Editorials:

Innovations in Phase 1 Trial Design: Where Do We Go Next?

Jerry M. Collins
Clin Cancer Res 2000 6: 3801 [Full Text] [PDF]  

Minireviews:

Molecular Assays for the Diagnosis of Minimal Residual Head-and-Neck Cancer: Methods, Reliability, Pitfalls, and Solutions

Vida M. M. van Houten, Maarten P. Tabor, Michiel W. M. van den Brekel, Fedor Denkers, Richard G. A. Wishaupt, J. Alain Kummer, Gordon B. Snow, and Ruud H. Brakenhoff
Clin Cancer Res 2000 6: 3803 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Detection of Circulating Cancer Cells with von Hippel-Lindau Gene Mutation in Peripheral Blood of Patients with Renal Cell Carcinoma

Shingo Ashida, Heiwa Okuda, Masakazu Chikazawa, Masanobu Tanimura, Osamu Sugita, Yukio Yamamoto, Syoichiro Nakamura, Masatoshi Moriyama, and Taro Shuin
Clin Cancer Res 2000 6: 3817 [Abstract] [Full Text] [PDF]  

Telomerase RNA as a Detection Marker in the Serum of Breast Cancer Patients

Xu qi Chen, Hervé Bonnefoi, Marie-Françoise Pelte, Jacqueline Lyautey, Christine Lederrey, Sina Movarekhi, Pierre Schaeffer, Hugh E. Mulcahy, Pierre Meyer, Maurice Stroun, and Philippe Anker
Clin Cancer Res 2000 6: 3823 [Abstract] [Full Text] [PDF]  

Antisense Inhibition of hMLH1 Is Not Sufficient for Loss of DNA Mismatch Repair Function in the HCT116+Chromosome 3 Cell Line

Dharam P. Chauhan, Qinghua Yang, John M. Carethers, Giancarlo Marra, Christina L. Chang, Sherman M. Chamberlain, and C. Richard Boland
Clin Cancer Res 2000 6: 3827 [Abstract] [Full Text] [PDF]  

Adenovirus 5 Early Region 1A Does Not Induce Expression of the Ewing Sarcoma Fusion Product EWS-FLI1 in Breast and Ovarian Cancer Cell Lines

Funda Meric, Yong Liao, Wei-Ping Lee, Raphael E. Pollock, and Mien-Chie Hung
Clin Cancer Res 2000 6: 3832 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Lung Cancer Proliferation Correlates with [F-18]Fluorodeoxyglucose Uptake by Positron Emission Tomography

Hubert Vesselle, Rodney A. Schmidt, Jeffrey M. Pugsley, Melissa Li, Steve G. Kohlmyer, Eric Vallières, and Douglas E. Wood
Clin Cancer Res 2000 6: 3837 [Abstract] [Full Text] [PDF]  

Effect of 13-cis-Retinoic Acid on Serum Prostate-specific Antigen Levels in Patients with Recurrent Prostate Cancer after Radical Prostatectomy

Moshe Shalev, Timothy C. Thompson, Anna Frolov, Scott M. Lippman, Waun Ki Hong, Herbert Fritsche, and Dov Kadmon
Clin Cancer Res 2000 6: 3845 [Abstract] [Full Text] [PDF]  

Bioavailability Study of Oral Liquid and Tablet Forms of -Difluoromethylornithine

Paul P. Carbone, Jeffrey A. Douglas, James Thomas, Kendra Tutsch, Marcia Pomplun, Mary Hamielec, and Diane Pauk
Clin Cancer Res 2000 6: 3850 [Abstract] [Full Text] [PDF]  

A Phase I Radioimmunotherapy Trial Evaluating ⁹⁰Yttrium-labeled Anti-Carcinoembryonic Antigen (CEA) Chimeric T84.66 in Patients with Metastatic CEA-producing Malignancies

Jeffrey Y. C. Wong, David Z. Chu, Dave M. Yamauchi, Lawrence E. Williams, An Liu, Sharon Wilczynski, Anna M. Wu, John E. Shively, James H. Doroshow, and Andrew A. Raubitschek
Clin Cancer Res 2000 6: 3855 [Abstract] [Full Text] [PDF]  

Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-induced Pyrimidine Dimers in DNA

Santosh K. Katiyar, Anaibelith Perez, and Hasan Mukhtar
Clin Cancer Res 2000 6: 3864 [Abstract] [Full Text] [PDF]  

Chronic Daily Low Dose of 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in Patients with Previously Resected Colon Polyps and First-Degree Female Relatives of Breast Cancer Patients

Al B. Benson, III, Olufunmilayo I. Olopade, Mark J. Ratain, Alfred Rademaker, Sohrab Mobarhan, Lisa Stucky-Marshall, Suzanne French, and M. Eileen Dolan
Clin Cancer Res 2000 6: 3870 [Abstract] [Full Text] [PDF]  

Phase III Randomized Study of Postradiotherapy Chemotherapy with -Difluoromethylornithine-Procarbazine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosurea, Vincristine (DFMO-PCV) Versus PCV for Glioblastoma Multiforme

Victor A. Levin, Joon H. Uhm, Kurt A. Jaeckle, Ali Choucair, Patrick J. Flynn, W. K. Alfred Yung, Michael D. Prados, Janet M. Bruner, Susan M. Chang, Athanassios P. Kyritsis, Mary Jo Gleason, and Kenneth R. Hess
Clin Cancer Res 2000 6: 3878 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacologic Evaluation of the DNA Intercalator CI-958 in Patients with Advanced Solid Tumors

E. Claire Dees, Lloyd R. Whitfield, William R. Grove, Sue Rummel, Louise B. Grochow, and Ross C. Donehower
Clin Cancer Res 2000 6: 3885 [Abstract] [Full Text] [PDF]  

Unexpected Cytokines in Serum of Malignant Melanoma Patients during Sequential Biochemotherapy

Elizabeth A. Grimm, Christine M. Smid, J. Jack Lee, Chi-Hong Tseng, Omar Eton, and Antonio C. Buzaid
Clin Cancer Res 2000 6: 3895 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Loss of B7.2 (CD86) and Intracellular Adhesion Molecule 1 (CD54) Expression Is Associated with Decreased Tumor-infiltrating T Lymphocytes in Diffuse B-cell Large-cell Lymphoma

Alison T. Stopeck, Andrea Gessner, Thomas P. Miller, Evan M. Hersh, Cynthia S. Johnson, Haiyan Cui, Yvette Frutiger, and Thomas M. Grogan
Clin Cancer Res 2000 6: 3904 [Abstract] [Full Text] [PDF]  

p73 Gene Expression in Ovarian Cancer Tissues and Cell Lines

Chun-Ling Chen, Sin-Ming Ip, Danny Cheng, Ling-Chui Wong, and Hextan Y. S. Ngan
Clin Cancer Res 2000 6: 3910 [Abstract] [Full Text] [PDF]  

Expression of Cancer Testis Genes in Human Brain Tumors

Ugur Sahin, Michael Koslowski, Özlem Türeci, Thomas Eberle, Carsten Zwick, Bernd Romeike, Jean-Richard Moringlane, Karl Schwechheimer, Wolfgang Feiden, and Michael Pfreundschuh
Clin Cancer Res 2000 6: 3916 [Abstract] [Full Text] [PDF]  

Heterogeneity in the Clinical Phenotype of TP53 Mutations in Breast Cancer Patients

Jan Alsner, Mette Yilmaz, Per Guldberg, Lise Lotte Hansen, and Jens Overgaard
Clin Cancer Res 2000 6: 3923 [Abstract] [Full Text] [PDF]  

Contrasted Frequencies of p53 Accumulation in the Two Age Groups of North African Nasopharyngeal Carcinomas

Ahmed Khabir, Abdelmasid Sellami, Mohamed Sakka, Abdel Monem Ghorbel, Jamel Daoud, Mounir Frikha, Mohamed M. Drira, Pierre Busson, and Rachid Jlidi
Clin Cancer Res 2000 6: 3932 [Abstract] [Full Text] [PDF]  

Functional Evaluation of p53 and PTEN Gene Mutations in Gliomas

Hideaki Kato, Shunsuke Kato, Toshihiro Kumabe, Yukihiko Sonoda, Takashi Yoshimoto, Satoshi Kato, Shuang-Yin Han, Takao Suzuki, Hiroyuki Shibata, Ryunosuke Kanamaru, and Chikashi Ishioka
Clin Cancer Res 2000 6: 3937 [Abstract] [Full Text] [PDF]  

Overexpression of Matrix Metalloproteinase 2 Predicts Unfavorable Outcome in Early-Stage Non-Small Cell Lung Cancer

Bernward Passlick, Wulf Sienel, Rita Seen-Hibler, Werner Wöckel, Olaf Thetter, Wolf Mutschler, and Klaus Pantel
Clin Cancer Res 2000 6: 3944 [Abstract] [Full Text] [PDF]  

Identification of ß-Tubulin Isoforms as Tumor Antigens in Neuroblastoma

Latha Prasannan, David E. Misek, Robert Hinderer, Jean Michon, James D. Geiger, and Samir M. Hanash
Clin Cancer Res 2000 6: 3949 [Abstract] [Full Text] [PDF]  

WT1 Splicing Alterations in Wilms’ Tumors

Dominique Baudry, Muriel Hamelin, Marie-Odile Cabanis, Jean-Christophe Fournet, Marie-France Tournade, Sabine Sarnacki, Claudine Junien, and Cécile Jeanpierre
Clin Cancer Res 2000 6: 3957 [Abstract] [Full Text] [PDF]  

Acquired Expression of p27 Is a Favorable Prognostic Indicator in Patients with Hepatocellular Carcinoma

Michelangelo Fiorentino, Annalisa Altimari, Antonia D’Errico, Barry Cukor, Chiara Barozzi, Massimo Loda, and Walter Franco Grigioni
Clin Cancer Res 2000 6: 3966 [Abstract] [Full Text] [PDF]  

Different Patterns of Allelic Loss (Loss of Heterozygosity) in Recurrent Human Pituitary Tumors Provide Evidence for Multiclonal Origins

Richard N. Clayton, Marija Pfeifer, A. Brew Atkinson, Paul Belchetz, John A. H. Wass, Effie Kyrodimou, Mark Vanderpump, David Simpson, John Bicknell, and William E. Farrell
Clin Cancer Res 2000 6: 3973 [Abstract] [Full Text] [PDF]  

Nonhistological Diagnosis of Human Cerebral Tumors by H Magnetic Resonance Spectroscopy and Amino Acid Analysis

José M. Roda, José M. Pascual, Fernando Carceller, Francisco González-Llanos, Antonio Pérez-Higueras, Juan Solivera, Laura Barrios, and Sebastián Cerdán
Clin Cancer Res 2000 6: 3983 [Abstract] [Full Text] [PDF]  

High Frequency of Clonally Related Tumors in Cases of Multiple Synchronous Lung Cancers as Revealed by Molecular Diagnosis

Shigeki Shimizu, Yasushi Yatabe, Takashi Koshikawa, Nobuhiro Haruki, Shunzo Hatooka, Masayuki Shinoda, Motokazu Suyama, Makoto Ogawa, Nobuyuki Hamajima, Ryuzo Ueda, Takashi Takahashi, and Tetsuya Mitsudomi
Clin Cancer Res 2000 6: 3994 [Abstract] [Full Text] [PDF]  

Genomic Aberrations in Human Hepatocellular Carcinomas of Differing Etiologies

Nathalie Wong, Paul Lai, Elizabeth Pang, Lai-Fan Fung, Zhong Sheng, Vanesse Wong, Weiping Wang, Yoshitake Hayashi, Elizabeth Perlman, Shao Yuna, Joseph W-Y. Lau, and Philip J. Johnson
Clin Cancer Res 2000 6: 4000 [Abstract] [Full Text] [PDF]  

Presence of Human Papilloma Virus in Tumor Tissue from Children with Retinoblastoma: An Alternative Mechanism for Tumor Development

Manuela Orjuela, Veronica Ponce Castaneda, Cecilia Ridaura, Evelia Lecona, Carlos Leal, David H. Abramson, Irene Orlow, William Gerald, and Carlos Cordon-Cardo
Clin Cancer Res 2000 6: 4010 [Abstract] [Full Text] [PDF]  

Racial Differences in the Prognostic Usefulness of MUC1 and MUC2 in Colorectal Adenocarcinomas

Upender Manne, Heidi L. Weiss, and William E. Grizzle
Clin Cancer Res 2000 6: 4017 [Abstract] [Full Text] [PDF]  

Loss of Estrogen Receptor (ER) Expression in Endometrial Tumors Is Not Associated with de Novo Methylation of the 5' End of the ER Gene

Jason R. Navari, Philip Y. Roland, Pacita Keh, Helga B. Salvesen, Lars A. Akslen, Ole E. Iversen, Soma Das, Rajul Kothari, Susan Howey, and Benette Phillips
Clin Cancer Res 2000 6: 4026 [Abstract] [Full Text] [PDF]  

The Evolution of Loss of Heterozygosity on Chromosome 17 during the Progression to Barrett’s Adenocarcinoma Involves a Unique Combination of Target Sites in Individual Specimens

Julie R. Dunn, Julie Garde, Kevin Dolan, John R. Gosney, Beverly C. Oates, Alastair J. M. Watson, Patricia Fielding, and John K. Field
Clin Cancer Res 2000 6: 4033 [Abstract] [Full Text] [PDF]  

Human Breast Cancer Susceptibility to Paclitaxel Therapy Is Independent of Bcl-2 Expression

Susan M. Poelman, Moses O. Adeyanju, Maria-Antonia Robertson, Wendy M. Recant, Theodore Karrison, Gini F. Fleming, Olufunmilayo I. Olopade, and Suzanne D. Conzen
Clin Cancer Res 2000 6: 4043 [Abstract] [Full Text] [PDF]  

Expression of Prostate-specific Membrane Antigen in Transitional Cell Carcinoma of the Bladder: Prognostic Value?

Jean-Luc Gala, Sylvain Loric, Yves Guiot, Samuel Ray Denmeade, Alyssa Gady, Francis Brasseur, Michel Heusterspreute, Pascal Eschwège, Philippe De Nayer, Paul Van Cangh, and Bertrand Tombal
Clin Cancer Res 2000 6: 4049 [Abstract] [Full Text] [PDF]  

Prognostic Significance of p53 Alterations in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

T. Mitsudomi, N. Hamajima, M. Ogawa, and T. Takahashi
Clin Cancer Res 2000 6: 4055 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression Correlates with Tumor Neovascularization and Prognosis in Human Colorectal Carcinoma Patients

Reiko Masunaga, Hitoshi Kohno, Dipok Kumar Dhar, Satoshi Ohno, Muneaki Shibakita, Syoichi Kinugasa, Hiroshi Yoshimura, Mitsuo Tachibana, Hirofumi Kubota, and Naofumi Nagasue
Clin Cancer Res 2000 6: 4064 [Abstract] [Full Text] [PDF]  

Evaluation of Serum KL-6, a Mucin-like Glycoprotein, as a Tumor Marker for Breast Cancer

Yoshinari Ogawa, Tetsuro Ishikawa, Katsumi Ikeda, Bunzo Nakata, Tetsuji Sawada, Kana Ogisawa, Yasuyuki Kato, and Kosei Hirakawa
Clin Cancer Res 2000 6: 4069 [Abstract] [Full Text] [PDF]  

Prognostic Significance of p27^KIP1 Protein and Ki-67 Growth Fraction in Non-small Cell Lung Cancers

Fumihiro Hommura, Hirotoshi Dosaka-Akita, Takayuki Mishina, Motoi Nishi, Tetsuya Kojima, Hiromitsu Hiroumi, Shigeaki Ogura, Michio Shimizu, Hiroyuki Katoh, and Yoshikazu Kawakami
Clin Cancer Res 2000 6: 4073 [Abstract] [Full Text] [PDF]  

Study of Dose Escalation and Sequence Switching of Administration of the Combination of Docetaxel and Doxorubicin in Advanced Breast Cancer

Kuniaki Itoh, Yasutsuna Sasaki, Hirofumi Fujii, Hironobu Minami, Tomoko Ohtsu, Hisashi Wakita, Tadahiko Igarashi, Yuko Watanabe, Yusuke Onozawa, Masaki Kashimura, and Yasuo Ohashi
Clin Cancer Res 2000 6: 4082 [Abstract] [Full Text] [PDF]  

Analysis of Genetic Polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese Patients with Therapy-related Leukemia/Myelodysplastic Syndrome and de novo Acute Myeloid Leukemia

Tomoki Naoe, Kunihiko Takeyama, Toshiya Yokozawa, Hitoshi Kiyoi, Masao Seto, Naokuni Uike, Teruo Ino, Atae Utsunomiya, Atsuo Maruta, Itsuro Jin-nai, Nanao Kamada, Yoshitsugu Kubota, Hiroyuki Nakamura, Chihiro Shimazaki, Shigeo Horiike, Yoshihisa Kodera, Hidehiko Saito, Ryuzo Ueda, Joseph Wiemels, and Ryuzo Ohno
Clin Cancer Res 2000 6: 4091 [Abstract] [Full Text] [PDF]  

Overexpression of Retinoblastoma Protein Predicts Decreased Survival and Correlates with Loss of p16^INK4 Protein in Gallbladder Carcinomas

Ya-Zhou Shi, Ai-Min Hui, Xin Li, Tadatoshi Takayama, and Masatoshi Makuuchi
Clin Cancer Res 2000 6: 4096 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Prostate Cancer Gene Therapy: Comparison of Adenovirus-mediated Expression of Interleukin 12 with Interleukin 12 plus B7-1 for in Situ Gene Therapy and Gene-modified, Cell-based Vaccines

Gerald W. Hull, Mark A. McCurdy, Yasutomo Nasu, Chris H. Bangma, Guang Yang, Satoru Shimura, Hon-Man Lee, Jianxiang Wang, Justin Albani, Shin Ebara, Takefumi Sato, Terry L. Timme, and Timothy C. Thompson
Clin Cancer Res 2000 6: 4101 [Abstract] [Full Text] [PDF]  

Antitumor Activity of Temozolomide Combined with Irinotecan Is Partly Independent of O⁶-Methylguanine-DNA Methyltransferase and Mismatch Repair Phenotypes in Xenograft Models

Peter J. Houghton, Clinton F. Stewart, Pamela J. Cheshire, Lois B. Richmond, Mark N. Kirstein, Catherine A. Poquette, Ming Tan, Henry S. Friedman, and Thomas P. Brent
Clin Cancer Res 2000 6: 4110 [Abstract] [Full Text] [PDF]  

Pediatric Rhabdomyosarcoma Cell Lines Are Resistant to Fas-induced Apoptosis and Highly Sensitive to TRAIL-induced Apoptosis

Istvan Petak, Leslie Douglas, David M. Tillman, Reka Vernes, and Janet A. Houghton
Clin Cancer Res 2000 6: 4119 [Abstract] [Full Text] [PDF]  

The Efficacy of a Broad-spectrum Sunscreen to Protect Engineered Human Skin from Tissue and DNA Damage Induced by Solar Ultraviolet Exposure

Vickram Bissonauth, Régen Drouin, David L. Mitchell, Marc Rhainds, Joël Claveau, and Mahmoud Rouabhia
Clin Cancer Res 2000 6: 4128 [Abstract] [Full Text] [PDF]  

Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH₂-Terminal Kinase 1

Jae-Won Soh, Yuehua Mao, Min-Gab Kim, Rifat Pamukcu, Han Li, Gary A. Piazza, W. Joseph Thompson, and I. Bernard Weinstein
Clin Cancer Res 2000 6: 4136 [Abstract] [Full Text] [PDF]  

Neutron Radiation Enhances Cisplatin Cytotoxicity Independently of Apoptosis in Human Head and Neck Carcinoma Cells

Harold E. Kim, Mary Ann Krug, Inn Han, John Ensley, George H. Yoo, Jeffrey D. Forman, and Hyeong-Reh Choi Kim
Clin Cancer Res 2000 6: 4142 [Abstract] [Full Text] [PDF]  

Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats

Amy B. Heimberger, Gary E. Archer, Roger E. McLendon, Christine Hulette, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and John H. Sampson
Clin Cancer Res 2000 6: 4148 [Abstract] [Full Text] [PDF]  

Schedule-dependent Activity of Temozolomide plus CPT-11 against a Human Central Nervous System Tumor-derived Xenograft

Vikas J. Patel, Gertrude B. Elion, Peter J. Houghton, Stephen Keir, Anthony E. Pegg, Stewart P. Johnson, M. Eileen Dolan, Darell D. Bigner, and Henry S. Friedman
Clin Cancer Res 2000 6: 4154 [Abstract] [Full Text] [PDF]  

Effective Treatment of Metastatic MDA-MB-435 Human Estrogen-independent Breast Carcinomas with a Targeted Cytotoxic Analogue of Luteinizing Hormone-releasing Hormone AN-207

Ioulia Chatzistamou, Andrew V. Schally, Attila Nagy, Patricia Armatis, Karoly Szepeshazi, and Gabor Halmos
Clin Cancer Res 2000 6: 4158 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: M. Fanciulli et al., Energy Metabolism of Human LoVo Colon Carcinoma Cells: Correlation to Drug Resistance and Influence of Lonidamine. Clin. Cancer Res., 6: 1590–1597, 2000.

Ofer Kaplan
Clin Cancer Res 2000 6: 4166 [Abstract] [Full Text] [PDF]  

Reply

Aristide Floridi
Clin Cancer Res 2000 6: 4166 [Abstract] [Full Text] [PDF]  

Correspondence re: G. C. de Gast et al., Phase I Trial of Combined Immunotherapy with Subcutaneous Granulocyte Macrophage Colony-stimulating Factor, Low-Dose Interleukin 2, and Interferon in Progressive Metastatic Melanoma and Renal Cell Carcinoma. Clin. Cancer Res., 6: 1267–1272, 2000.

Robert T. O’Donnell
Clin Cancer Res 2000 6: 4166 [Abstract] [Full Text] [PDF]  

Reply

Gijsbert C. de Gast
Clin Cancer Res 2000 6: 4166 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.