Editorials:

Cytochrome P-450 and Other Determinants of Pharmacokinetics, Toxicity, and Efficacy in Humans

Jerry M. Collins
Clin Cancer Res 2000 6: 1203 [Full Text] [PDF]  

Review:

Clinical Pharmacokinetics of Oxaliplatin: A Critical Review

Martin A. Graham, Graham F. Lockwood, Dennis Greenslade, Silvano Brienza, Martine Bayssas, and Erick Gamelin
Clin Cancer Res 2000 6: 1205 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Universal Inactivation of Both p16 and p15 but not Downstream Components Is an Essential Event in the Pathogenesis of T-Cell Acute Lymphoblastic Leukemia

Motoko Omura-Minamisawa, Mitchell B. Diccianni, Ayse Batova, Ray C. Chang, Louis J. Bridgeman, John Yu, Jeanette Pullen, W. Paul Bowman, and Alice L. Yu
Clin Cancer Res 2000 6: 1219 [Abstract] [Full Text] [PDF]  

Up-Regulation of Cyclooxygenase-2 in Squamous Carcinogenesis of the Esophagus

Awad Shamma, Hirofumi Yamamoto, Yuichiro Doki, Jiro Okami, Motoi Kondo, Yoshiyuki Fujiwara, Masahiko Yano, Masatoshi Inoue, Nariaki Matsuura, Hitoshi Shiozaki, and Morito Monden
Clin Cancer Res 2000 6: 1229 [Abstract] [Full Text] [PDF]  

Adenoviral Expression of p53 Represses Telomerase Activity through Down-Regulation of Human Telomerase Reverse Transcriptase Transcription

Taro Kanaya, Satoru Kyo, Katsuyuki Hamada, Masahiro Takakura, Yasuhide Kitagawa, Hironobu Harada, and Masaki Inoue
Clin Cancer Res 2000 6: 1239 [Abstract] [Full Text] [PDF]  

Carboxyamido-triazole Induces Apoptosis in Bovine Aortic Endothelial and Human Glioma Cells

Shugang Ge, Sandra A. Rempel, George Divine, and Tom Mikkelsen
Clin Cancer Res 2000 6: 1248 [Abstract] [Full Text] [PDF]  

Clinical Trials:

The Effect of an Individual’s Cytochrome CYP3A4 Activity on Docetaxel Clearance

JoAnn Hirth, Paul B. Watkins, Myla Strawderman, Anne Schott, René Bruno, and Laurence H. Baker
Clin Cancer Res 2000 6: 1255 [Abstract] [Full Text] [PDF]  

A Safety and Pharmacokinetic Study of a Mixed-Backbone Oligonucleotide (GEM231) Targeting the Type I Protein Kinase A by Two-hour Infusions in Patients with Refractory Solid Tumors

Helen X. Chen, John L. Marshall, Elizabeth Ness, R. Russell Martin, Barry Dvorchik, Naiyer Rizvi, Judith Marquis, Margo McKinlay, William Dahut, and Michael J. Hawkins
Clin Cancer Res 2000 6: 1259 [Abstract] [Full Text] [PDF]  

Phase I Trial of Combined Immunotherapy with Subcutaneous Granulocyte Macrophage Colony-stimulating Factor, Low-Dose Interleukin 2, and Interferon in Progressive Metastatic Melanoma and Renal Cell Carcinoma

Gijsbert C. de Gast, Heinz-Joseph Klümpen, Florry A. Vyth-Dreese, Marie-José Kersten, Natascha C. V. Verra, Johan Sein, Dian Batchelor, Willem J. Nooijen, and Jan H. Schornagel
Clin Cancer Res 2000 6: 1267 [Abstract] [Full Text] [PDF]  

Mouse Mammary Tumor Virus-like ENV Gene Sequences in Human Breast Tumors and in a Lymphoma of a Breast Cancer Patient

Polly Etkind, Juan Du, Ateeque Khan, Joan Pillitteri, and Peter H. Wiernik
Clin Cancer Res 2000 6: 1273 [Abstract] [Full Text] [PDF]  

(F-18) Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Pathologic Grade and Other Prognostic Variables in Bone and Soft Tissue Sarcoma

Andrew L. Folpe, Robert H. Lyles, Jason T. Sprouse, E. U. Conrad, III, and Janet F. Eary
Clin Cancer Res 2000 6: 1279 [Abstract] [Full Text] [PDF]  

Topotecan Lacks Third Space Sequestration

Hans Gelderblom, Walter J. Loos, Jaap Verweij, Maja J. A. de Jonge, and Alex Sparreboom
Clin Cancer Res 2000 6: 1288 [Abstract] [Full Text] [PDF]  

Novel Marine-derived Anticancer Agents: A Phase I Clinical, Pharmacological, and Pharmacodynamic Study of Dolastatin 10 (NSC 376128) in Patients with Advanced Solid Tumors

Timothy Madden, Hai T. Tran, Debrah Beck, Reeves Huie, Robert A. Newman, Lajos Pusztai, John J. Wright, and James L. Abbruzzese
Clin Cancer Res 2000 6: 1293 [Abstract] [Full Text] [PDF]  

A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma

Richard A. Messmann, Ellen S. Vitetta, Donna Headlee, Adrian M. Senderowicz, William D. Figg, John Schindler, Dennis F. Michiel, Steven Creekmore, Seth M. Steinberg, David Kohler, Elaine S. Jaffe, Maryalice Stetler-Stevenson, Huachun Chen, Victor Ghetie, and Edward A. Sausville
Clin Cancer Res 2000 6: 1302 [Abstract] [Full Text] [PDF]  

Intravenous Ifosfamide/Mesna Is Associated with Depletion of Plasma Thiols without Depletion of Leukocyte Glutathione

Lakshmi Pendyala, Patrick J. Creaven, Gary Schwartz, Neal J. Meropol, Wanda Bolanowska-Higdon, Joseph Zdanowicz, Michael Murphy, and Raymond Perez
Clin Cancer Res 2000 6: 1314 [Abstract] [Full Text] [PDF]  

Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

Dennis Salonga, Kathleen D. Danenberg, Martin Johnson, Ralf Metzger, Susan Groshen, Denice D. Tsao-Wei, Heinz-Josef Lenz, C. Gail Leichman, Lawrence Leichman, Robert B. Diasio, and Peter V. Danenberg
Clin Cancer Res 2000 6: 1322 [Abstract] [Full Text] [PDF]  

Sequential Treatment of a Resistant Chronic Lymphocytic Leukemia Patient with Bryostatin 1 Followed by 2-Chlorodeoxyadenosine: Case Report

Ishtiaq Ahmad, Ayad M. Al-Katib, Frances W. J. Beck, and Ramzi M. Mohammad
Clin Cancer Res 2000 6: 1328 [Abstract] [Full Text] [PDF]  

A Multicenter Phase II Trial of Losoxantrone (DuP-941) in Hormone-refractory Metastatic Prostate Cancer

Susan D. Huan, Ronald B. Natale, David J. Stewart, George P. Sartiano, Philip J. Stella, John D. Roberts, Aston L. Symes, and Michael Finizio
Clin Cancer Res 2000 6: 1333 [Abstract] [Full Text] [PDF]  

7-Monohydroxyethylrutoside Protects against Chronic Doxorubicin-induced Cardiotoxicity When Administered Only Once Per Week

Frédérique A. A. van Acker, Saskia A. B. E. van Acker, Klaas Kramer, Guido R. M. M. Haenen, Aalt Bast, and Wim J. F. van der Vijgh
Clin Cancer Res 2000 6: 1337 [Abstract] [Full Text] [PDF]  

Altered Pharmacokinetics and Metabolism of CPT-11 in Liver Dysfunction: A Need for Guidelines

C. J. van Groeningen, W. J. F. Van der Vijgh, J. J. Baars, H. Stieltjes, K. Huibregtse, and H. M. Pinedo
Clin Cancer Res 2000 6: 1342 [Abstract] [Full Text] [PDF]  

Delayed-Type Hypersensitivity Response Is a Predictor of Peripheral Blood T-Cell Immunity after HER-2/neu Peptide Immunization

Mary L. Disis, Kathy Schiffman, Theodore A. Gooley, Douglas G. McNeel, Kristine Rinn, and Keith L. Knutson
Clin Cancer Res 2000 6: 1347 [Abstract] [Full Text] [PDF]  

Spontaneous Apoptosis of CD8⁺ T Lymphocytes in Peripheral Blood of Patients with Advanced Melanoma

Takao Saito, Grzegorz Dworacki, William Gooding, Michael T. Lotze, and Theresa L. Whiteside
Clin Cancer Res 2000 6: 1351 [Abstract] [Full Text] [PDF]  

The Orally Administered P-glycoprotein Inhibitor R101933 Does Not Alter the Plasma Pharmacokinetics of Docetaxel

Lia van Zuylen, Alex Sparreboom, Ate van der Gaast, Maria E. L. van der Burg, Vera van Beurden, Cornelis J. Bol, Robert Woestenborghs, Peter A. Palmer, and Jaap Verweij
Clin Cancer Res 2000 6: 1365 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Definition and Refinement of Chromosome 8p Regions of Loss of Heterozygosity in Gastric Cancer

Raffaele Baffa, Roberto Santoro, Florencia Bullrich, Bernadette Mandes, Hideshi Ishii, and Carlo M. Croce
Clin Cancer Res 2000 6: 1372 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Expression: An Independent Prognostic Factor for Local Recurrence, Distant Metastasis, Disease-free and Overall Survival in Rectal Cancer

David Edler, Marja Hallström, Patrick G. Johnston, Inger Magnusson, Peter Ragnhammar, and Henric Blomgren
Clin Cancer Res 2000 6: 1378 [Abstract] [Full Text] [PDF]  

Marked Increase of Trypsin(ogen) in Serum of Linitis Plastica (Gastric Cancer, Borrmann 4) Patients

Yasushi Ichikawa, Naohiko Koshikawa, Satoshi Hasegawa, Takashi Ishikawa, Nobuyoshi Momiyama, Chikara Kunizaki, Masazumi Takahashi, Yoshihiro Moriwaki, Hirotoshi Akiyama, Hiroyuki Yamaoka, Shunsuke Yanoma, Akira Tsuburaya, Yoji Nagashima, Hiroshi Shimada, and Kaoru Miyazaki
Clin Cancer Res 2000 6: 1385 [Abstract] [Full Text] [PDF]  

Concentrations of Galectin-3 in the Sera of Normal Controls and Cancer Patients

Ida Iurisci, Nicola Tinari, Clara Natoli, Domenico Angelucci, Ettore Cianchetti, and Stefano Iacobelli
Clin Cancer Res 2000 6: 1389 [Abstract] [Full Text] [PDF]  

Overexpression of the hOGG1 Gene and High 8-Hydroxy-2'-deoxyguanosine (8-OHdG) Lyase Activity in Human Colorectal Carcinoma: Regulation Mechanism of the 8-OHdG Level in DNA

Shohei Kondo, Shinya Toyokuni, Tomoyuki Tanaka, Hiroshi Hiai, Hisashi Onodera, Hiroshi Kasai, and Masayuki Imamura
Clin Cancer Res 2000 6: 1394 [Abstract] [Full Text] [PDF]  

BAX and PKC Modulate the Prognostic Impact of BCL2 Expression in Acute Myelogenous Leukemia

Steven M. Kornblau, Ha T. Vu, Peter Ruvolo, Zeev Estrov, Susan O’Brien, Jorge Cortes, Hagop Kantarjian, Michael Andreeff, and W. Stratford May
Clin Cancer Res 2000 6: 1401 [Abstract] [Full Text] [PDF]  

Allelic Loss and Microsatellite Alterations of Chromosome 3p14.2 Are More Frequent in Recurrent Cervical Dysplasias

W. Michael Lin, Eugenia A. Michalopulos, Nina Dhurander, Pui C. Cheng, William Robinson, Raheela Ashfaq, Robert L. Coleman, and Carolyn Y. Muller
Clin Cancer Res 2000 6: 1410 [Abstract] [Full Text] [PDF]  

Analysis of MLH1 and MSH2 Expression in Ovarian Cancer before and after Platinum Drug-based Chemotherapy

Goli Samimi, Daniel Fink, Nissi M. Varki, Amreen Husain, William J. Hoskins, David S. Alberts, and Stephen B. Howell
Clin Cancer Res 2000 6: 1415 [Abstract] [Full Text] [PDF]  

A Large 6q Deletion Is a Common Cytogenetic Alteration in Fibroadenomas, Pre-malignant Lesions, and Carcinomas of the Breast

Maria Grazia Tibiletti, Fausto Sessa, Barbara Bernasconi, Roberta Cerutti, Barbara Broggi, Daniela Furlan, Francesco Acquati, Marco Bianchi, Antonella Russo, Carlo Capella, and Roberto Taramelli
Clin Cancer Res 2000 6: 1422 [Abstract] [Full Text] [PDF]  

CpG Island Arrays: An Application toward Deciphering Epigenetic Signatures of Breast Cancer

Pearlly S. Yan, Martin R. Perry, Douglas E. Laux, Adam L. Asare, Charles W. Caldwell, and Tim Hui-Ming Huang
Clin Cancer Res 2000 6: 1432 [Abstract] [Full Text] [PDF]  

Detection of Circulating Tumor Cells in Carcinoma Patients by a Novel Epidermal Growth Factor Receptor Reverse Transcription-PCR Assay

Antonella De Luca, Sandro Pignata, Amelia Casamassimi, Antonio D’Antonio, Cesare Gridelli, Antonio Rossi, Francesco Cremona, Valerio Parisi, Andrea De Matteis, and Nicola Normanno
Clin Cancer Res 2000 6: 1439 [Abstract] [Full Text] [PDF]  

Clinical Significance of Serum Soluble Interleukin 2 Receptor- in Esophageal Squamous Cell Carcinoma

Liang-Shun Wang, Kuan-Chih Chow, Wing-Yin Li, Chia-Chuan Liu, Yu-Chung Wu, and Min-Hsiung Huang
Clin Cancer Res 2000 6: 1445 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

A Novel Approach for Nasopharyngeal Carcinoma Treatment Uses Phenylbutyrate as a Protein Kinase C Modulator: Implications for Radiosensitization and EBV-targeted Therapy

Yih-Lin Chung, Yan-Hwa Wu Lee, Sang-Hue Yen, and Kwan-Hwa Chi
Clin Cancer Res 2000 6: 1452 [Abstract] [Full Text] [PDF]  

High Avidity Melanoma-reactive Cytotoxic T Lymphocytes Are Efficiently Induced from Peripheral Blood Lymphocytes on Stimulation by Peptide-pulsed Melanoma Cells

Nadine Gervois, Nathalie Labarriere, Soizic Le Guiner, Marie-Christine Pandolfino, Jean-François Fonteneau, Yannik Guilloux, Elisabeth Diez, Brigitte Dreno, and Francine Jotereau
Clin Cancer Res 2000 6: 1459 [Abstract] [Full Text] [PDF]  

Preclinical Toxicity and Efficacy Study of a 14-day Schedule of Oral 5-Iodo-2-pyrimidinone-2'-deoxyribose as a Prodrug for 5-Iodo-2'-deoxyuridine Radiosensitization in U251 Human Glioblastoma Xenografts

Timothy J. Kinsella, Kathleen A. Vielhuber, Keith A. Kunugi, Jane Schupp, Thomas W. Davis, and Howard Sands
Clin Cancer Res 2000 6: 1468 [Abstract] [Full Text] [PDF]  

Cytotoxic Activity of Disulfide-stabilized Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) toward Fresh Malignant Cells from Patients with B-Cell Leukemias

Robert J. Kreitman, Inger Margulies, Maryalice Stetler-Stevenson, Qing-Cheng Wang, David J. P. FitzGerald, and Ira Pastan
Clin Cancer Res 2000 6: 1476 [Abstract] [Full Text] [PDF]  

Differential Cytotoxic Pathways of Topoisomerase I and II Anticancer Agents after Overexpression of the E2F-1/DP-1 Transcription Factor Complex

Kenneth Hofland, Birgit O. Petersen, Jacob Falck, Kristian Helin, Peter B. Jensen, and Maxwell Sehested
Clin Cancer Res 2000 6: 1488 [Abstract] [Full Text] [PDF]  

The in Vivo Effect of Bryostatin-1 on Paclitaxel-induced Tumor Growth, Mitotic Entry, and Blood Flow

Jason A. Koutcher, Monica Motwani, Kristen L. Zakian, Xiao-Kui Li, Cornelia Matei, Jonathan P. Dyke, Douglas Ballon, Hyok He Yoo, and Gary K. Schwartz
Clin Cancer Res 2000 6: 1498 [Abstract] [Full Text] [PDF]  

Synergistic Effect of Prochlorperazine and Dipyridamole on the Cellular Retention and Cytotoxicity of Doxorubicin

Awtar Krishan, Kasi S. Sridhar, Caihong Mou, Wilfred D. Stein, Elena Lyubimov, Yang-Ping Hu, and Hugo Fernandez
Clin Cancer Res 2000 6: 1508 [Abstract] [Full Text] [PDF]  

Requirement for the von Hippel-Lindau Tumor Suppressor Gene for Functional Epidermal Growth Factor Receptor Blockade by Monoclonal Antibody C225 in Renal Cell Carcinoma

Ayesh D. Perera, Elena V. Kleymenova, and Cheryl L. Walker
Clin Cancer Res 2000 6: 1518 [Abstract] [Full Text] [PDF]  

Differential Antiproliferative and Apoptotic Response of Sanguinarine for Cancer Cells versus Normal Cells

Nihal Ahmad, Sanjay Gupta, Mirza M. Husain, Kaisa M. Heiskanen, and Hasan Mukhtar
Clin Cancer Res 2000 6: 1524 [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Activity of 5-Fluorouracil in Combination with 2'-Deoxyinosine in Human Colorectal Cell Lines and Human Colon Tumor Xenografts

Joseph Ciccolini, Laurent Peillard, Alexandre Evrard, Pierre Cuq, Claude Aubert, André Pelegrin, Patricia Formento, Gérard Milano, and Jacques Catalin
Clin Cancer Res 2000 6: 1529 [Abstract] [Full Text] [PDF]  

Apoptosis-inducing Vanadocene Compounds against Human Testicular Cancer

Phalguni Ghosh, Osmond J. D’Cruz, Rama Krishna Narla, and Fatih M. Uckun
Clin Cancer Res 2000 6: 1536 [Abstract] [Full Text] [PDF]  

Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Apoptosis-inducing Anticancer Agent

Rama Krishna Narla, Yanhong Dong, Osmond J. D’Cruz, Christopher Navara, and Fatih M. Uckun
Clin Cancer Res 2000 6: 1546 [Abstract] [Full Text] [PDF]  

Homocamptothecin, an E-Ring-modified Camptothecin, Exerts More Potent Antiproliferative Activity than Other Topoisomerase I Inhibitors in Human Colon Cancers Obtained from Surgery and Maintained in Vitro under Histotypical Culture Conditions

Patrick Philippart, Luke Harper, Carole Chaboteaux, Christine Decaestecker, Yves Bronckart, Laurence Gordover, Laurence Lesueur-Ginot, Hughes Malonne, Olivier Lavergne, Dennis C. H. Bigg, Pierre Mendes da Costa, and Robert Kiss
Clin Cancer Res 2000 6: 1557 [Abstract] [Full Text] [PDF]  

Identification of Receptor-selective Retinoids That Are Potent Inhibitors of the Growth of Human Head and Neck Squamous Cell Carcinoma Cells

Shi-Yong Sun, Ping Yue, Li Mao, Marcia I. Dawson, Braham Shroot, William W. Lamph, Richard A. Heyman, Roshantha A. S. Chandraratna, Koichi Shudo, Waun K. Hong, and Reuben Lotan
Clin Cancer Res 2000 6: 1563 [Abstract] [Full Text] [PDF]  

The New Dioxolane, (-)-2'-Deoxy-3'-oxacytidine (BCH-4556, Troxacitabine), Has Activity against Pancreatic Human Tumor Xenografts

Steve Weitman, Jennifer Marty, Jacques Jolivet, Celine Locas, and Daniel D. Von Hoff
Clin Cancer Res 2000 6: 1574 [Abstract] [Full Text] [PDF]  

Caspase Activation and Changes in Bcl-2 Family Member Protein Expression Associated with E2F-1-mediated Apoptosis in Human Esophageal Cancer Cells

Hai Liang Yang, Yan Bin Dong, Mary Jane Elliott, Ta Jen Liu, and Kelly M. McMasters
Clin Cancer Res 2000 6: 1579 [Abstract] [Full Text] [PDF]  

Energy Metabolism of Human LoVo Colon Carcinoma Cells: Correlation to Drug Resistance and Influence of Lonidamine

Maurizio Fanciulli, Tiziana Bruno, Aldo Giovannelli, Francesco P. Gentile, Monica Di Padova, Oriana Rubiu, and Aristide Floridi
Clin Cancer Res 2000 6: 1590 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: W. M. Lin et al., Loss of Heterozygosity and Mutational Analysis of the PTEN/MMAC1 Gene in Synchronous Endometrial and Ovarian Carcinomas. Clin. Cancer Res., 4: 2577–2583, 1998.

Xavier Matias-Guiu, Elena Bussaglia, Lluis Catasus, Helena Lagarda, Esther Gras, Pilar Machin, Jaime Prat, W. Michael Lin, and Carolyn Y. Muller
Clin Cancer Res 2000 6: 1598 [Full Text] [PDF]  

Correspondence re: M. S. Tockman et al., Prospective Detection of Preclinical Lung Cancer: Results from Two Studies of Heterogeneous Nuclear Ribonucleoprotein A2/B1 Overexpression. Clin. Cancer Res., 3: 2237–2246, 1997.

C. Martin Tammemagi, Melvyn S. Tockman, James L. Mulshine, and Steven Piantadosi
Clin Cancer Res 2000 6: 1601 [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.