Editorials:

Need and Potential for Predictive Tests of Hepatic Metabolism of Anticancer Drugs

Clinton F. Stewart and Erin G. Schuetz
Clin Cancer Res 2000 6: 3391 [Abstract] [Full Text] [PDF]  

Insights into the Pharmacokinetics and Pharmacodynamics of Irinotecan

Mark J. Ratain
Clin Cancer Res 2000 6: 3393 [Abstract] [Full Text] [PDF]  

Minireviews:

The Development of Conditionally Replicative Adenoviruses for Cancer Therapy

David T. Curiel
Clin Cancer Res 2000 6: 3395 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Flavopiridol Metabolism in Cancer Patients Is Associated with the Occurrence of Diarrhea

Federico Innocenti, Walter M. Stadler, Lalitha Iyer, Jacqueline Ramírez, Everett E. Vokes, and Mark J. Ratain
Clin Cancer Res 2000 6: 3400 [Abstract] [Full Text] [PDF]  

A Phase I Trial of a Human Papillomavirus (HPV) Peptide Vaccine for Women with High-Grade Cervical and Vulvar Intraepithelial Neoplasia Who Are HPV 16 Positive

Laila Muderspach, Sharon Wilczynski, Linda Roman, Liz Bade, Juan Felix, L. A. Small, W. Martin Kast, Grace Fascio, Verna Marty, and Jeffrey Weber
Clin Cancer Res 2000 6: 3406 [Abstract] [Full Text] [PDF]  

Clinical Relevance of the Lung Resistance Protein in Diffuse Large B-Cell Lymphomas

Martin Filipits, Ulrich Jaeger, Ingrid Simonitsch, Claudia Chizzali-Bonfadin, Harald Heinzl, and Robert Pirker
Clin Cancer Res 2000 6: 3417 [Abstract] [Full Text] [PDF]  

KAI1 Protein Is Down-Regulated during the Progression of Human Breast Cancer

Xiaohong Yang, Lisa Wei, Careen Tang, Rebecca Slack, Elizabeth Montgomery, and Marc Lippman
Clin Cancer Res 2000 6: 3424 [Abstract] [Full Text] [PDF]  

Elevated Caveolin-1 Levels in African-American versus White-American Prostate Cancer

Guang Yang, Josephine Addai, Michael Ittmann, Thomas M. Wheeler, and Timothy C. Thompson
Clin Cancer Res 2000 6: 3430 [Abstract] [Full Text] [PDF]  

Compensatory Stabilization of RII_ß Protein, Cell Cycle Deregulation, and Growth Arrest in Colon and Prostate Carcinoma Cells by Antisense-directed Down-Regulation of Protein Kinase A RI Protein

Maria Nesterova, Kohei Noguchi, Yun Gyu Park, Youl Nam Lee, and Yoon S. Cho-Chung
Clin Cancer Res 2000 6: 3434 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase II Trial of Interleukin 2, Interferon , and 5-Fluorouracil in Metastatic Renal Cell Cancer: A Cytokine Working Group Study

Janice P. Dutcher, Theodore Logan, Michael Gordon, Jeffrey Sosman, Geoffrey Weiss, Kim Margolin, Terry Plasse, James Mier, Michael Lotze, Joseph Clark, and Michael Atkins
Clin Cancer Res 2000 6: 3442 [Abstract] [Full Text] [PDF]  

Factors Involved in Prolongation of the Terminal Disposition Phase of SN-38: Clinical and Experimental Studies

Diederik F. S. Kehrer, Wataru Yamamoto, Jaap Verweij, Maja J. A. de Jonge, Peter de Bruijn, and Alex Sparreboom
Clin Cancer Res 2000 6: 3451 [Abstract] [Full Text] [PDF]  

Oral Paclitaxel and Concurrent Cyclosporin A: Targeting Clinically Relevant Systemic Exposure to Paclitaxel

Carolyn D. Britten, Sharyn D. Baker, Louis J. Denis, Thomas Johnson, Ronald Drengler, Lillian L. Siu, Ken Duchin, John Kuhn, and Eric K. Rowinsky
Clin Cancer Res 2000 6: 3459 [Abstract] [Full Text] [PDF]  

Outcomes of Dysplastic Nodules in Human Cirrhotic Liver: A Clinicopathological Study

Shuichi Seki, Hiroki Sakaguchi, Takuya Kitada, Akihiro Tamori, Tadashi Takeda, Norifumi Kawada, Daiki Habu, Kazuki Nakatani, Shuhei Nishiguchi, and Susumu Shiomi
Clin Cancer Res 2000 6: 3469 [Abstract] [Full Text] [PDF]  

A Phase I/II Trial of Paclitaxel, Carboplatin, and Gemcitabine in Untreated Patients with Advanced Non-Small Cell Lung Cancer

Karen Kelly, Nadine Mikhaeel-Kamel, Zhaoxing Pan, James Murphy, Sheila Prindiville, and Paul A. Bunn, Jr.
Clin Cancer Res 2000 6: 3474 [Abstract] [Full Text] [PDF]  

Optimizing the Erythromycin Breath Test for Use in Cancer Patients

Laurent P. Rivory, Kellie Slaviero, J. Paul Seale, Janelle M. Hoskins, Michael Boyer, Philip J. Beale, Michael J. Millward, James F. Bishop, and Stephen J. Clarke
Clin Cancer Res 2000 6: 3480 [Abstract] [Full Text] [PDF]  

Phase III Evaluation of Octreotide versus Chemotherapy with 5-Fluorouracil or 5-Fluorouracil Plus Leucovorin in Advanced Exocrine Pancreatic Cancer: A North Central Cancer Treatment Group Study

Patrick A. Burch, Margaret Block, Georgene Schroeder, John W. Kugler, Daniel J. Sargent, Theodore A. Braich, James A. Mailliard, John C. Michalak, Alan K. Hatfield, Keith Wright, and Steven A. Kuross
Clin Cancer Res 2000 6: 3486 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of 10-Propargyl-10-deazaaminopterin, a New Antifolate

Lee M. Krug, Kenneth K. Ng, Mark G. Kris, Vincent A. Miller, William Tong, Robert T. Heelan, Larry Leon, Denis Leung, Jean Kelly, and F. M. Sirotnak
Clin Cancer Res 2000 6: 3493 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

p53 Mutations in Primary and Metastatic Tumors and Circulating Tumor Cells from Colorectal Carcinoma Patients

Zulfiqar A. J. Khan, Sonja K. Jonas, Nadia Le-Marer, Hitesh Patel, Richard Q. Wharton, Antonio Tarragona, Angela Ivison, and Timothy G. Allen-Mersh
Clin Cancer Res 2000 6: 3499 [Abstract] [Full Text] [PDF]  

Loss of Fhit Expression in Invasive Cervical Carcinomas and Intraepithelial Lesions Associated with Invasive Disease

Denise C. Connolly, David L. Greenspan, Rong Wu, Xiaodan Ren, Rodney L. Dunn, Keerti V. Shah, Ronald W. Jones, F. Xavier Bosch, Nubia Muñoz, and Kathleen R. Cho
Clin Cancer Res 2000 6: 3505 [Abstract] [Full Text] [PDF]  

CDKN2A Mutation and Deletion Status in Thin and Thick Primary Melanoma

Adrian R. Cachia, James O. Indsto, Kathryn M. McLaren, Graham J. Mann, and Mark J. Arends
Clin Cancer Res 2000 6: 3511 [Abstract] [Full Text] [PDF]  

Frequent p15 Promoter Methylation in Tumor and Peripheral Blood from Hepatocellular Carcinoma Patients

Ivy H. N. Wong, Y. M. Dennis Lo, Winnie Yeo, Wan Y. Lau, and Philip J. Johnson
Clin Cancer Res 2000 6: 3516 [Abstract] [Full Text] [PDF]  

Molecular Heterogeneity and Function of EWS-WT1 Fusion Transcripts in Desmoplastic Small Round Cell Tumors

Jun Liu, Marion M. Nau, Jimmy C. Yeh, Carmen J. Allegra, Edward Chu, and John J. Wright
Clin Cancer Res 2000 6: 3522 [Abstract] [Full Text] [PDF]  

Expression of Stromal Cell-derived Factor 1 and CXCR4 Ligand Receptor System in Pancreatic Cancer: A Possible Role for Tumor Progression

Takatomo Koshiba, Ryo Hosotani, Yoshiharu Miyamoto, Jun Ida, Shoichiro Tsuji, Sanae Nakajima, Michiya Kawaguchi, Hiroyuki Kobayashi, Ryuichiro Doi, Toshiyuki Hori, Nobutaka Fujii, and Masayuki Imamura
Clin Cancer Res 2000 6: 3530 [Abstract] [Full Text] [PDF]  

Abnormal Expression of the ATM and TP53 Genes in Sporadic Breast Carcinomas

Sandra Angèle, Isabelle Treilleux, Philippe Tanière, Ghyslaine Martel-Planche, Michèle Vuillaume, Christiane Bailly, Alain Brémond, Ruggero Montesano, and Janet Hall
Clin Cancer Res 2000 6: 3536 [Abstract] [Full Text] [PDF]  

Angiogenin Expression in Human Colorectal Cancer: The Role of Focal Macrophage Infiltration

Tsuyoshi Etoh, Kenji Shibuta, Graham F. Barnard, Seigo Kitano, and Masaki Mori
Clin Cancer Res 2000 6: 3545 [Abstract] [Full Text] [PDF]  

Reliable and Sensitive Analysis of Occult Bone Marrow Metastases Using Automated Cellular Imaging

Kenneth D. Bauer, Jose de la Torre-Bueno, Ingo J. Diel, Debra Hawes, William J. Decker, Carl Priddy, Blaise Bossy, Susan Ludmann, Karen Yamamoto, Aneal S. Masih, Froilan P. Espinoza, and Douglas S. Harrington
Clin Cancer Res 2000 6: 3552 [Abstract] [Full Text] [PDF]  

Frequency of Apoptosis of Tumor-infiltrating Lymphocytes Induced by Fas Counterattack in Human Colorectal Carcinoma and Its Correlation with Prognosis

Kazuya Okada, Ko Komuta, Satoshi Hashimoto, Sumihiro Matsuzaki, Takashi Kanematsu, and Takehiko Koji
Clin Cancer Res 2000 6: 3560 [Abstract] [Full Text] [PDF]  

Refinement of Regions with Allelic Loss on Chromosome 18p11.2 and 18q12.2 in Esophageal Squamous Cell Carcinoma

Jayaprakash D. Karkera, Saleh Ayache, Rodman J. Ransome, Jr., Marvin A. Jackson, Ahmed F. Elsayem, Rajagopalan Sridhar, Sevilla D. Detera-Wadleigh, and Robert G. Wadleigh
Clin Cancer Res 2000 6: 3565 [Abstract] [Full Text] [PDF]  

Expression of a Subset of Steroid Receptor Cofactors Is Associated with Progesterone Receptor Expression in Meningiomas

Rona S. Carroll, Myles Brown, Jianping Zhang, James DiRenzo, Jaime Font De Mora, and Peter McL. Black
Clin Cancer Res 2000 6: 3570 [Abstract] [Full Text] [PDF]  

Serum Soluble Fas Level as a Prognostic Factor in Patients with Gynecological Malignancies

Ryo Konno, Tadao Takano, Shinji Sato, and Akira Yajima
Clin Cancer Res 2000 6: 3576 [Abstract] [Full Text] [PDF]  

Clinicopathological Features and Overexpression of Matrix Metalloproteinases in Intramucosal Gastric Carcinoma with Lymph Node Metastasis

Akira Kabashima, Yoshihiko Maehara, Yoshihiro Kakeji, Hideo Baba, Tadashi Koga, and Keizo Sugimachi
Clin Cancer Res 2000 6: 3581 [Abstract] [Full Text] [PDF]  

Evaluation of Two New Urinary Tumor Markers: Bladder Tumor Fibronectin and Cytokeratin 18 for the Diagnosis of Bladder Cancer

Marta Sánchez-Carbayo, Manuel Urrutia, Jose Manuel González de Buitrago, and Juan Alejandro Navajo
Clin Cancer Res 2000 6: 3585 [Abstract] [Full Text] [PDF]  

The Role of nm23-H1 in the Progression of Transitional Cell Bladder Cancer

Nan-Haw Chow, Hsiao-Sheng Liu, and Shih-Huang Chan
Clin Cancer Res 2000 6: 3595 [Abstract] [Full Text] [PDF]  

Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax Expression in Invasive and in Situ Squamous Cell Carcinoma of the Uterine Cervix

Clin Cancer Res 2000 6: 3600 [Abstract] [Full Text] [PDF]  

Methylation of hMLH1 in a Population-based Series of Endometrial Carcinomas

Helga B. Salvesen, Nicola MacDonald, Andy Ryan, Ole Erik Iversen, Ian J. Jacobs, Lars A. Akslen, and Soma Das
Clin Cancer Res 2000 6: 3607 [Abstract] [Full Text] [PDF]  

Levels of Cyclin D1 and D3 in Malignant Melanoma: Deregulated Cyclin D3 Expression Is Associated with Poor Clinical Outcome in Superficial Melanoma

Vivi Ann Flørenes, Ragnar S. Faye, Gunhild M. Mælandsmo, Jahn M. Nesland, and Ruth Holm
Clin Cancer Res 2000 6: 3614 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Therapeutic Efficacy of Anti-Lewis^y Humanized 3S193 Radioimmunotherapy in a Breast Cancer Model: Enhanced Activity When Combined with Taxol Chemotherapy

Kerrie Clarke, Fook-Thean Lee, Martin W. Brechbiel, Fiona E. Smyth, Lloyd J. Old, and Andrew M. Scott
Clin Cancer Res 2000 6: 3621 [Abstract] [Full Text] [PDF]  

Epitope-specific Antibody Response to HT-1080 Fibrosarcoma Cells by Mimotope Immunization

Mikhail Popkov, Salwa Sidrac-Ghali, Valery Alakhov, and Rosemonde Mandeville
Clin Cancer Res 2000 6: 3629 [Abstract] [Full Text] [PDF]  

Topical Delivery of 13-cis-Retinoic Acid by Inhalation Up-Regulates Expression of Rodent Lung but not Liver Retinoic Acid Receptors

Da Li Wang, Melissa Marko, Alan R. Dahl, Kory S. Engelke, Michael E. Placke, Anthony R. Imondi, James L. Mulshine, and Luigi M. De Luca
Clin Cancer Res 2000 6: 3636 [Abstract] [Full Text] [PDF]  

Leucovorin Rescue from Raltitrexed (Tomudex)-induced Antiproliferative Effects: In Vitro Cell Line and in Vivo Mouse Studies

D. C. Farrugia, G. W. Aherne, L. Brunton, S. J. Clarke, and A. L. Jackman
Clin Cancer Res 2000 6: 3646 [Abstract] [Full Text] [PDF]  

Alterations in Polyamine Catabolic Enzymes in Human Breast Cancer Tissue

Heather M. Wallace, Jane Duthie, Deborah M. Evans, Scott Lamond, Kirstie M. Nicoll, and Steven D. Heys
Clin Cancer Res 2000 6: 3657 [Abstract] [Full Text] [PDF]  

Plasma and Cerebrospinal Fluid Pharmacokinetics of O⁶-Benzylguanine and Analogues in Nonhuman Primates

Lina Long, Stacey L. Berg, Sandip K. Roy, Cindy L. McCully, Hee-Won Song-Yoo, Robert C. Moschel, Frank M. Balis, and M. Eileen Dolan
Clin Cancer Res 2000 6: 3662 [Abstract] [Full Text] [PDF]  

Preclinical Study of the Systemic Toxicity and Pharmacokinetics of 5-Iodo-2-deoxypyrimidinone-2'-deoxyribose as a Radiosensitizing Prodrug in Two, Non-Rodent Animal Species: Implications for Phase I Study Design

Timothy J. Kinsella, Jane E. Schupp, Thomas W. Davis, Suzanne E. Berry, Hwa-Shin Hwang, Kathy Warren, Frank Balis, John Barnett, and Howard Sands
Clin Cancer Res 2000 6: 3670 [Abstract] [Full Text] [PDF]  

Treatment of Anthracycline Extravasation with Dexrazoxane

Seppo W. Langer, Maxwell Sehested, and Peter Buhl Jensen
Clin Cancer Res 2000 6: 3680 [Abstract] [Full Text] [PDF]  

The Mechanism of Transport of the Multitargeted Antifolate (MTA) and Its Cross-resistance Pattern in Cells with Markedly Impaired Transport of Methotrexate

Rongbao Zhao, Solomon Babani, Feng Gao, Laibin Liu, and I. David Goldman
Clin Cancer Res 2000 6: 3687 [Abstract] [Full Text] [PDF]  

9-cis-Retinoic Acid Suppresses Mammary Tumorigenesis in C3(1)-Simian Virus 40 T Antigen-transgenic Mice

Kendall Wu, Hee-Tae Kim, Jenny L. Rodriquez, Deborah Munoz-Medellin, Syed K. Mohsin, Susan G. Hilsenbeck, William W. Lamph, Marco M. Gottardis, Michael A. Shirley, John G. Kuhn, Jeff E. Green, and Powel H. Brown
Clin Cancer Res 2000 6: 3696 [Abstract] [Full Text] [PDF]  

Co-administration of Probenecid, an Inhibitor of a cMOAT/MRP- like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10-Deazaaminopterin against Human Solid Tumors in Vivo

F. M. Sirotnak, H. Guido Wendel, William G. B. Bornmann, William P. Tong, Vincent A. Miller, Howard I. Scher, and Mark G. Kris
Clin Cancer Res 2000 6: 3705 [Abstract] [Full Text] [PDF]  

Intranasal Therapy with an Adenoviral Vector Containing the Murine Interleukin-12 Gene Eradicates Osteosarcoma Lung Metastases

Laura L. Worth, Shu-Fang Jia, Zhichao Zhou, Ling Chen, and Eugenie S. Kleinerman
Clin Cancer Res 2000 6: 3713 [Abstract] [Full Text] [PDF]  

Lack of Multicellular Drug Resistance Observed in Human Ovarian and Prostate Carcinoma Treated with the Proteasome Inhibitor PS-341

Andrea Frankel, Shan Man, Peter Elliott, Julian Adams, and Robert S. Kerbel
Clin Cancer Res 2000 6: 3719 [Abstract] [Full Text] [PDF]  

Perforin-mediated Lysis of Tumor Cells by Mycobacterium Bovis Bacillus Calmette-Guérin-activated Killer Cells

Sven Brandau, Henrik Suttmann, Josef Riemensberger, Ulrike Seitzer, Judith Arnold, Christoph Durek, Dieter Jocham, Hans-Dieter Flad, and Andreas Böhle
Clin Cancer Res 2000 6: 3729 [Abstract] [Full Text] [PDF]  

Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells

Fortunato Ciardiello, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Rosa Caputo, Grazia Pomatico, Sabino De Placido, A. Raffaele Bianco, John Mendelsohn, and Giampaolo Tortora
Clin Cancer Res 2000 6: 3739 [Abstract] [Full Text] [PDF]  

Hyperthermia Increases Accumulation of Technetium-99m-labeled Liposomes in Feline Sarcomas

Mark L. Matteucci, Gopal Anyarambhatla, Gary Rosner, Chieko Azuma, Paul E. Fisher, Mark W. Dewhirst, David Needham, and Donald E. Thrall
Clin Cancer Res 2000 6: 3748 [Abstract] [Full Text] [PDF]  

Early Caspase Activation in Leukemic Cells Subject to Etoposide-induced G₂-M Arrest: Evidence of Commitment to Apoptosis Rather Than Mitotic Cell Death

Robert J. Sleiman and Bernard W. Stewart
Clin Cancer Res 2000 6: 3756 [Abstract] [Full Text] [PDF]  

In Vitro Evaluation of Schedule-dependent Interactions between Docetaxel and Doxorubicin against Human Breast and Ovarian Cancer Cells

Su Zeng, Yao Zu Chen, Liwu Fu, Korey R. Johnson, and Weimin Fan
Clin Cancer Res 2000 6: 3766 [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Pharmacological Characterizations of the Antitumor Properties of Two New Olivacine Derivatives, S16020-2 and S30972-1

Hugues Malonne, Sophie Farinelle, Christine Decaestecker, Laurence Gordower, Jeanine Fontaine, Françoise Chaminade, Jean-Marie Saucier, Ghanem Atassi, and Robert Kiss
Clin Cancer Res 2000 6: 3774 [Abstract] [Full Text] [PDF]  

Cancer Biology:

Reactive Oxygen Species Are Critical for the Growth and Differentiation of Medullary Thyroid Carcinoma Cells

Hyo Chol Ha, Arunthathi Thiagalingam, Barry D. Nelkin, and Robert A. Casero, Jr.
Clin Cancer Res 2000 6: 3783 [Abstract] [Full Text] [PDF]  

HET/SAF-B Overexpression Causes Growth Arrest and Multinuclearity and Is Associated with Aneuploidy in Human Breast Cancer

Steven M. Townson, Toby Sullivan, QingPing Zhang, Gary M. Clark, C. Kent Osborne, Adrian V. Lee, and Steffi Oesterreich
Clin Cancer Res 2000 6: 3788 [Abstract] [Full Text] [PDF]  

Corrections:

Correction

Clin Cancer Res 2000 6: 3797 [Full Text] [PDF]  

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