Minireviews:

Temozolomide and Treatment of Malignant Glioma

Henry S. Friedman, Tracy Kerby, and Hilary Calvert
Clin Cancer Res 2000 6: 2585 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Role of Intestinal P-glycoprotein in the Plasma and Fecal Disposition of Docetaxel in Humans

Lia van Zuylen, Jaap Verweij, Kees Nooter, Eric Brouwer, Gerrit Stoter, and Alex Sparreboom
Clin Cancer Res 2000 6: 2598 [Abstract] [Full Text] [PDF]  

Molecular Changes in the Bronchial Epithelium of Patients with Small Cell Lung Cancer

Ignacio I. Wistuba, Jarett Berry, Carmen Behrens, Anirban Maitra, Narayan Shivapurkar, Sara Milchgrub, Bruce Mackay, John D. Minna, and Adi F. Gazdar
Clin Cancer Res 2000 6: 2604 [Abstract] [Full Text] [PDF]  

Intranodal Antitumor Immunocyte Infiltration in Node-negative Gastric Cancers

Sumiya Ishigami, Shoji Natsugoe, Shuichi Hokita, Che Xiangming, Kuniaki Aridome, Hirofumi Iwashige, Koki Tokuda, Akihiro Nakajo, Futoshi Miyazono, and Takashi Aikou
Clin Cancer Res 2000 6: 2611 [Abstract] [Full Text] [PDF]  

Detection of Bladder Cancer Using a Novel Nuclear Matrix Protein, BLCA-4

Badrinath R. Konety, Thu-Suong T. Nguyen, Rajiv Dhir, Roger S. Day, Michael J. Becich, Walter M. Stadler, and Robert H. Getzenberg
Clin Cancer Res 2000 6: 2618 [Abstract] [Full Text] [PDF]  

BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin

Carla Manzotti, Graziella Pratesi, Ernesto Menta, Roberto Di Domenico, Ennio Cavalletti, Heinz H. Fiebig, Lloyd R. Kelland, Nicholas Farrell, Donatella Polizzi, Rosanna Supino, Gabriella Pezzoni, and Franco Zunino
Clin Cancer Res 2000 6: 2626 [Abstract] [Full Text] [PDF]  

Treatment of Human Metastatic Transitional Cell Carcinoma of the Bladder in a Murine Model with the Anti-Vascular Endothelial Growth Factor Receptor Monoclonal Antibody DC101 and Paclitaxel

Keiji Inoue, Joel W. Slaton, Darren W. Davis, Daniel J. Hicklin, David J. McConkey, Takashi Karashima, Robert Radinsky, and Colin P. N. Dinney
Clin Cancer Res 2000 6: 2635 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Combination Immunotherapy of Relapsed or Refractory Low-Grade or Follicular Non-Hodgkin’s Lymphoma with Rituximab and Interferon--2a

Thomas A. Davis, David G. Maloney, Antonio J. Grillo-López, Christine A. White, Michael E. Williams, George J. Weiner, Sue Dowden, and Ronald Levy
Clin Cancer Res 2000 6: 2644 [Abstract] [Full Text] [PDF]  

Induction of Ab3 and Ab3' Antibody Was Associated with Long-Term Survival after Anti-G_D2 Antibody Therapy of Stage 4 Neuroblastoma

Nai-Kong V. Cheung, Hong-fen Guo, Glenn Heller, and Irene Y. Cheung
Clin Cancer Res 2000 6: 2653 [Abstract] [Full Text] [PDF]  

A Dose-Escalation and Pharmacokinetic Study of Subcutaneously Administered Recombinant Human Interleukin 12 and Its Biological Effects in Japanese Patients with Advanced Malignancies

Ryuzo Ohno, Yoshiyuki Yamaguchi, Tetsuya Toge, Toshiaki Kinouchi, Toshihiko Kotake, Masahiko Shibata, Yoshio Kiyohara, Shigeo Ikeda, Iwao Fukui, Akira Gohchi, Yasuyuki Sugiyama, Shigetoyo Saji, Shouichi Hazama, Masaaki Oka, Kazunori Ohnishi, Yasuo Ohhashi, Shigeru Tsukagoshi, and Tetsuo Taguchi
Clin Cancer Res 2000 6: 2661 [Abstract] [Full Text] [PDF]  

Phase II Trial of Paclitaxel by 96-Hour Continuous Infusion in Combination with Cisplatin for Patients with Advanced Non-Small Cell Lung Cancer

O. S. Breathnach, M. S. Georgiadis, B. S. Schuler, P. Pizzella, V. Llorens, V. Kasturi, S. M. Steinberg, K. O’Neil, C. H. Takimoto, and Bruce E. Johnson
Clin Cancer Res 2000 6: 2670 [Abstract] [Full Text] [PDF]  

Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034

Howard L. McLeod, James Cassidy, Robert H. Powrie, David G. Priest, Mark A. Zorbas, Timothy W. Synold, Stephen Shibata, Darcy Spicer, Donald Bissett, Yazdi K. Pithavala, Mary A. Collier, Linda J. Paradiso, and John D. Roberts
Clin Cancer Res 2000 6: 2677 [Abstract] [Full Text] [PDF]  

Inter- and Intrapatient Variability in Oral Topotecan Pharmacokinetics: Implications for Body-Surface Area Dosage Regimens

Walter J. Loos, Hans Gelderblom, Alex Sparreboom, Jaap Verweij, and Maja J. A. de Jonge
Clin Cancer Res 2000 6: 2685 [Abstract] [Full Text] [PDF]  

Bayesian Estimate of Vinorelbine Pharmacokinetic Parameters in Elderly Patients with Advanced Metastatic Cancer

Amélie Gauvin, Frédéric Pinguet, Stéphane Culine, Cécile Astre, Roberto Gomeni, and Françoise Bressolle
Clin Cancer Res 2000 6: 2690 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

High Telomerase Activity Is an Independent Prognostic Indicator of Poor Outcome in Colorectal Cancer

Naokuni Tatsumoto, Eiso Hiyama, Yoshiaki Murakami, Yuji Imamura, Jerry W. Shay, Yuichiro Matsuura, and Takashi Yokoyama
Clin Cancer Res 2000 6: 2696 [Abstract] [Full Text] [PDF]  

Serum Interleukin 6 as a Prognostic Factor in Patients with Prostate Cancer

Jun Nakashima, Masaaki Tachibana, Yutaka Horiguchi, Mototsugu Oya, Takashi Ohigashi, Hirotaka Asakura, and Masaru Murai
Clin Cancer Res 2000 6: 2702 [Abstract] [Full Text] [PDF]  

Thymidylate Synthase Expression Correlates Closely with E2F1 Expression in Colon Cancer

Mitsuko Kasahara, Yasuo Takahashi, Toshihito Nagata, Satoshi Asai, Teruo Eguchi, Yukimoto Ishii, Masashi Fujii, and Koichi Ishikawa
Clin Cancer Res 2000 6: 2707 [Abstract] [Full Text] [PDF]  

Differences in 20q13.2 Copy Number between Colorectal Cancers with and without Liver Metastasis

Shigekazu Hidaka, Toru Yasutake, Hiroaki Takeshita, Masamichi Kondo, Takashi Tsuji, Atsushi Nanashima, Terumitu Sawai, Hiroyuki Yamaguchi, Tohru Nakagoe, Hiroyoshi Ayabe, and Yutaka Tagawa
Clin Cancer Res 2000 6: 2712 [Abstract] [Full Text] [PDF]  

Detection of Minimal Residual Cancer to Investigate Why Oral Tumors Recur Despite Seemingly Adequate Treatment

Max Partridge, Shu-Rui Li, Stelios Pateromichelakis, Rebecca Francis, E. Phillips, Xiao Hong Huang, Fis Tesfa-Selase, and John D. Langdon
Clin Cancer Res 2000 6: 2718 [Abstract] [Full Text] [PDF]  

Differential Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, and Membrane Type 1-MMP in Hepatocellular and Pancreatic Adenocarcinoma: Implications for Tumor Progression and Clinical Prognosis

Marko Määttä, Ylermi Soini, Annikki Liakka, and Helena Autio-Harmainen
Clin Cancer Res 2000 6: 2726 [Abstract] [Full Text] [PDF]  

Regulation of Disease-Progression Genes in Human Gastric Carcinoma Cells by Interleukin 8

Yasuhiko Kitadai, Ken Haruma, Naofumi Mukaida, Yasukazu Ohmoto, Norimasa Matsutani, Wataru Yasui, Shigeru Yamamoto, Koji Sumii, Goro Kajiyama, Isaiah J. Fidler, and Eiichi Tahara
Clin Cancer Res 2000 6: 2735 [Abstract] [Full Text] [PDF]  

Analytical Variables of Reverse Transcription-Polymerase Chain Reaction-based Detection of Disseminated Prostate Cancer Cells

Alfred Zippelius, Ralf Lutterbüse, Gert Riethmüller, and Klaus Pantel
Clin Cancer Res 2000 6: 2741 [Abstract] [Full Text] [PDF]  

p53 but not bcl-2 Immunostaining Is Predictive of Poor Clinical Complete Response to Primary Chemotherapy in Breast Cancer Patients

Alberto Bottini, Alfredo Berruti, Alessandra Bersiga, Maria Pia Brizzi, Antonio Brunelli, Gabriella Gorzegno, Bianca DiMarco, Sergio Aguggini, Giovanna Bolsi, Fernando Cirillo, Luciano Filippini, Enrico Betri, Giovanni Bertoli, Palmiro Alquati, and Luigi Dogliotti
Clin Cancer Res 2000 6: 2751 [Abstract] [Full Text] [PDF]  

Mutations of the INI1 Rhabdoid Tumor Suppressor Gene in Medulloblastomas and Primitive Neuroectodermal Tumors of the Central Nervous System

Jaclyn A. Biegel, Benjamin Fogelgren, Jun-Ying Zhou, C. David James, Anna J. Janss, Jeffrey C. Allen, David Zagzag, Corey Raffel, and Lucy B. Rorke
Clin Cancer Res 2000 6: 2759 [Abstract] [Full Text] [PDF]  

Expression of Gonadotropin and Activin Receptor Messenger Ribonucleic Acid in Human Ovarian Epithelial Neoplasms

Takashi Minegishi, Takashi Kameda, Takashi Hirakawa, Kazuko Abe, Mari Tano, and Yoshito Ibuki
Clin Cancer Res 2000 6: 2764 [Abstract] [Full Text] [PDF]  

Comparison of Telomerase Activity in Bladder Carcinoma and Exfoliated Cells Collected in Urine and Bladder Washings, Using a Quantitative Assay

Stefania Gelmini, Alfonso Crisci, Benedetta Salvadori, Mario Pazzagli, Cesare Selli, and Claudio Orlando
Clin Cancer Res 2000 6: 2771 [Abstract] [Full Text] [PDF]  

INK4a Gene Expression and Methylation in Primary Breast Cancer: Overexpression of p16^INK4a Messenger RNA Is a Marker of Poor Prognosis

Rina Hui, R. Douglas Macmillan, Frances S. Kenny, Elizabeth A. Musgrove, Roger W. Blamey, Robert I. Nicholson, John F. R. Robertson, and Robert L. Sutherland
Clin Cancer Res 2000 6: 2777 [Abstract] [Full Text] [PDF]  

Monoclonality of Multifocal Myxoid Liposarcoma: Confirmation by Analysis of TLS-CHOP or EWS-CHOP Rearrangements

Cristina R. Antonescu, Abul Elahi, John H. Healey, Murray F. Brennan, Man Yee Lui, Jonathan Lewis, Suresh C. Jhanwar, James M. Woodruff, and Marc Ladanyi
Clin Cancer Res 2000 6: 2788 [Abstract] [Full Text] [PDF]  

Human Leukocyte Antigen Class I Allelic and Haplotype Loss in Squamous Cell Carcinoma of the Head and Neck: Clinical and Immunogenetic Consequences

Jennifer Rubin Grandis, Dewayne M. Falkner, Mona F. Melhem, William E. Gooding, Stephanie D. Drenning, and Penelope A. Morel
Clin Cancer Res 2000 6: 2794 [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor Can Predict Event-free Survival in Stage II Colon Cancer

Stefano Cascinu, Maria Pia Staccioli, Giampietro Gasparini, Paolo Giordani, Vincenzo Catalano, Roberto Ghiselli, Cristina Rossi, Anna Maria Baldelli, Francesco Graziano, Vittorio Saba, Pietro Muretto, and Giuseppina Catalano
Clin Cancer Res 2000 6: 2803 [Abstract] [Full Text] [PDF]  

Expression of the Hypoxically Regulated Angiogenic Factor Adrenomedullin Correlates with Uterine Leiomyoma Vascular Density

Stephen Hague, Lyna Zhang, Martin K. Oehler, Sanjiv Manek, Ian Z. MacKenzie, Roy Bicknell, and Margaret C. P. Rees
Clin Cancer Res 2000 6: 2808 [Abstract] [Full Text] [PDF]  

Relationship between Chromosomal Instability and Intratumoral Regional DNA Ploidy Heterogeneity in Primary Gastric Cancers

Tomoko Furuya, Tetsuji Uchiyama, Takuo Murakami, Atsushi Adachi, Shigeto Kawauchi, Atsunori Oga, Takashi Hirano, and Kohsuke Sasaki
Clin Cancer Res 2000 6: 2815 [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor and Microvessel Density in Head and Neck Tumorigenesis

Kyung Tae, Adel K. El-Naggar, Enise Yoo, Lei Feng, J. Jack Lee, Waun Ki Hong, Walter N. Hittelman, and Dong M. Shin
Clin Cancer Res 2000 6: 2821 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Tumor Irradiation Enhances the Tumor-specific Distribution of Poly(L-glutamic acid)-conjugated Paclitaxel and Its Antitumor Efficacy

Chun Li, Shi Ke, Qing-Ping Wu, Wayne Tansey, Nancy Hunter, Lara M. Buchmiller, Luka Milas, Chusilp Charnsangavej, and Sidney Wallace
Clin Cancer Res 2000 6: 2829 [Abstract] [Full Text] [PDF]  

Immunotoxins with Increased Activity against Epidermal Growth Factor Receptor vIII-expressing Cells Produced by Antibody Phage Display

Richard Beers, Partha Chowdhury, Darell Bigner, and Ira Pastan
Clin Cancer Res 2000 6: 2835 [Abstract] [Full Text] [PDF]  

Delayed Micromolar Elevation in Intracellular Calcium Precedes Induction of Apoptosis in Thapsigargin-treated Breast Cancer Cells

Christian Jackisch, Hillary A. Hahm, Bertrand Tombal, Diane McCloskey, Kimberly Butash, Nancy E. Davidson, and Samuel R. Denmeade
Clin Cancer Res 2000 6: 2844 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes: Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation

Takahiro Itoshima, Toshiyoshi Fujiwara, Toshihiko Waku, Jianghua Shao, Masafumi Kataoka, Wendell G. Yarbrough, Ta-Jen Liu, Jack A. Roth, Noriaki Tanaka, and Masashi Kodama
Clin Cancer Res 2000 6: 2851 [Abstract] [Full Text] [PDF]  

Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines

Carol A. Delaney, Lan-Z Wang, Suzanne Kyle, Alex W. White, A. Hilary Calvert, Nicola J. Curtin, Barbara W. Durkacz, Zdenek Hostomsky, and David R. Newell
Clin Cancer Res 2000 6: 2860 [Abstract] [Full Text] [PDF]  

Demethylating Reagent 5-Azacytidine Inhibits Telomerase Activity in Human Prostate Cancer Cells through Transcriptional Repression of hTERT

Yasuhide Kitagawa, Satoru Kyo, Masahiro Takakura, Taro Kanaya, Kiyoshi Koshida, Mikio Namiki, and Masaki Inoue
Clin Cancer Res 2000 6: 2868 [Abstract] [Full Text] [PDF]  

9-Nitrocamptothecin Liposome Aerosol Treatment of Melanoma and Osteosarcoma Lung Metastases in Mice

Nadezhda V. Koshkina, Eugenie S. Kleinerman, Clifford Waldrep, Shu-Fang Jia, Laura L. Worth, Brian E. Gilbert, and Vernon Knight
Clin Cancer Res 2000 6: 2876 [Abstract] [Full Text] [PDF]  

Augmentation of Antitumor Activity of 5-Fluorouracil by Interferon Is Associated with Up-Regulation of p27^Kip1 in Human Hepatocellular Carcinoma Cells

Hidetoshi Eguchi, Hiroaki Nagano, Hirofumi Yamamoto, Atsushi Miyamoto, Motoi Kondo, Keizo Dono, Shoji Nakamori, Koji Umeshita, Masato Sakon, and Morito Monden
Clin Cancer Res 2000 6: 2881 [Abstract] [Full Text] [PDF]  

Molecular and Pharmacokinetic Properties Associated with the Therapeutics of Bcl-2 Antisense Oligonucleotide G3139 Combined with Free and Liposomal Doxorubicin

Daniel E. Lopes de Menezes, Norma Hudon, Natashia McIntosh, and Lawrence D. Mayer
Clin Cancer Res 2000 6: 2891 [Abstract] [Full Text] [PDF]  

Antitumor Efficacy, Pharmacokinetics, and Biodistribution of NX 211: A Low-Clearance Liposomal Formulation of Lurtotecan

David L. Emerson, Ray Bendele, Eric Brown, SuMing Chiang, John P. Desjardins, Larry C. Dihel, Stan C. Gill, Marta Hamilton, Jeremy D. LeRay, Lotus Moon-McDermott, Karen Moynihan, Frank C. Richardson, Blake Tomkinson, Michael J. Luzzio, and David Baccanari
Clin Cancer Res 2000 6: 2903 [Abstract] [Full Text] [PDF]  

Effectiveness of Combined Interleukin 2 and B7.1 Vaccination Strategy Is Dependent on the Sequence and Order: A Liposome-mediated Gene Therapy Treatment for Bladder Cancer

William A. Larchian, Yutaka Horiguchi, Smita K. Nair, William R. Fair, Warren D. W. Heston, and Eli Gilboa
Clin Cancer Res 2000 6: 2913 [Abstract] [Full Text] [PDF]  

A Polyphenolic Fraction from Grape Seeds Causes Irreversible Growth Inhibition of Breast Carcinoma MDA-MB468 Cells by Inhibiting Mitogen-activated Protein Kinases Activation and Inducing G₁ Arrest and Differentiation

Chapla Agarwal, Yogesh Sharma, Jifu Zhao, and Rajesh Agarwal
Clin Cancer Res 2000 6: 2921 [Abstract] [Full Text] [PDF]  

Effects of SU101 in Combination with Cytotoxic Agents on the Growth of Subcutaneous Tumor Xenografts

Laurie M. Strawn, Fairooz Kabbinavar, Donna P. Schwartz, Elaina Mann, Laura K. Shawver, Dennis J. Slamon, and Julie M. Cherrington
Clin Cancer Res 2000 6: 2931 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor

Keith R. Laderoute, Rodolfo M. Alarcon, Michael D. Brody, Joy M. Calaoagan, Eunice Y. Chen, A. Merrill Knapp, Zhong Yun, Nicholas C. Denko, and Amato J. Giaccia
Clin Cancer Res 2000 6: 2941 [Abstract] [Full Text] [PDF]  

Changes in E2F Binding after Phenylbutyrate-induced Differentiation of Caco-2 Colon Cancer Cells

Qing Mei Wang, Rena Feinman, Fatah Kashanchi, Jean Marie Houghton, George P. Studzinski, and Lawrence E. Harrison
Clin Cancer Res 2000 6: 2951 [Abstract] [Full Text] [PDF]  

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