The Biology Behind...:

Protease Inhibitors in Oral Carcinogenesis and Chemoprevention

Scott M. Lippman and Lynn M. Matrisian
Clin Cancer Res 2000 6: 4599 [Full Text] [PDF]  

Editorials:

Angiogenesis and Lung Cancer: Potential for Therapy

Roy S. Herbst and Isaiah J. Fidler
Clin Cancer Res 2000 6: 4604 [Full Text] [PDF]  

On Receptor Inhibitors and Chemotherapy

Paula D. Ryan and Bruce A. Chabner
Clin Cancer Res 2000 6: 4607 [Full Text] [PDF]  

Advances in Brief:

Paclitaxel-induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration: Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment

W. Fraser Symmans, Matthew D. Volm, Richard L. Shapiro, A. Bridget Perkins, Alice Y. Kim, Sandra Demaria, Herman T. Yee, Heather McMullen, Ruth Oratz, Paula Klein, Silvia C. Formenti, and Franco Muggia
Clin Cancer Res 2000 6: 4610 [Abstract] [Full Text] [PDF]  

MDR1 Gene Overexpression and Altered Degree of Methylation at the Promoter Region in Bladder Cancer during Chemotherapeutic Treatment

Yasuhiro Tada, Morimasa Wada, Kentaro Kuroiwa, Naoko Kinugawa, Taishi Harada, Jun Nagayama, Masayuki Nakagawa, Seiji Naito, and Michihiko Kuwano
Clin Cancer Res 2000 6: 4618 [Abstract] [Full Text] [PDF]  

Serum Endostatin Levels Are Elevated and Correlate with Serum Vascular Endothelial Growth Factor Levels in Patients with Stage IV Clear Cell Renal Cancer

Andrew L. Feldman, Lawrence Tamarkin, Giulio F. Paciotti, Byron W. Simpson, W. Marston Linehan, James C. Yang, William E. Fogler, Ewa M. Turner, H. Richard Alexander, Jr., and Steven K. Libutti
Clin Cancer Res 2000 6: 4628 [Abstract] [Full Text] [PDF]  

Expression of Cytoplasmic Galectin-3 as a Prognostic Marker in Tongue Carcinoma

Yuichiro Honjo, Hidenori Inohara, Shiro Akahani, Tadashi Yoshii, Yukinori Takenaka, Jun-ichi Yoshida, Kenji Hattori, Yoichiro Tomiyama, Avraham Raz, and Takeshi Kubo
Clin Cancer Res 2000 6: 4635 [Abstract] [Full Text] [PDF]  

Detection of Germ-Cell Tumor Cells in Peripheral Blood Progenitor Cell Harvests: Impact on Clinical Outcome

Martin Hildebrandt, Oliver Rick, Abdulgabar Salama, Wolfgang Siegert, Dieter Huhn, and Jörg Beyer
Clin Cancer Res 2000 6: 4641 [Abstract] [Full Text] [PDF]  

8pter–p23 Deletion Is Associated with Racial Differences in Prostate Cancer Outcome

Joseph G. Washburn, Kirk J. Wojno, Jyotirmoy Dey, Isaac J. Powell, and Jill A. Macoska
Clin Cancer Res 2000 6: 4647 [Abstract] [Full Text] [PDF]  

Expression of Metastases-associated Genes in Cervical Cancers Resected in the Proliferative and Secretory Phases of the Menstrual Cycle

Silvia Formenti, Juan Felix, Dennis Salonga, Kathy Danenberg, Malcolm C. Pike, and Peter Danenberg
Clin Cancer Res 2000 6: 4653 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Vaccination with a Bivalent G_M2 and G_D2 Ganglioside Conjugate Vaccine: A Trial Comparing Doses of G_D2-Keyhole Limpet Hemocyanin

Paul B. Chapman, Donna Morrisey, Katherine S. Panageas, Linda Williams, Jonathan J. Lewis, Robert J. Israel, W. Bradley Hamilton, and Philip O. Livingston
Clin Cancer Res 2000 6: 4658 [Abstract] [Full Text] [PDF]  

Locoregional Cellular Immunotherapy for Patients with Advanced Esophageal Cancer

Uhi Toh, Hideaki Yamana, Susumu Sueyoshi, Toshiaki Tanaka, Fumihiko Niiya, Katsuko Katagiri, Hiromasa Fujita, Kazuo Shirozou, and Kyogo Itoh
Clin Cancer Res 2000 6: 4663 [Abstract] [Full Text] [PDF]  

Phase I Clinical Trial of the Chimeric Monoclonal Antibody (c30.6) in Patients with Metastatic Colorectal Cancer

Robyn L. Ward, Deborah Packham, Anne M. Smythe, Jayne Murray, Peter Anderson-Stewart, Neil Kitchen, Rosyln Muirhead, Peter Phillips, Peter Gray, Grant Bigg-Wither, Krishnan Prabakaran, Judy Freund, Michael Fullham, Michele Rule, David Dalley, Alan Meagher, Nicholas J. Hawkins, and Glenn M. Smith
Clin Cancer Res 2000 6: 4674 [Abstract] [Full Text] [PDF]  

Clinical Modulation of Oral Leukoplakia and Protease Activity by Bowman-Birk Inhibitor Concentrate in a Phase IIa Chemoprevention Trial

William B. Armstrong, Ann R. Kennedy, X. Steven Wan, Thomas H. Taylor, Quoc A. Nguyen, Jerald Jensen, Wayne Thompson, Westley Lagerberg, and Frank L. Meyskens, Jr.
Clin Cancer Res 2000 6: 4684 [Abstract] [Full Text] [PDF]  

Pharmacokinetics of the Chemopreventive Agent Oltipraz and of Its Metabolite M3 in Human Subjects after a Single Oral Dose

Peter J. O’Dwyer, Christine Szarka, James M. Brennan, Paul B. Laub, and James M. Gallo
Clin Cancer Res 2000 6: 4692 [Abstract] [Full Text] [PDF]  

A Phase II Study of Razoxane, an Antiangiogenic Topoisomerase II Inhibitor, in Renal Cell Cancer with Assessment of Potential Surrogate Markers of Angiogenesis

Jeremy P. Braybrooke, Kenneth J. O’Byrne, David J. Propper, Andrew Blann, Mark Saunders, Nicola Dobbs, Cheng Han, Jane Woodhull, Karen Mitchell, Jeremy Crew, Kenneth Smith, Ross Stephens, Trivadi S. Ganesan, Denis C. Talbot, and Adrian L. Harris
Clin Cancer Res 2000 6: 4697 [Abstract] [Full Text] [PDF]  

Clinical Implications of Dihydropyrimidine Dehydrogenase (DPD) Deficiency in Patients with Severe 5-Fluorouracil-associated Toxicity: Identification of New Mutations in the DPD Gene

André B. P. van Kuilenburg, Janet Haasjes, Dick J. Richel, Lida Zoetekouw, Henk Van Lenthe, Ronney A. De Abreu, Jan G. Maring, Peter Vreken, and Albert H. van Gennip
Clin Cancer Res 2000 6: 4705 [Abstract] [Full Text] [PDF]  

White Blood Cell Count: A Prognostic Factor and Possible Subset Indicator of Optimal Treatment with Low-Dose Adjuvant Interferon in Primary Melanoma

Pauline de La Salmonière, Jean-Jacques Grob, Brigitte Dreno, Michèle Delaunay, and Claude Chastang
Clin Cancer Res 2000 6: 4713 [Abstract] [Full Text] [PDF]  

Phase I/II Study of G17-DT, an Anti-Gastrin Immunogen, in Advanced Colorectal Cancer

Andrew M. Smith, Timothy Justin, Dor Michaeli, and Susan A. Watson
Clin Cancer Res 2000 6: 4719 [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics of the Novel Marine-derived Anticancer Agent Ecteinascidin 743 in a Phase I Dose-finding Study

Charlotte van Kesteren, Esteban Cvitkovic, Adelkrim Taamma, Luis López-Lázaro, Jose M. Jimeno, Cecilia Guzman, Ron A. A. Mathôt, Jan H. M. Schellens, Jean-Louis Misset, Etienne Brain, Michael J. X. Hillebrand, Hilde Rosing, and Jos H. Beijnen
Clin Cancer Res 2000 6: 4725 [Abstract] [Full Text] [PDF]  

Multi-Institutional Validation Study of Carboplatin Dosing Formula Using Adjusted Serum Creatinine Level

Masahiko Ando, Hironobu Minami, Yuichi Ando, Hideo Saka, Shuzo Sakai, Masashi Yamamoto, Yasutsuna Sasaki, Kaoru Shimokata, and Yoshinori Hasegawa
Clin Cancer Res 2000 6: 4733 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Nitric Oxide Synthase, Cyclooxygenase 2, and Vascular Endothelial Growth Factor in the Angiogenesis of Non-Small Cell Lung Carcinoma

Aizen J. Marrogi, William D. Travis, Judith A. Welsh, Mohammed A. Khan, Haress Rahim, Henry Tazelaar, Peter Pairolero, Victor Trastek, James Jett, Neil E. Caporaso, Lance A. Liotta, and Curtis C. Harris
Clin Cancer Res 2000 6: 4739 [Abstract] [Full Text] [PDF]  

Relationship between c-erbB-2 and Other Tumor Characteristics in Breast Cancer Prognosis

Magali Ferrero-Poüs, Kamel Hacène, Cécile Bouchet, Viviane Le Doussal, Michèle Tubiana-Hulin, and Frédérique Spyratos
Clin Cancer Res 2000 6: 4745 [Abstract] [Full Text] [PDF]  

Spontaneous Apoptosis in Advanced Esophageal Carcinoma: Its Relation to Fas Expression

Muneaki Shibakita, Mitsuo Tachibana, Dipok K. Dhar, Satoshi Ohno, Hirofumi Kubota, Hiroshi Yoshimura, Shoichi Kinugasa, Reiko Masunaga, and Naofumi Nagasue
Clin Cancer Res 2000 6: 4755 [Abstract] [Full Text] [PDF]  

Detection of Epidermal Growth Factor Receptor in the Serum of Patients with Cervical Carcinoma

Min-Jeong Oh, Jin-Hyuk Choi, In Ho Kim, Yong Ho Lee, Joon Yong Huh, Yong Kyun Park, Kyu Wan Lee, Soo Yong Chough, Kap Soon Joo, Byung Sam Ku, and Ho-Suk Saw
Clin Cancer Res 2000 6: 4760 [Abstract] [Full Text] [PDF]  

PGP9.5 as a Prognostic Factor in Pancreatic Cancer

Ekmel Tezel, Kenji Hibi, Tetsuro Nagasaka, and Akimasa Nakao
Clin Cancer Res 2000 6: 4764 [Abstract] [Full Text] [PDF]  

Inducible Nitric Oxide Synthase and Nitrotyrosine in Human Metastatic Melanoma Tumors Correlate with Poor Survival

Suhendan Ekmekcioglu, Julie Ellerhorst, Christine M. Smid, Victor G. Prieto, Mark Munsell, Antonio C. Buzaid, and Elizabeth A. Grimm
Clin Cancer Res 2000 6: 4768 [Abstract] [Full Text] [PDF]  

Telomerase Activity in Soft-Tissue and Bone Sarcomas

Kenjiro Aogi, Anthony Woodman, Virginia Urquidi, David C. Mangham, David Tarin, and Steve Goodison
Clin Cancer Res 2000 6: 4776 [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity and Microsatellite Instability as Predictive Markers for Neoadjuvant Treatment in Gastric Carcinoma

Tobias Grundei, Holger Vogelsang, Katja Ott, James Mueller, Michael Scholz, Karen Becker, Ulrich Fink, Jörg Rüdiger Siewert, Heinz Höfler, and Gisela Keller
Clin Cancer Res 2000 6: 4782 [Abstract] [Full Text] [PDF]  

Expression of E-cadherin and ß-Catenin in Human Non-Small Cell Lung Cancer and the Clinical Significance

Shinichiro Kase, Kenji Sugio, Koji Yamazaki, Tatsuro Okamoto, Tokujiro Yano, and Keizo Sugimachi
Clin Cancer Res 2000 6: 4789 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Protein Expression in Primary Colorectal Cancer Compared with the Corresponding Distant Metastases and Relationship with the Clinical Response to 5-Fluorouracil

Carlo Aschele, Domizia Debernardis, Gianni Tunesi, Frank Maley, and Alberto Sobrero
Clin Cancer Res 2000 6: 4797 [Abstract] [Full Text] [PDF]  

Expression of the Human Telomerase Reverse Transcriptase Is Not Related to Telomerase Activity in Normal and Malignant Renal Tissue

Volker Rohde, Hans-Peter Sattler, Thorsten Bund, Helmut Bonkhoff, Thomas Fixemer, Christa Bachmann, Ramona Lensch, Gerhard Unteregger, Michael Stoeckle, and Bernd Wullich
Clin Cancer Res 2000 6: 4803 [Abstract] [Full Text] [PDF]  

A Genetic Epidemiological Study of Hereditary Prostate Cancer (HPC) in Finland: Frequent HPCX Linkage in Families with Late-onset Disease

Johanna Schleutker, Mika Matikainen, Jeffrey Smith, Pasi Koivisto, Agnes Baffoe-Bonnie, Tommi Kainu, Elizabeth Gillanders, Risto Sankila, Eero Pukkala, John Carpten, Dietrich Stephan, Teuvo Tammela, Michael Brownstein, Joan Bailey-Wilson, Jeffrey Trent, and Olli-P. Kallioniemi
Clin Cancer Res 2000 6: 4810 [Abstract] [Full Text] [PDF]  

p27^Kip1 Expression Is Associated with Clinical Outcome in Advanced Epithelial Ovarian Cancer: Multivariate Analysis

Valeria Masciullo, Gabriella Ferrandina, Bruna Pucci, Francesco Fanfani, Silvia Lovergine, Juan Palazzo, Gianfranco Zannoni, Salvatore Mancuso, Giovanni Scambia, and Antonio Giordano
Clin Cancer Res 2000 6: 4816 [Abstract] [Full Text] [PDF]  

Interstitial Collagenases as Markers of Tumor Progression

Constance E. Brinckerhoff, Joni L. Rutter, and Ulrike Benbow
Clin Cancer Res 2000 6: 4823 [Abstract] [Full Text] [PDF]  

Paucity of Functional T-Cell Memory to Melanoma Antigens in Healthy Donors and Melanoma Patients

Madhav V. Dhodapkar, James W. Young, Paul B. Chapman, William I. Cox, Jean Francois Fonteneau, Sebastian Amigorena, Alan N. Houghton, Ralph M. Steinman, and Nina Bhardwaj
Clin Cancer Res 2000 6: 4831 [Abstract] [Full Text] [PDF]  

Preferential Adhesion of Prostate Cancer Cells to Bone Is Mediated by Binding to Bone Marrow Endothelial Cells as Compared to Extracellular Matrix Components in Vitro

Carlton R. Cooper, Lisa McLean, Michael Walsh, Jeremy Taylor, Satoru Hayasaka, Jasmine Bhatia, and Kenneth J. Pienta
Clin Cancer Res 2000 6: 4839 [Abstract] [Full Text] [PDF]  

The Angiogenesis Inhibitor SU5416 Has Long-lasting Effects on Vascular Endothelial Growth Factor Receptor Phosphorylation and Function

Dirk B. Mendel, Randall E. Schreck, David C. West, Guangmin Li, Laurie M. Strawn, Sheila S. Tanciongco, Stefan Vasile, Laura K. Shawver, and Julie M. Cherrington
Clin Cancer Res 2000 6: 4848 [Abstract] [Full Text] [PDF]  

CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers

Hiroshi Miyata, Yuichiro Doki, Hitoshi Shiozaki, Msatoshi Inoue, Msahiko Yano, Yoshiyuki Fujiwara, Hirofumi Yamamoto, Kiyonori Nishioka, Kentaro Kishi, and Morito Monden
Clin Cancer Res 2000 6: 4859 [Abstract] [Full Text] [PDF]  

The Prognostic Value of Angiogenesis Factor Expression for Predicting Recurrence and Metastasis of Bladder Cancer after Neoadjuvant Chemotherapy and Radical Cystectomy

Keiji Inoue, Joel W. Slaton, Takashi Karashima, Chiaki Yoshikawa, Taro Shuin, Paul Sweeney, Randall Millikan, and Colin P. N. Dinney
Clin Cancer Res 2000 6: 4866 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Paclitaxel Enhances the Effects of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody ImClone C225 in Mice with Metastatic Human Bladder Transitional Cell Carcinoma

Keiji Inoue, Joel W. Slaton, Paul Perrotte, Darren W. Davis, Christiane J. Bruns, Daniel J. Hicklin, David J. McConkey, Paul Sweeney, Robert Radinsky, and Colin P. N. Dinney
Clin Cancer Res 2000 6: 4874 [Abstract] [Full Text] [PDF]  

Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase

Francis M. Sirotnak, Maureen F. Zakowski, Vincent A. Miller, Howard I. Scher, and Mark G. Kris
Clin Cancer Res 2000 6: 4885 [Abstract] [Full Text] [PDF]  

Cross-Resistance of Triphenylethylene-type Antiestrogens but not ICI 182,780 in Tamoxifen-stimulated Breast Tumors Grown in Athymic Mice

Eun Sook Lee, Jennifer MacGregor Schafer, Kathy Yao, Gale England, Ruth M. O’Regan, Alexander De Los Reyes, and V. Craig Jordan
Clin Cancer Res 2000 6: 4893 [Abstract] [Full Text] [PDF]  

Cure of Metastatic Human Colonic Cancer in Mice with Radiolabeled Monoclonal Antibody Fragments

Thomas M. Behr, Rosalyn D. Blumenthal, Stavros Memtsoudis, Robert M. Sharkey, Stefan Gratz, Wolfgang Becker, and David M. Goldenberg
Clin Cancer Res 2000 6: 4900 [Abstract] [Full Text] [PDF]  

Efficacy with a Replication-selective Adenovirus Plus Cisplatin-based Chemotherapy: Dependence on Sequencing but not p53 Functional Status or Route of Administration

Carla Heise, Marilyn Lemmon, and David Kirn
Clin Cancer Res 2000 6: 4908 [Abstract] [Full Text] [PDF]  

Antisense of Human Peroxiredoxin II Enhances Radiation-induced Cell Death

Sun-Hee Park, Young Min Chung, Yong-Sik Lee, Hyung Jung Kim, Jun Suk Kim, Ho Zoon Chae, and Young Do Yoo
Clin Cancer Res 2000 6: 4915 [Abstract] [Full Text] [PDF]  

In Vivo Targeting of Malignant Melanoma by ¹²⁵Iodine- and ^99mTechnetium-labeled Single-chain Fv Fragments against High Molecular Weight Melanoma-associated Antigen

Norbert Kang, Stephen Hamilton, Joy Odili, George Wilson, and Jörg Kupsch
Clin Cancer Res 2000 6: 4921 [Abstract] [Full Text] [PDF]  

Response and Determinants of Sensitivity to Paclitaxel in Human Non-Small Cell Lung Cancer Tumors Heterotransplanted in Nude Mice

Roman Perez-Soler, Bonnie Kemp, Qing Ping Wu, Li Mao, Jorge Gomez, Anne Zeleniuch-Jacquotte, Herman Yee, Jin Soo Lee, Jaishree Jagirdar, and Yi He Ling
Clin Cancer Res 2000 6: 4932 [Abstract] [Full Text] [PDF]  

Pegylated Liposome-encapsulated Doxorubicin and Cisplatin Enhance the Effect of Radiotherapy in a Tumor Xenograft Model

Kevin J. Harrington, Gail Rowlinson-Busza, Konstantinos N. Syrigos, Richard G. Vile, Paul S. Uster, A. Michael Peters, and J. Simon W. Stewart
Clin Cancer Res 2000 6: 4939 [Abstract] [Full Text] [PDF]  

The Addition of Bryostatin 1 to Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) Chemotherapy Improves Response in a CHOP-resistant Human Diffuse Large Cell Lymphoma Xenograft Model

Ramzi M. Mohammad, Nathan R. Wall, Julie A. Dutcher, and Ayad M. Al-Katib
Clin Cancer Res 2000 6: 4950 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Arsenic Trioxide-mediated Cytotoxicity and Apoptosis in Prostate and Ovarian Carcinoma Cell Lines

Ruchan Uslu, Ulus Ali Sanli, Canfeza Sezgin, Bulent Karabulut, Ender Terzioglu, Serdar Bedii Omay, and Erdem Goker
Clin Cancer Res 2000 6: 4957 [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Correspondence re: M. Kondo et al., Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma. Clin. Cancer Res., 5: 4005–4012, 1999.

Tohru Utsunomiya, Mitsuo Shimada, Tatsuya Rikimaru, Keizo Sugimachi, Ken-Ichi Ohkura, Shihoko Kaku, Koji Yamada, and Ken-Ichi Taguchi
Clin Cancer Res 2000 6: 4965 [Abstract] [Full Text] [PDF]  

Errata:

Erratum/Correction

Clin Cancer Res 2000 6: 4967 [Full Text] [PDF]  

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