Editorials:

Aerosolized Delivery and Lung Cancer Prevention: Pre-Clinical Models Show Promise

Michael J. Spinella and Ethan Dmitrovsky
Clin Cancer Res 2000 6: 2963 [Full Text] [PDF]  

Clinical Use of Tyrosine Kinase Inhibitors: Therapy for Chronic Myelogenous Leukemia and Other Cancers

Nicholas J. Donato and Moshe Talpaz
Clin Cancer Res 2000 6: 2965 [Full Text] [PDF]  

Can O⁶-Alkylguanine-DNA Alkyltransferase Depletion Enhance Alkylator Activity in the Clinic?

Henry S. Friedman
Clin Cancer Res 2000 6: 2967 [Full Text] [PDF]  

Minireviews:

Progression Model for Pancreatic Cancer

Ralph H. Hruban, Michael Goggins, Jennifer Parsons, and Scott E. Kern
Clin Cancer Res 2000 6: 2969 [Full Text] [PDF]  

Advances in Brief:

N-(4-Hydroxyphenyl)Retinamide in the Chemoprevention of Squamous Metaplasia and Dysplasia of the Bronchial Epithelium

Jonathan M. Kurie, Jin S. Lee, Fadlo R. Khuri, Li Mao, Rodolfo C. Morice, J. Jack Lee, Garrett L. Walsh, Anita Broxson, Scott M. Lippman, Jae Y. Ro, Bonnie L. Kemp, Diane Liu, Herbert A. Fritsche, Xiaochun Xu, Reuben Lotan, and Waun K. Hong
Clin Cancer Res 2000 6: 2973 [Abstract] [Full Text] [PDF]  

Telomerase Activity and Bcl-2 Expression in Non-Small Cell Lung Cancer

Yasushi Ohmura, Motoi Aoe, Akio Andou, and Nobuyoshi Shimizu
Clin Cancer Res 2000 6: 2980 [Abstract] [Full Text] [PDF]  

C-CAM1, a Candidate Tumor Suppressor Gene, Is Abnormally Expressed in Primary Lung Cancers

Luo Wang, Sue Hwa Lin, Wei Guo Wu, Bonnie L. Kemp, Garrett L. Walsh, Waun Ki Hong, and Li Mao
Clin Cancer Res 2000 6: 2988 [Abstract] [Full Text] [PDF]  

Risk of Gastric Cancer in Hereditary Nonpolyposis Colorectal Cancer in Korea

Young Jin Park, Ki-Hyuk Shin, and Jae-Gahb Park
Clin Cancer Res 2000 6: 2994 [Abstract] [Full Text] [PDF]  

Racial Disparity in the Frequency of PTEN Mutations, but not Microsatellite Instability, in Advanced Endometrial Cancers

G. Larry Maxwell, John I. Risinger, Kate A. Hayes, Angeles A. Alvarez, Richard K. Dodge, J. Carl Barrett, and Andrew Berchuck
Clin Cancer Res 2000 6: 2999 [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Effect of Chemotherapy and Antisense-mediated Ablation of the Cell Cycle Inhibitor p27^KIP-1

Tatjana V. Achenbach, Rolf Müller, and Emily P. Slater
Clin Cancer Res 2000 6: 3006 [Abstract] [Full Text] [PDF]  

Inhaled Isotretinoin (13-cis Retinoic Acid) Is an Effective Lung Cancer Chemopreventive Agent in A/J Mice at Low doses: A Pilot Study

Alan R. Dahl, Irma M. Grossi, David P. Houchens, Laurie J. Scovell, Michael E. Placke, Anthony R. Imondi, Gary D. Stoner, Luigi M. De Luca, Dali Wang, and James L. Mulshine
Clin Cancer Res 2000 6: 3015 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase I Clinical and Pharmacological Study of O⁶-Benzylguanine Followed by Carmustine in Patients with Advanced Cancer

Richard L. Schilsky, M. Eileen Dolan, Donna Bertucci, Reginald B. Ewesuedo, Nicholas J. Vogelzang, Sridhar Mani, Lynette R. Wilson, and Mark J. Ratain
Clin Cancer Res 2000 6: 3025 [Abstract] [Full Text] [PDF]  

Comparative Pharmacokinetic Analysis of 5-Fluorouracil and Its Major Metabolite 5-Fluoro-5,6-dihydrouracil after Conventional and Reduced Test Dose in Cancer Patients

Guido Bocci, Romano Danesi, Antonello Di Paolo, Federico Innocenti, Giacomo Allegrini, Alfredo Falcone, Alessandro Melosi, Mario Battistoni, Gemma Barsanti, Pier Franco Conte, and Mario Del Tacca
Clin Cancer Res 2000 6: 3032 [Abstract] [Full Text] [PDF]  

Marked 24-h Rest/Activity Rhythms Are Associated with Better Quality of Life, Better Response, and Longer Survival in Patients with Metastatic Colorectal Cancer and Good Performance Status

Marie-Christine Mormont, James Waterhouse, Pascal Bleuzen, Sylvie Giacchetti, Alain Jami, André Bogdan, Joseph Lellouch, Jean-Louis Misset, Yvan Touitou, and Francis Lévi
Clin Cancer Res 2000 6: 3038 [Abstract] [Full Text] [PDF]  

Safety and Biodistribution of ^99mTechnetium-labeled Anti-CD44v6 Monoclonal Antibody BIWA 1 in Head and Neck Cancer Patients

Joep W. G. Stroomer, Jan C. Roos, Marlies Sproll, Jasper J. Quak, Karl-Heinz Heider, Bram J. Wilhelm, Jonas A. Castelijns, Reiner Meyer, Marthin O. Kwakkelstein, Gordon B. Snow, Günther R. Adolf, and Guus A. M. S. van Dongen
Clin Cancer Res 2000 6: 3046 [Abstract] [Full Text] [PDF]  

Targeted Antiangiogenic Therapy for Cancer Using Vitaxin: A Humanized Monoclonal Antibody to the Integrin ß₃

John C. Gutheil, Thomas N. Campbell, Paul R. Pierce, Jeffry D. Watkins, William D. Huse, David J. Bodkin, and David A. Cheresh
Clin Cancer Res 2000 6: 3056 [Abstract] [Full Text] [PDF]  

A Phase I-II Study of Isolated Hepatic Perfusion Using Melphalan with or without Tumor Necrosis Factor for Patients with Ocular Melanoma Metastatic to Liver

H. Richard Alexander, Steven K. Libutti, David L. Bartlett, Markus Puhlmann, Douglas L. Fraker, and Lisa C. Bachenheimer
Clin Cancer Res 2000 6: 3062 [Abstract] [Full Text] [PDF]  

Phase I Pharmacokinetic Trial of Perillyl Alcohol (NSC 641066) in Patients with Refractory Solid Malignancies

Gary R. Hudes, Christine E. Szarka, Andrea Adams, Sulabha Ranganathan, Robert A. McCauley, Louis M. Weiner, Corey J. Langer, Samuel Litwin, Gwen Yeslow, Theresa Halberr, Mingxin Qian, and James M. Gallo
Clin Cancer Res 2000 6: 3071 [Abstract] [Full Text] [PDF]  

A Cancer Gene Therapy Approach Utilizing an Anti-erbB-2 Single-Chain Antibody-encoding Adenovirus (AD21): A Phase I Trial

Ronald D. Alvarez, Mack N. Barnes, Jesus Gomez-Navarro, Minghui Wang, Theresa V. Strong, Waleed Arafat, Ramin B. Arani, Martin R. Johnson, Bruce L. Roberts, Gene P. Siegal, and David T. Curiel
Clin Cancer Res 2000 6: 3081 [Abstract] [Full Text] [PDF]  

Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377

Patricia M. LoRusso, Brenda J. Foster, Antoinette Wozniak, Lance K. Heilbrun, Julie I. McCormick, Paul E. Ruble, Martin A. Graham, Joseph Purvis, James Rake, Marion Drozd, Graham F. Lockwood, and Thomas H. Corbett
Clin Cancer Res 2000 6: 3088 [Abstract] [Full Text] [PDF]  

High-Dose Therapy with ⁹⁰Yttrium-labeled Monoclonal Antibody CC49: A Phase I Trial

Margaret Tempero, Peter Leichner, Janina Baranowska-Kortylewicz, Katherine Harrison, Sam Augustine, Jeffrey Schlom, James Anderson, James Wisecarver, and David Colcher
Clin Cancer Res 2000 6: 3095 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Predictive Value of p53, mdm-2, p21, and mib-1 for Chemotherapy Response in Advanced Breast Cancer

Johanna Sjöström, Carl Blomqvist, Päivi Heikkilä, Kristina von Boguslawski, Anne Räisänen-Sokolowski, Nils-Olof Bengtsson, Ingvil Mjaaland, Per Malmström, Björn Ostenstadt, Jonas Bergh, Erik Wist, Vahur Valvere, and Eero Saksela
Clin Cancer Res 2000 6: 3103 [Abstract] [Full Text] [PDF]  

Prognostic Value of Bone Marrow Angiogenesis in Multiple Myeloma

S. Vincent Rajkumar, Traci Leong, Patrick C. Roche, Rafael Fonseca, Angela Dispenzieri, Martha Q. Lacy, John A. Lust, Thomas E. Witzig, Robert A. Kyle, Morie A. Gertz, and Philip R. Greipp
Clin Cancer Res 2000 6: 3111 [Abstract] [Full Text] [PDF]  

Detection of MUC1-expressing Mammary Carcinoma Cells in the Peripheral Blood of Breast Cancer Patients by Real-Time Polymerase Chain Reaction

P. de Cremoux, J. M. Extra, M. G. Denis, J. Y. Pierga, E. Bourstyn, C. Nos, K. B. Clough, E. Boudou, E. C. Martin, A. Müller, P. Pouillart, and H. Magdelénat
Clin Cancer Res 2000 6: 3117 [Abstract] [Full Text] [PDF]  

Residual Bone Marrow Leukemic Progenitor Cell Burden after Induction Chemotherapy in Pediatric Patients with Acute Lymphoblastic Leukemia

Fatih M. Uckun, Linda Stork, Nita Seibel, Mireille Sarquis, Charles Bedros, Harland Sather, Martha Sensel, Gregory H. Reaman, and Paul S. Gaynon
Clin Cancer Res 2000 6: 3123 [Abstract] [Full Text] [PDF]  

Loss of p21^Waf1 Expression Is a Strong Predictor of Reduced Survival in Primary Superficial Bladder Cancers

Mario Migaldi, Alessandro Sgambato, Lorella Garagnani, Raffaele Ardito, Paolo Ferrari, Carmela De Gaetani, Achille Cittadini, and Gian Paolo Trentini
Clin Cancer Res 2000 6: 3131 [Abstract] [Full Text] [PDF]  

Different Vulnerability among Chromosomes to Numerical Instability in Gastric Carcinogenesis: Stage-dependent Analysis by FISH with the Use of Microwave Irradiation

Yasuhiko Kitayama, Hisaki Igarashi, and Haruhiko Sugimura
Clin Cancer Res 2000 6: 3139 [Abstract] [Full Text] [PDF]  

Correlation of Plasma and Serum Vascular Endothelial Growth Factor Levels with Platelet Count in Colorectal Cancer: Clinical Evidence of Platelet Scavenging?

Mark L. George, Suzanne A. Eccles, Matthew G. Tutton, A. Muti Abulafi, and R. Ian Swift
Clin Cancer Res 2000 6: 3147 [Abstract] [Full Text] [PDF]  

p53 Mutational Status Improves Estimation of Prognosis in Patients with Curatively Resected Adenocarcinoma in Barrett’s Esophagus

Paul M. Schneider, Oliver Stoeltzing, Jack A. Roth, Arnulf H. Hoelscher, Sieglinde Wegerer, Seiichi Mizumoto, Karen Becker, Hans-J. Dittler, Ulrich Fink, and J. Ruediger Siewert
Clin Cancer Res 2000 6: 3153 [Abstract] [Full Text] [PDF]  

Potential Role of Microvessel Density in Predicting Radiosensitivity of T₁ and T₂ Stage Laryngeal Squamous Cell Carcinoma Treated with Radiotherapy

Tomoyuki Kamijo, Tomoyuki Yokose, Takahiro Hasebe, Hiroyuki Yonou, Satoshi Sasaki, Ryuichi Hayashi, Satoshi Ebihara, Hiroshi Miyahara, Hiroshi Hosoi, and Atsushi Ochiai
Clin Cancer Res 2000 6: 3159 [Abstract] [Full Text] [PDF]  

Detection of Circulating Cancer Cells by Reverse Transcription-Polymerase Chain Reaction for Uroplakin II in Peripheral Blood of Patients with Urothelial Cancer

Jia-Ju Lu, Yoshiyuki Kakehi, Takeshi Takahashi, Xiu-Xien Wu, Takeshi Yuasa, Tatsuhiro Yoshiki, Yusaku Okada, Toshiro Terachi, and Osamu Ogawa
Clin Cancer Res 2000 6: 3166 [Abstract] [Full Text] [PDF]  

Loss of Imprinting and Genetic Alterations of the Cyclin-dependent Kinase Inhibitor p57^KIP2 Gene in Head and Neck Squamous Cell Carcinoma

Syeling Lai, Helmuth Goepfert, Ann M. Gillenwater, Mario A. Luna, and Adel K. El-Naggar
Clin Cancer Res 2000 6: 3172 [Abstract] [Full Text] [PDF]  

EMS1 Gene Amplification Correlates with Poor Prognosis in Squamous Cell Carcinomas of the Head and Neck

Juan P. Rodrigo, Luis A. García, Sofía Ramos, Pedro S. Lazo, and Carlos Suárez
Clin Cancer Res 2000 6: 3177 [Abstract] [Full Text] [PDF]  

Superoxide Dismutases in Gastric and Esophageal Cancer and the Prognostic Impact in Gastric Cancer

A. Miranda, L. Janssen, Coen B. Bosman, Wim van Duijn, Marjan M. Oostendorp-van de Ruit, Frank J. G. M. Kubben, Gerrit Griffioen, Cornelis B. H. W. Lamers, J. Han, J. M. van Krieken, Cornelis J. H. van de Velde, and Hein W. Verspaget
Clin Cancer Res 2000 6: 3183 [Abstract] [Full Text] [PDF]  

Allelic Loss at 1p34–36 Predicts Poor Prognosis in Node-negative Breast Cancer

Yoshihito Utada, Mitsuru Emi, Masataka Yoshimoto, Fujio Kasumi, Futoshi Akiyama, Goi Sakamoto, Shunsuke Haga, Tetsuro Kajiwara, and Yusuke Nakamura
Clin Cancer Res 2000 6: 3193 [Abstract] [Full Text] [PDF]  

Enhanced Expression of N-myc Messenger RNA in Neuroblastomas Found by Mass Screening

Tadashi Matsunaga, Hiroshi Shirasawa, Tomoro Hishiki, Hideo Yoshida, Katsunori Kouchi, Yasuhiro Ohtsuka, Kenji Kawamura, Takao Etoh, and Naomi Ohnuma
Clin Cancer Res 2000 6: 3199 [Abstract] [Full Text] [PDF]  

P-glycoprotein and Multidrug Resistance Protein Activities in Relation to Treatment Outcome in Acute Myeloid Leukemia

Dorina M. van der Kolk, Elisabeth G. E. de Vries, Wim L. J. van Putten, Leo F. Verdonck, Gert J. Ossenkoppele, Gregor E. G. Verhoef, and Edo Vellenga
Clin Cancer Res 2000 6: 3205 [Abstract] [Full Text] [PDF]  

Alteration of DNA Ploidy Status and Cell Proliferation Induced by Preoperative Radiotherapy Is a Prognostic Factor in Rectal Cancer

Guido Lammering, Mohiuddin M. Taher, Hans-Helmut Gruenagel, Franz Borchard, and Rainer Porschen
Clin Cancer Res 2000 6: 3215 [Abstract] [Full Text] [PDF]  

11q23 Allelic Loss Is Associated with Regional Lymph Node Metastasis in Melanoma

Rudolf A. Herbst, Susanne Mommert, Uta Casper, Edith K. Podewski, Peter Kiehl, Alexander Kapp, and Jürgen Weiss
Clin Cancer Res 2000 6: 3222 [Abstract] [Full Text] [PDF]  

Somatic Mutation of PTEN in Vulvar Cancer

Antonia H. Holway, Kimberly M. Rieger-Christ, Wendy R. Miner, Jason W. Cain, John M. Dugan, John A. Pezza, Mark L. Silverman, Anne Shapter, Robert McLellan, and Ian C. Summerhayes
Clin Cancer Res 2000 6: 3228 [Abstract] [Full Text] [PDF]  

Angiostatin Expression in Non-Small Cell Lung Cancer

Manfred Volm, Jürgen Mattern, and Reet Koomägi
Clin Cancer Res 2000 6: 3236 [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-activated Receptor Is an Androgen-responsive Gene in Human Prostate and Is Highly Expressed in Prostatic Adenocarcinoma

Gavin P. Collett, Alan M. Betts, Mark I. Johnson, Anna B. Pulimood, Susan Cook, David E. Neal, and Craig N. Robson
Clin Cancer Res 2000 6: 3241 [Abstract] [Full Text] [PDF]  

Expression of a Retinoid-inducible Tumor Suppressor, Tazarotene-inducible Gene-3, Is Decreased in Psoriasis and Skin Cancer

Madeleine Duvic, Bharati Helekar, Claudia Schulz, Mimi Cho, Dan DiSepio, Carina Hager, Dominique DiMao, Parul Hazarika, Brooke Jackson, Joan Breuer-McHam, John Young, Gary Clayman, Scott M. Lippman, Roshandra A. S. Chandraratna, Nancy A. Robinson, Anne Deucher, Richard L. Eckert, and Sunil Nagpal
Clin Cancer Res 2000 6: 3249 [Abstract] [Full Text] [PDF]  

Evidence for a Dose-Response Effect between p53 (but not p21^WAF1/Cip1) Protein Concentrations, Survival, and Responsiveness in Patients with Epithelial Ovarian Cancer Treated with Platinum-based Chemotherapy

Michael A. Levesque, Dionyssios Katsaros, Marco Massobrio, Franco Genta, Herb Yu, Giovanni Richiardi, Stefano Fracchioli, Antonio Durando, Riccardo Arisio, and Eleftherios P. Diamandis
Clin Cancer Res 2000 6: 3260 [Abstract] [Full Text] [PDF]  

Overexpression of H-Ryk in Epithelial Ovarian Cancer: Prognostic Significance of Receptor Expression

Roy M. T. Katso, Sanjiv Manek, Hooman Ganjavi, Simon Biddolph, Mark F. L. Charnock, Mike Bradburn, Michael Wells, and Trivadi S. Ganesan
Clin Cancer Res 2000 6: 3271 [Abstract] [Full Text] [PDF]  

Inhibition of Gelatinolytic Activity in Tumor Tissues by Synthetic Matrix Metalloproteinase Inhibitor: Application of Film in Situ Zymography

Minoru Ikeda, Ryuji Maekawa, Hidekazu Tanaka, Mitsunobu Matsumoto, Yukihiro Takeda, Yutaka Tamura, Ryoichi Nemori, and Takayuki Yoshioka
Clin Cancer Res 2000 6: 3290 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Significance of Macrophage Chemoattractant Protein-1 in Macrophage Recruitment, Angiogenesis, and Survival in Human Breast Cancer

Takayuki Ueno, Masakazu Toi, Hisashi Saji, Mariko Muta, Hiroko Bando, Katsumasa Kuroi, Morio Koike, Hidekuni Inadera, and Kouji Matsushima
Clin Cancer Res 2000 6: 3282 [Abstract] [Full Text] [PDF]  

Role of Human Cytochrome P450 3A4 in Metabolism of Medroxyprogesterone Acetate

Kaoru Kobayashi, Nobuhito Mimura, Hirofumi Fujii, Hironobu Minami, Yasutsuna Sasaki, Noriaki Shimada, and Kan Chiba
Clin Cancer Res 2000 6: 3297 [Abstract] [Full Text] [PDF]  

Sensitivity to 5,10-Dideazatetrahydrofolate Is Fully Conserved in a Murine Leukemia Cell Line Highly Resistant to Methotrexate Due to Impaired Transport Mediated by the Reduced Folate Carrier

Rongbao Zhao, Feng Gao, Solomon Babani, and I. David Goldman
Clin Cancer Res 2000 6: 3304 [Abstract] [Full Text] [PDF]  

Induction of a Heat Shock Factor 1-dependent Stress Response Alters the Cytotoxic Activity of Hsp90-binding Agents

Rochelle Bagatell, Gillian D. Paine-Murrieta, Charles W. Taylor, Elizabeth J. Pulcini, Shiro Akinaga, Ivor J. Benjamin, and Luke Whitesell
Clin Cancer Res 2000 6: 3312 [Abstract] [Full Text] [PDF]  

The Selective Tyrosine Kinase Inhibitor STI571 Inhibits Small Cell Lung Cancer Growth

Geoffrey W. Krystal, Sittisak Honsawek, Julie Litz, and Elisabeth Buchdunger
Clin Cancer Res 2000 6: 3319 [Abstract] [Full Text] [PDF]  

In Vivo Potentiation of Radiation Response by Topotecan in Human Rhabdomyosarcoma Xenografted into Nude Mice

P. Chastagner, J. L. Merlin, C. Marchal, S. Hoffstetter, M. Barberi-Heyob, G. Vassal, and A. Duprez
Clin Cancer Res 2000 6: 3327 [Abstract] [Full Text] [PDF]  

Synergistic Interaction between Anti-p185^HER-2 Ricin A Chain Immunotoxins and Radionuclide Conjugates for Inhibiting Growth of Ovarian and Breast Cancer Cells That Overexpress HER-2

Fengji Xu, S. Anthony Leadon, Yinhua Yu, Cinda M. Boyer, Kathy O’Briant, Kristine Ward, Amanda McWatters, Xiaoguang Zhao, Duk Soo Bae, Karen DeSombre, Michael R. Zalutsky, and Robert C. Bast, Jr.
Clin Cancer Res 2000 6: 3334 [Abstract] [Full Text] [PDF]  

Oncolytic Herpes Simplex Virus-1 Lacking ICP34.5 Induces p53-independent Death and Is Efficacious against Chemotherapy-resistant Ovarian Cancer

George Coukos, Antonis Makrigiannakis, Eugene H. Kang, Stephen C. Rubin, Steven M. Albelda, and Katherine L. Molnar-Kimber
Clin Cancer Res 2000 6: 3342 [Abstract] [Full Text] [PDF]  

Efficient Inhibition of In Vivo Human Malignant Glioma Growth and Angiogenesis by Interferon-ß Treatment at Early Stage of Tumor Development

Yong-Kil Hong, Dong-Sup Chung, Young-Ae Joe, Youn-Joo Yang, Kyung-Mi Kim, Young-Sup Park, W. K. Alfred Yung, and Joon-Ki Kang
Clin Cancer Res 2000 6: 3354 [Abstract] [Full Text] [PDF]  

Tumor Biology: Use of Tiled Images in Conjunction with Measurements of Cellular Proliferation and Death in Response to Drug Treatments

Eric J. Wexler, Ellen M. Gravallese, Philip M. Czerniak, James J. Devenny, Janina Longtine, Michael K. K. Wong, Andrew M. Slee, and Janet S. Kerr
Clin Cancer Res 2000 6: 3361 [Abstract] [Full Text] [PDF]  

1,25-Dihydroxyvitamin D₃ Down-Regulates Estrogen Receptor Abundance and Suppresses Estrogen Actions in MCF-7 Human Breast Cancer Cells

Srilatha Swami, Aruna V. Krishnan, and David Feldman
Clin Cancer Res 2000 6: 3371 [Abstract] [Full Text] [PDF]  

Antitumor Effect of -Galactosylceramide (KRN7000) on Spontaneous Hepatic Metastases Requires Endogenous Interleukin 12 in the Liver

Nobuaki Fuji, Yuji Ueda, Hitoshi Fujiwara, Tsuyoshi Itoh, Tetsunori Yoshimura, and Hisakazu Yamagishi
Clin Cancer Res 2000 6: 3380 [Abstract] [Full Text] [PDF]  

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