Editorials:

Dihydropyrimidine Dehydrogenase Activity: Prognostic Partner of 5-Fluorouracil?

Carmen J. Allegra
Clin Cancer Res 1999 5: 1947 [Full Text] [PDF]  

Review:

Molecular Detection of Micrometastases and Circulating Tumor Cells in Solid Tumors

Ronald A. Ghossein, Satyajit Bhattacharya, and Juan Rosai
Clin Cancer Res 1999 5: 1950 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Detection of Tumor Messenger RNA in the Serum of Patients with Malignant Melanoma

Michael S. Kopreski, Floyd A. Benko, Larry W. Kwak, and Christopher D. Gocke
Clin Cancer Res 1999 5: 1961 [Abstract] [Full Text] [PDF]  

Tissue Microarrays for Gene Amplification Surveys in Many Different Tumor Types

Peter Schraml, Juha Kononen, Lukas Bubendorf, Holger Moch, Heidi Bissig, Antonio Nocito, Michael J. Mihatsch, Olli-P. Kallioniemi, and Guido Sauter
Clin Cancer Res 1999 5: 1966 [Abstract] [Full Text] [PDF]  

Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues

Jerry M. Collins, Raymond W. Klecker, and Aspandiar G. Katki
Clin Cancer Res 1999 5: 1976 [Abstract] [Full Text] [PDF]  

Inhibition of Matrix Metalloproteinase-2 Expression and Bladder Carcinoma Metastasis by Halofuginone

Michael Elkin, Reuven Reich, Arnon Nagler, Elena Aingorn, Mark Pines, Nathan de-Groot, Avraham Hochberg, and Israel Vlodavsky
Clin Cancer Res 1999 5: 1982 [Abstract] [Full Text] [PDF]  

Clinical Trials:

A Phase I and Pharmacokinetic Study of TNP-470 Administered Weekly to Patients with Advanced Cancer

Pankaj Bhargava, John L. Marshall, Naiyer Rizvi, William Dahut, Joseph Yoe, Manuela Figuera, Kim Phipps, Voon S. Ong, Allen Kato, and Michael J. Hawkins
Clin Cancer Res 1999 5: 1989 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Protein Expression in Advanced Colon Cancer: Correlation with the Site of Metastasis and the Clinical Response to Leucovorin-modulated Bolus 5-Fluorouracil

Stefano Cascinu, Carlo Aschele, Sandro Barni, Domizia Debernardis, Chiara Baldo, Gianni Tunesi, Vincenzo Catalano, Maria Pia Staccioli, Ambrogio Brenna, Pietro Muretto, and Giuseppina Catalano
Clin Cancer Res 1999 5: 1996 [Abstract] [Full Text] [PDF]  

Pharmacokinetic Study of S-1, a Novel Oral Fluorouracil Antitumor Drug

Koichi Hirata, Noboru Horikoshi, Keisuke Aiba, Minoru Okazaki, Ryuichi Denno, Kazuaki Sasaki, Yasuyuki Nakano, Hikaru Ishizuka, Yasuhide Yamada, Shinji Uno, Tetsuo Taguchi, and Tetsuhiko Shirasaka
Clin Cancer Res 1999 5: 2000 [Abstract] [Full Text] [PDF]  

Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil

Martin R. Johnson, Alexander Hageboutros, Kangsheng Wang, Lisa High, Jeffrey B. Smith, and Robert B. Diasio
Clin Cancer Res 1999 5: 2006 [Abstract] [Full Text] [PDF]  

Drug-Administration Sequence Does Not Change Pharmacodynamics and Kinetics of Irinotecan and Cisplatin

Maja J. A. de Jonge, Jaap Verweij, André S. T. Planting, Maria E. L. van der Burg, Gerrit Stoter, Maureen M. de Boer-Dennert, Peter de Bruijn, Eric Brouwer, Laurent Vernillet, and Alex Sparreboom
Clin Cancer Res 1999 5: 2012 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Overexpression of Cyclooxygenase-2 in Carcinoma of the Pancreas

Jiro Okami, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Masaki Tsujie, Motoi Kondo, Shingo Noura, Satoshi Oshima, Hiroaki Nagano, Keizo Dono, Koji Umeshita, Osamu Ishikawa, Masato Sakon, Nariaki Matsuura, Shoji Nakamori, and Morito Monden
Clin Cancer Res 1999 5: 2018 [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity in Epithelial Cells Obtained by Bronchial Brushing: Clinical Utility in Lung Cancer

Charles A. Powell, Scott Klares, George O’Connor, and Jerome S. Brody
Clin Cancer Res 1999 5: 2025 [Abstract] [Full Text] [PDF]  

Prognostic Value of Ornithine Decarboxylase and Polyamines in Human Breast Cancer: Correlation with Clinicopathologic Parameters

Francisco Cañizares, Juan Salinas, Manuel de las Heras, Julian Diaz, Isabel Tovar, Pedro Martinez, and Rafael Peñafiel
Clin Cancer Res 1999 5: 2035 [Abstract] [Full Text] [PDF]  

Association between Molecular Detection of GAGE and Survival in Patients with Malignant Melanoma: A Retrospective Cohort Study

Irene Y. Cheung, Nai-Kong V. Cheung, Ronald A. Ghossein, Jaya M. Satagopan, Satyajit Bhattacharya, and Daniel G. Coit
Clin Cancer Res 1999 5: 2042 [Abstract] [Full Text] [PDF]  

Expression of DNA Topoisomerase II and Topoisomerase IIß Genes Predicts Survival and Response to Chemotherapy in Patients with Small Cell Lung Cancer

Anne-Marie C. Dingemans, M. Adhiambo Witlox, Roland A. L. M. Stallaert, Paul van der Valk, Pieter E. Postmus, and Giuseppe Giaccone
Clin Cancer Res 1999 5: 2048 [Abstract] [Full Text] [PDF]  

O⁶-Alkylguanine-DNA Alkyltransferase in Cutaneous T-Cell Lymphoma: Implications for Treatment with Alkylating Agents

M. Eileen Dolan, Bradford L. McRae, Elizabeth Ferries-Rowe, Michael Belanich, Gijs A. van Seventer, Joan Guitart, David Pezen, Timothy M. Kuzel, and Daniel B. Yarosh
Clin Cancer Res 1999 5: 2059 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Perirectal Lymph Node Micrometastases in Dukes’ B Rectal Carcinoma: An Immunohistochemical Study by CAM5.2

Naohide Isaka, Mutsumi Nozue, Mikio Doy, and Katashi Fukao
Clin Cancer Res 1999 5: 2065 [Abstract] [Full Text] [PDF]  

Overexpression of Cyclin D1 Messenger RNA Predicts for Poor Prognosis in Estrogen Receptor-positive Breast Cancer

Frances S. Kenny, Rina Hui, Elizabeth A. Musgrove, Julia M.W. Gee, Roger W. Blamey, Robert I. Nicholson, Robert L. Sutherland, and John F. R. Robertson
Clin Cancer Res 1999 5: 2069 [Abstract] [Full Text] [PDF]  

Telomerase Activity as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer

Antonio Marchetti, Gloria Bertacca, Fiamma Buttitta, Antonio Chella, Gianluca Quattrocolo, Carlo Alberto Angeletti, and Generoso Bevilacqua
Clin Cancer Res 1999 5: 2077 [Abstract] [Full Text] [PDF]  

Inactivation of the p53 Pathway in Prostate Cancer: Impact on Tumor Progression

Iman Osman, Marija Drobnjak, Melissa Fazzari, Joseph Ferrara, Howard I. Scher, and Carlos Cordon-Cardo
Clin Cancer Res 1999 5: 2082 [Abstract] [Full Text] [PDF]  

Wild-Type p53 Epitope Naturally Processed and Presented by an HLA-B Haplotype on Human Breast Carcinoma Cells

Kyriakos P. Papadopoulos, Charles S. Hesdorffer, Nicole Suciu-Foca, Hanina Hibshoosh, and Paul E. Harris
Clin Cancer Res 1999 5: 2089 [Abstract] [Full Text] [PDF]  

Expression of Plasminogen Activator Inhibitors 1 and 2 in Lung Cancer and Their Role in Tumor Progression

Catherine Robert, Isabelle Bolon, Sylvie Gazzeri, Sylvie Veyrenc, Christian Brambilla, and Elisabeth Brambilla
Clin Cancer Res 1999 5: 2094 [Abstract] [Full Text] [PDF]  

The Human Orphan Receptor PXR Messenger RNA Is Expressed in Both Normal and Neoplastic Breast Tissue

Helmut Dotzlaw, Etienne Leygue, Peter Watson, and Leigh C. Murphy
Clin Cancer Res 1999 5: 2103 [Abstract] [Full Text] [PDF]  

Sequences Homologous to the Mouse Mammary Tumor Virus env Gene in Human Breast Carcinoma Correlate with Overexpression of Laminin Receptor

Beatriz G-T. Pogo, Stella M. Melana, James F. Holland, John F. Mandeli, Silvana Pilotti, Patrizia Casalini, and Sylvie Ménard
Clin Cancer Res 1999 5: 2108 [Abstract] [Full Text] [PDF]  

Expression of Dominant-Negative Ikaros Isoforms in T-Cell Acute Lymphoblastic Leukemia

Lei Sun, Mya-Lisa Crotty, Martha Sensel, Harland Sather, Christopher Navara, James Nachman, Peter G. Steinherz, Paul S. Gaynon, Nita Seibel, Chen Mao, Alexei Vassilev, Gregory H. Reaman, and Fatih M. Uckun
Clin Cancer Res 1999 5: 2112 [Abstract] [Full Text] [PDF]  

Minichromosome Maintenance Proteins as Biological Markers of Dysplasia and Malignancy

Alex Freeman, Lesley S. Morris, Anthony D. Mills, Kai Stoeber, Ronald A. Laskey, Gareth H. Williams, and Nicholas Coleman
Clin Cancer Res 1999 5: 2121 [Abstract] [Full Text] [PDF]  

Analysis of Cyclin D1 (CCND1) Allelic Imbalance and Overexpression in Sporadic Human Pituitary Tumors

Nigel A. Hibberts, David J. Simpson, John E. Bicknell, John C. Broome, Paul R. Hoban, Richard N. Clayton, and William E. Farrell
Clin Cancer Res 1999 5: 2133 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Adenovirus-mediated p53 Gene Transduction Inhibits Telomerase Activity Independent of Its Effects on Cell Cycle Arrest and Apoptosis in Human Pancreatic Cancer Cells

Masahiro Kusumoto, Takahiro Ogawa, Kazuhiro Mizumoto, Hikaru Ueno, Hideaki Niiyama, Norihiro Sato, Masafumi Nakamura, and Masao Tanaka
Clin Cancer Res 1999 5: 2140 [Abstract] [Full Text] [PDF]  

Oral Administration of the Immunomodulator JBT-3002 Induces Endogenous Interleukin 15 in Intestinal Macrophages for Protection against Irinotecan-mediated Destruction of Intestinal Epithelium

Hisashi Shinohara, Jerald J. Killion, Corazon D. Bucana, Seiji Yano, and Isaiah J. Fidler
Clin Cancer Res 1999 5: 2148 [Abstract] [Full Text] [PDF]  

Efficacy of Recombinant Methioninase in Combination with Cisplatin on Human Colon Tumors in Nude Mice

Yuying Tan, Xinghua Sun, Mingxu Xu, Xuezhong Tan, Aaron Sasson, Babak Rashidi, Qinghong Han, Xiuying Tan, Xiaoen Wang, Zili An, Fan-xian Sun, and Robert M. Hoffman
Clin Cancer Res 1999 5: 2157 [Abstract] [Full Text] [PDF]  

Decreased Src Tyrosine Kinase Activity Inhibits Malignant Human Ovarian Cancer Tumor Growth in a Nude Mouse Model

Jon R. Wiener, Kayo Nakano, Russell P. Kruzelock, Corazon D. Bucana, Robert C. Bast, Jr., and Gary E. Gallick
Clin Cancer Res 1999 5: 2164 [Abstract] [Full Text] [PDF]  

Androgen and Epidermal Growth Factor Down-Regulate Cyclin-dependent Kinase Inhibitor p27^Kip1 and Costimulate Proliferation of MDA PCa 2a and MDA PCa 2b Prostate Cancer Cells

Dingwei Ye, John Mendelsohn, and Zhen Fan
Clin Cancer Res 1999 5: 2171 [Abstract] [Full Text] [PDF]  

Chlorambucil Induction of HsRad51 in B-Cell Chronic Lymphocytic Leukemia

Garyfallia Christodoulopoulos, Areti Malapetsa, Hymen Schipper, Efim Golub, Charles Radding, and Lawrence C. Panasci
Clin Cancer Res 1999 5: 2178 [Abstract] [Full Text] [PDF]  

UFT and Its Metabolites Inhibit the Angiogenesis Induced by Murine Renal Cell Carcinoma, as Determined by a Dorsal Air Sac Assay in Mice

Kazuhiko Yonekura, Yuji Basaki, Lumi Chikahisa, Soko Okabe, Akihiro Hashimoto, Kazutaka Miyadera, Konstanty Wierzba, and Yuji Yamada
Clin Cancer Res 1999 5: 2185 [Abstract] [Full Text] [PDF]  

Metabolic Activation of Dacarbazine by Human Cytochromes P450: The Role of CYP1A1, CYP1A2, and CYP2E1

Joel M. Reid, Mary J. Kuffel, Jennifer K. Miller, Robert Rios, and Matthew M. Ames
Clin Cancer Res 1999 5: 2192 [Abstract] [Full Text] [PDF]  

Anticancer Drug Sensitivity and Expression of Multidrug Resistance Markers in Early Passage Human Sarcomas

Jens Hoffmann, Peter Schmidt-Peter, Wolfgang Hänsch, Helga Naundorf, Andreas Bunge, Michael Becker, and Iduna Fichtner
Clin Cancer Res 1999 5: 2198 [Abstract] [Full Text] [PDF]  

The Trk Tyrosine Kinase Inhibitor CEP-701 (KT-5555) Exhibits Significant Antitumor Efficacy in Preclinical Xenograft Modelsof Human Pancreatic Ductal Adenocarcinoma

Sheila J. Miknyoczki, Hong Chang, Andres Klein-Szanto, Craig A. Dionne, and Bruce A. Ruggeri
Clin Cancer Res 1999 5: 2205 [Abstract] [Full Text] [PDF]  

Paclitaxel and Radiotherapy: Sequence-dependent Efficacy—A Preclinical Model

Alessandra Niero, Ermanno Emiliani, Giuseppe Monti, Flavio Pironi, Livia Turci, Anna Maria Valenti, and Maurizio Marangolo
Clin Cancer Res 1999 5: 2213 [Abstract] [Full Text] [PDF]  

Lovastatin Augments Apoptosis Induced by Chemotherapeutic Agents in Colon Cancer Cells

Banke Agarwal, Sanjay Bhendwal, Balasz Halmos, Steven F. Moss, William G. Ramey, and Peter R. Holt
Clin Cancer Res 1999 5: 2223 [Abstract] [Full Text] [PDF]  

Fenretinide Activates Caspases and Induces Apoptosis in Gliomas

Vinaykumar K. Puduvalli, Yoshiki Saito, Ruishu Xu, Gregory P. Kouraklis, Victor A. Levin, and Athanassios P. Kyritsis
Clin Cancer Res 1999 5: 2230 [Abstract] [Full Text] [PDF]  

Identification of a MAGE-2-encoded Human Leukocyte Antigen-A24-binding Synthetic Peptide That Induces Specific Antitumor Cytotoxic T Lymphocytes

Kouichirou Tahara, Kazutoh Takesako, Alessandro Sette, Esteban Celis, Seigo Kitano, and Tsuyoshi Akiyoshi
Clin Cancer Res 1999 5: 2236 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated E2F-1 Gene Transfer Inhibits MDM2 Expression and Efficiently Induces Apoptosis in MDM2-overexpressing Tumor Cells

Hai Liang Yang, Yan Bin Dong, Mary Jane Elliott, Ta Jen Liu, Cesar Atienza, Jr., Ariel Stilwell, and Kelly M. McMasters
Clin Cancer Res 1999 5: 2242 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

A Role for Phospholipase C--mediated Signaling in Tumor Cell Invasion

Jareer Kassis, Jason Moellinger, Han Lo, Norman M. Greenberg, Hyung-Gyoon Kim, and Alan Wells
Clin Cancer Res 1999 5: 2251 [Abstract] [Full Text] [PDF]  

Surface Membrane-expressed CD40 Is Present on Tumor Cells from Squamous Cell Cancer of the Head and Neck in Vitro and in Vivo and Regulates Cell Growth in Tumor Cell Lines

Marshall R. Posner, Lisa A. Cavacini, Melissa P. Upton, Karl C. Tillman, Eric R. Gornstein, and Charles M. Norris, Jr.
Clin Cancer Res 1999 5: 2261 [Abstract] [Full Text] [PDF]  

Osteopontin: Possible Role in Prostate Cancer Progression

George N. Thalmann, R. A. Sikes, R. E. Devoll, J. A. Kiefer, R. Markwalder, I. Klima, C. M. Farach-Carson, U. E. Studer, and L. W. K. Chung
Clin Cancer Res 1999 5: 2271 [Abstract] [Full Text] [PDF]  

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