Editorials:

Can Molecular Assessment Improve Classification of Head and Neck Premalignancy?

Li Mao
Clin Cancer Res 2000 6: 321 [Full Text] [PDF]  

Modulation of Molecular Targets to Enhance Radiation

Paul M. Harari and Shyh-Min Huang
Clin Cancer Res 2000 6: 323 [Full Text] [PDF]  

Minireviews:

Targeted Toxins

Arthur E. Frankel, Robert J. Kreitman, and Edward A. Sausville
Clin Cancer Res 2000 6: 326 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Molecular Determinants of Response to TRAIL in Killing of Normal and Cancer Cells

Kunhong Kim, Michael J. Fisher, Shi-Qiong Xu, and Wafik S. El-Deiry
Clin Cancer Res 2000 6: 335 [Abstract] [Full Text] [PDF]  

Genetic Progression and Clonal Relationship of Recurrent Premalignant Head and Neck Lesions

Joseph Califano, William H. Westra, Glenn Meininger, Russel Corio, Wayne M. Koch, and David Sidransky
Clin Cancer Res 2000 6: 347 [Abstract] [Full Text] [PDF]  

Characterization of Intracellular Prostate-specific Antigen from Laser Capture Microdissected Benign and Malignant Prostatic Epithelium

David K. Ornstein, Chad Englert, John W. Gillespie, Cloud P. Paweletz, W. Marston Linehan, Michael R. Emmert-Buck, and Emanuel F. Petricoin, III
Clin Cancer Res 2000 6: 353 [Abstract] [Full Text] [PDF]  

Use of Allelic Loss to Predict Malignant Risk for Low-grade Oral Epithelial Dysplasia

Miriam P. Rosin, Xing Cheng, Catherine Poh, Wan L. Lam, Yongqian Huang, John Lovas, Ken Berean, Joel B. Epstein, Robert Priddy, Nhu D. Le, and Lewei Zhang
Clin Cancer Res 2000 6: 357 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Successful Surgical Removal of Occult Metastases of Medullary Thyroid Carcinoma Recurrences with the Help of Immunoscintigraphy and Radioimmunoguided Surgery

Claire de Labriolle-Vaylet, Pierre Cattan, Emile Sarfati, Michel Wioland, Claire Billotey, Claude Brochériou, Eric Rouvier, Anne de Roquancourt, William Rostène, Serge Askienazy, Jacques Barbet, Gérard Milhaud, and Anne Gruaz-Guyon
Clin Cancer Res 2000 6: 363 [Abstract] [Full Text] [PDF]  

Molecular Remission Induction with Retinoic Acid and Anti-CD33 Monoclonal Antibody HuM195 in Acute Promyelocytic Leukemia

Joseph G. Jurcic, Tony DeBlasio, Larry Dumont, Tzy-Jyun Yao, and David A. Scheinberg
Clin Cancer Res 2000 6: 372 [Abstract] [Full Text] [PDF]  

Angiogenesis, Thymidine Phosphorylase, and Resistance of Squamous Cell Head and Neck Cancer to Cytotoxic and Radiation Therapy

Michael I. Koukourakis, Alexandra Giatromanolaki, George Fountzilas, Efthimios Sivridis, Kevin C. Gatter, and Adrian L. Harris
Clin Cancer Res 2000 6: 381 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of Perillyl Alcohol Administered Four Times a Day

Gregory H. Ripple, Michael N. Gould, Rhoda Z. Arzoomanian, Dona Alberti, Chris Feierabend, Kris Simon, Kim Binger, Kendra D. Tutsch, Marcia Pomplun, Amy Wahamaki, Rebecca Marnocha, George Wilding, and Howard H. Bailey
Clin Cancer Res 2000 6: 390 [Abstract] [Full Text] [PDF]  

Phase I Study of ONO-4007, a Synthetic Analogue of the Lipid A Moiety of Bacterial Lipopolysaccharide

Johann Sebastian de Bono, Angus George Dalgleish, James Carmichael, Joseph Diffley, Fiona Jane Lofts, David Fyffe, Susan Ellard, Robert J. Gordon, Charles J. Brindley, and Thomas Ronald Jeffrey Evans
Clin Cancer Res 2000 6: 397 [Abstract] [Full Text] [PDF]  

Phase II Trial of Yttrium-90-DOTA-Biotin Pretargeted by NR-LU-10 Antibody/Streptavidin in Patients with Metastatic Colon Cancer

Susan J. Knox, Michael L. Goris, Margaret Tempero, Paul L. Weiden, Louis Gentner, Hazel Breitz, Gregory P. Adams, Donald Axworthy, Sally Gaffigan, Kyle Bryan, Darrell R. Fisher, David Colcher, Ivan D. Horak, and Louis M. Weiner
Clin Cancer Res 2000 6: 406 [Abstract] [Full Text] [PDF]  

Modulation of Clinical Drug Resistance in a B Cell Lymphoma Patient by the Protein Kinase Inhibitor 7-Hydroxystaurosporine: Presentation of a Novel Therapeutic Paradigm

Wyndham H. Wilson, Lynn Sorbara, William D. Figg, Erik K. Mont, Edward Sausville, Katherine E. Warren, Frank M. Balis, Ken Bauer, Mark Raffeld, Adrian M. Senderowicz, and Anne Monks
Clin Cancer Res 2000 6: 415 [Abstract] [Full Text] [PDF]  

A Neoadjuvant Clinical Trial in Colorectal Cancer Patients of the Human Anti-Idiotypic Antibody 105AD7, Which Mimics CD55

Lindy G. Durrant, Charles Maxwell-Armstrong, Declan Buckley, Schwann Amin, R. Adrian Robins, James Carmichael, and John H. Scholefield
Clin Cancer Res 2000 6: 422 [Abstract] [Full Text] [PDF]  

Effect of Food on the Pharmacokinetics of Oral MMI270B (CGS 27023A), a Novel Matrix Metalloproteinase Inhibitor

Ferry A. L. M. Eskens, Nicky C. Levitt, Alex Sparreboom, Les Choi, Richard Mather, Jaap Verweij, and Adrian L. Harris
Clin Cancer Res 2000 6: 431 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Detection and Analysis of Cancer Cells in Blood and Bone Marrow Using a Rare Event Imaging System

Stine-Kathrein Kraeft, Rebecca Sutherland, Laura Gravelin, Guan-Hong Hu, Louis H. Ferland, Paul Richardson, Anthony Elias, and Lan Bo Chen
Clin Cancer Res 2000 6: 434 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Mutations to Different Structural and Functional Regions of the p53 Gene in Breast Cancer

Brenda Powell, Richie Soong, Barry Iacopetta, Ram Seshadri, and Duncan R. Smith
Clin Cancer Res 2000 6: 443 [Abstract] [Full Text] [PDF]  

Quantitation of hTERT Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Ivan Bièche, Catherine Noguès, Valérie Paradis, Martine Olivi, Pierre Bedossa, Rosette Lidereau, and Michel Vidaud
Clin Cancer Res 2000 6: 452 [Abstract] [Full Text] [PDF]  

Altered Expression of ß-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of ß-catenin Gene Mutations

Vladimir Bilim, Takashi Kawasaki, Akiyoshi Katagiri, Shun-ji Wakatsuki, Kota Takahashi, and Yoshihiko Tomita
Clin Cancer Res 2000 6: 460 [Abstract] [Full Text] [PDF]  

Serum Total and Free Prostate-specific Antigen for Breast Cancer Diagnosis in Women

Margot H. Black, Maurizia Giai, Riccardo Ponzone, Piero Sismondi, He Yu, and Eleftherios P. Diamandis
Clin Cancer Res 2000 6: 467 [Abstract] [Full Text] [PDF]  

Loss of Imprinting of the IGF-II and H19 Genes in Epithelial Ovarian Cancer

Chun-Ling Chen, Sin-Ming Ip, Danny Cheng, Ling-Chui Wong, and Hextan Y. S. Ngan
Clin Cancer Res 2000 6: 474 [Abstract] [Full Text] [PDF]  

Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment

Nicholas Denko, Cornelia Schindler, Albert Koong, Keith Laderoute, Christopher Green, and Amato Giaccia
Clin Cancer Res 2000 6: 480 [Abstract] [Full Text] [PDF]  

Immunohistochemically Detected Thymidylate Synthase in Colorectal Cancer: An Independent Prognostic Factor of Survival

David Edler, Ulf Kressner, Peter Ragnhammar, Patrick G. Johnston, Inger Magnusson, Bengt Glimelius, Lars Påhlman, Gudrun Lindmark, and Henric Blomgren
Clin Cancer Res 2000 6: 488 [Abstract] [Full Text] [PDF]  

Enhanced GBX2 Expression Stimulates Growth of Human Prostate Cancer Cells via Transcriptional Up-Regulation of the Interleukin 6 Gene

Allen C. Gao, Wei Lou, and John T. Isaacs
Clin Cancer Res 2000 6: 493 [Abstract] [Full Text] [PDF]  

Vitamin D Receptor Polymorphisms Are Associated with Altered Prognosis in Patients with Malignant Melanoma

Peter E. Hutchinson, Joy E. Osborne, John T. Lear, Andrew G. Smith, P. William Bowers, Paul N. Morris, Peter W. Jones, Christopher York, Richard C. Strange, and Anthony A. Fryer
Clin Cancer Res 2000 6: 498 [Abstract] [Full Text] [PDF]  

Cysteine Proteinase Inhibitors Stefin A, Stefin B, and Cystatin C in Sera from Patients with Colorectal Cancer: Relation to Prognosis

Janko Kos, Marta Krasovec, Nina Cimerman, Hans Jørgen Nielsen, Ib Jarle Christensen, and Nils Brünner
Clin Cancer Res 2000 6: 505 [Abstract] [Full Text] [PDF]  

Expression Levels of Estrogen Receptor-, Estrogen Receptor-ß, Coactivators, and Corepressors in Breast Cancer

Junichi Kurebayashi, Takemi Otsuki, Hironori Kunisue, Katsuhiko Tanaka, Shigeru Yamamoto, and Hiroshi Sonoo
Clin Cancer Res 2000 6: 512 [Abstract] [Full Text] [PDF]  

Increased Expression of Cyclooxygenase-2 Protein in Human Gastric Carcinoma

Ho Yeong Lim, Hee Jae Joo, Jin Hyuk Choi, Jong Wook Yi, Mal Sook Yang, Do Yeun Cho, Hyun Soo Kim, Dong Ki Nam, Kyi Beom Lee, and Hugh Chul Kim
Clin Cancer Res 2000 6: 519 [Abstract] [Full Text] [PDF]  

p53 Gene Mutations Are Associated with Shortened Survival in Patients with Advanced Non-small Cell Lung Cancer: An Analysis of Medically Managed Patients

Isao Murakami, Keiko Hiyama, Shinichi Ishioka, Michio Yamakido, Fumiyoshi Kasagi, and Yasuyuki Yokosaki
Clin Cancer Res 2000 6: 526 [Abstract] [Full Text] [PDF]  

Serum Tumor Marker CA 125 Is an Early and Sensitive Indicator of Veno-Occlusive Disease in Children Undergoing Bone Marrow Transplantation

Jari Petäjä, Sari Pitkänen, Kim Vettenranta, Anders Fasth, and Markku Heikinheimo
Clin Cancer Res 2000 6: 531 [Abstract] [Full Text] [PDF]  

Mutational Analysis of the Transforming Growth Factor ß Receptor Type II Gene in Hereditary Nonpolyposis Colorectal Cancer and Early-onset Colorectal Cancer Patients

Ki-Hyuk Shin, Young Jin Park, and Jae-Gahb Park
Clin Cancer Res 2000 6: 536 [Abstract] [Full Text] [PDF]  

Topological Analysis of p21^WAF1/CIP1 Expression in Esophageal Squamous Dysplasia

Yasuhiro Shirakawa, Yoshio Naomoto, Masashi Kimura, Ryuichi Kawashima, Tomoki Yamatsuji, Takahiko Tamaki, Madoka Hamada, Minoru Haisa, and Noriaki Tanaka
Clin Cancer Res 2000 6: 541 [Abstract] [Full Text] [PDF]  

Expression of Protein Gene Product 9.5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors

Yinglin Wang, Peggy Einhorn, Timothy J. Triche, Robert C. Seeger, and C. Patrick Reynolds
Clin Cancer Res 2000 6: 551 [Abstract] [Full Text] [PDF]  

Prognostic Implication of Microsatellite Alteration Profiles in Early-Stage Non-small Cell Lung Cancer

Xiao Zhou, Bonnie L. Kemp, Fadlo R. Khuri, Diane Liu, Jack J. Lee, Weiguo Wu, Waun Ki Hong, and Li Mao
Clin Cancer Res 2000 6: 559 [Abstract] [Full Text] [PDF]  

Neurotensin Receptor-1 mRNA Analysis in Normal Pancreas and Pancreatic Disease

Li Wang, Helmut Friess, Zhaowen Zhu, Hans Graber, Arthur Zimmermann, Murray Korc, Jean-Claude Reubi, and Markus W. Büchler
Clin Cancer Res 2000 6: 566 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Expression in Untreated Osteosarcoma Is Predictive of Pulmonary Metastasis and Poor Prognosis

Mitsunori Kaya, Takuro Wada, Tomohiro Akatsuka, Satoshi Kawaguchi, Satoshi Nagoya, Masanobu Shindoh, Fumihiro Higashino, Fumie Mezawa, Futoshi Okada, and Seiichi Ishii
Clin Cancer Res 2000 6: 572 [Abstract] [Full Text] [PDF]  

Cathepsin B, a Prognostic Indicator in Lymph Node-negative Breast Carcinoma Patients: Comparison with Cathepsin D, Cathepsin L, and Other Clinical Indicators

Tamara T. Lah, Andrej Blejec, Janko Kos, Ella Gorodetsky, Robert Somers, and Ierachmiel Daskal
Clin Cancer Res 2000 6: 578 [Abstract] [Full Text] [PDF]  

In Multiple Myeloma, Circulating Hyperdiploid B Cells Have Clonotypic Immunoglobulin Heavy Chain Rearrangements and May Mediate Spread of Disease

Linda M. Pilarski, Nadia V. Giannakopoulos, Agnieszka J. Szczepek, Anna M. Masellis, Michael J. Mant, and Andrew R. Belch
Clin Cancer Res 2000 6: 585 [Abstract] [Full Text] [PDF]  

Significance of Neuron-specific Enolase Levels before and during Therapy for Small Cell Lung Cancer

James A. Bonner, Jeff A. Sloan, Kendrith M. Rowland, Jr., George G. Klee, John W. Kugler, James A. Mailliard, Martin Wiesenfeld, James E. Krook, Andrew W. Maksymiuk, Edward G. Shaw, Randolph S. Marks, and Edith A. Perez
Clin Cancer Res 2000 6: 597 [Abstract] [Full Text] [PDF]  

Alterations in the Expression of the DNA Repair/Redox Enzyme APE/ref-1 in Epithelial Ovarian Cancers

David H. Moore, Helen Michael, Renee Tritt, Stephen H. Parsons, and Mark R. Kelley
Clin Cancer Res 2000 6: 602 [Abstract] [Full Text] [PDF]  

Bladder Cancer: Allelic Deletions at and around the Retinoblastoma Tumor Suppressor Gene in Relation to Stage and Grade

Takashi Wada, Jari Louhelainen, Kari Hemminki, Jan Adolfsson, Hans Wijkström, Ulf Norming, Erik Borgström, Johan Hansson, Bengt Sandstedt, and Gunnar Steineck
Clin Cancer Res 2000 6: 610 [Abstract] [Full Text] [PDF]  

Prediction of Clinical Outcome from Primary Tamoxifen by Expression of Biologic Markers in Breast Cancer Patients

Jenny Chang, Trevor J. Powles, D. Craig Allred, Sue E. Ashley, Andreas Makris, R. Kate Gregory, C. Kent Osborne, and Mitch Dowsett
Clin Cancer Res 2000 6: 616 [Abstract] [Full Text] [PDF]  

Enhancement of Angiogenesis, Tumor Growth, and Metastasis by Transfection of Vascular Endothelial Growth Factor into LoVo Human Colon Cancer Cell Line

Yoko Kondo, Shigeki Arii, Akira Mori, Masaharu Furutani, Tsutomu Chiba, and Masayuki Imamura
Clin Cancer Res 2000 6: 622 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

The Combined Use of an Immunotoxin and a Radioimmunoconjugate to Treat Disseminated Human B-Cell Lymphoma in Immunodeficient Mice

Bih-Rong Wei, Maria-Ana Ghetie, and Ellen S. Vitetta
Clin Cancer Res 2000 6: 631 [Abstract] [Full Text] [PDF]  

Methionine Depletion Enhances the Antitumoral Efficacy of Cytotoxic Agents in Drug-resistant Human Tumor Xenografts

F. Poirson-Bichat, R. A. Bras Gonçalves, L. Miccoli, B. Dutrillaux, and M. F. Poupon
Clin Cancer Res 2000 6: 643 [Abstract] [Full Text] [PDF]  

Prolonged Response to Antisense Cyclin D1 in a Human Squamous Cancer Xenograft Model

Edward R. Sauter, Meenhard Herlyn, Shao-Chen Liu, Samuel Litwin, and John A. Ridge
Clin Cancer Res 2000 6: 654 [Abstract] [Full Text] [PDF]  

Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol

Keith C. Bible, Scott A. Boerner, Kathryn Kirkland, Kari L. Anderl, Duane Bartelt, Jr., Phyllis A. Svingen, Timothy J. Kottke, Yean K. Lee, Steven Eckdahl, Paul G. Stalboerger, Robert B. Jenkins, and Scott H. Kaufmann
Clin Cancer Res 2000 6: 661 [Abstract] [Full Text] [PDF]  

Mismatch Repair and p53 Independently Affect Sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea

Gabriele Aquilina, Sabrina Ceccotti, Simone Martinelli, Silvia Soddu, Marco Crescenzi, Pauline Branch, Peter Karran, and Margherita Bignami
Clin Cancer Res 2000 6: 671 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis in Malignant B Cells by Phenylbutyrate or Phenylacetate in Combination with Chemotherapeutic Agents

Thomas E. Witzig, Michael Timm, Mary Stenson, Phyllis A. Svingen, and Scott H. Kaufmann
Clin Cancer Res 2000 6: 681 [Abstract] [Full Text] [PDF]  

Hairy Cell Leukemia, a B-Cell Neoplasm That Is Particularly Sensitive to the Cytotoxic Effect of Anti-Tac(Fv)-PE38 (LMB-2)

David H. Robbins, Inger Margulies, Maryalice Stetler-Stevenson, and Robert J. Kreitman
Clin Cancer Res 2000 6: 693 [Abstract] [Full Text] [PDF]  

In Vivo Enhancement of Tumor Radioresponse by C225 Antiepidermal Growth Factor Receptor Antibody

Luka Milas, Kathy Mason, Nancy Hunter, Sven Petersen, Michitaka Yamakawa, Kian Ang, John Mendelsohn, and Zhen Fan
Clin Cancer Res 2000 6: 701 [Abstract] [Full Text] [PDF]  

Regression of U-87 MG Human Glioblastomas in Nude Mice after Treatment with a Cytotoxic Somatostatin Analog AN-238

Hippokratis Kiaris, Andrew V. Schally, Attila Nagy, Baodong Sun, Karoly Szepeshazi, and Gabor Halmos
Clin Cancer Res 2000 6: 709 [Abstract] [Full Text] [PDF]  

Overexpression of Bax Enhances Antitumor Activity of Chemotherapeutic Agents in Human Head and Neck Squamous Cell Carcinoma

Bin Guo, Shousong Cao, Károly Tóth, Rami G. Azrak, and Youcef M. Rustum
Clin Cancer Res 2000 6: 718 [Abstract] [Full Text] [PDF]  

Treatment of Isografted 9L Rat Brain Tumors with ß-5-o-Carboranyl-2'-Deoxyuridine Neutron Capture Therapy

Raymond F. Schinazi, Selwyn J. Hurwitz, Irina Liberman, Amy S. Juodawlkis, Phillip Tharnish, Junxing Shi, Dennis C. Liotta, Jeffrey A. Coderre, and Jeffrey Olson
Clin Cancer Res 2000 6: 725 [Abstract] [Full Text] [PDF]  

The Topoisomerase I Inhibitor DX-8951f Is Active in a Severe Combined Immunodeficient Mouse Model of Human Acute Myelogenous Leukemia

Norbert Vey, Francis J. Giles, Hagop Kantarjian, Terry L. Smith, Miloslav Beran, and Sima Jeha
Clin Cancer Res 2000 6: 731 [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Activity of Protein Kinase C Inhibitor Chelerythrine Chloride Induces Tumor Cell Toxicity and Growth Delay in Vivo

Steven J. Chmura, M. Eileen Dolan, Amy Cha, Helena J. Mauceri, Donald W. Kufe, and Ralph R. Weichselbaum
Clin Cancer Res 2000 6: 737 [Abstract] [Full Text] [PDF]  

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