Editorials:

Inhibitors of Histone Deacetylase Are Potentially Effective Anticancer Agents

Paul A. Marks, Richard A. Rifkind, Victoria M. Richon, and Ronald Breslow
Clin Cancer Res 2001 7: 759 [Full Text] [PDF]  

Review:

Technology Transfer: A Review for Biomedical Researchers

Robert Kneller
Clin Cancer Res 2001 7: 761 [Abstract] [Full Text] [PDF]  

Minireviews:

Pharmacologic Interruption of the Mitogen-activated Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Signal Transduction Pathway: Potential Role in PromotingCytotoxic Drug Action

Paul Dent and Steven Grant
Clin Cancer Res 2001 7: 775 [Full Text] [PDF]  

Clinical Trials:

Role of Tumor Necrosis Factor on Toxicity and Cytokine Production after Isolated Hepatic Perfusion

Titia E. Lans, David L. Bartlett, Steven K. Libutti, Michael F.X. Gnant, David J. Liewehr, David J. Venzon, Ewa M. Turner, and H. Richard Alexander
Clin Cancer Res 2001 7: 784 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Future Development of Lymphoproliferative Disorders in Patients with Autoimmune Hemolytic Anemia

Sabah Sallah, Jim Y. Wan, and L. Robert Hanrahan
Clin Cancer Res 2001 7: 791 [Abstract] [Full Text] [PDF]  

High Levels of Vascular Endothelial Growth Factor Receptor-2 Correlate with Shortened Survival in Chronic Lymphocytic Leukemia

Alessandra Ferrajoli, Taghi Manshouri, Zeev Estrov, Michael J. Keating, Susan O’Brien, Susan Lerner, Miloslav Beran, Hagop M. Kantarjian, Emil J. Freireich, and Maher Albitar
Clin Cancer Res 2001 7: 795 [Abstract] [Full Text] [PDF]  

A Multi-Institutional Phase II Study of SU101, a Platelet-derived Growth Factor Receptor Inhibitor, for Patients with Hormone-Refractory Prostate Cancer

Yoo-Joung Ko, Eric J. Small, Fairooz Kabbinavar, Abraham Chachoua, Samir Taneja, David Reese, Ann DePaoli, Alison Hannah, Steven P. Balk, and Glenn J. Bubley
Clin Cancer Res 2001 7: 800 [Abstract] [Full Text] [PDF]  

The Human KLK8 (Neuropsin/Ovasin) Gene: Identification of Two Novel Splice Variants and Its Prognostic Value in Ovarian Cancer

Angeliki Magklara, Andreas Scorilas, Dionyssios Katsaros, Marco Massobrio, George M. Yousef, Stefano Fracchioli, Saverio Danese, and Eleftherios P. Diamandis
Clin Cancer Res 2001 7: 806 [Abstract] [Full Text] [PDF]  

Expression of the Tumor Suppressor Gene Maspin in Human Pancreatic Cancers

Nicolai Maass, Takashi Hojo, Michael Ueding, Jutta Lüttges, Günter Klöppel, Walter Jonat, and Koichi Nagasaki
Clin Cancer Res 2001 7: 812 [Abstract] [Full Text] [PDF]  

Association of ARNT Splice Variants with Estrogen Receptor-negative Breast Cancer, Poor Induction of Vascular Endothelial Growth Factor under Hypoxia, and Poor Prognosis

Chunhua Qin, Cody Wilson, Christine Blancher, Marian Taylor, Stephen Safe, and Adrian L. Harris
Clin Cancer Res 2001 7: 818 [Abstract] [Full Text] [PDF]  

Elevated and Altered Expression of the Multifunctional DNA Base Excision Repair and Redox Enzyme Ape1/ref-1 in Prostate Cancer

Mark R. Kelley, Liang Cheng, Richard Foster, Renee Tritt, Jiazhong Jiang, John Broshears, and Michael Koch
Clin Cancer Res 2001 7: 824 [Abstract] [Full Text] [PDF]  

The p53 Mutational Spectrum Associated with BRCA1 Mutant Ovarian Cancer

Richard E. Buller, Thomas A. Lallas, Mark S. Shahin, Anil K. Sood, Melanie Hatterman-Zogg, Barrie Anderson, Joel I. Sorosky, and Patricia A. Kirby
Clin Cancer Res 2001 7: 831 [Abstract] [Full Text] [PDF]  

Molecular Subtypes of Anaplastic Oligodendroglioma: Implications for Patient Management at Diagnosis

Yasushi Ino, Rebecca A. Betensky, Magdalena C. Zlatescu, Hikaru Sasaki, David R. Macdonald, Anat O. Stemmer-Rachamimov, David A. Ramsay, J. Gregory Cairncross, and David N. Louis
Clin Cancer Res 2001 7: 839 [Abstract] [Full Text] [PDF]  

Zinc -2-Glycoprotein Is Expressed by Malignant Prostatic Epithelium and May Serve as a Potential Serum Marker for Prostate Cancer

Laura P. Hale, David T. Price, Luis M. Sanchez, Wendy Demark-Wahnefried, and John F. Madden
Clin Cancer Res 2001 7: 846 [Abstract] [Full Text] [PDF]  

Semenogelins Are Ectopically Expressed in Small Cell Lung Carcinoma

Rui G. Rodrigues, Angel Panizo-Santos, JoAnne A. Cashel, Henry C. Krutzsch, Maria J. Merino, and David D. Roberts
Clin Cancer Res 2001 7: 854 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Overexpression Is a Marker of Poor Prognosis in Stage I Non-Small Cell Lung Cancer

Fadlo R. Khuri, Hong Wu, J. Jack Lee, Bonnie L. Kemp, Reuben Lotan, Scott M. Lippman, Lei Feng, Waun K. Hong, and Xiao-Chun Xu
Clin Cancer Res 2001 7: 861 [Abstract] [Full Text] [PDF]  

Amplification and Expression of Splice Variants of the Gene Encoding the P450 Cytochrome 25-Hydroxyvitamin D₃ 1,-Hydroxylase (CYP 27B1) in Human Malignant Glioma

Ruth Maria Maas, Katrin Reus, Britta Diesel, Wolf-Ingo Steudel, Wolfgang Feiden, Ulrike Fischer, and Eckart Meese
Clin Cancer Res 2001 7: 868 [Abstract] [Full Text] [PDF]  

Allelic Losses of Loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 Correlate with Postoperative Recurrence in Breast Cancer

Akira Hirano, Mitsuru Emi, Michiko Tsuneizumi, Yoshihito Utada, Masataka Yoshimoto, Fujio Kasumi, Futoshi Akiyama, Goi Sakamoto, Shunsuke Haga, Tetsuro Kajiwara, and Yusuke Nakamura
Clin Cancer Res 2001 7: 876 [Abstract] [Full Text] [PDF]  

Frequent Inactivation of the TP53 Gene in Esophageal Squamous Cell Carcinoma from a High-Risk Population in China

Nan Hu, Jing Huang, Michael R. Emmert-Buck, Ze-Zhong Tang, Mark J. Roth, Chaoyu Wang, Sanford M. Dawsey, Guang Li, Wen-Jun Li, Quan-Hong Wang, Xiao-You Han, Ti Ding, Carol Giffen, Alisa M. Goldstein, and Philip R. Taylor
Clin Cancer Res 2001 7: 883 [Abstract] [Full Text] [PDF]  

Correlation between Loss of PTEN Expression and Akt Phosphorylation in Endometrial Carcinoma

Yasunobu Kanamori, Junzo Kigawa, Hiroaki Itamochi, Muneaki Shimada, Masakuni Takahashi, Syunji Kamazawa, Shinya Sato, Ryoji Akeshima, and Naoki Terakawa
Clin Cancer Res 2001 7: 892 [Abstract] [Full Text] [PDF]  

Expression of the ₂ Chain of Laminin-5 at the Invasive Front Is Associated with Recurrence and Poor Prognosis in Human Esophageal Squamous Cell Carcinoma

Hiroyuki Yamamoto, Fumio Itoh, Shouhei Iku, Masao Hosokawa, and Kohzoh Imai
Clin Cancer Res 2001 7: 896 [Abstract] [Full Text] [PDF]  

Frequent Deletions and Mutations of the ß-Catenin Gene Are Associated with Overexpression of Cyclin D1 and Fibronectin and Poorly Differentiated Histology in Childhood Hepatoblastoma

Hajime Takayasu, Hiroshi Horie, Eiso Hiyama, Tadashi Matsunaga, Yutaka Hayashi, Yoshio Watanabe, Sachiyo Suita, Michio Kaneko, Fumiaki Sasaki, Kohei Hashizume, Toshinori Ozaki, Keiji Furuuchi, Mitsuhiro Tada, Naomi Ohnuma, and Akira Nakagawara
Clin Cancer Res 2001 7: 901 [Abstract] [Full Text] [PDF]  

S-Phase Fraction and DNA Ploidy in 633 T1T2 Breast Cancers: A Standardized Flow Cytometric Study

Agnès Chassevent, Marie-Lise Jourdan, Sylvie Romain, Françoise Descotes, Marc Colonna, Pierre-Marie Martin, Michel Bolla, and Frédérique Spyratos
Clin Cancer Res 2001 7: 909 [Abstract] [Full Text] [PDF]  

Angiopoietin-1 Is Inversely Related to Thymidine Phosphorylase Expression in Human Breast Cancer, Indicating a Role in Vascular Remodeling

Margaret J. Currie, Sarah P. Gunningham, Cheng Han, Prudence A. E. Scott, Bridget A. Robinson, Adrian L. Harris, and Stephen B. Fox
Clin Cancer Res 2001 7: 918 [Abstract] [Full Text] [PDF]  

Glucose Transporter Glut-1 Expression Correlates with Tumor Hypoxia and Predicts Metastasis-free Survival in Advanced Carcinoma of the Cervix

Rachel Airley, Juliette Loncaster, Susan Davidson, Mike Bromley, Stephen Roberts, Adam Patterson, Robin Hunter, Ian Stratford, and Catharine West
Clin Cancer Res 2001 7: 928 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Circumvention of Breast Cancer Resistance Protein (BCRP)-mediated Resistance to Camptothecins in Vitro Using Non-Substrate Drugs or the BCRP Inhibitor GF120918

Marc Maliepaard, Margôt A. van Gastelen, Akiko Tohgo, Frederick H. Hausheer, Robert C. A. M. van Waardenburg, Laurina A. de Jong, Dick Pluim, Jos H. Beijnen, and Jan H. M. Schellens
Clin Cancer Res 2001 7: 935 [Abstract] [Full Text] [PDF]  

Folylpoly--glutamate Synthetase Gene mRNA Splice Variants and Protein Expression in Primary Human Leukemia Cells, Cell Lines, and Normal Human Tissues

Guy J. Leclerc and Julio C. Barredo
Clin Cancer Res 2001 7: 942 [Abstract] [Full Text] [PDF]  

Effective Particle-mediated Vaccination against Mouse Melanoma by Coadministration of Plasmid DNA Encoding Gp100 and Granulocyte-Macrophage Colony-Stimulating Factor

Alexander L. Rakhmilevich, Michael Imboden, Zhengling Hao, Michael D. Macklin, Timothy Roberts, Kelly M. Wright, Mark R. Albertini, Ning-Sun Yang, and Paul M. Sondel
Clin Cancer Res 2001 7: 952 [Abstract] [Full Text] [PDF]  

Inhibition of Transformed Cell Growth and Induction of Cellular Differentiation by Pyroxamide, an Inhibitor of Histone Deacetylase

Lisa M. Butler, Yael Webb, David B. Agus, Brian Higgins, Thomas R. Tolentino, Martha C. Kutko, Michael P. LaQuaglia, Marija Drobnjak, Carlos Cordon-Cardo, Howard I. Scher, Ronald Breslow, Victoria M. Richon, Richard A. Rifkind, and Paul A. Marks
Clin Cancer Res 2001 7: 962 [Abstract] [Full Text] [PDF]  

Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo

David M. Vigushin, Simak Ali, Paul E. Pace, Nina Mirsaidi, Kazuhiro Ito, Ian Adcock, and R. Charles Coombes
Clin Cancer Res 2001 7: 971 [Abstract] [Full Text] [PDF]  

The Angiogenesis Inhibitor TNP-470 Effectively Inhibits Human Neuroblastoma Xenograft Growth, Especially in the Setting of Subclinical Disease

Suzanne Shusterman, Stephan A. Grupp, Rosalind Barr, David Carpentieri, Huaqing Zhao, and John M. Maris
Clin Cancer Res 2001 7: 977 [Abstract] [Full Text] [PDF]  

Efficacy of Local versus Systemic Application of Antibody-Cytokine Fusion Proteins in Tumor Therapy

Oliver Christ, Simone Seiter, Siegfried Matzku, Christa Burger, and Margot Zöller
Clin Cancer Res 2001 7: 985 [Abstract] [Full Text] [PDF]  

Thymidine Kinase, Thymidylate Synthase, and Dihydropyrimidine Dehydrogenase Profiles of Cell Lines of the National Cancer Institute’s Anticancer Drug Screen

Jean L. Grem, Kathleen D. Danenberg, Katherine Behan, Allyson Parr, Lauren Young, Peter V. Danenberg, Diana Nguyen, James Drake, Anne Monks, and Carmen J. Allegra
Clin Cancer Res 2001 7: 999 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis in Colon Cancer Cells by Cyclooxygenase-2 Inhibitor NS398 through a Cytochrome c-dependent Pathway

Ming Li, Xiuyuan Wu, and Xiao-Chun Xu
Clin Cancer Res 2001 7: 1010 [Abstract] [Full Text] [PDF]  

Enhanced Turnover of all-trans-Retinoic Acid and Increased Formation of Polar Metabolites in Head and Neck Squamous Cell Carcinoma Lines Compared with Normal Oral Keratinocytes

Ingeborg Klaassen, Ruud H. Brakenhoff, Serge J. Smeets, Gordon B. Snow, and Boudewijn J. M. Braakhuis
Clin Cancer Res 2001 7: 1017 [Abstract] [Full Text] [PDF]  

Angiogenesis Inhibitor TNP-470 during Bone Marrow Transplant: Safety in a Preclinical Model

Julie W. Stern, Junjie Fang, Suzanne Shusterman, Giuliana Pierson, Rosalind Barr, Bruce Pawel, Lisa Diller, and Stephan A. Grupp
Clin Cancer Res 2001 7: 1026 [Abstract] [Full Text] [PDF]  

Detection of Mitomycin C-DNA Adducts in Human Breast Cancer Cells Grown in Culture, as Xenografted Tumors in Nude Mice, and in Biopsies of Human Breast Cancer Patient Tumors as Determined by ³²P-Postlabeling

Amy J. Warren, David J. Mustra, and Joshua W. Hamilton
Clin Cancer Res 2001 7: 1033 [Abstract] [Full Text] [PDF]  

Calcitriol (1,25-Dihydroxycholecalciferol) Enhances Paclitaxel Antitumor Activity in Vitro and in Vivo and Accelerates Paclitaxel-induced Apoptosis

Pamela A. Hershberger, Wei-Dong Yu, Ruth A. Modzelewski, Robert M. Rueger, Candace S. Johnson, and Donald L. Trump
Clin Cancer Res 2001 7: 1043 [Abstract] [Full Text] [PDF]  

Combretastatin A4 Prodrug Study of Effect on the Growth and the Microvasculature of Colorectal Liver Metastases in a Murine Model

Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Stewart Skinner, Chris Christophi, David Sherris, and Paul E. O’Brien
Clin Cancer Res 2001 7: 1052 [Abstract] [Full Text] [PDF]  

Biodistribution Properties of ¹¹¹Indium-labeled C-Functionalized trans-Cyclohexyl Diethylenetriaminepentaacetic Acid Humanized 3S193 Diabody and F(ab')₂ Constructs in a Breast Carcinoma Xenograft Model

Kiki Tahtis, Fook-Thean Lee, Fiona E. Smyth, Barbara E. Power, Christoph Renner, Martin W. Brechbiel, Lloyd J. Old, Peter J. Hudson, and Andrew M. Scott
Clin Cancer Res 2001 7: 1061 [Abstract] [Full Text] [PDF]  

The Angiotensin-I-converting Enzyme Inhibitor Perindopril Suppresses Tumor Growth and Angiogenesis: Possible Role of the Vascular Endothelial Growth Factor

Hitoshi Yoshiji, Shigeki Kuriyama, Mitsuhiro Kawata, Junichi Yoshii, Yasuhide Ikenaka, Ryuichi Noguchi, Toshiya Nakatani, Hirohisa Tsujinoue, and Hiroshi Fukui
Clin Cancer Res 2001 7: 1073 [Abstract] [Full Text] [PDF]  

Schedule Dependency of Antitumor Activity in Combination Therapy with Capecitabine/5'-Deoxy-5-fluorouridine and Docetaxel in Breast Cancer Models

Kaori Fujimoto-Ouchi, Yutaka Tanaka, and Takeshi Tominaga
Clin Cancer Res 2001 7: 1079 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Antisense Urokinase-Type Plasminogen Activator Receptor Gene Transfer Reduces Tumor Cell Invasion and Metastasis in Non-Small Cell Lung Cancer Cell Lines

Sajani S. Lakka, Ramesh Rajagopal, Mannari K. Rajan, Pamarthi M. Mohan, Yoshiaki Adachi, Dzung H. Dinh, Willaim C. Olivero, Meena Gujrati, Francis Ali-Osman, Jack A. Roth, W. K. Alfred Yung, Athanassios P. Kyritsis, and Jasti S. Rao
Clin Cancer Res 2001 7: 1087 [Abstract] [Full Text] [PDF]  

Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Antileukemic Agent with Matrix Metalloproteinase Inhibitory Activity

Rama Krishna Narla, Yanhong Dong, Dan Klis, and Fatih M. Uckun
Clin Cancer Res 2001 7: 1094 [Abstract] [Full Text] [PDF]  

Errata:

Corrections

Clin Cancer Res 2001 7: 1101 [Full Text] [PDF]  

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