Editorials:

Telomerase and Cancer: Where and When?

William C. Hahn
Clin Cancer Res 2001 7: 2953 [Full Text] [PDF]  

Where to Next with Retinoids for Cancer Therapy?

Malcolm A. Smith and Barry Anderson
Clin Cancer Res 2001 7: 2955 [Full Text] [PDF]  

Review:

A Novel Approach in the Treatment of Cancer: Targeting the Epidermal Growth Factor Receptor

Fortunato Ciardiello and Giampaolo Tortora
Clin Cancer Res 2001 7: 2958 [Abstract] [Full Text] [PDF]  

Minireviews:

Sequential Tumor Biopsies in Early Phase Clinical Trials of Anticancer Agents for Pharmacodynamic Evaluation

Afshin Dowlati, John Haaga, Scot C. Remick, Timothy P. Spiro, Stanton L. Gerson, Lili Liu, Sosamma J. Berger, Nathan A. Berger, and James K. V. Willson
Clin Cancer Res 2001 7: 2971 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Serum Osteoprotegerin Levels Are Increased in Patients with Advanced Prostate Cancer

Julie M. Brown, Robert L. Vessella, Paul J. Kostenuik, Colin R. Dunstan, Paul H. Lange, and Eva Corey
Clin Cancer Res 2001 7: 2977 [Abstract] [Full Text] [PDF]  

Correlation of p53 Mutations with Resistance to Platinum-based Chemotherapy and Shortened Survival in Ovarian Cancer

Angela Reles, Wen H. Wen, Annette Schmider, Conway Gee, Ingo B. Runnebaum, Uta Kilian, Lovell A. Jones, Adel El-Naggar, Carmen Minguillon, Ines Schönborn, Olaf Reich, Rolf Kreienberg, Werner Lichtenegger, and Michael F. Press
Clin Cancer Res 2001 7: 2984 [Abstract] [Full Text] [PDF]  

Elevated Expression of hTERT Is Associated with Dysplastic Cell Transformation during Human Oral Carcinogenesis in Situ

Hae-Ryun Kim, Russell Christensen, Noh-Hyun Park, Philip Sapp, Mo K. Kang, and No-Hee Park
Clin Cancer Res 2001 7: 3079 [Abstract] [Full Text] [PDF]  

Thioredoxin Expression Is Associated with Lymph Node Status and Prognosis in Early Operable Non-Small Cell Lung Cancer

Stylianos Kakolyris, Alexandra Giatromanolaki, Michael Koukourakis, Garth Powis, John Souglakos, Efthimios Sivridis, Vassilis Georgoulias, Kevin C. Gatter, and Adrian L. Harris
Clin Cancer Res 2001 7: 3087 [Abstract] [Full Text] [PDF]  

Allelic Variants of Aromatase and the Androgen and Estrogen Receptors: Toward a Multigenic Model of Prostate Cancer Risk

Francesmary Modugno, Joel L. Weissfeld, Donald L. Trump, Joseph M. Zmuda, Patrick Shea, Jane A. Cauley, and Robert E. Ferrell
Clin Cancer Res 2001 7: 3092 [Abstract] [Full Text] [PDF]  

Cancer-associated Myofibroblasts Possess Various Factors to Promote Endometrial Tumor Progression

Akira Orimo, Yasuhiro Tomioka, Yoshihiko Shimizu, Miyuki Sato, Satoko Oigawa, Koichi Kamata, Yasuhisa Nogi, Satoshi Inoue, Masakazu Takahashi, Toshio Hata, and Masami Muramatsu
Clin Cancer Res 2001 7: 3097 [Abstract] [Full Text] [PDF]  

Reduced Expression of Focal Adhesion Kinase in Liver Metastases Compared with Matched Primary Human Colorectal Adenocarcinomas

Masako Ayaki, Keiko Komatsu, Mutsuko Mukai, Kohei Murata, Masao Kameyama, Shingo Ishiguro, Jun Miyoshi, Masaharu Tatsuta, and Hiroyuki Nakamura
Clin Cancer Res 2001 7: 3106 [Abstract] [Full Text] [PDF]  

Increased Expression of Matrix Metalloproteinases 2 and 9 and Tissue Inhibitors of Metalloproteinases 1 and 2 Correlate with Poor Prognostic Variables in Renal Cell Carcinoma

Bhaskar V. S. Kallakury, Shridevi Karikehalli, Aptullah Haholu, Christine E. Sheehan, Norio Azumi, and Jeffrey S. Ross
Clin Cancer Res 2001 7: 3113 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Multidrug Resistance Protein in Adult T-cell Leukemia

Nobuhito Ohno, Ayako Tani, Zhe-Sheng Chen, Kimiharu Uozumi, Shuichi Hanada, Suminori Akiba, Xiao-Qin Ren, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Terukatsu Arima, and Shin-ichi Akiyama
Clin Cancer Res 2001 7: 3120 [Abstract] [Full Text] [PDF]  

Cyclin D1 and p16 Alterations in Advanced Premalignant Lesions of the Upper Aerodigestive Tract: Role in Response to Chemoprevention and Cancer Development

Vassiliki A. Papadimitrakopoulou, Julie Izzo, Li Mao, Jamie Keck, David Hamilton, Dong Moon Shin, Adel El-Naggar, Petra den Hollander, Diane Liu, Walter N. Hittelman, and Waun K. Hong
Clin Cancer Res 2001 7: 3127 [Abstract] [Full Text] [PDF]  

Molecular Detection of p16 Promoter Methylation in the Serum of Patients with Esophageal Squamous Cell Carcinoma

Kenji Hibi, Masumi Taguchi, Hiroshi Nakayama, Tsunenobu Takase, Yasushi Kasai, Katsuki Ito, Seiji Akiyama, and Akimasa Nakao
Clin Cancer Res 2001 7: 3135 [Abstract] [Full Text] [PDF]  

Deletions on Chromosome 8p22 May Predict Disease Progression As Well As Pathological Staging in Prostate Cancer

Hideyasu Matsuyama, Yi Pan, Kazuo Oba, Satoru Yoshihiro, Kenji Matsuda, Lars Hägarth, David Kudren, Katsusuke Naito, Ulf S. R. Bergerheim, and Peter Ekman
Clin Cancer Res 2001 7: 3139 [Abstract] [Full Text] [PDF]  

Mutational Analysis of BRCA1 and BRCA2 and Clinicopathologic Analysis of Ovarian Cancer in 82 Ovarian Cancer Families: Two Common Founder Mutations of BRCA1 in Japanese Population

Masayuki Sekine, Hiroshi Nagata, Shoji Tsuji, Yasuo Hirai, Seiichiro Fujimoto, Masayuki Hatae, Iwao Kobayashi, Tsuneo Fujii, Ichiro Nagata, Kimio Ushijima, Koshiro Obata, Mitsuaki Suzuki, Mitsuhiro Yoshinaga, Naohiko Umesaki, Shinji Satoh, Takayuki Enomoto, Satoru Motoyama, and Kenichi Tanaka
Clin Cancer Res 2001 7: 3144 [Abstract] [Full Text] [PDF]  

Nuclear Expression of the Y-Box Binding Protein, YB-1, as a Novel Marker of Disease Progression in Non-Small Cell Lung Cancer

Kotaro Shibahara, Kenji Sugio, Toshihiro Osaki, Takeshi Uchiumi, Yoshihiko Maehara, Kimitoshi Kohno, Kosei Yasumoto, Keizo Sugimachi, and Michihiko Kuwano
Clin Cancer Res 2001 7: 3151 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

A Selective Cyclooxygenase-2 Inhibitor, NS-398, Enhances the Effect of Radiation in Vitro and in Vivo Preferentially on the Cells That Express Cyclooxygenase-2

Hongryull Pyo, Hak Choy, George P. Amorino, Jae-sung Kim, Qianwen Cao, Sherri K. Hercules, and Raymond N. DuBois
Clin Cancer Res 2001 7: 2998 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis of Integrin-expressing Human Prostate Cancer Cells by Cyclic Arg-Gly-Asp Peptides

Subhendra Chatterjee, Kathleen Hiemstra Brite, and Akiko Matsumura
Clin Cancer Res 2001 7: 3006 [Abstract] [Full Text] [PDF]  

Novel Antitumor Effect of Estradiol in Athymic Mice Injected with a T47D Breast Cancer Cell Line Overexpressing Protein Kinase C

Michael J. Chisamore, Yasmin Ahmed, David J. Bentrem, V. Craig Jordan, and Debra A. Tonetti
Clin Cancer Res 2001 7: 3156 [Abstract] [Full Text] [PDF]  

A New Antiestrogen, 2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), Inhibits the Growth of Tamoxifen-sensitive and -resistant Tumors and Is Devoid of Uterotropic Effects in Mice and Rats

Lee M. Greenberger, Tami Annable, Karen I. Collins, Barry S. Komm, C. Richard Lyttle, Chris P. Miller, Pondichery G. Satyaswaroop, Yixian Zhang, and Philip Frost
Clin Cancer Res 2001 7: 3166 [Abstract] [Full Text] [PDF]  

Chronotherapy and Chronotoxicity of the Cyclooxygenase-2 Inhibitor, Celecoxib, in Athymic Mice Bearing Human Breast Cancer Xenografts

Rosalyn D. Blumenthal, Chris Waskewich, David M. Goldenberg, Walter Lew, Christine Flefleh, and Jack Burton
Clin Cancer Res 2001 7: 3178 [Abstract] [Full Text] [PDF]  

Therapeutic Advantage of ⁹⁰Yttrium- versus ¹³¹Iodine-labeled PAM4 Antibody in Experimental Pancreatic Cancer

Thomas M. Cardillo, Zhiliang Ying, and David V. Gold
Clin Cancer Res 2001 7: 3186 [Abstract] [Full Text] [PDF]  

In Vitro Prevention of the Emergence of Multidrug Resistance in a Pediatric Rhabdomyosarcoma Cell Line

Hilary A. Cocker, Nicki Tiffin, Kathy Pritchard-Jones, C. Ross Pinkerton, and Lloyd R. Kelland
Clin Cancer Res 2001 7: 3193 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics with a New 10-Deazaaminopterin in Human Mesothelioma: Further Improving Efficacy through Structural Design, Pharmacologic Modulation at the Level of MRP ATPases, and Combined Therapy with Platinums

Nushmia Z. Khokhar, Yuhong She, Valerie W. Rusch, and F. M. Sirotnak
Clin Cancer Res 2001 7: 3199 [Abstract] [Full Text] [PDF]  

Antiapoptotic Activity Is Dispensable for Insulin-like Growth Factor I Receptor-mediated Clonogenic Radioresistance after -Irradiation

Mikio Tezuka, Hiroshi Watanabe, Shin Nakamura, Dong Yu, Winn Aung, Takehito Sasaki, Hitoshi Shibuya, and Masahiko Miura
Clin Cancer Res 2001 7: 3206 [Abstract] [Full Text] [PDF]  

Motexafin Gadolinium: A Redox Active Drug That Enhances the Efficacy of Bleomycin and Doxorubicin

Richard A. Miller, Kathryn W. Woodburn, Qing Fan, Intae Lee, Dale Miles, George Duran, Branimir Sikic, and Darren Magda
Clin Cancer Res 2001 7: 3215 [Abstract] [Full Text] [PDF]  

Schedule-dependent Activity of Topotecan in OVCAR-3 Ovarian Carcinoma Xenograft: Pharmacokinetic and Pharmacodynamic Evaluation

Sylvie Guichard, Ashraf Montazeri, Etienne Chatelut, Isabelle Hennebelle, Roland Bugat, and Pierre Canal
Clin Cancer Res 2001 7: 3222 [Abstract] [Full Text] [PDF]  

Tumor Targeting by Covalent Conjugation of a Natural Fatty Acid to Paclitaxel

Matthews O. Bradley, Nigel L. Webb, Forrest H. Anthony, Prabu Devanesan, Philip A. Witman, S. Hemamalini, Madhavi C. Chander, Sharyn D. Baker, Lifeng He, Susan Band Horwitz, and Charles S. Swindell
Clin Cancer Res 2001 7: 3229 [Abstract] [Full Text] [PDF]  

Expression of Her-2/neu in Human Lung Cancer Cell Lines by Immunohistochemistry and Fluorescence in Situ Hybridization and its Relationship to in Vitro Cytotoxicity by Trastuzumab and Chemotherapeutic Agents

Paul A. Bunn, Jr., Barbara Helfrich, Ariel F. Soriano, Wilbur A. Franklin, Marileila Varella-Garcia, Fred R. Hirsch, Anna Baron, Chan Zeng, and Daniel C. Chan
Clin Cancer Res 2001 7: 3239 [Abstract] [Full Text] [PDF]  

Sequence-dependent Enhancement of Cytotoxicity Produced by Ecteinascidin 743 (ET-743) with Doxorubicin or Paclitaxel in Soft Tissue Sarcoma Cells

Naoto Takahashi, Wei Wei Li, Debabrata Banerjee, Kathleen W. Scotto, and Joseph R. Bertino
Clin Cancer Res 2001 7: 3251 [Abstract] [Full Text] [PDF]  

Paclitaxel Liposome Aerosol Treatment Induces Inhibition of Pulmonary Metastases in Murine Renal Carcinoma Model

Nadezhda V. Koshkina, J. Clifford Waldrep, Luz E. Roberts, Eva Golunski, Sara Melton, and Vernon Knight
Clin Cancer Res 2001 7: 3258 [Abstract] [Full Text] [PDF]  

Tumor Uptake and Elimination of 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine) after Deoxycytidine Kinase Gene Transfer: Correlation with in Vivo Tumor Response

A. William Blackstock, Harry Lightfoot, L. Doug Case, Joel E. Tepper, Suresh K. Mukherji, Beverly S. Mitchell, Steve G. Swarts, and Suzanne M. Hess
Clin Cancer Res 2001 7: 3263 [Abstract] [Full Text] [PDF]  

Wortmannin Inhibits PKB/Akt Phosphorylation and Promotes Gemcitabine Antitumor Activity in Orthotopic Human Pancreatic Cancer Xenografts in Immunodeficient Mice

Sylvia S. W. Ng, Ming-Sound Tsao, Trudey Nicklee, and David W. Hedley
Clin Cancer Res 2001 7: 3269 [Abstract] [Full Text] [PDF]  

The T Cell Death Knell: Immune-mediated Tumor Death in Renal Cell Carcinoma

Robert G. Uzzo, Vladimir Kolenko, Christopher J. Froelich, Charles Tannenbaum, Luis Molto, Andrew C. Novick, Neil H. Bander, Ronald Bukowski, and James H. Finke
Clin Cancer Res 2001 7: 3276 [Abstract] [Full Text] [PDF]  

Functional Impairment of Melanoma-associated p16^INK4a Mutants in Melanoma Cells despite Retention of Cyclin-dependent Kinase 4 Binding

Therese M. Becker, Helen Rizos, Richard F. Kefford, and Graham J. Mann
Clin Cancer Res 2001 7: 3282 [Abstract] [Full Text] [PDF]  

Matrilysin Mediates Extracellular Cleavage of E-Cadherin from Prostate Cancer Cells: A Key Mechanism in Hepatocyte Growth Factor/Scatter Factor-induced Cell-Cell Dissociation and in Vitro Invasion

Gaynor Davies, Wen G. Jiang, and Malcolm D. Mason
Clin Cancer Res 2001 7: 3289 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase I Trial of a Melanoma Vaccine with gp100_280–288 Peptide and Tetanus Helper Peptide in Adjuvant: Immunologic and Clinical Outcomes

Craig L. Slingluff, Jr., Galina Yamshchikov, Patrice Neese, Holly Galavotti, Shannon Eastham, Victor H. Engelhard, Dave Kittlesen, Donna Deacon, Sarah Hibbitts, William W. Grosh, Gina Petroni, Roger Cohen, Catie Wiernasz, James W. Patterson, Brian P. Conway, and William G. Ross
Clin Cancer Res 2001 7: 3012 [Abstract] [Full Text] [PDF]  

Development of Tumor-infiltrating Lymphocytes in Breast Cancer after Neoadjuvant Paclitaxel Chemotherapy

Sandra Demaria, Matthew D. Volm, Richard L. Shapiro, Herman T. Yee, Ruth Oratz, Silvia C. Formenti, Franco Muggia, and W. Fraser Symmans
Clin Cancer Res 2001 7: 3025 [Abstract] [Full Text] [PDF]  

Clinical and Molecular Responses in High-Grade Intraepithelial Neoplasia Treated with Topical Imiquimod 5%

Concepcion Diaz-Arrastia, Istvan Arany, Sonia C. Robazetti, Tung V. Dinh, Zoran Gatalica, Stephen K. Tyring, and Edward Hannigan
Clin Cancer Res 2001 7: 3031 [Abstract] [Full Text] [PDF]  

A Phase I Trial and Pharmacokinetic Study of 9-cis-Retinoic Acid (ALRT1057) in Pediatric Patients with Refractory Cancer: A Joint Pediatric Oncology Branch, National Cancer Institute, and Children’s Cancer Group Study

Peter C. Adamson, Brigitte C. Widemann, Gregory H. Reaman, Nita L. Seibel, Robert F. Murphy, Andrea F. Gillespie, and Frank M. Balis
Clin Cancer Res 2001 7: 3034 [Abstract] [Full Text] [PDF]  

Phase I Study of Doxil-Cisplatin Combination Chemotherapy in Patients with Advanced Malignancies

Olga Lyass, Ayala Hubert, and Alberto A. Gabizon
Clin Cancer Res 2001 7: 3040 [Abstract] [Full Text] [PDF]  

A Phase I Clinical and Pharmacological Evaluation of Sodium Phenylbutyrate on an 120-h Infusion Schedule

Michael A. Carducci, Jill Gilbert, M. Katherine Bowling, Dennis Noe, Mario A. Eisenberger, Victoria Sinibaldi, Yelena Zabelina, Tian-ling Chen, Louise B. Grochow, and Ross C. Donehower
Clin Cancer Res 2001 7: 3047 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacological Study of a New Camptothecin Derivative, Exatecan Mesylate (DX-8951f), Infused Over 30 Minutes Every Three Weeks

Hironobu Minami, Hirofumi Fujii, Tadahiko Igarashi, Kuniaki Itoh, Kyoji Tamanoi, Toshihiro Oguma, and Yasutsuna Sasaki
Clin Cancer Res 2001 7: 3056 [Abstract] [Full Text] [PDF]  

Lack of Correlation of Functional Scintigraphy with ^99mTechnetium-Methoxyisobutylisonitrile with Histological Necrosis following Induction Chemotherapy or Measures of P-Glycoprotein Expression in High-Grade Osteosarcoma

Richard Gorlick, Alfred C. Liao, Cristina Antonescu, Andrew G. Huvos, John H. Healey, Rebecca Sowers, Mariza Daras, Elizabeth Calleja, Leonard H. Wexler, David Panicek, Paul A. Meyers, Samuel D. Yeh, and Steven M. Larson
Clin Cancer Res 2001 7: 3065 [Abstract] [Full Text] [PDF]  

Forearm Blood Flow and Local Responses to Peptide Vasodilators: A Novel Pharmacodynamic Measure in the Phase I Trial of Antagonist G, a Neuropeptide Growth Factor Antagonist

Sally Clive, David J. Webb, Alex MacLellan, Anne Young, Bernie Byrne, Lesley Robson, John F. Smyth, and Duncan I. Jodrell
Clin Cancer Res 2001 7: 3071 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Expression of Interleukin 8 and Its Receptors in Human Colon Carcinoma Cells with Different Metastatic Potentials

Aihua Li, Michelle L. Varney, and Rakesh K. Singh
Clin Cancer Res 2001 7: 3298 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: E. Sabo et al., Microscopic Analysis and Significance of Vascular Architectural Complexity in Renal Cell Carcinoma. Clin. Cancer Res., 7: 533–537, 2001.

Fabio Grizzi, Piergiuseppe Colombo, Barbara Barbieri, Barbara Franceschini, Massimo Roncalli, Maurizio Chiriva-Internati, Pier Carlo Muzzio, and Nicola Dioguardi
Clin Cancer Res 2001 7: 3305 [Full Text] [PDF]  

Reply

Edmond Sabo and Murray B Resnick
Clin Cancer Res 2001 7: 3307 [Full Text] [PDF]  

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