thomas Robbins, Daniel Vicario, Saeeda Kirmani, Lisa A. Orloff, Robert Weisman, and Stephen B. Howell
Clin Cancer Res 1999 5: 1610 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Paclitaxel Chemotherapy after Autologous Stem-Cell Transplantation and Engraftment of Hematopoietic Cells Transduced with a Retrovirus Containing the Multidrug Resistance Complementary DNA (MDR1) in Metastatic Breast Cancer Patients

Kenneth H. Cowan, Jeffrey A. Moscow, Hui Huang, Jo Anne Zujewski, Joyce O’Shaughnessy, Brian Sorrentino, Kenneth Hines, Charles Carter, Erasmus Schneider, Georgie Cusack, Marianne Noone, Cynthia Dunbar, Seth Steinberg, Wyndham Wilson, Barrie Goldspiel, Elizabeth J. Read, Susan F. Leitman, Kevin McDonagh, Catherine Chow, Andrea Abati, Yu Chiang, Yawen N. Chang, Michael M. Gottesman, Ira Pastan, and Arthur Nienhuis
Clin Cancer Res 1999 5: 1619 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Temozolomide and Cisplatin in Patients with Advanced Solid Malignancies

Carolyn D. Britten, Eric K. Rowinsky, Sharyn D. Baker, Sanjiv S. Agarwala, John R. Eckardt, Rebecca Barrington, Sami G. Diab, Lisa A. Hammond, Tom Johnson, Miguel Villalona-Calero, Uwe Fraass, Paul Statkevich, Daniel D. Von Hoff, and S. Gail Eckhardt
Clin Cancer Res 1999 5: 1629 [Abstract] [Full Text] [PDF]  

The Induction of Spermidine/Spermine N¹-Acetyltransferase (SSAT) Is a Common Event in the Response of Human Primary Non-Small Cell Lung Carcinomas to Exposure to the New Antitumor Polyamine Analogue N¹,N¹¹-Bis(ethyl)norspermine¹

Edward W. Gabrielson, Anthony E. Pegg, and Robert A. Casero, Jr.
Clin Cancer Res 1999 5: 1638 [Abstract] [Full Text] [PDF]  

Evaluation of Tamoxifen plus Letrozole with Assessment of Pharmacokinetic Interaction in Postmenopausal Women with Metastatic Breast Cancer

James N. Ingle, Vera J. Suman, Patricia A. Johnson, James E. Krook, James A. Mailliard, Richard H. Wheeler, Charles L. Loprinzi, Edith A. Perez, V. Craig Jordan, and Mitchell Dowsett
Clin Cancer Res 1999 5: 1642 [Abstract] [Full Text] [PDF]  

Hyperthermic Isolated Limb Perfusion with Tumor Necrosis Factor- and Melphalan in Patients with Locally Advanced Soft Tissue Sarcomas: Treatment Response and Clinical Outcome Related to Changes in Proliferation and Apoptosis

Boudewijn E. C. Plaat, Willemina M. Molenaar, Mirjam F. Mastik, Jan Koudstaal, Eva van den Berg, Heimen Schraffordt Koops, and Harald J. Hoekstra
Clin Cancer Res 1999 5: 1650 [Abstract] [Full Text] [PDF]  

A Phase I Study of LGD1069 in Adults with Advanced Cancer

Naiyer A. Rizvi, John L. Marshall, William Dahut, Elizabeth Ness, Joseph A. Truglia, Gordon Loewen, George M. Gill, Edgar H. Ulm, Rita Geiser, Dinah Jaunakais, and Michael J. Hawkins
Clin Cancer Res 1999 5: 1658 [Abstract] [Full Text] [PDF]  

Minimal Residual Disease in Patients with Hairy Cell Leukemia in Complete Remission Treated with 2-Chlorodeoxyadenosine or 2'-Deoxycoformycin and Prediction of Early Relapse

Martin S. Tallman, David Hakimian, Kenneth J. Kopecky, Susan Wheaton, Eric Wollins, Kathy Foucar, Peter A. Cassileth, Thomas Habermann, Michael Grever, Jacob M. Rowe, and LoAnn C. Peterson
Clin Cancer Res 1999 5: 1665 [Abstract] [Full Text] [PDF]  

Up-Regulation of Retinoic Acid Receptor ß Expression in Renal Cancers in Vivo Correlates with Response to 13-cis-Retinoic Acid and Interferon--2a

William J. Berg, David M. Nanus, Abraham Leung, Karen T. Brown, Brian Hutchinson, Madhu Mazumdar, Xiao-Chun Xu, Reuben Lotan, Victor E. Reuter, and Robert J. Motzer
Clin Cancer Res 1999 5: 1671 [Abstract] [Full Text] [PDF]  

Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma

Thomas W. T. Leung, Yehuda Z. Patt, Wan-yee Lau, Stephen K. W. Ho, Simon C. H. Yu, Anthony T. C. Chan, Tony S. K. Mok, Winnie Yeo, Choong-tsek Liew, Nancy W. Y. Leung, Amanda M. Y. Tang, and Philip J. Johnson
Clin Cancer Res 1999 5: 1676 [Abstract] [Full Text] [PDF]  

Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects

David J. Propper, Mark P. Saunders, Amanda J. Salisbury, Louise Long, Ken J. O’Byrne, Jeremy P. Braybrooke, Mitchell Dowsett, Marion Taylor, Denis C. Talbot, Trivadi S. Ganesan, and Adrian L. Harris
Clin Cancer Res 1999 5: 1682 [Abstract] [Full Text] [PDF]  

Pharmacological Analysis of Etoposide in Elderly Patients with Lung Cancer

Masahiko Ando, Hironobu Minami, Yuichi Ando, Shuzo Sakai, Yohei Shimono, Seiji Sugiura, Hideo Saka, Kaoru Shimokata, and Yoshinori Hasegawa
Clin Cancer Res 1999 5: 1690 [Abstract] [Full Text] [PDF]  

Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites

Chris Twelves, Robert Glynne-Jones, Jim Cassidy, Johannes Schüller, Timothy Goggin, Brigitte Roos, Ludger Banken, Masahiro Utoh, Erhard Weidekamm, and Bruno Reigner
Clin Cancer Res 1999 5: 1696 [Abstract] [Full Text] [PDF]  

Doxorubicin Gradients in Human Breast Cancer

Jan Lankelma, Henk Dekker, Rafael Fernández Luque, Sylvia Luykx, Klaas Hoekman, Paul van der Valk, Paul J. van Diest, and Herbert M. Pinedo
Clin Cancer Res 1999 5: 1703 [Abstract] [Full Text] [PDF]  

Ovarian Cancer BRCA1 Gene Therapy: Phase I and II Trial Differences in Immune Response and Vector Stability

David L. Tait, Patrice S. Obermiller, Allison R. Hatmaker, Sheryl Redlin-Frazier, and Jeffrey T. Holt
Clin Cancer Res 1999 5: 1708 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Wild-Type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers

Gary L. Clayman, Douglas K. Frank, Patricia A. Bruso, and Helmuth Goepfert
Clin Cancer Res 1999 5: 1715 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacologic Study of a 3-Hour Infusion of Paclitaxel followed by Cisplatinum and 5-Fluorouracil in Patients with Advanced Solid Tumors

Kapil N. Bhalla, Gondi N. Kumar, U. Kristina Walle, Ana Maria Ibrado, Tahir Javed, Robert K. Stuart, Carolyn Reed, Susan G. Arbuck, and Thomas Walle
Clin Cancer Res 1999 5: 1723 [Abstract] [Full Text] [PDF]  

Phase II Trial of High-Dose Chemotherapy with Autologous Stem Cell Transplant for Stage IV Breast Cancer with Minimal Metastatic Disease

Yago Nieto, Pablo J. Cagnoni, Elizabeth J. Shpall, Steve Matthes, Anna Barón, Roy B. Jones, and Scott I. Bearman
Clin Cancer Res 1999 5: 1731 [Abstract] [Full Text] [PDF]  

Therapy of Advanced Prostate Cancer with Granulocyte Macrophage Colony-stimulating Factor

Eric J. Small, David M. Reese, Bonnie Um, Sarah Whisenant, Shannon C. Dixon, and William D. Figg
Clin Cancer Res 1999 5: 1738 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

tie-1 Protein Tyrosine Kinase: A Novel Independent Prognostic Marker for Gastric Cancer

Wen-chang Lin, Anna F-Y. Li, Chin-Wen Chi, Wen-Wei Chung, Chen Lung Huang, Wing-Yiu Lui, Hsing-Jien Kung, and Chew-Wun Wu
Clin Cancer Res 1999 5: 1745 [Abstract] [Full Text] [PDF]  

Expression of nm23 in the Primary Tumor and the Metastatic Regional Lymph Nodes of Patients with Gastric Cardiac Cancer

Nan-Yung Hsu, Kuan-Chih Chow, Wei-Jen Chen, Cheng-Ching Lin, Fong-Fu Chou, and Chao-Long Chen
Clin Cancer Res 1999 5: 1752 [Abstract] [Full Text] [PDF]  

The Prognostic Impact of BCL2 Protein Expression in Acute Myelogenous Leukemia Varies with Cytogenetics

Steven M. Kornblau, Peter F. Thall, Zeev Estrov, Monica Walterscheid, Shilpen Patel, Alexandra Theriault, Michael J. Keating, Hagop Kantarjian, Elihu Estey, and Michael Andreeff
Clin Cancer Res 1999 5: 1758 [Abstract] [Full Text] [PDF]  

BRK/Sik Expression in the Gastrointestinal Tract and in Colon Tumors

Xavier Llor, Michael S. Serfas, Wenjun Bie, Valeri Vasioukhin, Marina Polonskaia, Jason Derry, Catherine M. Abbott, and Angela L. Tyner
Clin Cancer Res 1999 5: 1767 [Abstract] [Full Text] [PDF]  

Immunoenzymatically Determined Pepsinogen C Concentration in Breast Tumor Cytosols: An Independent Favorable Prognostic Factor in Node-positive Patients

Andreas Scorilas, Eleftherios P. Diamandis, Michael A. Levesque, Anastasia Papanastasiou-Diamandi, M. Javad Khosravi, Maurizia Giai, Riccardo Ponzone, Riccardo Roagna, Piero Sismondi, and Carlos López-Otin
Clin Cancer Res 1999 5: 1778 [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Expression and Gene Amplification in High-Grade Non-Brainstem Gliomas of Childhood

Markus Bredel, Ian F. Pollack, Ronald L. Hamilton, and C. David James
Clin Cancer Res 1999 5: 1786 [Abstract] [Full Text] [PDF]  

Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas

Frank A. Sinicrope, John Hart, Hai-An Hsu, Michael Lemoine, Fabrizio Michelassi, and L. Clifton Stephens
Clin Cancer Res 1999 5: 1793 [Abstract] [Full Text] [PDF]  

Paradoxical Increase in Retinoblastoma Protein in Colorectal Carcinomas May Protect Cells from Apoptosis

Hirofumi Yamamoto, Jae-Won Soh, Takushi Monden, Micheal G. Klein, Li Ming Zhang, Haim Shirin, Nadir Arber, Naohiro Tomita, Ira Schieren, C. A. Stein, and I. Bernard Weinstein
Clin Cancer Res 1999 5: 1805 [Abstract] [Full Text] [PDF]  

Differential Expression of Antiapoptotic Gene BAG-1 in Human Breast Normal and Cancer Cell Lines and Tissues

Xiaolong Yang, Yawei Hao, Zhihu Ding, Alan Pater, and Shou-Ching Tang
Clin Cancer Res 1999 5: 1816 [Abstract] [Full Text] [PDF]  

Role of Vascular Endothelial Growth Factor C Expression in the Development of Lymph Node Metastasis in Gastric Cancer

Yutaka Yonemura, Yoshio Endo, Hideto Fujita, Sachio Fushida, Itasu Ninomiya, Etsurou Bandou, Keizou Taniguchi, Kouichi Miwa, Sigekazu Ohoyama, Kazuo Sugiyama, and Takuma Sasaki
Clin Cancer Res 1999 5: 1823 [Abstract] [Full Text] [PDF]  

Detection of Disseminated Colorectal Cancer Cells in Lymph Nodes, Blood and Bone Marrow

Jürgen Weitz, Peter Kienle, Achim Magener, Moritz Koch, Andrea Schrödel, Frank Willeke, Frank Autschbach, Jeannine Lacroix, Thomas Lehnert, Christian Herfarth, and Magnus von Knebel Doeberitz
Clin Cancer Res 1999 5: 1830 [Abstract] [Full Text] [PDF]  

Increased Cyclin D1 Expression Is Associated with Features of Malignancy and Disease Recurrence in Ovarian Tumors

Federica Barbieri, Monica Cagnoli, Nicola Ragni, Gianni Foglia, Cristina Bruzzo, Francesco Pedullà, and Angela Alama
Clin Cancer Res 1999 5: 1837 [Abstract] [Full Text] [PDF]  

Prognostic Significance of the Detection of Circulating Malignant Cells by Reverse Transcriptase-Polymerase Chain Reaction in Long-Term Clinically Disease-free Melanoma Patients

Begoña Mellado, Lorena Gutierrez, Teresa Castel, Dolors Colomer, Montserrat Fontanillas, Josefa Castro, and Jordi Estapé
Clin Cancer Res 1999 5: 1843 [Abstract] [Full Text] [PDF]  

Genetic Susceptibility Associated with Rare HRAS1 Variable Number of Tandem Repeats Alleles in Spanish Non-Small Cell Lung Cancer Patients

Rafael Rosell, Roser Calvo, José J. Sánchez, Joan Maurel, Mónica Guillot, Mariano Monzó, Laura Núñez, and Agustí Barnadas
Clin Cancer Res 1999 5: 1849 [Abstract] [Full Text] [PDF]  

The Prognostic Significance of p16^INK4a/p14^ARF and p15^INK4b Deletions in Adult Acute Lymphoblastic Leukemia

Stefan Faderl, Hagop M. Kantarjian, Taghi Manshouri, Chin-Yung Chan, Sherry Pierce, Kimberly J. Hays, Jorge Cortes, Deborah Thomas, Zeev Estrov, and Maher Albitar
Clin Cancer Res 1999 5: 1855 [Abstract] [Full Text] [PDF]  

Second Esophageal Tumors in Patients with Head and Neck Squamous Cell Carcinoma: An Assessment of Clonal Relationships

Joseph Califano, Paul L. Leong, Wayne M. Koch, Claus F. Eisenberger, David Sidransky, and William H. Westra
Clin Cancer Res 1999 5: 1862 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Adjuvant Treatment of Canine Osteosarcoma with the Human Cytotoxic T-Cell Line TALL-104

Sophie Visonneau, Alessandra Cesano, K. Ann Jeglum, and Daniela Santoli
Clin Cancer Res 1999 5: 1868 [Abstract] [Full Text] [PDF]  

Sequential Dependent Enhancement of Caspase Activation and Apoptosis by Flavopiridol on Paclitaxel-treated Human Gastric and Breast Cancer Cells

Monica Motwani, Thomas M. Delohery, and Gary K. Schwartz
Clin Cancer Res 1999 5: 1876 [Abstract] [Full Text] [PDF]  

Curcumin Inhibits Tyrosine Kinase Activity of p185^neu and Also Depletes p185^neu

Ruey-Long Hong, William H. Spohn, and Mien-Chie Hung
Clin Cancer Res 1999 5: 1884 [Abstract] [Full Text] [PDF]  

Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3',5'-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor ß and Apoptosis: Involvement of Mitochondria

Rakesh K. Srivastava, Aparna R. Srivastava, Yoon S. Cho-Chung, and Dan L. Longo
Clin Cancer Res 1999 5: 1892 [Abstract] [Full Text] [PDF]  

Marked Antiangiogenic and Antitumor Efficacy of AG3340 in Chemoresistant Human Non-Small Cell Lung Cancer Tumors: Single Agent and Combination Chemotherapy Studies

David R. Shalinsky, John Brekken, Helen Zou, Laura A. Bloom, Charles D. McDermott, Scott Zook, Nissi M. Varki, and Krzysztof Appelt
Clin Cancer Res 1999 5: 1905 [Abstract] [Full Text] [PDF]  

Immunization of Chimpanzees with Tumor Antigen MUC1 Mucin Tandem Repeat Peptide Elicits Both Helper and CytotoxicT-Cell Responses

Simon M. Barratt-Boyes, Anda Vlad, and Olivera J. Finn
Clin Cancer Res 1999 5: 1918 [Abstract] [Full Text] [PDF]  

Antitumor Activity of ZD1694 (Tomudex) against Human Head and Neck Cancer in Nude Mouse Models: Role of Dosing Schedule and Plasma Thymidine

Shousong Cao, John J. McGuire, and Youcef M. Rustum
Clin Cancer Res 1999 5: 1925 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling

Giuseppe Pandini, Riccardo Vigneri, Angela Costantino, Francesco Frasca, Antonio Ippolito, Yoko Fujita-Yamaguchi, Kenneth Siddle, Ira D. Goldfine, and Antonino Belfiore
Clin Cancer Res 1999 5: 1935 [Abstract] [Full Text] [PDF]  

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