Editorials:

Understanding Academic Medical Centers: Simone’s Maxims

Joseph V. Simone
Clin Cancer Res 1999 5: 2281 [Full Text] [PDF]  

Should Therapy of Ovarian Cancer Patients Be Individualized Based on Underlying Genetic Defects?

Gordon B. Mills, Rosemarie Schmandt, David Gershenson, and Robert C. Bast
Clin Cancer Res 1999 5: 2286 [Full Text] [PDF]  

Minireviews:

The Oral Fluoropyrimidines in Cancer Chemotherapy

Elizabeth B. Lamont and Richard L. Schilsky
Clin Cancer Res 1999 5: 2289 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Detecting Tumor-related Alterations in Plasma or Serum DNA of Patients Diagnosed with Breast Cancer

Xu qi Chen, Hervé Bonnefoi, Sophie Diebold-Berger, Jacqueline Lyautey, Christine Lederrey, Ellen Faltin-Traub, Maurice Stroun, and Philippe Anker
Clin Cancer Res 1999 5: 2297 [Abstract] [Full Text] [PDF]  

Inhibition of Angiogenesis and Intrahepatic Growth of Colon Cancer by TAC-101

Koji Murakami, Rieko Sakukawa, Masaki Sano, Akihiro Hashimoto, Jiro Shibata, Yuji Yamada, and Ikuo Saiki
Clin Cancer Res 1999 5: 2304 [Abstract] [Full Text] [PDF]  

Hepatotoxicity in Cancer Patients Receiving erb-38, a Recombinant Immunotoxin That Targets the erbB2 Receptor

Lee H. Pai-Scherf, Jacy Villa, Deborah Pearson, Thelma Watson, Edison Liu, Mark C. Willingham, and Ira Pastan
Clin Cancer Res 1999 5: 2311 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Aerosol Granulocyte Macrophage-Colony Stimulating Factor: A Low Toxicity, Lung-specific Biological Therapy in Patients with Lung Metastases

Peter M. Anderson, Svetomir N. Markovic, Jeffery A. Sloan, Mary Lou Clawson, Mark Wylam, Carola A. S. Arndt, William A. Smithson, Patrick Burch, Michael Gornet, and Emel Rahman
Clin Cancer Res 1999 5: 2316 [Abstract] [Full Text] [PDF]  

A Pharmacokinetically Guided Phase II Study of Carboxyamido-triazole in Androgen-independent Prostate Cancer

Kenneth S. Bauer, William D. Figg, J. Michael Hamilton, Elizabeth C. Jones, Ahalya Premkumar, Seth M. Steinberg, Valerie Dyer, W. Marsten Linehan, James M. Pluda, and Eddie Reed
Clin Cancer Res 1999 5: 2324 [Abstract] [Full Text] [PDF]  

Phase I Trial of a Recombinant Vaccinia Virus Encoding Carcinoembryonic Antigen in Metastatic Adenocarcinoma: Comparison of Intradermal versus Subcutaneous Administration

Robert M. Conry, Muhamad B. Khazaeli, Mansoor N. Saleh, Karen O. Allen, Daunte L. Barlow, Susan E. Moore, Dayle Craig, Ramin B. Arani, Jeffrey Schlom, and Albert F. LoBuglio
Clin Cancer Res 1999 5: 2330 [Abstract] [Full Text] [PDF]  

Impact of Tamoxifen on the Pharmacokinetics and Endocrine Effects of the Aromatase Inhibitor Letrozole in Postmenopausal Women with Breast Cancer

M. Dowsett, C. Pfister, S. R. D. Johnston, D. W. Miles, S. J. Houston, J. A. Verbeek, H. Gundacker, A. Sioufi, and I. E. Smith
Clin Cancer Res 1999 5: 2338 [Abstract] [Full Text] [PDF]  

A Phase I Trial of Bryostatin-1 in Children with Refractory Solid Tumors: A Pediatric Oncology Group Study

Steven Weitman, Anne-Marie Langevin, Roger L. Berkow, Paul J. Thomas, Craig A. Hurwitz, Andrew S. Kraft, Ronald L. Dubowy, Debra L. Smith, and Mark Bernstein
Clin Cancer Res 1999 5: 2344 [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics of Lobaplatin (D-19466) in Patients with Advanced Solid Tumors, Including Patients with Impaired Renal or Liver Function

Jan Welink, Epie Boven, Jan B. Vermorken, Helen E. Gall, and Wim J. F. van der Vijgh
Clin Cancer Res 1999 5: 2349 [Abstract] [Full Text] [PDF]  

Interleukin 2 Gene Therapy of Colorectal Carcinoma with Autologous Irradiated Tumor Cells and GeneticallyEngineered Fibroblasts: A Phase I Study

Robert E. Sobol, Daniel L. Shawler, Colette Carson, Charles Van Beveren, Dan Mercola, Habib Fakhrai, Mia A. Garrett, Robert Barone, Paul Goldfarb, Richard M. Bartholomew, Steven Brostoff, Dennis J. Carlo, Ivor Royston, and Daniel P. Gold
Clin Cancer Res 1999 5: 2359 [Abstract] [Full Text] [PDF]  

A Phase II Study of High-Dose Tamoxifen in Patients with Hormone-refractory Prostate Cancer

Raymond C. Bergan, Eddie Reed, Charles E. Myers, Donna Headlee, Otis Brawley, Hea-Kyoung Cho, W. Douglas Figg, Anne Tompkins, W. Marston Linehan, David Kohler, Seth M. Steinberg, and Mikhail V. Blagosklonny
Clin Cancer Res 1999 5: 2366 [Abstract] [Full Text] [PDF]  

Daily Subcutaneous Ultra-Low-Dose Interleukin 2 with Daily Low-Dose Interferon- in Patients with Advanced Renal Cell Carcinoma

Joseph I. Clark, Ellen R. Gaynor, Brenda Martone, Susan C. Budds, Rajini Manjunath, Robert C. Flanigan, W. Bedford Waters, and Jeffrey A. Sosman
Clin Cancer Res 1999 5: 2374 [Abstract] [Full Text] [PDF]  

A Phase I Study of Raltitrexed, an Antifolate Thymidylate Synthase Inhibitor, in Adult Patients with Advanced Solid Tumors

Jean L. Grem, J. Mel Sorensen, Ellen Cullen, Chris H. Takimoto, Seth M. Steinberg, Alice P. Chen, J. Michael Hamilton, Susan G. Arbuck, Nanette McAtee, David Lawrence, Barry Goldspiel, Patrick G. Johnston, and Carmen J. Allegra
Clin Cancer Res 1999 5: 2381 [Abstract] [Full Text] [PDF]  

A Phase II Study of Adjuvant Therapy with Anti-B4-blocked Ricin after Autologous Bone Marrow Transplantation for Patients with Relapsed B-Cell Non-Hodgkin’s Lymphoma

Michael L. Grossbard, Pratik S. Multani, Arnold S. Freedman, Steven O’Day, John G. Gribben, Catherine Rhuda, Donna Neuberg, and Lee M. Nadler
Clin Cancer Res 1999 5: 2392 [Abstract] [Full Text] [PDF]  

A Pilot Study of Interferon -2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma

Jeremy D. Shapiro, Nancy Harold, Chris Takimoto, J. Michael Hamilton, David Vaughn, Alice Chen, Seth M. Steinberg, David Liewehr, Carmen Allegra, Brian Monahan, Alex Lash, Frank Grollman, Donald Flemming, Katherine Behan, Patrick G. Johnston, Daniel Haller, Mary Quinn, Geraldine Morrison, and Jean L. Grem
Clin Cancer Res 1999 5: 2399 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Loss of FHIT Expression in Acute Lymphoblastic Leukemia

Cora Hallas, Maher Albitar, Jean Letofsky, Michael J. Keating, Kay Huebner, and Carlo M. Croce
Clin Cancer Res 1999 5: 2409 [Abstract] [Full Text] [PDF]  

Paucity of Leukemic Progenitor Cells in the Bone Marrow of Pediatric B-Lineage Acute Lymphoblastic Leukemia Patients with an Isolated Extramedullary First Relapse

Fatih M. Uckun, Paul S. Gaynon, Daniel O. Stram, Martha G. Sensel, Mireille B. Sarquis, Kenneth H. Lazarus, and Michael Willoughby
Clin Cancer Res 1999 5: 2415 [Abstract] [Full Text] [PDF]  

Cellular Proliferation and Prevalence of Micrometastatic Cells in the Bone Marrow of Patients with Clinically Localized Prostate Cancer

Michael L. Cher, Jose G. de Oliveira, Andrew A. Beaman, Jeffrey A. Nemeth, Maha Hussain, and David P. Wood, Jr.
Clin Cancer Res 1999 5: 2421 [Abstract] [Full Text] [PDF]  

Expression of the Lung Resistance Protein Predicts Poor Outcome in Patients with Multiple Myeloma

Martin Filipits, Johannes Drach, Gudrun Pohl, Judith Schuster, Thomas Stranzl, Jutta Ackermann, Robert Königsberg, Hannes Kaufmann, Heinz Gisslinger, Heinz Huber, Heinz Ludwig, and Robert Pirker
Clin Cancer Res 1999 5: 2426 [Abstract] [Full Text] [PDF]  

Genetic Alterations of the Tumor Suppressor Gene PTEN/MMAC1 in Human Brain Metastases

Matthias Hahn, Ivonne Wieland, Olga N. Koufaki, Heike Görgens, Stephan B. Sobottka, Gabriele Schackert, and Hans K. Schackert
Clin Cancer Res 1999 5: 2431 [Abstract] [Full Text] [PDF]  

Biochemical Pharmacology and Resistance to 2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, a Novel Analogue of Cladribine in Human Leukemic Cells

Kourosh Lotfi, Emma Månsson, Tatjana Spasokoukotskaja, Birgitta Pettersson, Jan Liliemark, Curt Peterson, Staffan Eriksson, and Freidoun Albertioni
Clin Cancer Res 1999 5: 2438 [Abstract] [Full Text] [PDF]  

Expression of p21^WAF1/Cip1 in the p53-dependent Pathway Is Related to Prognosis in Patients with Advanced Esophageal Carcinoma

Shoji Natsugoe, Saburo Nakashima, Masataka Matsumoto, Che Xiangming, Hiroshi Okumura, Fumio Kijima, Sumiya Ishigami, Yuji Takebayashi, Masamichi Baba, Sonshin Takao, and Takashi Aikou
Clin Cancer Res 1999 5: 2445 [Abstract] [Full Text] [PDF]  

Molecular Detection of Neoplastic Cells in Lymph Nodes of Metastatic Colorectal Cancer Patients Predicts Recurrence

Montserrat Sanchez-Cespedes, Manel Esteller, Kenji Hibi, Frederick O. Cope, William H. Westra, Steven Piantadosi, James G. Herman, Jin Jen, and David Sidransky
Clin Cancer Res 1999 5: 2450 [Abstract] [Full Text] [PDF]  

Patterns of p53 Gene Mutations in Head and Neck Cancer: Full-Length Gene Sequencing and Results of Primary Radiotherapy

M. Elizabeth Saunders, Robert MacKenzie, Rob Shipman, Edmee Fransen, Ralph Gilbert, and Richard C. K. Jordan
Clin Cancer Res 1999 5: 2455 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Fas and Fas Ligand Expressions in Human Esophageal Cancer

Muneaki Shibakita, Mitsuo Tachibana, Dipok K. Dhar, Tsukasa Kotoh, Shoichi Kinugasa, Hirofumi Kubota, Reiko Masunaga, and Naofumi Nagasue
Clin Cancer Res 1999 5: 2464 [Abstract] [Full Text] [PDF]  

Telomerase Assay for Differentiating between Malignancy-related and Nonmalignant Ascites

Pisit Tangkijvanich, Dumrong Tresukosol, Pichet Sampatanukul, Sairoong Sakdikul, Narin Voravud, Varocha Mahachai, and Apiwat Mutirangura
Clin Cancer Res 1999 5: 2470 [Abstract] [Full Text] [PDF]  

Predicting Tumor Failure in Prostate Carcinoma after Definitive Radiation Therapy: Limitations of Models Based on Prostate-specific Antigen, Clinical Stage, and Gleason Score

Robin T. Vollmer and Gustavo S. Montana
Clin Cancer Res 1999 5: 2476 [Abstract] [Full Text] [PDF]  

Distant Metastases in Ovarian Cancer: Association with p53 Mutations

Anil K. Sood, Joel I. Sorosky, Marisa Dolan, Barrie Anderson, and Richard E. Buller
Clin Cancer Res 1999 5: 2485 [Abstract] [Full Text] [PDF]  

Persistence of Peripheral Blood and Bone Marrow Blasts during Remission Induction in Adult Acute Lymphoblastic Leukemia Confers a Poor Prognosis Depending on Treatment Intensity

Jorge Cortes, Luis Fayad, Susan O’Brien, Michael Keating, and Hagop Kantarjian
Clin Cancer Res 1999 5: 2491 [Abstract] [Full Text] [PDF]  

Quantitative Analysis of Transforming Growth Factor ß1 and 2 in Ovarian Carcinoma

Mary Evelyn Gordinier, Hua-Zhong Zhang, Rebecca Patenia, Lawrence B. Levy, E. Neely Atkinson, Micheal A. Nash, Ruth L. Katz, Chris D. Platsoucas, and Ralph S. Freedman
Clin Cancer Res 1999 5: 2498 [Abstract] [Full Text] [PDF]  

Enhanced Expression of Tie2, Its Ligand Angiopoietin-1, Vascular Endothelial Growth Factor, and CD31 in Human Non-Small Cell Lung Carcinomas

Makoto Takahama, Masahiro Tsutsumi, Toshifumi Tsujiuchi, Kunimoto Nezu, Keiji Kushibe, Shigeki Taniguchi, Yashige Kotake, and Yoichi Konishi
Clin Cancer Res 1999 5: 2506 [Abstract] [Full Text] [PDF]  

A Novel Putative Low-Affinity Insulin-like Growth Factor-binding Protein, LIBC (Lost in Inflammatory Breast Cancer), and RhoC GTPase Correlate with the Inflammatory Breast Cancer Phenotype

Kenneth L. van Golen, Seena Davies, Zhi Fen Wu, YunFang Wang, Corazon D. Bucana, Holly Root, Settara Chandrasekharappa, Myla Strawderman, Stephen P. Ethier, and Sofia D. Merajver
Clin Cancer Res 1999 5: 2511 [Abstract] [Full Text] [PDF]  

Decreased Expression of Transforming Growth Factor ß Receptor Type I Is Associated with Poor Prognosis in Bladder Transitional Cell Carcinoma Patients

Hideo Tokunaga, Dong-Hyeon Lee, Isaac Yi Kim, Thomas M. Wheeler, and Seth P. Lerner
Clin Cancer Res 1999 5: 2520 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Gains of 1q21–q22 and 13q12–q14 Are Potential Indicators for Resistance to Cisplatin-based Chemotherapy in Ovarian Cancer Patients

Kazuya Kudoh, Masashi Takano, Tomoyuki Koshikawa, Misako Hirai, Sadao Yoshida, Yoshinori Mano, Kenji Yamamoto, Kenji Ishii, Tsunekazu Kita, Yoshihiro Kikuchi, Ichiro Nagata, Masanao Miwa, and Kazuhiko Uchida
Clin Cancer Res 1999 5: 2526 [Abstract] [Full Text] [PDF]  

Human Colon Cancer Cell Proliferation Mediated by the M₃ Muscarinic Cholinergic Receptor

Harold Frucht, Robert T. Jensen, Dwayne Dexter, Wan-Lin Yang, and Yinghua Xiao
Clin Cancer Res 1999 5: 2532 [Abstract] [Full Text] [PDF]  

Retinoic Acid Modulates a Bimodal Effect on Cell Cycle Progression in Human Adult T-Cell Leukemia Cells

Jamil Dierov, Bassel E. Sawaya, Misha Prosniak, and Ronald B. Gartenhaus
Clin Cancer Res 1999 5: 2540 [Abstract] [Full Text] [PDF]  

Impact of Polyglutamation on Sensitivity to Raltitrexed and Methotrexate in Relation to Drug-induced Inhibition of de Novo Thymidylate and Purine Biosynthesis in CCRF-CEM Cell Lines

Matthew J. Barnes, Edward J. Estlin, Gordon A. Taylor, G. Wynne Aherne, A. Hardcastle, J. J. McGuire, Joanne A. Calvete, John Lunec, Andrew D. J. Pearson, and David R. Newell
Clin Cancer Res 1999 5: 2548 [Abstract] [Full Text] [PDF]  

Antagonistic Interplay between Antimitotic and G₁-S Arresting Agents Observed in Experimental Combination Therapy

Korey R. Johnson, Kristy K. Young, and Weimin Fan
Clin Cancer Res 1999 5: 2559 [Abstract] [Full Text] [PDF]  

Regulation of Dihydropyrimidine Dehydrogenase in Colorectal Cancer

Stephen J. Johnston, Susan A. Ridge, James Cassidy, and Howard L. McLeod
Clin Cancer Res 1999 5: 2566 [Abstract] [Full Text] [PDF]  

Selective Gene Delivery to Head and Neck Cancer Cells via an Integrin Targeted Adenoviral Vector

Keizo Kasono, Jerry L. Blackwell, Joanne T. Douglas, Igor Dmitriev, Theresa V. Strong, Paul Reynolds, David A. Kropf, William R. Carroll, Glenn E. Peters, R. Pat Bucy, David T. Curiel, and Victor Krasnykh
Clin Cancer Res 1999 5: 2571 [Abstract] [Full Text] [PDF]  

Apoptosis as a Predictor of Paclitaxel-induced Radiosensitization in Human Tumor Cell Lines

Belma Kurdoglu, Nge Cheong, Jun Guan, Benjamin W. Corn, Walter J. Curran, Jr., and George Iliakis
Clin Cancer Res 1999 5: 2580 [Abstract] [Full Text] [PDF]  

Increase of Cisplatin Sensitivity by c-myc Antisense Oligodeoxynucleotides in a Human Metastatic Melanoma Inherently Resistant to Cisplatin

Carlo Leonetti, Annamaria Biroccio, Antonio Candiloro, Gennaro Citro, Cristina Fornari, Marcella Mottolese, Donatella Del Bufalo, and Gabriella Zupi
Clin Cancer Res 1999 5: 2588 [Abstract] [Full Text] [PDF]  

RB Status as a Determinant of Response to UCN-01 in Non-Small Cell Lung Carcinoma

Philip C. Mack, David R. Gandara, Cai Bowen, Martin J. Edelman, Teresa Paglieroni, Joachim B. Schnier, Edward P. Gelmann, and Paul H. Gumerlock
Clin Cancer Res 1999 5: 2596 [Abstract] [Full Text] [PDF]  

Synergistic Cytotoxicity and Apoptosis by Apo-2 Ligand and Adriamycin against Bladder Cancer Cells

Youichi Mizutani, Osamu Yoshida, Tsuneharu Miki, and Benjamin Bonavida
Clin Cancer Res 1999 5: 2605 [Abstract] [Full Text] [PDF]  

Radioimmunotherapy of Human Colon Cancer Xenografts Using a Dimeric Single-Chain Fv Antibody Construct

Gabriela Pavlinkova, Barbara J. M. Booth, Surinder K. Batra, and David Colcher
Clin Cancer Res 1999 5: 2613 [Abstract] [Full Text] [PDF]  

Low-Dose Cisplatin and 5-Fluorouracil in Combination CanRepress Increased Gene Expression of Cellular Resistance Determinants to Themselves

Masahiko Nishiyama, Wataru Yamamoto, Ji-Seon Park, Ryo Okamoto, Hoken Hanaoka, Hiroshi Takano, Norio Saito, Masaaki Matsukawa, Tetsuhiko Shirasaka, and Minoru Kurihara
Clin Cancer Res 1999 5: 2620 [Abstract] [Full Text] [PDF]  

Toxicology and Pharmacokinetics of Intravesical Gemcitabine: A Preclinical Study in Dogs

Paul J. Cozzi, Dean F. Bajorin, William Tong, Hai Nguyen, Joe Scott, Warren D. W. Heston, and Guido Dalbagni
Clin Cancer Res 1999 5: 2629 [Abstract] [Full Text] [PDF]  

The Proteasome Inhibitor PS-341 in Cancer Therapy

Beverly A. Teicher, Gulshan Ara, Roy Herbst, Vito J. Palombella, and Julian Adams
Clin Cancer Res 1999 5: 2638 [Abstract] [Full Text] [PDF]  

Regional Treatment of Epidermal Growth Factor Receptor vIII-expressing Neoplastic Meningitis with a Single-Chain Immunotoxin, MR-1

Gary E. Archer, John H. Sampson, Ian A. J. Lorimer, Roger E. McLendon, Chien-Tsun Kuan, Allan H. Friedman, Henry S. Friedman, Ira H. Pastan, and Darell D. Bigner
Clin Cancer Res 1999 5: 2646 [Abstract] [Full Text] [PDF]  

Inhalation Chemotherapy for Macroscopic Primary or Metastatic Lung Tumors: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model

A. Elizabeth Hershey, Ilene D. Kurzman, Lisa J. Forrest, Cheryl A. Bohling, Michael Stonerook, Michael E. Placke, Anthony R. Imondi, and David M. Vail
Clin Cancer Res 1999 5: 2653 [Abstract] [Full Text] [PDF]  

Elimination of Anemia-inducing Substance by Cyclic Plasma Perfusion of Tumor-bearing Rabbits

Osamu Ishiko, Kouzo Hirai, Sadako Nishimura, Toshiyuki Sumi, Ken-ichi Honda, Masaaki Deguchi, Ichiro Tatsuta, and Sachio Ogita
Clin Cancer Res 1999 5: 2660 [Abstract] [Full Text] [PDF]  

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