Advances in Brief:

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study

George J. Brewer, Robert D. Dick, Damanjit K. Grover, Virginia LeClaire, Michael Tseng, Max Wicha, Kenneth Pienta, Bruce G. Redman, Thierry Jahan, Vernon K. Sondak, Myla Strawderman, Gerald LeCarpentier, and Sofia D. Merajver
Clin Cancer Res 2000 6: 1 [Abstract] [Full Text] [PDF]  

Cyclin E Expression, a Potential Prognostic Marker for Non-Small Cell Lung Cancers

Takayuki Mishina, Hirotoshi Dosaka-Akita, Fumihiro Hommura, Motoi Nishi, Tetsuya Kojima, Shigeaki Ogura, Michio Shimizu, Hiroyuki Katoh, and Yoshikazu Kawakami
Clin Cancer Res 2000 6: 11 [Abstract] [Full Text] [PDF]  

Effects of the Polyamine Analogues N¹ -Ethyl-N¹¹-((cyclopropyl)methyl)-4,8-diazaundecane and N¹-Ethyl-N¹¹-((cycloheptyl)methyl)-4,8- diazaundecane in Human Prostate Cancer Cells

Diane E. McCloskey, Patrick M. Woster, Robert A. Casero, Jr., and Nancy E. Davidson
Clin Cancer Res 2000 6: 17 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Specific Cytolytic T-Cell Responses to Human CEA from Patients Immunized with Recombinant Avipox-CEA Vaccine

MingZhu Zhu, John Marshall, David Cole, Jeffrey Schlom, and Kwong Y. Tsang
Clin Cancer Res 2000 6: 24 [Abstract] [Full Text] [PDF]  

Human Autoantibodies to Carcinoembryonic Antigen (CEA) Induced by a Vaccinia-CEA Vaccine

Robert M. Conry, Karen O. Allen, Seung-won Lee, Susan E. Moore, Denise R. Shaw, and Albert F. LoBuglio
Clin Cancer Res 2000 6: 34 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of the Mitochondrial-specific Rhodacyanine Dye Analog MKT 077

Carolyn D. Britten, Eric K. Rowinsky, Sharyn D. Baker, Geoffrey R. Weiss, Lon Smith, Joseph Stephenson, Mace Rothenberg, Leslie Smetzer, Jeffrey Cramer, William Collins, Daniel D. Von Hoff, and S. Gail Eckhardt
Clin Cancer Res 2000 6: 42 [Abstract] [Full Text] [PDF]  

TP53 Mutation and p53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients

Daniela Kandioler-Eckersberger, Carmen Ludwig, Margarethe Rudas, Sonja Kappel, Elisabeth Janschek, Catharina Wenzel, Hermine Schlagbauer-Wadl, Martina Mittlböck, Michael Gnant, Günter Steger, and Raimund Jakesz
Clin Cancer Res 2000 6: 50 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Melphalan Using a 24-hour Continuous Infusion in Patients with Advanced Malignancies

Frédéric Pinguet, Stéphane Culine, Françoise Bressolle, Cécile Astre, Marie-Pierre Serre, Claude Chevillard, and Michel Fabbro
Clin Cancer Res 2000 6: 57 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of Docetaxel Administered in Combination with Continuous Intravenous Infusion of 5-Fluorouracil in Patients with Advanced Solid Tumors

Eric Van Den Neste, Dominique de Valeriola, Joseph Kerger, Harry Bleiberg, Zlatko Kusenda, Christiane Brassinne, Sylvie Bartholomeus, Jean Selleslags, Philippe Hennebert, Hilda Wythouck, Isabelle Cazenave, Florence Lefresne-Soulas, and Martine Piccart
Clin Cancer Res 2000 6: 64 [Abstract] [Full Text] [PDF]  

Cyclophosphamide and Carboplatin and Selective Consolidation in Advanced Seminoma

Robert J. Amato, Randall Millikan, Dania Daliani, Lori Wood, Christopher Logothetis, and Alan Pollack
Clin Cancer Res 2000 6: 72 [Abstract] [Full Text] [PDF]  

Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatous Polyposis

Rosalind van Stolk, Gary Stoner, William L. Hayton, Kenneth Chan, Barry DeYoung, Laura Kresty, Brian H. Kemmenoe, Paul Elson, Lisa Rybicki, James Church, Kim Provencher, Denise McLain, Ernest Hawk, Ben Fryer, Gary Kelloff, Ram Ganapathi, and G. Thomas Budd
Clin Cancer Res 2000 6: 78 [Abstract] [Full Text] [PDF]  

Patients Treated with Antitumor Drugs Displaying Neurological Deficits Are Characterized by a Low Circulating Level of Nerve Growth Factor

Stefano De Santis, Andrea Pace, Loredana Bove, Francesco Cognetti, Francesca Properzi, Marco Fiore, Viviana Triaca, Antonella Savarese, Maria Domenica Simone, Bruno Jandolo, Luigi Manzione, and Luigi Aloe
Clin Cancer Res 2000 6: 90 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Significance of Integrin 5 Gene Expression as a Prognostic Factor in Node-negative Non-Small Cell Lung Cancer

Masashi Adachi, Toshihiko Taki, Masahiko Higashiyama, Nobuoki Kohno, Haruhiko Inufusa, and Masayuki Miyake
Clin Cancer Res 2000 6: 96 [Abstract] [Full Text] [PDF]  

Identification and Localization of the Cytokine SDF1 and Its Receptor, CXC Chemokine Receptor 4, to Regions of Necrosis and Angiogenesis in Human Glioblastoma

Sandra A. Rempel, Steve Dudas, Shugang Ge, and Jorge A. Gutiérrez
Clin Cancer Res 2000 6: 102 [Abstract] [Full Text] [PDF]  

Correlations Among p53, Her-2/neu, and ras Overexpression and Aneuploidy by Multiparameter Flow Cytometry in Human Breast Cancer: Evidence for a Common Phenotypic Evolutionary Pattern in Infiltrating Ductal Carcinomas

Charles A. Smith, Agnese A. Pollice, Ling-Ping Gu, Kathryn A. Brown, Sarita G. Singh, Laura E. Janocko, Ronald Johnson, Thomas Julian, David Hyams, Norman Wolmark, Lillian Sweeney, Jan F. Silverman, and Stanley E. Shackney
Clin Cancer Res 2000 6: 112 [Abstract] [Full Text] [PDF]  

Expression of survivin and Its Relationship to Loss of Apoptosis in Breast Carcinomas

Keitaro Tanaka, Shinji Iwamoto, Goki Gon, Takehiro Nohara, Mitsuhiko Iwamoto, and Nobuhiko Tanigawa
Clin Cancer Res 2000 6: 127 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression Is Related to Prostaglandin Biosynthesis and Angiogenesis in Human Gastric Cancer

Kazuhiko Uefuji, Takashi Ichikura, and Hidetaka Mochizuki
Clin Cancer Res 2000 6: 135 [Abstract] [Full Text] [PDF]  

The Prognostic Value of Angiogenesis by Chalkley Counting in a Confirmatory Study Design on 836 Breast Cancer Patients

Steinbjørn Hansen, Dorthe A. Grabau, Flemming B. Sørensen, Martin Bak, Werner Vach, and Carsten Rose
Clin Cancer Res 2000 6: 139 [Abstract] [Full Text] [PDF]  

Serum ß-2 Microglobulin Levels Are a Significant Prognostic Factor in Philadelphia Chromosome-positive Chronic Myelogenous Leukemia

Jose Rodriguez, Jorge Cortes, Moshe Talpaz, Susan O’Brien, Terry L. Smith, Mary Beth Rios, and Hagop Kantarjian
Clin Cancer Res 2000 6: 147 [Abstract] [Full Text] [PDF]  

Loss of Nuclear p16 Protein Expression Is Not Associated with Promoter Methylation but Defines a Subgroup of Aggressive Endometrial Carcinomas with Poor Prognosis

Helga B. Salvesen, Soma Das, and Lars A. Akslen
Clin Cancer Res 2000 6: 153 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Tissue Prostate-specific Antigen in Endocrine-treated Prostate Carcinomas

Reinhard Stege, Mirtha Grande, Kjell Carlström, Bernhard Tribukait, and Åke Pousette
Clin Cancer Res 2000 6: 160 [Abstract] [Full Text] [PDF]  

Platelet and Coagulation Activation with Vascular Endothelial Growth Factor Generation in Soft Tissue Sarcomas

Henk M. W. Verheul, Klaas Hoekman, Florea Lupu, Henk J. Broxterman, Paul van der Valk, Ajay K. Kakkar, and Herbert M. Pinedo
Clin Cancer Res 2000 6: 166 [Abstract] [Full Text] [PDF]  

Increased Expression of S100A6 (Calcyclin), a Calcium-binding Protein of the S100 Family, in Human Colorectal Adenocarcinomas

Keiko Komatsu, Akiko Andoh, Shingo Ishiguro, Noriko Suzuki, Hiroko Hunai, Yoshiko Kobune-Fujiwara, Masao Kameyama, Jun Miyoshi, Hitoshi Akedo, and Hiroyuki Nakamura
Clin Cancer Res 2000 6: 172 [Abstract] [Full Text] [PDF]  

Prognostic Significance of DNA Ploidy, S-Phase Fraction, and Tissue Levels of Aspartic, Cysteine, and Serine Proteases in Operable Gastric Carcinoma

Antonio Russo, Viviana Bazan, Manuela Migliavacca, Ines Zanna, Carla Tubiolo, Francesca Maria Tumminello, Gabriella Dardanoni, Massimo Cajozzo, Pietro Bazan, Giuseppe Modica, Mario Latteri, Rosa Maria Tomasino, Giuseppe Colucci, Nicola Gebbia, and Gaetano Leto
Clin Cancer Res 2000 6: 178 [Abstract] [Full Text] [PDF]  

In Vitro Adenoviral Vector p53-mediated Transduction and Killing Correlates with Expression of Coxsackie-Adenovirus Receptor and ß₅ Integrin in SUDHL-1 Cells Derived from Anaplastic Large-Cell Lymphoma

Francesco Turturro, Prem Seth, and Charles J. Link, Jr.
Clin Cancer Res 2000 6: 185 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

EGF Receptor and p21WAF1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity

Nicholas J. Donato, Margot Perez, Hyunseok Kang, Zahid H. Siddik, Yi-He Ling, and Roman Perez-Soler
Clin Cancer Res 2000 6: 193 [Abstract] [Full Text] [PDF]  

Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway

Carlos G. Ferreira, Christos Tolis, Simone W. Span, Godefridus J. Peters, Thea van Lopik, Alain J. Kummer, Herbert M. Pinedo, and Giuseppe Giaccone
Clin Cancer Res 2000 6: 203 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis in Oral Cancer Cells by an Anti-bcl-2 Ribozyme Delivered by an Adenovirus Vector

Sandra A. Gibson, Christopher Pellenz, Robert E. Hutchison, Frederick R. Davey, and Edward J. Shillitoe
Clin Cancer Res 2000 6: 213 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis and Inhibition of c-erbB-2 in Breast Cancer Cells by Flavopiridol

Yiwei Li, Mahbubur Bhuiyan, Samir Alhasan, Adrian M. Senderowicz, and Fazlul H. Sarkar
Clin Cancer Res 2000 6: 223 [Abstract] [Full Text] [PDF]  

The Potential of Soybean Foods as a Chemoprevention Approach for Human Urinary Tract Cancer

Shu-Jem Su, Trai-Ming Yeh, Huan-Yao Lei, and Nan-Haw Chow
Clin Cancer Res 2000 6: 230 [Abstract] [Full Text] [PDF]  

Effects of the bcr/abl Kinase Inhibitors AG957 and NSC 680410 on Chronic Myelogenous Leukemia Cells in Vitro

Phyllis A. Svingen, Ayalew Tefferi, Timothy J. Kottke, Gurmeet Kaur, Ven L. Narayanan, Edward A. Sausville, and Scott H. Kaufmann
Clin Cancer Res 2000 6: 237 [Abstract] [Full Text] [PDF]  

E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway

Naoto T. Ueno, Chandra Bartholomeusz, John L. Herrmann, Zeev Estrov, Ruping Shao, Michael Andreeff, Janet Price, Ralph W. Paul, Pervin Anklesaria, Dihua Yu, and Mien-Chie Hung
Clin Cancer Res 2000 6: 250 [Abstract] [Full Text] [PDF]  

Anti-HER2 Antibody and Heregulin Suppress Growth of HER2-Overexpressing Human Breast Cancer Cells through Different Mechanisms

Xiao-Feng Le, Amanda McWatters, Jon Wiener, Ji-Yuan Wu, Gordon B. Mills, and Robert C. Bast, Jr.
Clin Cancer Res 2000 6: 260 [Abstract] [Full Text] [PDF]  

Cellular ATP Depletion by LY309887 as a Predictor of Growth Inhibition in Human Tumor Cell Lines

Xiaohong Lu, Julie Errington, Victor J. Chen, Nicola J. Curtin, Alan V. Boddy, and David R. Newell
Clin Cancer Res 2001 6: 271 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Expression of p53 or p21 in a Papillary Serous Endometrial Carcinoma Cell Line (SPEC-2) Results in Both Growth Inhibition and Apoptotic Cell Death: Potential Application of Gene Therapy to Endometrial Cancer

Lois Ramondetta, Gorden B. Mills, Thomas W. Burke, and Judith K. Wolf
Clin Cancer Res 2000 6: 278 [Abstract] [Full Text] [PDF]  

Balb/c Mice as a Preclinical Model for Raltitrexed-induced Gastrointestinal Toxicity

S. J. Clarke, D. C. Farrugia, G. W. Aherne, D. M. Pritchard, J. Benstead, and A. L. Jackman
Clin Cancer Res 2000 6: 285 [Abstract] [Full Text] [PDF]  

Histology and Sensitivity to Anticancer Drugs of Two Human Non-Small Cell Lung Carcinomas Implanted in the Pleural Cavity of Nude Mice

Laurence Kraus-Berthier, Michel Jan, Nicolas Guilbaud, Monique Naze, Alain Pierré, and Ghanem Atassi
Clin Cancer Res 2000 6: 297 [Abstract] [Full Text] [PDF]  

Maternal Exposure to Tamoxifen during Pregnancy Increases Carcinogen-induced Mammary Tumorigenesis among Female Rat Offspring

Leena Hilakivi-Clarke, Elizabeth Cho, Ighovie Onojafe, Dezhong Joshua Liao, and Robert Clarke
Clin Cancer Res 2000 6: 305 [Abstract] [Full Text] [PDF]  

Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity

Leslie L. Muldoon, Michael A. Pagel, Robert A. Kroll, Robert E. Brummett, Nancy D. Doolittle, Eleanor G. Zuhowski, Merrill J. Egorin, and Edward A. Neuwelt
Clin Cancer Res 2000 6: 309 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Sydney E. Salmon

Raymond Alexanian, Kenneth Anderson, Bart Barlogie, James Berenson, William S. Dalton, and Robert A. Kyle
Clin Cancer Res 2000 6: 316 [Full Text] [PDF]  

Correspondence re: T. Davis et al., Therapy of B-Cell Lymphoma with Anti-CD20 Antibodies Can Result in Loss of CD20 Antigen Expression. Clin. Cancer Res., 5: 611–615, 1999.

Lori Kunkel and Thomas A. Davis
Clin Cancer Res 2000 6: 317 [Full Text] [PDF]  

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