Editorials:

Stealth Liposomes and Tumor Targeting: One Step Further in the Quest for the Magic Bullet

Alberto A. Gabizon
Clin Cancer Res 2001 7: 223 [Full Text] [PDF]  

The Clinical Implications of Gemcitabine Radiosensitization

Todd H. Doyle, Francoise Mornex, and W. Gillies McKenna
Clin Cancer Res 2001 7: 226 [Full Text] [PDF]  

Why Drugs Fail: Of Mice and Men Revisited

Chris H. Takimoto
Clin Cancer Res 2001 7: 229 [Full Text] [PDF]  

Clinical Trials:

Phase I and Pharmacokinetic Study of Ecteinascidin 743 Administered as a 72-Hour Continuous Intravenous Infusion in Patients with Solid Malignancies

David P. Ryan, Jeffrey G. Supko, J. Paul Eder, Michael V. Seiden, George Demetri, Thomas J. Lynch, Alan J. Fischman, John Davis, Jose Jimeno, and Jeffrey W. Clark
Clin Cancer Res 2001 7: 231 [Abstract] [Full Text] [PDF]  

Effective Targeting of Solid Tumors in Patients With Locally Advanced Cancers by Radiolabeled Pegylated Liposomes

Kevin J. Harrington, Sima Mohammadtaghi, Paul S. Uster, Daphne Glass, A. Michael Peters, Richard G. Vile, and J. Simon W. Stewart
Clin Cancer Res 2001 7: 243 [Abstract] [Full Text] [PDF]  

The Toxicity of Deglycosylated Ricin A Chain-containing Immunotoxins in Patients with Non-Hodgkin’s Lymphoma Is Exacerbated by Prior Radiotherapy: A Retrospective Analysis of Patients in Five Clinical Trials

John Schindler, Edward Sausville, Richard Messmann, Jonathan W. Uhr, and Ellen S. Vitetta
Clin Cancer Res 2001 7: 255 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Multiple High-Grade Bronchial Dysplasia and Squamous Cell Carcinoma: Concordant and Discordant Mutations

Jay O. Boyle, Fulvio Lonardo, Jeffrey H. Chang, David Klimstra, Valerie Rusch, and Ethan Dmitrovsky
Clin Cancer Res 2001 7: 259 [Abstract] [Full Text] [PDF]  

Regulation of the Urokinase-type Plasminogen Activator Receptor Gene in Different Grades of Human Glioma Cell Lines

Anuradha Bhattacharya, Sajani S. Lakka, Sanjeeva Mohanam, Douglas Boyd, and Jasti S. Rao
Clin Cancer Res 2001 7: 267 [Abstract] [Full Text] [PDF]  

Preserved Smad4 Expression in the Transforming Growth Factor ß Signaling Pathway Is a Favorable Prognostic Factor in Patients with Advanced Gastric Cancer

Che Xiangming, Shoji Natsugoe, Sonshin Takao, Shuichi Hokita, Sumiya Ishigami, Gen Tanabe, Masamichi Baba, Kazunao Kuroshima, and Takashi Aikou
Clin Cancer Res 2001 7: 277 [Abstract] [Full Text] [PDF]  

Search for Mouse Mammary Tumor Virus-like env Sequences in Cancer and Normal Breast from the Same Individuals

Stella M. Melana, James F. Holland, and Beatriz G-T. Pogo
Clin Cancer Res 2001 7: 283 [Abstract] [Full Text] [PDF]  

Correlation of Tissue and Plasma RANTES Levels with Disease Course in Patients with Breast or Cervical Cancer

Yukie Niwa, Hirohiko Akamatsu, Hayato Niwa, Hajime Sumi, Yukio Ozaki, and Akio Abe
Clin Cancer Res 2001 7: 285 [Abstract] [Full Text] [PDF]  

Overexpression of p53 in Tumor-distant Epithelia of Head and Neck Cancer Patients Is Associated with an Increased Incidence of Second Primary Carcinoma

Nils Homann, Matthias Nees, Christian Conradt, Andreas Dietz, Hagen Weidauer, Heinz Maier, and Franz X. Bosch
Clin Cancer Res 2001 7: 290 [Abstract] [Full Text] [PDF]  

Cloning and Characterization of a Novel Gene, DRH1, Down-Regulated in Advanced Human Hepatocellular Carcinoma

Yoshiya Yamamoto, Michiie Sakamoto, Gen Fujii, Kengo Kanetaka, Masahiro Asaka, and Setsuo Hirohashi
Clin Cancer Res 2001 7: 297 [Abstract] [Full Text] [PDF]  

Mutations of PTEN/MMAC1 in Primary Prostate Cancers from Chinese Patients

Jin-Tang Dong, Chang-Ling Li, Tavis W. Sipe, and Henry F. Frierson, Jr.
Clin Cancer Res 2001 7: 304 [Abstract] [Full Text] [PDF]  

Expression of p8 in Human Pancreatic Cancer

Shi-Bing Su, Yoshiharu Motoo, Juan Lucio Iovanna, Min-Jue Xie, Hisatsugu Mouri, Koushiro Ohtsubo, Yasushi Yamaguchi, Hiroyuki Watanabe, Takashi Okai, Fujitsugu Matsubara, and Norio Sawabu
Clin Cancer Res 2001 7: 309 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

The Role of Apoptosis in 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine)-mediated Radiosensitization

Theodore S. Lawrence, Mary A. Davis, Amanda Hough, and Alnawaz Rehemtulla
Clin Cancer Res 2001 7: 314 [Abstract] [Full Text] [PDF]  

Interactions between 2-Fluoroadenine 9-ß-D-Arabinofuranoside and the Kinase Inhibitor UCN-01 in Human Leukemia and Lymphoma Cells

Sarah Harvey, Roy Decker, Yun Dai, Gregory Schaefer, Lin Tang, Lora Kramer, Paul Dent, and Steven Grant
Clin Cancer Res 2001 7: 320 [Abstract] [Full Text] [PDF]  

Activating Transcription Factor 2-derived Peptides Alter Resistance of Human Tumor Cell Lines to Ultraviolet Irradiation and Chemical Treatment

Anindita Bhoumik, Vladimir Ivanov, and Ze’ev Ronai
Clin Cancer Res 2001 7: 331 [Abstract] [Full Text] [PDF]  

Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol

Melissa E. S. Kahn, Adrian Senderowicz, Edward A. Sausville, and Kim E. Barrett
Clin Cancer Res 2001 7: 343 [Abstract] [Full Text] [PDF]  

Cotreatment with STI-571 Enhances Tumor Necrosis Factor -related Apoptosis-inducing Ligand (TRAIL or Apo-2L)- induced Apoptosis of Bcr-Abl-positive Human Acute Leukemia Cells

Ramadevi Nimmanapalli, Mercedes Porosnicu, Diep Nguyen, Elizabeth Worthington, Erica O’Bryan, Charles Perkins, and Kapil Bhalla
Clin Cancer Res 2001 7: 350 [Abstract] [Full Text] [PDF]  

Relation between 9-Aminocamptothecin Systemic Exposure and Tumor Response in Human Solid Tumor Xenografts

Mark N. Kirstein, Peter J. Houghton, Pamela J. Cheshire, Lois B. Richmond, Audrey K. Smith, Suzan K. Hanna, and Clinton F. Stewart
Clin Cancer Res 2001 7: 358 [Abstract] [Full Text] [PDF]  

Retinoid Receptor Expression and Its Correlation to Retinoid Sensitivity in Non-M3 Acute Myeloid Leukemia Blast Cells

Sören Lehmann, Crister Paul, and Hans Törmä
Clin Cancer Res 2001 7: 367 [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of Motexafin Lutetium-mediated Intraperitoneal Photodynamic Therapy in a Canine Model

Greg M. Griffin, Timothy Zhu, Michael Solonenko, Fabio Del Piero, Amy Kapakin, Theresa M. Busch, Arjun Yodh, Glenn Polin, Todd Bauer, Douglas Fraker, and Stephen M. Hahn
Clin Cancer Res 2001 7: 374 [Abstract] [Full Text] [PDF]  

Genistein Potentiates the Radiation Effect on Prostate Carcinoma Cells

Gilda G. Hillman, Jeffrey D. Forman, Omer Kucuk, Mark Yudelev, Richard L. Maughan, Johanna Rubio, Andrey Layer, Samuel Tekyi-Mensah, Judith Abrams, and Fazlul H. Sarkar
Clin Cancer Res 2001 7: 382 [Abstract] [Full Text] [PDF]  

Combination of Standard Cytotoxic Agents with Polyamine Analogues in the Treatment of Breast Cancer Cell Lines

Hillary A. Hahm, Valerie R. Dunn, Kimberly A. Butash, Wendy L. Deveraux, Patrick M. Woster, Robert A. Casero, Jr., and Nancy E. Davidson
Clin Cancer Res 2001 7: 391 [Abstract] [Full Text] [PDF]  

Efficacy of Treatment with Antisense Oligonucleotides Complementary to Immunoglobulin Sequences of bcl-2/Immunoglobulin Fusion Transcript in a t(14;18) Human Lymphoma-scid Mouse Model

Mitchell R. Smith, Tao Xie, Zhao-Zong Zhou, and Indira Joshi
Clin Cancer Res 2001 7: 400 [Abstract] [Full Text] [PDF]  

Combination of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Actinomycin D Induces Apoptosis Even in TRAIL-resistant Human Pancreatic Cancer Cells

Hosei Matsuzaki, Bruno M. Schmied, Alexis Ulrich, Jens Standop, Matthias B. Schneider, Surinder K. Batra, Kathleen S. Picha, and Parviz M. Pour
Clin Cancer Res 2001 7: 407 [Abstract] [Full Text] [PDF]  

Tamoxifen Modulates Apoptotic Pathways in Primary Endometrial Cell Cultures

Rodica Stackievicz, Liat Drucker, Judith Radnay, Yoram Beyth, Shai Yarkoni, and Ilan Cohen
Clin Cancer Res 2001 7: 415 [Abstract] [Full Text] [PDF]  

Thresholds of O⁶-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide

Demetrius M. Kokkinakis, Dora B. Bocangel, S. Clifford Schold, Robert C. Moschel, and Anthony E. Pegg
Clin Cancer Res 2001 7: 421 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer

Swati Kulkarni, Janet S. Rader, Fan Zhang, Helen Liapis, Alane T. Koki, Jaime L. Masferrer, Kotha Subbaramaiah, and Andrew J. Dannenberg
Clin Cancer Res 2001 7: 429 [Abstract] [Full Text] [PDF]  

Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-B Signal Pathways

Caren C. Bancroft, Zhong Chen, Gang Dong, John B. Sunwoo, Ning Yeh, Catherine Park, and Carter Van Waes
Clin Cancer Res 2001 7: 435 [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Correspondence re: M. L. George et al., Correlation of Plasma and Serum Vascular Endothelial Growth Factor Levels with Platelet Count in Colorectal Cancer: Clinical Evidence of Platelet Scavenging? Clin. Cancer Res., 6: 3147–3152, 2000.

Eberhard Gunsilius, Joerg Tschmelitsch, and Andreas. L. Petzer
Clin Cancer Res 2001 7: 443 [Full Text] [PDF]  

Reply

Mark George, Suzanne Eccles, Gary Box, Matthew Tutton, Muti Abulafi, and Ian Swift
Clin Cancer Res 2001 7: 444 [Full Text] [PDF]  

Correspondence re: C. F. M. Sier et al., Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers. Clin. Cancer Res., 6: 2333–2340, 2000.

Susanne Gerhards, Frank Koenig, Dmitri Daniltchenko, Steffen Hauptmann, Dietmar Schnorr, and Stefan A. Loening
Clin Cancer Res 2001 7: 445 [Full Text] [PDF]  

Reply

Cornelis F. M. Sier, Jan H. Verheijen, Natascha van Lent, and Roeland Hanemaaijer
Clin Cancer Res 2001 7: 447 [Full Text] [PDF]  

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