Editorials:

Treating Hodgkin’s Disease with Bispecific Antibodies: Both Patients and Antibody Are Limiting

Richard I. Fisher
Clin Cancer Res 2001 7: 1835 [Full Text] [PDF]  

The Unfulfilled Promise of Melanoma Vaccines

Philip Livingston
Clin Cancer Res 2001 7: 1837 [Full Text] [PDF]  

Special Article:

Adjuvant Systemic Therapy for Early Breast Cancer: Progress and Controversies

Gabriel N. Hortobagyi
Clin Cancer Res 2001 7: 1839 [Full Text] [PDF]  

The Cooperative Breast Cancer Tissue Resource: Archival Tissue for the Investigation of Tumor Markers

Andrew G. Glass, Helen Donis-Keller, Carolyn Mies, Jose Russo, Barbara Zehnbauer, Sheila Taube, and Roger Aamodt
Clin Cancer Res 2001 7: 1843 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Epidermal Growth Factor Receptor and HER2-neu mRNA Expression in Non-Small Cell Lung Cancer Is Correlated with Survival

Jan Brabender, Kathleen D. Danenberg, Ralf Metzger, Paul M. Schneider, JiMin Park, Dennis Salonga, Arnulf H. Hölscher, and Peter V. Danenberg
Clin Cancer Res 2001 7: 1850 [Abstract] [Full Text] [PDF]  

Circulating Epstein-Barr Virus DNA in the Serum of Patients with Gastric Carcinoma

Y. M. Dennis Lo, Wing Y. Chan, Enders K. W. Ng, Lisa Y. S. Chan, Paul B. S. Lai, John S. Tam, and S. C. Sydney Chung
Clin Cancer Res 2001 7: 1856 [Abstract] [Full Text] [PDF]  

Profiling Clonality and Progression in Multiple Premalignant and Malignant Oral Lesions Identifies a Subgroup of Cases with a Distinct Presentation of Squamous Cell Carcinoma

Max Partridge, Stelios Pateromichelakis, Elaine Phillips, Gracy Emilion, and John Langdon
Clin Cancer Res 2001 7: 1860 [Abstract] [Full Text] [PDF]  

Protein Binding Alters the Activity of Suramin, Carboxyamidotriazole, and UCN-01 in an ex Vivo Rat Aortic Ring Angiogenesis Assay

Erwin A. Krüger and William D. Figg
Clin Cancer Res 2001 7: 1867 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Anti-CD16/CD30 Bispecific Antibody Treatment for Hodgkin’s Disease: Role of Infusion Schedule and Costimulation with Cytokines

Frank Hartmann, Christoph Renner, Wolfram Jung, Ligia da Costa, Sandra Tembrink, Gerhard Held, Alexandra Sek, Jochen König, Stefan Bauer, Michael Kloft, and Michael Pfreundschuh
Clin Cancer Res 2001 7: 1873 [Abstract] [Full Text] [PDF]  

Double-Blind Trial of a Polyvalent, Shed-Antigen, Melanoma Vaccine

Jean-Claude Bystryn, Anne Zeleniuch-Jacquotte, Ruth Oratz, Richard L. Shapiro, Matthew N. Harris, and Daniel F. Roses
Clin Cancer Res 2001 7: 1882 [Abstract] [Full Text] [PDF]  

A Randomized Phase II Trial of Thalidomide, an Angiogenesis Inhibitor, in Patients with Androgen-independent Prostate Cancer

William D. Figg, William Dahut, Paul Duray, Michael Hamilton, Anne Tompkins, Seth M. Steinberg, Elizabeth Jones, Ahalya Premkumar, W. Marston Linehan, Mary Kay Floeter, Clara C. Chen, Shannon Dixon, David R. Kohler, Erwin A. Krüger, Ed Gubish, James M. Pluda, and Eddie Reed
Clin Cancer Res 2001 7: 1888 [Abstract] [Full Text] [PDF]  

Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer

Ricky A. Sharma, Heather R. McLelland, Kirsti A. Hill, Christopher R. Ireson, Stephanie A. Euden, Margaret M. Manson, Munir Pirmohamed, Lawrence J. Marnett, Andreas J. Gescher, and William P. Steward
Clin Cancer Res 2001 7: 1894 [Abstract] [Full Text] [PDF]  

A Phase I and Pharmacokinetic Study of 1843U89, a Noncompetitive Inhibitor of Thymidylate Synthase, in Patients with Advanced Solid Malignancies

Garry Schwartz, Thomas R. Johnson, Andrew Goetz, Howard Burris, Leslie Smetzer, Thomas Lampkin, Jeffrey Sailstad, John A. Hohneker, Daniel D. Von Hoff, and Eric K. Rowinsky
Clin Cancer Res 2001 7: 1901 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacological Study of the Oral Matrix Metalloproteinase Inhibitor, MMI270 (CGS27023A), in Patients with Advanced Solid Cancer

Nicola C. Levitt, Ferry A. L. M. Eskens, Ken J. O’Byrne, David J. Propper, Louis J. Denis, Samantha J. Owen, Les Choi, John A. Foekens, Sue Wilner, Jeanette M. Wood, Motowo Nakajima, Denis C. Talbot, William P. Steward, Adrian L. Harris, and Jaap Verweij
Clin Cancer Res 2001 7: 1912 [Abstract] [Full Text] [PDF]  

Molecular Oncology:

Expression of Cyclooxygenase-2 in Dysplasia of the Stomach and in Intestinal-type Gastric Adenocarcinoma

Kirsi Saukkonen, Outi Nieminen, Bastiaan van Rees, Susa Vilkki, Matti Härkönen, Matti Juhola, Jukka-Pekka Mecklin, Pentti Sipponen, and Ari Ristimäki
Clin Cancer Res 2001 7: 1923 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Plasma Vascular Endothelial Growth Factor Levels in Patients with Hormone-refractory Prostate Cancer Treated on Cancer and Leukemia Group B 9480

Daniel J. George, Susan Halabi, Timothy F. Shepard, Nicholas J. Vogelzang, Daniel F. Hayes, Eric J. Small, and Philip W. Kantoff
Clin Cancer Res 2001 7: 1932 [Abstract] [Full Text] [PDF]  

Breast Tumor Immunophenotype of BRCA1-Mutation Carriers Is Influenced by Age at Diagnosis

Susan A. J. Vaziri, Lisa M. Krumroy, Paul Elson, G. Thomas Budd, Gerarda Darlington, Jonathan Myles, Raymond R. Tubbs, and Graham Casey
Clin Cancer Res 2001 7: 1937 [Abstract] [Full Text] [PDF]  

Induction of Interleukin-8 by Epstein-Barr Virus Latent Membrane Protein-1 and Its Correlation to Angiogenesis in Nasopharyngeal Carcinoma

Tomokazu Yoshizaki, Toshiyuki Horikawa, Ren Qing-chun, Naohiro Wakisaka, Hajime Takeshita, Tzung-Shiahn Sheen, Shiann-Yann Lee, Hiroshi Sato, and Mitsuru Furukawa
Clin Cancer Res 2001 7: 1946 [Abstract] [Full Text] [PDF]  

A Novel Single-Nucleotide Polymorphism in the 3'-Untranslated Region of the Human Dihydrofolate Reductase Gene with Enhanced Expression

Yoshinori Goto, Lijie Yue, Ayano Yokoi, Ryosei Nishimura, Takahiro Uehara, Shoichi Koizumi, and Yutaka Saikawa
Clin Cancer Res 2001 7: 1952 [Abstract] [Full Text] [PDF]  

Expression Profiles of ErbB Family Receptors and Prognosis in Primary Transitional Cell Carcinoma of the Urinary Bladder

Nan-Haw Chow, Shih-Huang Chan, Tzong-Shin Tzai, Chung-Liang Ho, and Hsiao-Sheng Liu
Clin Cancer Res 2001 7: 1957 [Abstract] [Full Text] [PDF]  

Allelic Losses in OraTest-directed Biopsies of Patients with Prior Upper Aerodigestive Tract Malignancy

Zhongmin Guo, Kengo Yamaguchi, Montserrat Sanchez-Cespedes, William H. Westra, Wayne M. Koch, and David Sidransky
Clin Cancer Res 2001 7: 1963 [Abstract] [Full Text] [PDF]  

Combined Automatic Immunological and Molecular Cytogenetic Analysis Allows Exact Identification and Quantification of Tumor Cells in the Bone Marrow

Gábor Méhes, Andrea Luegmayr, Inge M. Ambros, Ruth Ladenstein, and Peter F. Ambros
Clin Cancer Res 2001 7: 1969 [Abstract] [Full Text] [PDF]  

Diagnosis of Pancreatic Adenocarcinoma by Detection of Human Telomerase Reverse Transcriptase Messenger RNA in Pancreatic Juice with Sample Qualification

Keiichi Seki, Takeshi Suda, Yutaka Aoyagi, Satoshi Sugawara, Masaaki Natsui, Hirotaka Motoyama, Yoshio Shirai, Teruo Sekine, Hirokazu Kawai, Yusaku Mita, Nobuo Waguri, Takashi Kuroiwa, Masato Igarashi, and Hitoshi Asakura
Clin Cancer Res 2001 7: 1976 [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of Multiple Genes in Carcinoma of the Uterine Cervix

Seung Myung Dong, Hy-Sook Kim, Seo-Hee Rha, and David Sidransky
Clin Cancer Res 2001 7: 1982 [Abstract] [Full Text] [PDF]  

Integrin-linked Kinase Expression Increases with Prostate Tumor Grade

Jeremy R. Graff, James A. Deddens, Bruce W. Konicek, Bruce M. Colligan, Bernadette M. Hurst, Harry W. Carter, and Julia H. Carter
Clin Cancer Res 2001 7: 1987 [Abstract] [Full Text] [PDF]  

Soluble Tie2 and Flt1 Extracellular Domains in Serum of Patients with Renal Cancer and Response to Antiangiogenic Therapy

Adrian L. Harris, Petra Reusch, Bernhard Barleon, Cheng Hang, Nicola Dobbs, and Dieter Marme
Clin Cancer Res 2001 7: 1992 [Abstract] [Full Text] [PDF]  

Aberrant Methylation of the Adenomatous Polyposis Coli (APC) Gene Promoter 1A in Breast and Lung Carcinomas

Arvind K. Virmani, Asha Rathi, Ubaradka G. Sathyanarayana, Asha Padar, Chun Xian Huang, H. Thomas Cunnigham, Alfredo J. Farinas, Sara Milchgrub, David M. Euhus, Michael Gilcrease, James Herman, John D. Minna, and Adi F. Gazdar
Clin Cancer Res 2001 7: 1998 [Abstract] [Full Text] [PDF]  

Circulating Hepatitis B Virus Nucleic Acids in Chronic Infection : Representation of Differently Polyadenylated Viral Transcripts during Progression to Nonreplicative Stages

Qin Su, Shu-Fang Wang, Tian-En Chang, Raoul Breitkreutz, Holger Hennig, Kunio Takegoshi, Lutz Edler, and Claus H. Schröder
Clin Cancer Res 2001 7: 2005 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Preclinical Pharmacology of BMS-275183, an Orally Active Taxane

William C. Rose, Byron H. Long, Craig R. Fairchild, Francis Y. F. Lee, and John F. Kadow
Clin Cancer Res 2001 7: 2016 [Abstract] [Full Text] [PDF]  

Controlled Ribozyme Targeting Demonstrates an Antiapoptotic Effect of Carcinoembryonic Antigen in HT29 Colon Cancer Cells

Edlyn Soeth, Thomas Wirth, Heinz-Joachim List, Shilpa Kumbhani, Antje Petersen, Michael Neumaier, Frank Czubayko, and Hartmut Juhl
Clin Cancer Res 2001 7: 2022 [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Antitumor Effect of the Anti-CD26 Monoclonal Antibody 1F7 on Human CD30+ Anaplastic Large Cell T-Cell Lymphoma Karpas 299

Linus Ho, Ugur Aytac, L. Clifton Stephens, Kei Ohnuma, Gordon B. Mills, Kathryn S. McKee, Christopher Neumann, Ruth LaPushin, Fernando Cabanillas, James L. Abbruzzese, Chikao Morimoto, and Nam H. Dang
Clin Cancer Res 2001 7: 2031 [Abstract] [Full Text] [PDF]  

Three Percent Dietary Fish Oil Concentrate Increased Efficacy of Doxorubicin Against MDA-MB 231 Breast Cancer Xenografts

W. Elaine Hardman, C. P. Reddy Avula, Gabriel Fernandes, and Ivan L. Cameron
Clin Cancer Res 2001 7: 2041 [Abstract] [Full Text] [PDF]  

Treatment of Meningeal Breast Cancer Xenografts in the Rat Using an Anti-P185/HER2 Antibody

Ira Bergman, Mamdouha A. Barmada, Judith A. Griffin, and Dennis J. Slamon
Clin Cancer Res 2001 7: 2050 [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Soluble FLT-1 Gene Therapy for Ovarian Carcinoma

Parameshwar J. Mahasreshti, Jesus G. Navarro, Manjula Kataram, Ming H. Wang, Delicia Carey, Gene P. Siegal, Mack N. Barnes, Dirk M. Nettelbeck, Ronald D. Alvarez, Akseli Hemminki, and David T. Curiel
Clin Cancer Res 2001 7: 2057 [Abstract] [Full Text] [PDF]  

Cerivastatin Triggers Tumor-specific Apoptosis with Higher Efficacy than Lovastatin

W. Wei-Lynn Wong, Melissa M. Tan, Zhenlei Xia, Jim Dimitroulakos, Mark D. Minden, and Linda Z. Penn
Clin Cancer Res 2001 7: 2067 [Abstract] [Full Text] [PDF]  

Destabilization of Steroid Receptors by Heat Shock Protein 90-binding Drugs: A Ligand-independent Approach to Hormonal Therapy of Breast Cancer

Rochelle Bagatell, Omar Khan, Gillian Paine-Murrieta, Charles W. Taylor, Shiro Akinaga, and Luke Whitesell
Clin Cancer Res 2001 7: 2076 [Abstract] [Full Text] [PDF]  

Kinetics of Neutrophil Production in Normal and Neutropenic Animals during the Response to Filgrastim (r-metHu G-CSF) or Filgrastim SD/01 (PEG-r-metHu G-CSF)

Brian I. Lord, Lorna B. Woolford, and Graham Molineux
Clin Cancer Res 2001 7: 2085 [Abstract] [Full Text] [PDF]  

The Olivacine S16020 Enhances the Antitumor Effect of Ionizing Radiation without Increasing Radio-induced Mucositis

Laurence Maggiorella, Valérie Frascogna, Marie-Gwenaëlle Poullain, Maryse Berlion, Catherine Lucas, Setha Douc Razy, François Eschwege, and Jean Bourhis
Clin Cancer Res 2001 7: 2091 [Abstract] [Full Text] [PDF]  

Preventive Effect of FK143, a 5-Reductase Inhibitor, on Chemical Hepatocarcinogenesis in Rats

Seiji Maruyama, Naofumi Nagasue, Dipok Kumar Dhar, Akira Yamanoi, Osama N. El-Assal, Kimihiko Satoh, and Kiwamu Okita
Clin Cancer Res 2001 7: 2096 [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity

Peter G. Smith, Huw D. Thomas, Hannah C. Barlow, Roger J. Griffin, Bernard T. Golding, A. Hilary Calvert, David R. Newell, and Nicola J. Curtin
Clin Cancer Res 2001 7: 2105 [Abstract] [Full Text] [PDF]  

The Impact of p53 Status on Cellular Sensitivity to Antifolate Drugs

Xiaohong Lu, Julie Errington, Nicola J. Curtin, John Lunec, and David R. Newell
Clin Cancer Res 2001 7: 2114 [Abstract] [Full Text] [PDF]  

In Vivo Antitumor Activity of Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) {METVAN [VO(SO₄)(Me₂-Phen)₂]}

Rama Krishna Narla, Chun-Lin Chen, Yanhong Dong, and Fatih M. Uckun
Clin Cancer Res 2001 7: 2124 [Abstract] [Full Text] [PDF]  

Cancer Biology:

Intracellular Association of a Mutant Insulin-like Growth Factor Receptor with Endogenous Receptors

Krzysztof Reiss, Xiao Tu, Gaetano Romano, Francesca Peruzzi, Jin Ying Wang, and Renato Baserga
Clin Cancer Res 2001 7: 2134 [Abstract] [Full Text] [PDF]  

High Expression of the Cap43 Gene in Infiltrating Macrophages of Human Renal Cell Carcinomas

Akihiro Nishie, Katsuaki Masuda, Michihiro Otsubo, Toshiro Migita, Masazumi Tsuneyoshi, Kimitoshi Kohno, Taro Shuin, Seiji Naito, Mayumi Ono, and Michihiko Kuwano
Clin Cancer Res 2001 7: 2145 [Abstract] [Full Text] [PDF]  

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