Advances in Brief:

Detection and Quantitation of Human Papillomavirus (HPV) DNA in the Sera of Patients with HPV-associated Head and Neck Squamous Cell Carcinoma

Randolph B. Capone, Sara I. Pai, Wayne M. Koch, Maura L. Gillison, Homaira Nawroz Danish, William H. Westra, Richard Daniel, Keerti V. Shah, and David Sidransky
Clin Cancer Res 2000 6: 4171 [Abstract] [Full Text] [PDF]  

Clinical Significance of Micrometastases in Axillary Lymph Nodes Assessed by Reverse Transcription-Polymerase Chain Reaction in Breast Cancer Patients

Norikazu Masuda, Yasuhiro Tamaki, Isao Sakita, Masaru Ooka, Tadashi Ohnishi, Masao Kadota, Noriko Aritake, Kousaku Okubo, and Morito Monden
Clin Cancer Res 2000 6: 4176 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase I Trial of XR9576 in Healthy Volunteers Demonstrates Modulation of P-glycoprotein in CD56⁺ Lymphocytes after Oral and Intravenous Administration

Alistair Stewart, Jan Steiner, Graham Mellows, Bim Laguda, David Norris, and Paul Bevan
Clin Cancer Res 2000 6: 4186 [Abstract] [Full Text] [PDF]  

Peptide Priming of Cytolytic Activity to HER-2 Epitope 369–377 in Healthy Individuals

Brett W. Anderson, George E. Peoples, James L. Murray, Michael A. Gillogly, David M. Gershenson, and Constantin G. Ioannides
Clin Cancer Res 2000 6: 4192 [Abstract] [Full Text] [PDF]  

Phase I Trial of Paclitaxel Plus Megestrol Acetate in Patients with Paclitaxel-refractory Ovarian Cancer

Maurie Markman, Alexander Kennedy, Kenneth Webster, Barbara Kulp, Gertrude Peterson, and Jerome Belinson
Clin Cancer Res 2000 6: 4201 [Abstract] [Full Text] [PDF]  

Phase II Study of Dolastatin-10 in Patients with Hormone-refractory Metastatic Prostate Adenocarcinoma

Uika Vaishampayan, Michael Glode, Wei Du, Andrew Kraft, Gary Hudes, Jeremy Wright, and Maha Hussain
Clin Cancer Res 2000 6: 4205 [Abstract] [Full Text] [PDF]  

Clinical Phase I Dose Escalation and Pharmacokinetic Study of High-Dose Chemotherapy with Treosulfan and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Advanced Malignancies

Max E. Scheulen, Ralf A. Hilger, Carsten Oberhoff, Jochen Casper, Matthias Freund, Klaus M. Josten, Martin Bornhäuser, Gerhard Ehninger, Wolfgang E. Berdel, Joachim Baumgart, Andreas Harstrick, Peter Bojko, Hans-Heinrich Wolf, Adolf E. Schindler, and Siegfried Seeber
Clin Cancer Res 2000 6: 4209 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Prognostic Value of the Type I Growth Factor Receptors in a Large Series of Human Primary Breast Cancers Quantified with a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Valérie Pawlowski, Françoise Révillion, Mohamed Hebbar, Louis Hornez, and Jean-Philippe Peyrat
Clin Cancer Res 2000 6: 4217 [Abstract] [Full Text] [PDF]  

Human Herpesvirus 8 Open Reading Frame 26 and Open Reading Frame 65 Sequences from Multiple Myeloma Patients: A Shared Pattern Not Found in Kaposi’s Sarcoma or Primary Effusion Lymphoma

Hong J. Ma, Nelida N. Sjak-Shie, Robert A. Vescio, Marissa Kaminsky, Amy Mikail, Mehis Pold, Kimberly Parker, Meral Beksac, Daniel Belson, Thomas J. Moss, Chun H. Wu, Jin Zhou, Lan Zhang, Grace Chen, Jonathan W. Said, and James R. Berenson
Clin Cancer Res 2000 6: 4226 [Abstract] [Full Text] [PDF]  

Inverse Expression of S100A4 and E-Cadherin Is Associated with Metastatic Potential in Gastric Cancer

Yutaka Yonemura, Yoshio Endou, Keiichi Kimura, Sachio Fushida, Etsurou Bandou, Keizou Taniguchi, Kazuo Kinoshita, Itasu Ninomiya, Kazuo Sugiyama, Claus W. Heizmann, Beat W. Schafer, and Takuma Sasaki
Clin Cancer Res 2000 6: 4234 [Abstract] [Full Text] [PDF]  

E-Cadherin Expression Is Silenced by 5' CpG Island Methylation in Acute Leukemia

Paul G. Corn, B. Douglas Smith, Emily S. Ruckdeschel, Donna Douglas, Stephen B. Baylin, and James G. Herman
Clin Cancer Res 2000 6: 4243 [Abstract] [Full Text] [PDF]  

CYFRA 21-1 Serum Analysis in Patients with Esophageal Cancer

Jens G. Brockmann, Hubertus St. Nottberg, Bernhard Glodny, Achim Heinecke, and Norbert J. Senninger
Clin Cancer Res 2000 6: 4249 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Cyclin E Overexpression in Laryngeal Squamous Cell Carcinomas

Youyi Dong, Li Sui, Yuji Tai, Katsuyoshi Sugimoto, Tomohiro Hirao, and Masaaki Tokuda
Clin Cancer Res 2000 6: 4253 [Abstract] [Full Text] [PDF]  

BRCA1 and BRCA2 Mutations in Breast Cancer Families with Multiple Primary Cancers

Helen A. Shih, Katherine L. Nathanson, Sheila Seal, Nadine Collins, Michael R. Stratton, Timothy R. Rebbeck, and Barbara L. Weber
Clin Cancer Res 2000 6: 4259 [Abstract] [Full Text] [PDF]  

Expression and Prognostic Value of Wilms’ Tumor 1 and Early Growth Response 1 Proteins in Nephroblastoma

Mazen A. Ghanem, Theo H. Van der Kwast, Jan C. Den Hollander, Mondastri K. Sudaryo, Monique H. A. Oomen, Marinus A. Noordzij, Marry M. Van den Heuvel, Shoukri M. Nassef, Rien M. Nijman, and Gert J. Van Steenbrugge
Clin Cancer Res 2000 6: 4265 [Abstract] [Full Text] [PDF]  

Cyclin D1 Overexpression Is a Critical Event in Gallbladder Carcinogenesis and Independently Predicts Decreased Survival for Patients with Gallbladder Carcinoma

Ai-Min Hui, Xin Li, Ya-Zhou Shi, Tadatoshi Takayama, Guido Torzilli, and Masatoshi Makuuchi
Clin Cancer Res 2000 6: 4272 [Abstract] [Full Text] [PDF]  

The Short Form of the Alternatively Spliced flt-4 but not Its Ligand Vascular Endothelial Growth Factor C Is Related to Lymph Node Metastasis in Human Breast Cancers

Sarah P. Gunningham, Margaret J. Currie, Cheng Han, Bridget A. Robinson, Prudence A. E. Scott, Adrian L. Harris, and Stephen B. Fox
Clin Cancer Res 2000 6: 4278 [Abstract] [Full Text] [PDF]  

Relationship Between Vessel Density and Expression of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor in Small Cell Lung Cancer in Vivo and in Vitro

Eva L. Lund, Charlotte Thorsen, Minna W. B. Pedersen, Nanna Junker, and Paul E. G. Kristjansen
Clin Cancer Res 2000 6: 4287 [Abstract] [Full Text] [PDF]  

High Preoperative Plasma Tissue Inhibitor of Metalloproteinase-1 Levels Are Associated with Short Survival of Patients with Colorectal Cancer

Mads Nikolaj Holten-Andersen, Ross W. Stephens, Hans Jørgen Nielsen, Gillian Murphy, Ib Jarle Christensen, William Stetler-Stevenson, and Nils Brünner
Clin Cancer Res 2000 6: 4292 [Abstract] [Full Text] [PDF]  

FRA-1 Expression in Hyperplastic and Neoplastic Thyroid Diseases

Gennaro Chiappetta, Giovanni Tallini, Maria Cristina De Biasio, Francesca Pentimalli, Filomena de Nigris, Simona Losito, Monica Fedele, Sabrina Battista, Pasquale Verde, Massimo Santoro, and Alfredo Fusco
Clin Cancer Res 2000 6: 4300 [Abstract] [Full Text] [PDF]  

Increase in the Frequency of p16^INK4 Gene Inactivation by Hypermethylation in Lung Cancer during the Process of Metastasis and Its Relation to the Status of p53

Masahiro Seike, Akihiko Gemma, Yoko Hosoya, Shinobu Hemmi, Yasuyuki Taniguchi, Yuh Fukuda, Nobuaki Yamanaka, and Shoji Kudoh
Clin Cancer Res 2000 6: 4307 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Construction and Characterization of Bispecific Costimulatory Molecules Containing a Minimized CD86 (B7-2) Domain and Single-Chain Antibody Fragments for Tumor Targeting

Florian Rohrbach, Bernhard Gerstmayer, Markus Biburger, and Winfried Wels
Clin Cancer Res 2000 6: 4314 [Abstract] [Full Text] [PDF]  

Selectivity of TAG-72-targeted Adenovirus Gene Transfer to Primary Ovarian Carcinoma Cells versus Autologous Mesothelial Cells in Vitro

F. Joseph Kelly, C. Ryan Miller, Donald J. Buchsbaum, Jesus Gomez-Navarro, Mack N. Barnes, Ronald D. Alvarez, and David T. Curiel
Clin Cancer Res 2000 6: 4323 [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitors Decrease Proliferation and Modulate Cell Cycle Gene Expression in Normal Mammary Epithelial Cells

Tracey Davis, Catherine Kennedy, Yoke-Eng Chiew, Christine L. Clarke, and Anna deFazio
Clin Cancer Res 2000 6: 4334 [Abstract] [Full Text] [PDF]  

Antitumor Activity of Combined Treatment of Human Cancer Cells with Ionizing Radiation and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225 plus Type I Protein Kinase A Antisense Oligonucleotide

Cataldo Bianco, Roberto Bianco, Giampaolo Tortora, Vincenzo Damiano, Patrizia Guerrieri, Paolo Montemaggi, John Mendelsohn, Sabino De Placido, A. Raffaele Bianco, and Fortunato Ciardiello
Clin Cancer Res 2000 6: 4343 [Abstract] [Full Text] [PDF]  

Antitumor Therapeutic Potential of Activated Human Umbilical Cord Blood Cells against Leukemia and Breast Cancer

Shantaram S. Joshi, Stefano R. Tarantolo, Charles A. Kuszynski, and Anne Kessinger
Clin Cancer Res 2000 6: 4351 [Abstract] [Full Text] [PDF]  

Tamoxifen Inhibits Angiogenesis in Estrogen Receptor-negative Animal Models

Kimberly L. Blackwell, Zishan A. Haroon, Siging Shan, Willfred Saito, Gloria Broadwater, Charles S. Greenberg, and Mark W. Dewhirst
Clin Cancer Res 2000 6: 4359 [Abstract] [Full Text] [PDF]  

The Aromatic-L-Amino Acid Decarboxylase Inhibitor Carbidopa Is Selectively Cytotoxic to Human Pulmonary Carcinoid and Small Cell Lung Carcinoma Cells

Judith A. Gilbert, Linda M. Frederick, and Matthew M. Ames
Clin Cancer Res 2000 6: 4365 [Abstract] [Full Text] [PDF]  

Rapid Development of Tamoxifen-stimulated Mutant p53 Breast Tumors (T47D) in Athymic Mice

Jennifer MacGregor Schafer, Eun Sook Lee, Ruth M. O’Regan, Kathy Yao, and V. Craig Jordan
Clin Cancer Res 2000 6: 4373 [Abstract] [Full Text] [PDF]  

Induction of Antitumor Immunity with Combination of HER2/neu DNA Vaccine and Interleukin 2 Gene-modified Tumor Vaccine

Shi-An Chen, Ming-Huan Tsai Fu-Tien Wu, Ali Hsiang, Yi-Ling Chen, Huan-Yao Lei, Tzong-Shin Tzai, Henry W. C. Leung, Ying-Tai Jin, Chia-Ling Hsieh, Lih-Hwa Hwang, and Ming-Derg Lai
Clin Cancer Res 2000 6: 4381 [Abstract] [Full Text] [PDF]  

The Importance of p53-Independent Apoptosis in the Intestinal Toxicity Induced by Raltitrexed (ZD1694, Tomudex): Genetic Differences between BALB/c and DBA/2 Mice

D. Mark Pritchard, Lawrence Bower, Christopher S. Potten, Ann L. Jackman, and John A. Hickman
Clin Cancer Res 2000 6: 4389 [Abstract] [Full Text] [PDF]  

Specific Distribution of TOP-53 to the Lung and Lung-Localized Tumor Is Determined by its Interaction with Phospholipids

Masahiko Yoshida, Takashi Kobunai, Kumio Aoyagi, Hitoshi Saito, Teruhiro Utsugi, Konstanty Wierzba, and Yuji Yamada
Clin Cancer Res 2000 6: 4396 [Abstract] [Full Text] [PDF]  

Prostate Cancer Radiosensitization in Vivo with Adenovirus-mediated p53 Gene Therapy

Didier Cowen, Naji Salem, Faramarz Ashoori, Ray Meyn, Marvin L. Meistrich, Jack A. Roth, and Alan Pollack
Clin Cancer Res 2000 6: 4402 [Abstract] [Full Text] [PDF]  

Bioactivation of Tegafur to 5-Fluorouracil Is Catalyzed by Cytochrome P-450 2A6 in Human Liver Microsomes in Vitro

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima, Sekio Nagayama, Kaoru Kobayashi, Charles A. Tyson, Kan Chiba, and Yasuro Kawaguchi
Clin Cancer Res 2000 6: 4409 [Abstract] [Full Text] [PDF]  

Increased Oral Bioavailability of Paclitaxel by GF120918 in Mice through Selective Modulation of P-glycoprotein

Heleen A. Bardelmeijer, Jos H. Beijnen, Kenneth R. Brouwer, Hilde Rosing, Willem J. Nooijen, Jan H. M. Schellens, and Olaf van Tellingen
Clin Cancer Res 2000 6: 4416 [Abstract] [Full Text] [PDF]  

Gene Therapy of Human Bladder Cancer with Adenovirus-mediated Antisense Basic Fibroblast Growth Factor

Keiji Inoue, Paul Perrotte, Christopher G. Wood, Joel W. Slaton, Paul Sweeney, and Colin P. N. Dinney
Clin Cancer Res 2000 6: 4422 [Abstract] [Full Text] [PDF]  

p53 Dependence of Fas Induction and Acute Apoptosis in Response to 5-Fluorouracil-Leucovorin in Human Colon Carcinoma Cell Lines

Istvan Petak, David M. Tillman, and Janet A. Houghton
Clin Cancer Res 2000 6: 4432 [Abstract] [Full Text] [PDF]  

Genetically Modified CD34⁺ Cells Exert a Cytotoxic Bystander Effect on Human Endothelial and Cancer Cells

Waleed O. Arafat, Enrique Casado, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Joseph C. Glorioso, David T. Curiel, and Jesús Gómez-Navarro
Clin Cancer Res 2000 6: 4442 [Abstract] [Full Text] [PDF]  

Kupffer Cells Do Not Play a Role in Governing the Efficacy of Liposomal Mitoxantrone Used to Treat a Tumor Model Designed to Assess Drug Delivery to Liver

Howard J. Lim, Michael J. Parr, Dana Masin, Natashia L. McIntosh, Thomas D. Madden, Guoyang Zhang, Sharon Johnstone, and Marcel B. Bally
Clin Cancer Res 2000 6: 4449 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: A. E. Biemer-Huttmann et al., Mucin Core Protein Expression in Colorectal Cancers with High Levels of Microsatellite Instability Indicates a Novel Pathway of Morphogenesis. Clin. Cancer Res., 6: 1909–1916, 2000.

Leonor David, Filipe Silva, Raquel Seruca, Mafalda Pinto, Celso Reis, and Manuel Sobrinho-Simões
Clin Cancer Res 2000 6: 4461 [Abstract] [Full Text] [PDF]  

Reply

Jeremy R. Jass
Clin Cancer Res 2000 6: 4461 [Abstract] [Full Text] [PDF]  

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