The Biology Behind:

The Battle between Tumor Suppressors: Is Gene Therapy Using p16^INK4a More Efficacious Than p53 for Treatment of Ovarian Carcinoma? : Commentary re: S. C. Modesitt et al., In Vitro and In Vivo Adenovirus-mediated p53 and p16 Tumor Suppressor Therapy in Ovarian Cancer. Clin. Cancer Res., 7: 1765–1772, 2001.

Maureen E. Murphy
Clin Cancer Res 2001 7: 1487 [Full Text] [PDF]  

Report from the FDA:

Approval Summary: Gemtuzumab Ozogamicin in Relapsed Acute Myeloid Leukemia

Peter F. Bross, Julie Beitz, Gang Chen, Xiao Hong Chen, Eric Duffy, Lydia Kieffer, Sandip Roy, Rajeshwari Sridhara, Atiqur Rahman, Grant Williams, and Richard Pazdur
Clin Cancer Res 2001 7: 1490 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Induction of Topoisomerase II Activity after ErbB2 Activation Is Associated with a Differential Response to Breast Cancer Chemotherapy

L. N. Harris, Li Yang, Vlayka Liotcheva, Samuel Pauli, James Dirk Iglehart, O. Michael Colvin, and Tao Shih Hsieh
Clin Cancer Res 2001 7: 1497 [Abstract] [Full Text] [PDF]  

Therapy of Disseminated B-Cell Lymphoma Xenografts in Severe Combined Immunodeficient Mice with an Anti-CD74 Antibody Conjugated with ¹¹¹Indium, ⁶⁷Gallium, or ⁹⁰Yttrium

Rita Ochakovskaya, Louis Osorio, David M. Goldenberg, and M. Jules Mattes
Clin Cancer Res 2001 7: 1505 [Abstract] [Full Text] [PDF]  

Paclitaxel and Docetaxel Enhance the Metabolism of Doxorubicin to Toxic Species in Human Myocardium

Giorgio Minotti, Antonella Saponiero, Sabrina Licata, Pierantonio Menna, Antonio M. Calafiore, Giovanni Teodori, and Luca Gianni
Clin Cancer Res 2001 7: 1511 [Abstract] [Full Text] [PDF]  

Molecular Determination of Perivesical and Lymph Node Metastasis after Radical Cystectomy for Urothelial Carcinoma of the Bladder

M. Jabed Seraj, Alexander R. Thomas, Joseph L. Chin, and Dan Theodorescu
Clin Cancer Res 2001 7: 1516 [Abstract] [Full Text] [PDF]  

Persistence of Genetically Altered Fields in Head and Neck Cancer Patients: Biological and Clinical Implications

Maarten P. Tabor, Ruud H. Brakenhoff, Viola M. M. van Houten, J. Alain Kummer, Mireille H. J. Snel, Peter J. F. Snijders, Gordon B. Snow, C. René Leemans, and Boudewijn J. M. Braakhuis
Clin Cancer Res 2001 7: 1523 [Abstract] [Full Text] [PDF]  

Tumor Angiogenesis Is Associated with MUC1 Overexpression and Loss of Prostate-specific Antigen Expression in Prostate Cancer

Ilias Papadopoulos, Efthimios Sivridis, Alexandra Giatromanolaki, and Michael I. Koukourakis
Clin Cancer Res 2001 7: 1533 [Abstract] [Full Text] [PDF]  

Detection of Genetic Alterations in Esophageal Squamous Cell Carcinomas and Adjacent Normal Epithelia by Comparative DNA Fingerprinting Using Inter-Simple Sequence Repeat PCR

Johnny C. O. Tang, King Y. Lam, Simon Law, John Wong, and Gopesh Srivastava
Clin Cancer Res 2001 7: 1539 [Abstract] [Full Text] [PDF]  

Fez1/Lzts1 Alterations in Gastric Carcinoma

Andrea Vecchione, Hideshi Ishii, Yih-Horng Shiao, Francesco Trapasso, Massimo Rugge, Joseph F. Tamburrino, Yoshiki Murakumo, Hansjuerg Alder, Carlo M. Croce, and Raffaele Baffa
Clin Cancer Res 2001 7: 1546 [Abstract] [Full Text] [PDF]  

Expression of Human Endogenous Retrovirus K Envelope Transcripts in Human Breast Cancer

Feng Wang-Johanning, Andra R. Frost, Gary L. Johanning, M. B. Khazaeli, Albert F. LoBuglio, Denise R. Shaw, and Theresa V. Strong
Clin Cancer Res 2001 7: 1553 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Radioimmunotherapy with ¹¹¹In/⁹⁰Y-2IT-BAD-m170 for Metastatic Prostate Cancer

Robert T. O'Donnell, Sally J. DeNardo, Aina Yuan, Sui Shen, Carol M. Richman, Primo N. Lara, Irwin J. Griffith, Desiree S. Goldstein, David L. Kukis, Gerard S. Martinez, Gary R. Mirick, Gerald L. DeNardo, and Frederick J. Meyers
Clin Cancer Res 2001 7: 1561 [Abstract] [Full Text] [PDF]  

Phase I Trial of 96-Hour Continuous Infusion of Dexrazoxane in Patients with Advanced Malignancies

Merry L. Tetef, Timothy W. Synold, Warren Chow, Lucille Leong, Kim Margolin, Robert Morgan, James Raschko, Stephen Shibata, George Somlo, Yun Yen, Susan Groshen, Kay Johnson, Heinz-Josef Lenz, David Gandara, and James H. Doroshow
Clin Cancer Res 2001 7: 1569 [Abstract] [Full Text] [PDF]  

Chemotherapy Response of Breast Cancer Depends on HER-2 Status and Anthracycline Dose Intensity in the Neoadjuvant Setting

Thierry Petit, Christian Borel, Jean-Pierre Ghnassia, Jean-François Rodier, Anne Escande, Ricardo Mors, and Pierre Haegelé
Clin Cancer Res 2001 7: 1577 [Abstract] [Full Text] [PDF]  

Survival of Tumor Cells in Stem Cell Preparations and Bone Marrow of Patients with High-Risk or Metastatic Breast Cancer after Receiving Dose-intensive or High-Dose Chemotherapy

Sabine Kasimir-Bauer, Susanne Mayer, Peter Bojko, David Borquez, Rainer Neumann, and Siegfried Seeber
Clin Cancer Res 2001 7: 1582 [Abstract] [Full Text] [PDF]  

A Phase II Trial of the Cyclin-dependent Kinase Inhibitor Flavopiridol in Patients with Previously Untreated Stage IV Non-Small Cell Lung Cancer

Geoffrey I. Shapiro, Jeffrey G. Supko, Angus Patterson, Cathy Lynch, Joan Lucca, Patrick F. Zacarola, Alona Muzikansky, John J. Wright, Thomas J. Lynch, Jr., and Barrett J. Rollins
Clin Cancer Res 2001 7: 1590 [Abstract] [Full Text] [PDF]  

A Phase I Trial of Carboxyamido-triazole and Paclitaxel for Relapsed Solid Tumors: Potential Efficacy of the Combination and Demonstration of Pharmacokinetic Interaction

Elise C. Kohn, Eddie Reed, Gisele A. Sarosy, Lori Minasian, Kenneth S. Bauer, Frieda Bostick-Bruton, Vyta Kulpa, Eichi Fuse, Anne Tompkins, Marianne Noone, Barry Goldspiel, James Pluda, William D. Figg, and Lance A. Liotta
Clin Cancer Res 2001 7: 1600 [Abstract] [Full Text] [PDF]  

The P-Glycoprotein Antagonist PSC 833 Increases the Plasma Concentrations of 6-Hydroxypaclitaxel, a Major Metabolite of Paclitaxel

Min H. Kang, William D. Figg, Yuichi Ando, Mikhail V. Blagosklonny, David Liewehr, Tito Fojo, and Susan E. Bates
Clin Cancer Res 2001 7: 1610 [Abstract] [Full Text] [PDF]  

Molecular Oncology:

Defective Transforming Growth Factor ß Signaling Pathway in Head and Neck Squamous Cell Carcinoma as Evidenced by the Lack of Expression of Activated Smad2

Carlos A. Muro-Cacho, Karen Rosario-Ortiz, Sandra Livingston, and Teresita Muñoz-Antonia
Clin Cancer Res 2001 7: 1618 [Abstract] [Full Text] [PDF]  

Tumor Angiogenesis and Its Possible Role in Intravasation of Colorectal Epithelial Cells

Yu-Wen Tien, King-Jen Chang, Yung-Ming Jeng, Po-Huang Lee, Ming-Shi Wu, Jaw-Town Lin, and Su-Ming Hsu
Clin Cancer Res 2001 7: 1627 [Abstract] [Full Text] [PDF]  

Elevated Serum Levels of Type I Collagen Degradation Marker ICTP and Tissue Inhibitor of Metalloproteinase (TIMP) 1 Are Associated with Poor Prognosis in Lung Cancer

Sanna Ylisirniö, Matti Höyhtyä, Riitta Mäkitaro, Paavo Pääakkö, Juha Risteli, Vuokko L. Kinnula, Taina Turpeenniemi-Hujanen, and Arja Jukkola
Clin Cancer Res 2001 7: 1633 [Abstract] [Full Text] [PDF]  

Diagnostic Strategy for Analytical Scanning of BRCA1 Gene by Fluorescence-assisted Mismatch Analysis Using Large, Bifluorescently Labeled Amplicons

Enrico Ricevuto, Hagay Sobol, Dominique Stoppa-Lyonnet, Alberto Gulino, Paolo Marchetti, Corrado Ficorella, Stefano Martinotti, Tommaso Meo, and Mario Tosi
Clin Cancer Res 2001 7: 1638 [Abstract] [Full Text] [PDF]  

Prediction of Peritoneal Micrometastasis by Peritoneal Lavaged Cytology and Reverse Transcriptase-Polymerase Chain Reaction for Matrix Metalloproteinase-7 mRNA

Yutaka Yonemura, Takashi Fujimura, Itasu Ninomiya, Byung-Sik Kim, Etsurou Bandou, Toshiharu Sawa, Kazuo Kinoshita, Yoshio Endo, Kazuo Sugiyama, and Takuma Sasaki
Clin Cancer Res 2001 7: 1647 [Abstract] [Full Text] [PDF]  

The Expression of the Urokinase Plasminogen Activator System in Metastatic Murine Osteosarcoma: An in Vivo Mouse Model

Jane Lisette Fisher, Peter Scott Mackie, Monique Louise Howard, Hong Zhou, and Peter Fook Meng Choong
Clin Cancer Res 2001 7: 1654 [Abstract] [Full Text] [PDF]  

Expression of Hypoxia-inducible Factor 1 in Epithelial Ovarian Tumors: Its Impact on Prognosis and on Response to Chemotherapy

Peter Birner, Monika Schindl, Andreas Obermair, Gerhard Breitenecker, and Georg Oberhuber
Clin Cancer Res 2001 7: 1661 [Abstract] [Full Text] [PDF]  

Evaluation of the United States Food and Drug Administration-approved Scoring and Test System of HER-2 Protein Expression in Breast Cancer

Peter Birner, Georg Oberhuber, Josephine Stani, Cornelia Reithofer, Hellmut Samonigg, Hubert Hausmaninger, Ernst Kubista, Werner Kwasny, Daniela Kandioler-Eckersberger, Michael Gnant, and Raimund Jakesz
Clin Cancer Res 2001 7: 1669 [Abstract] [Full Text] [PDF]  

Alterations of the 9p21 and 9q33 Chromosomal Bands in Clinical Bladder Cancer Specimens by Fluorescence in Situ Hybridization

Walter M. Stadler, Gary Steinberg, Ximing Yang, Fitsum Hagos, Craig Turner, and Olufunmilayo I. Olopade
Clin Cancer Res 2001 7: 1676 [Abstract] [Full Text] [PDF]  

Loss of H-Cadherin Protein Expression in Human Non-Small Cell Lung Cancer Is Associated with Tumorigenicity

Yun Zhong, Yara Delgado, Jorge Gomez, Sam W. Lee, and Roman Perez-Soler
Clin Cancer Res 2001 7: 1683 [Abstract] [Full Text] [PDF]  

Nucleotide Substitution in the Ectodomain of TRAIL Receptor DR4 Is Associated with Lung Cancer and Head and Neck Cancer

Michael J. Fisher, Arvind K. Virmani, Li Wu, Richard Aplenc, Jeffrey C. Harper, Steven M. Powell, Timothy R. Rebbeck, David Sidransky, Adi F. Gazdar, and Wafik S. El-Deiry
Clin Cancer Res 2001 7: 1688 [Abstract] [Full Text] [PDF]  

Quantitation of Marrow Disease in Neuroblastoma by Real-Time Reverse Transcription-PCR

Irene Y. Cheung and Nai-Kong V. Cheung
Clin Cancer Res 2001 7: 1698 [Abstract] [Full Text] [PDF]  

Expression Pattern of Fatty Acid-binding Proteins in Human Normal and Cancer Prostate Cells and Tissues

Rina Das, Rasha Hammamieh, Roger Neill, Mona Melhem, and Marti Jett
Clin Cancer Res 2001 7: 1706 [Abstract] [Full Text] [PDF]  

Measures of Cell Turnover (Proliferation and Apoptosis) and Their Association with Survival in Breast Cancer

Shuqing Liu, Susan M. Edgerton, Dan H. Moore, II, and Ann D. Thor
Clin Cancer Res 2001 7: 1716 [Abstract] [Full Text] [PDF]  

Frequent Death-associated Protein Kinase Promoter Hypermethylation in Multiple Myeloma

Margaret H. L. Ng, K. W. To, K. W. Lo, S. Chan, K. S. Tsang, S. H. Cheng, and H. K. Ng
Clin Cancer Res 2001 7: 1724 [Abstract] [Full Text] [PDF]  

Clinicopathological and Molecular Evidence Indicating the Independence of Bronchioloalveolar Components from Other Subtypes of Human Peripheral Lung Adenocarcinoma

Takaomi Koga, Shuichi Hashimoto, Kenji Sugio, Ichiro Yoshino, Sepideh Mojtahedzadeh, Yoshio Matsuo, Yoshikazu Yonemitsu, Keizo Sugimachi, and Katsuo Sueishi
Clin Cancer Res 2001 7: 1730 [Abstract] [Full Text] [PDF]  

Pathological Features and BRCA1 Mutation Screening in Premenopausal Breast Cancer Patients

Jenny Chang, Susan G. Hilsenbeck, Jen Hwei Sng, John Wong, and G. C. Ragu
Clin Cancer Res 2001 7: 1739 [Abstract] [Full Text] [PDF]  

Association of Urokinase-Type Plasminogen Activator and Its Inhibitor with Disease Progression and Prognosis in Ovarian Cancer

Gottfried Konecny, Michael Untch, Astrid Pihan, Rainer Kimmig, Martina Gropp, Petra Stieber, Herrmann Hepp, Dennis Slamon, and Mark Pegram
Clin Cancer Res 2001 7: 1743 [Abstract] [Full Text] [PDF]  

Widespread Expression of Thioredoxin and Thioredoxin Reductase in Non-Small Cell Lung Carcinoma

Ylermi Soini, Katriina Kahlos, Ulla Näpänkangas, Riitta Kaarteenaho-Wiik, Marjaana Säily, Pirjo Koistinen, Paavo Pääakkö, Arne Holmgren, and Vuokko L. Kinnula
Clin Cancer Res 2001 7: 1750 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition

Lorina Dudkin, Michael B. Dilling, Pamela J. Cheshire, Franklin C. Harwood, Melinda Hollingshead, Susan G. Arbuck, Robert Travis, Edward A. Sausville, and Peter J. Houghton
Clin Cancer Res 2001 7: 1758 [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Adenovirus-mediated p53 and p16 Tumor Suppressor Therapy in Ovarian Cancer : See The Biology Behind: M. E. Murphy, The Battle between Tumor Suppressors: Is Gene Therapy Using p16^INK4a More Efficacious Than p53 for Treatment of Ovarian Carcinoma? Clin. Cancer Res., 7: 1487–1489, 2001.

Susan C. Modesitt, Pedro Ramirez, Zheife Zu, Diane Bodurka-Bevers, David Gershenson, and Judith K. Wolf
Clin Cancer Res 2001 7: 1765 [Abstract] [Full Text] [PDF]  

Interleukin-6 Induces Androgen Responsiveness in Prostate Cancer Cells through Up-Regulation of Androgen Receptor Expression

Din-Lii Lin, Mary C. Whitney, Zhi Yao, and Evan T. Keller
Clin Cancer Res 2001 7: 1773 [Abstract] [Full Text] [PDF]  

Differential Sensitivity of Normal and Malignant Breast Epithelial Cells to Genistein Is Partly Mediated by p21^WAF1

Sunil Upadhyay, Madhavi Neburi, Sreenivasa R. Chinni, Samir Alhasan, Fred Miller, and Fazlul H. Sarkar
Clin Cancer Res 2001 7: 1782 [Abstract] [Full Text] [PDF]  

Inhibition of Insulin-like Growth Factor I Receptor Increases the Antitumor Activity of Doxorubicin and Vincristine against Ewing’s Sarcoma Cells

Stefania Benini, Maria Cristina Manara, Nicola Baldini, Vanessa Cerisano, Massimo Serra, Mario Mercuri, Pier-Luigi Lollini, Patrizia Nanni, Piero Picci, and Katia Scotlandi
Clin Cancer Res 2001 7: 1790 [Abstract] [Full Text] [PDF]  

Multidrug Resistance Proteins MRP3, MRP1, and MRP2 in Lung Cancer: Correlation of Protein Levels with Drug Response and Messenger RNA Levels

Leah C. Young, Barbara G. Campling, Susan P. C. Cole, Roger G. Deeley, and James H. Gerlach
Clin Cancer Res 2001 7: 1798 [Abstract] [Full Text] [PDF]  

Carboxymethyl Benzylamide Dextran and Tamoxifen Combination Inhibits Tumor Growth and Angiogenesis

Rozita Bagheri-Yarmand, Yamina Hamma-Kourbali, Philippe Bissieres, Jean-François Morère, and Michel Crépin
Clin Cancer Res 2001 7: 1805 [Abstract] [Full Text] [PDF]  

IL (Interleukin)-1 Promotes Nuclear Factor-B and AP-1-induced IL-8 Expression, Cell Survival, and Proliferation in Head and Neck Squamous Cell Carcinomas

Jeffrey S. Wolf, Zhong Chen, Gang Dong, John B. Sunwoo, Caren C. Bancroft, David E. Capo, Ning T. Yeh, Naofumi Mukaida, and Carter Van Waes
Clin Cancer Res 2001 7: 1812 [Abstract] [Full Text] [PDF]  

Preferential Induction of Apoptosis by Interferon (IFN)-ß Compared with IFN-2: Correlation with TRAIL/Apo2L Induction in Melanoma Cell Lines

Mamta Chawla-Sarkar, Douglas W. Leaman, and Ernest C. Borden
Clin Cancer Res 2001 7: 1821 [Abstract] [Full Text] [PDF]  

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