Editorials:

Molecular Imaging in Oncology: The Diagnostic Imaging "Revolution"

Steven M. Larson
Clin Cancer Res 2000 6: 2125 [Full Text] [PDF]  

Are We Ready to Use Surrogate End Points and Surrogate Tissues to Evaluate Response to Chemopreventive and Therapeutic Intervention?

Reuben Lotan
Clin Cancer Res 2000 6: 2126 [Full Text] [PDF]  

Review:

Detection of Mutated KRAS2 Sequences as Tumor Markers in Plasma/Serum of Patients with Gastrointestinal Cancer

George D. Sorenson
Clin Cancer Res 2000 6: 2129 [Abstract] [Full Text] [PDF]  

Gain-of-Function Mutations in the Tumor Suppressor Gene p53

Monique G. C. T. van Oijen and Pieter J. Slootweg
Clin Cancer Res 2000 6: 2138 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Rapid in Vivo Monitoring of Chemotherapeutic Response Using Weighted Sodium Magnetic Resonance Imaging

Richard P. Kline, Ed X. Wu, Daniel P. Petrylak, Matthias Szabolcs, Philip O. Alderson, Myron L. Weisfeldt, Paul Cannon, and Jose Katz
Clin Cancer Res 2000 6: 2146 [Abstract] [Full Text] [PDF]  

Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma

Robert W. Rand, Robert J. Kreitman, Nicholas Patronas, Frederick Varricchio, Ira Pastan, and Raj K. Puri
Clin Cancer Res 2000 6: 2157 [Abstract] [Full Text] [PDF]  

Modulation of Radiation Response after Epidermal Growth Factor Receptor Blockade in Squamous Cell Carcinomas: Inhibition of Damage Repair, Cell Cycle Kinetics, and Tumor Angiogenesis

Shyh-Min Huang and Paul M. Harari
Clin Cancer Res 2000 6: 2166 [Abstract] [Full Text] [PDF]  

Priming Tissue-specific Cellular Immunity in a Phase I Trial of Autologous Dendritic Cells for Prostate Cancer

Patrick A. Burch, Jami K. Breen, Jan C. Buckner, Dennis A. Gastineau, Judith A. Kaur, Reiner L. Laus, Douglas J. Padley, Madhusudan V. Peshwa, Henry C. Pitot, Ronald L. Richardson, Bouwien J. Smits, Pitsata Sopapan, George Strang, Frank H. Valone, and Stanimir Vuk-Pavlovic
Clin Cancer Res 2000 6: 2175 [Abstract] [Full Text] [PDF]  

Quantitative Analysis of Circulating Tumor Cells in Peripheral Blood of Osteosarcoma Patients Using Osteoblast-specific Messenger RNA Markers: A Pilot Study

Ivy H. N. Wong, Andrew T. Chan, and Philip J. Johnson
Clin Cancer Res 2000 6: 2183 [Abstract] [Full Text] [PDF]  

Clinical Trials:

High Microvascular Blood Volume Is Associated with High Glucose Uptake and Tumor Angiogenesis in Human Gliomas

Hannu J. Aronen, Francisco S. Pardo, David N. Kennedy, John W. Belliveau, Scott D. Packard, Dora W. Hsu, Frederick H. Hochberg, Alan J. Fischman, and Bruce R. Rosen
Clin Cancer Res 2000 6: 2189 [Abstract] [Full Text] [PDF]  

A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Dacarbazine, Interleukin 2, and Interferon -2B in Patients with Metastatic Melanoma

David F. McDermott, James W. Mier, Donald P. Lawrence, Marcel R. M. van den Brink, Marquerite A. Clancy, Krista M. Rubin, and Michael B. Atkins
Clin Cancer Res 2000 6: 2201 [Abstract] [Full Text] [PDF]  

T Cell Adoptive Immunotherapy of Newly Diagnosed Gliomas

Gregory E. Plautz, David W. Miller, Gene H. Barnett, Glen H. J. Stevens, Scott Maffett, Julian Kim, Peter A. Cohen, and Suyu Shu
Clin Cancer Res 2000 6: 2209 [Abstract] [Full Text] [PDF]  

Pilot Study of a Dual Gene Recombinant Avipox Vaccine Containing Both Carcinoembryonic Antigen (CEA) and B7.1 Transgenes in Patients with Recurrent CEA-expressing Adenocarcinomas

Margaret von Mehren, Philip Arlen, Kwong Y. Tsang, André Rogatko, Neal Meropol, Harry S. Cooper, Monica Davey, Susan McLaughlin, Jeffrey Schlom, and Louis M. Weiner
Clin Cancer Res 2000 6: 2219 [Abstract] [Full Text] [PDF]  

The Effects of Neoadjuvant Anastrozole (Arimidex) on Tumor Volume in Postmenopausal Women with Breast Cancer: A Randomized, Double-Blind, Single-Center Study

J. Michael Dixon, Lorna Renshaw, Chris Bellamy, Mary Stuart, Guido Hoctin-Boes, and William R. Miller
Clin Cancer Res 2000 6: 2229 [Abstract] [Full Text] [PDF]  

Phase I Dose-finding and Pharmacokinetic Trial of Irinotecan Hydrochloride (CPT-11) Using a Once-Every-Three-Week Dosing Schedule for Patients with Advanced Solid Tumor Malignancy

Henry C. Pitot, Richard M. Goldberg, Joel M. Reid, Jeff A. Sloan, Pam Atherton Skaff, Charles Erlichman, Joseph Rubin, Patrick A. Burch, Alex A. Adjei, Steven A. Alberts, Larry J. Schaaf, Gary Elfring, and Langdon L. Miller
Clin Cancer Res 2000 6: 2236 [Abstract] [Full Text] [PDF]  

Determination of Intermediate Biomarker Expression Levels by Quantitative Reverse Transcription-Polymerase Chain Reaction in Oral Mucosa of Cancer Patients Treated with Liarozole

Qing Zeng, David C. Smith, Todd J. Suscovich, William E. Gooding, Donald L. Trump, and Jennifer Rubin Grandis
Clin Cancer Res 2000 6: 2245 [Abstract] [Full Text] [PDF]  

Imaging of Soft-Tissue Tumors Using L-3-[Iodine-123]Iodo--methyl-tyrosine Single Photon Emission Computed Tomography: Comparison with Proliferative and Mitotic Activity, Cellularity, and Vascularity

Pieter L. Jager, Boudewijn E. C. Plaat, Elisabeth G. E. de Vries, Willemina M. Molenaar, Willem Vaalburg, D. Albertus Piers, and Harald J. Hoekstra
Clin Cancer Res 2000 6: 2252 [Abstract] [Full Text] [PDF]  

Antiproliferative Effects of Idoxifene in a Placebo-controlled Trial in Primary Human Breast Cancer

Mitch Dowsett, J. Michael Dixon, Kieran Horgan, Janine Salter, Margaret Hills, and Eileen Harvey
Clin Cancer Res 2000 6: 2260 [Abstract] [Full Text] [PDF]  

Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon- and Recombinant Interleukin 2 with or without Tumor-infiltrating Lymphocytes in Patients with Ovarian or Peritoneal Carcinoma

Ralph S. Freedman, Andrzej P. Kudelka, John J. Kavanagh, Claire Verschraegen, Creighton L. Edwards, Micheal Nash, Lawrence Levy, Edward N. Atkinson, Hua-Zhong Zhang, Bohuslav Melichar, Rebecca Patenia, Stacie Templin, Wanza Scott, and Chris D. Platsoucas
Clin Cancer Res 2000 6: 2268 [Abstract] [Full Text] [PDF]  

Dose-finding and Pharmacologic Study of Chronic Oral Idarubicin Therapy in Metastatic Breast Cancer Patients

Giuseppe Toffoli, Roberto Sorio, Paola Aita, Diana Crivellari, Giuseppe Corona, Alessandra Bearz, Isabel Robieux, Anna Maria Colussi, Franco Stocco, and Mauro Boiocchi
Clin Cancer Res 2000 6: 2279 [Abstract] [Full Text] [PDF]  

Phase I Trial of Oral 2'-Deoxy-2'-methylidenecytidine: On a Daily x 14-day Schedule

Noriyuki Masuda, Kaoru Matsui, Nobuyuki Yamamoto, Toshiji Nogami, Kazuhiko Nakagawa, Shunichi Negoro, Kouji Takeda, Nobuhide Takifuji, Masaji Yamada, Shinzoh Kudoh, Teruyoshi Okuda, Shinjiroh Nemoto, Kanako Ogawa, Hiroshi Myobudani, Shinichi Nihira, and Masahiro Fukuoka
Clin Cancer Res 2000 6: 2288 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Relative Expression of Type IV Collagenase, E-cadherin, and Vascular Endothelial Growth Factor/Vascular Permeability Factor in Prostatectomy Specimens Distinguishes Organ-confined from Pathologically Advanced Prostate Cancers

Hiroki Kuniyasu, Patricia Troncoso, Dennis Johnston, Corazon D. Bucana, Eiichi Tahara, Isaiah J. Fidler, and Curtis A. Pettaway
Clin Cancer Res 2000 6: 2295 [Abstract] [Full Text] [PDF]  

Extracellular Catalytic Subunit Activity of the cAMP-dependent Protein Kinase in Prostate Cancer

Mary Ellen Cvijic, Tsunekazu Kita, Weichung Shih, Robert S. DiPaola, and Khew-Voon Chin
Clin Cancer Res 2000 6: 2309 [Abstract] [Full Text] [PDF]  

Comparison of Potential Markers of Farnesyltransferase Inhibition

Alex A. Adjei, Jenny N. Davis, Charles Erlichman, Phyllis A. Svingen, and Scott H. Kaufmann
Clin Cancer Res 2000 6: 2318 [Abstract] [Full Text] [PDF]  

Genetic Detection for Micrometastasis in Lymph Node of Biliary Tract Carcinoma

Jiro Okami, Keizo Dohno, Masato Sakon, Kyoko Iwao, Terumasa Yamada, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Hiroaki Nagano, Koji Umeshita, Nariaki Matsuura, Shoji Nakamori, and Morito Monden
Clin Cancer Res 2000 6: 2326 [Abstract] [Full Text] [PDF]  

Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers

Cornelis F. M. Sier, Giovanni Casetta, Jan H. Verheijen, Alessandro Tizzani, Vittorio Agape, Janko Kos, Francesco Blasi, and Roeland Hanemaaijer
Clin Cancer Res 2000 6: 2333 [Abstract] [Full Text] [PDF]  

Clinicopathological Significance of Fragile Histidine Triad Transcription Protein Expression in Endometrial Carcinomas

Tomoya Segawa, Toshiyuki Sasagawa, Kiyofumi Saijoh, and Masaki Inoue
Clin Cancer Res 2000 6: 2341 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase 9 and the Epidermal Growth Factor Signal Pathway in Operable Non-Small Cell Lung Cancer

Giles Cox, J. Louise Jones, and Kenneth J. O’Byrne
Clin Cancer Res 2000 6: 2349 [Abstract] [Full Text] [PDF]  

Circulating HER2 Extracellular Domain and Resistance to Chemotherapy in Advanced Breast Cancer

Ramon Colomer, Sagrario Montero, Ana Lluch, Belén Ojeda, Agustí Barnadas, Antonio Casado, Bartomeu Massutí, Hernán Cortés-Funes, and Belén Lloveras
Clin Cancer Res 2000 6: 2356 [Abstract] [Full Text] [PDF]  

The Presence of Soluble c-erbB-2 in Saliva and Serum among Women with Breast Carcinoma: A Preliminary Study

Charles Streckfus, Lenora Bigler, Tracy Dellinger, Xaoli Dai, Albert Kingman, and J. Tate Thigpen
Clin Cancer Res 2000 6: 2363 [Abstract] [Full Text] [PDF]  

Expression of BAX in Plasma Cell Dyscrasias

Stephen Renner, Jeffrey Weisz, Stanislaw Krajewski, Maryla Krajewska, John C. Reed, and Alan Lichtenstein
Clin Cancer Res 2000 6: 2371 [Abstract] [Full Text] [PDF]  

Noninvasive Diagnosis of Bladder Carcinoma by Enzyme-linked Immunosorbent Assay Detection of CD44 Isoforms in Exfoliated Urothelia

Anthony C. Woodman, Steve Goodison, Marcus Drake, Jeremy Noble, and David Tarin
Clin Cancer Res 2000 6: 2381 [Abstract] [Full Text] [PDF]  

Detection by Denaturant Gradient Gel Electrophoresis of Tumor-specific Mutations in Biopsies and Relative Bronchoalveolar Lavage Fluid from Resectable Non-Small Cell Lung Cancer

Gianluigi Ferretti, Giuseppe Curigliano, Ugo Pastorino, Achille Cittadini, Giovanna Flamini, Maria Grazia Calabrò, Tommaso De Pas, Laura Orlando, Mario Mandalà, Marco Colleoni, Lorenzo Spaggiari, Pier Luigi Granone, Gabriella Pagliari, Filippo de Braud, Nicola Fazio, and Aron Goldhirsch
Clin Cancer Res 2000 6: 2393 [Abstract] [Full Text] [PDF]  

Increased Expression of an ATP-binding Cassette Superfamily Transporter, Multidrug Resistance Protein 2, in Human Colorectal Carcinomas

Eiji Hinoshita, Takeshi Uchiumi, Ken-ichi Taguchi, Naoko Kinukawa, Masazumi Tsuneyoshi, Yoshihiko Maehara, Keizo Sugimachi, and Michihiko Kuwano
Clin Cancer Res 2000 6: 2401 [Abstract] [Full Text] [PDF]  

Inducible Nitric Oxide Synthase Expression, Apoptosis, and Angiogenesis in in Situ and Invasive Breast Carcinomas

Merja Vakkala, Katriina Kahlos, Essi Lakari, Paavo Pääkkö, Vuokko Kinnula, and Ylermi Soini
Clin Cancer Res 2000 6: 2408 [Abstract] [Full Text] [PDF]  

Immunohistochemical Analyses of Focal Adhesion Kinase Expression in Benign and Malignant Human Breast and Colon Tissues: Correlation with Preinvasive and Invasive Phenotypes

William G. Cance, Janet E. Harris, Mary V. Iacocca, Elizabeth Roche, XiHui Yang, Jinli Chang, Stephen Simkins, and LiHui Xu
Clin Cancer Res 2000 6: 2417 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression Is Up-Regulated in Transitional Cell Carcinoma and Its Preneoplastic Lesions in the Human Urinary Bladder

Tsutomu Shirahama
Clin Cancer Res 2000 6: 2424 [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factors A, B, C, and D and Their Relationships to Lymph Node Status in Lung Adenocarcinoma

Toshiro Niki, Sanae Iba, Masahide Tokunou, Tesshi Yamada, Yoshihiro Matsuno, and Setsuo Hirohashi
Clin Cancer Res 2000 6: 2431 [Abstract] [Full Text] [PDF]  

Association between Polymorphism in p21^Waf1/Cip1 Cyclin-dependent Kinase Inhibitor Gene and Human Oral Cancer

Ranju Ralhan, Sandhya Agarwal, Meera Mathur, Bohdan Wasylyk, and Anurag Srivastava
Clin Cancer Res 2000 6: 2440 [Abstract] [Full Text] [PDF]  

Production and Pro-Apoptotic Activity of Soluble CD95 Ligand in Pancreatic Carcinoma

Graziella Bellone, Carlo Smirne, Anna Carbone, Katia Mareschi, Luca Dughera, Enzo C. Farina, Oscar Alabiso, Guido Valente, Giorgio Emanuelli, and Ulrich Rodeck
Clin Cancer Res 2000 6: 2448 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Calpain Inhibitor II Induces Caspase-dependent Apoptosis in Human Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Cells as Well as Some Solid Tumor Cells

De-Min Zhu and Fatih M. Uckun
Clin Cancer Res 2000 6: 2456 [Abstract] [Full Text] [PDF]  

Antimetastatic Intraoperative Chemotherapy of Human Colon Tumors in the Livers of Nude Mice

Babak Rashidi, Zili An, Fang-Xian Sun, A. R. Moossa, and Robert M. Hoffman
Clin Cancer Res 2000 6: 2464 [Abstract] [Full Text] [PDF]  

Successful Treatment of Intracranial Gliomas in Rat by Oligodeoxynucleotides Containing CpG Motifs

Antoine F. Carpentier, Jun Xie, Karima Mokhtari, and Jean-Yves Delattre
Clin Cancer Res 2000 6: 2469 [Abstract] [Full Text] [PDF]  

Cytotoxic Chemotherapy Regimens That Increase Dose per Cycle (Dose Intensity) by Extending Daily Dosing from 5 Consecutive Days to 28 Consecutive Days and Beyond

Kristan A. Keyes, Beatriz Albella, Patricia M. LoRusso, Juan A. Bueren, and Ralph E. Parchment
Clin Cancer Res 2000 6: 2474 [Abstract] [Full Text] [PDF]  

Constitutive and Lysophosphatidic Acid (LPA)-induced LPA Production: Role of Phospholipase D and Phospholipase A₂

Astrid M. Eder, Takayo Sasagawa, Muling Mao, Junken Aoki, and Gordon B. Mills
Clin Cancer Res 2000 6: 2482 [Abstract] [Full Text] [PDF]  

Eradication of Human Non-Hodgkin’s Lymphoma in SCID Mice by BCL-2 Antisense Oligonucleotides Combined with Low-Dose Cyclophosphamide

Richard J. Klasa, Marcel B. Bally, Rebecca Ng, James H. Goldie, Randy D. Gascoyne, and Frances M. P. Wong
Clin Cancer Res 2000 6: 2492 [Abstract] [Full Text] [PDF]  

The Relationship between Intracellular and Extracellular pH in Spontaneous Canine Tumors

Deborah M. Prescott, H. Cecil Charles, Jean M. Poulson, Rodney L. Page, Donald E. Thrall, Zeljko Vujaskovic, and Mark W. Dewhirst
Clin Cancer Res 2000 6: 2501 [Abstract] [Full Text] [PDF]  

Oral Antisense that Targets Protein Kinase A Cooperates with Taxol and Inhibits Tumor Growth, Angiogenesis, and Growth Factor Production

Giampaolo Tortora, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Sabino De Placido, A. Raffaele Bianco, and Fortunato Ciardiello
Clin Cancer Res 2000 6: 2506 [Abstract] [Full Text] [PDF]  

Enhancement of Intrinsic Tumor Cell Radiosensitivity Induced by a Selective Cyclooxygenase-2 Inhibitor

Cordula Petersen, Sven Petersen, Luka Milas, Frederick F. Lang, and Philip J. Tofilon
Clin Cancer Res 2000 6: 2513 [Abstract] [Full Text] [PDF]  

Purging of Epithelial Tumor Cells from Peripheral Blood Stem Cells by Means of the Bispecific Antibody BIS-1

Carolien P. Schröder, Bart-Jan Kroesen, Lou F. M. H. de Leij, and Elisabeth G. E. de Vries
Clin Cancer Res 2000 6: 2521 [Abstract] [Full Text] [PDF]  

Pegylated Liposomes Have Potential as Vehicles for Intratumoral and Subcutaneous Drug Delivery

Kevin J. Harrington, Gail Rowlinson-Busza, Konstantinos N. Syrigos, Paul S. Uster, Richard G. Vile, and J. Simon W. Stewart
Clin Cancer Res 2000 6: 2528 [Abstract] [Full Text] [PDF]  

Comparison of Thymidylate Synthase (TS) Protein Up-Regulation after Exposure to TS Inhibitors in Normal and Tumor Cell Lines and Tissues

Sarah J. Welsh, Jenny Titley, Lisa Brunton, Melanie Valenti, Paul Monaghan, Ann L. Jackman, and G. Wynne Aherne
Clin Cancer Res 2000 6: 2538 [Abstract] [Full Text] [PDF]  

A Novel Bispecific Antisense Oligonucleotide Inhibiting Both bcl-2 and bcl-xL Expression Efficiently Induces Apoptosis in Tumor Cells

Uwe Zangemeister-Wittke, Siân H. Leech, Robert A. Olie, A. Paula Simões-Wüst, Oliver Gautschi, Gerd H. Luedke, François Natt, Robert Häner, Pierre Martin, Jonathan Hall, Carlo M. Nalin, and Rolf A. Stahel
Clin Cancer Res 2000 6: 2547 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

An Orthotopic Mouse Model of Remetastasis of Human Colon Cancer Liver Metastasis

Babak Rashidi, Reza Gamagami, Aaron Sasson, Fang Xian Sun, Jack Geller, A. R. Moossa, and Robert M. Hoffman
Clin Cancer Res 2000 6: 2556 [Abstract] [Full Text] [PDF]  

The Relevance of Cell Proliferation, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor Production to Angiogenesis and Tumorigenicity in Human Glioma Cell Lines

Li Dao Ke, Yue-Xi Shi, Seock-Ah Im, Xiashan Chen, and W. K. Alfred Yung
Clin Cancer Res 2000 6: 2562 [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice

Suyun Huang, Ariel DeGuzman, Corazon D. Bucana, and Isaiah J. Fidler
Clin Cancer Res 2000 6: 2573 [Abstract] [Full Text] [PDF]  

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