The Biology Behind:

Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.

Edward A. Sausville
Clin Cancer Res 2001 7: 2155 [Full Text] [PDF]  

Minireviews:

Cancer Genomics: Promises and Complexities

Wei Zhang, Pilar M. Labordé, Kevin R. Coombes, Donald A. Berry, and Stanley R. Hamilton
Clin Cancer Res 2001 7: 2159 [Abstract] [Full Text] [PDF]  

Cell Cycle-mediated Drug Resistance: An Emerging Concept in Cancer Therapy

Manish A. Shah and Gary K. Schwartz
Clin Cancer Res 2001 7: 2168 [Abstract] [Full Text] [PDF]  

Clinical Pharmacokinetics and Metabolism of Irinotecan (CPT-11)

Ron H. J. Mathijssen, Robbert J. van Alphen, Jaap Verweij, Walter J. Loos, Kees Nooter, Gerrit Stoter, and Alex Sparreboom
Clin Cancer Res 2001 7: 2182 [Abstract] [Full Text] [PDF]  

Current Clinical and Laboratory Strategies to Augment the Efficacy of Immunotherapy in Multiple Myeloma

Marcus Gorschlüter, Carsten Ziske, Axel Glasmacher, and Ingo G. H. Schmidt-Wolf
Clin Cancer Res 2001 7: 2195 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Influence of Cellular Factors and Pharmacokinetics on the Formation of Platinum-DNA Adducts in Leukocytes of Children Receiving Cisplatin Therapy

Gareth J. Veal, Cinara Dias, Lisa Price, Annie Parry, Julie Errington, Juliet Hale, Andrew D. J. Pearson, Alan V. Boddy, David R. Newell, and Michael J. Tilby
Clin Cancer Res 2001 7: 2205 [Abstract] [Full Text] [PDF]  

Identification of Differentially Expressed Genes in Esophageal Squamous Cell Carcinoma (ESCC) by cDNA Expression Array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B Genes in ESCC

Ying Chuan Hu, King Yin Lam, Simon Law, John Wong, and Gopesh Srivastava
Clin Cancer Res 2001 7: 2213 [Abstract] [Full Text] [PDF]  

p53 Mutation in Plasma DNA and Its Prognostic Value in Breast Cancer Patients

Zhi-Ming Shao, Jun Wu, Zhen-Zhou Shen, and Mai Nguyen
Clin Cancer Res 2001 7: 2222 [Abstract] [Full Text] [PDF]  

Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner : See The Biology Behind: E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., 7: 2155–2158, 2001.

Pamela N. Münster, Andrea Basso, David Solit, Larry Norton, and Neal Rosen
Clin Cancer Res 2001 7: 2228 [Abstract] [Full Text] [PDF]  

Pan-trk Inhibition Decreases Metastasis and Enhances Host Survival in Experimental Models as a Result of Its Selective Induction of Apoptosis of Prostate Cancer Cells

Ashani T. Weeraratna, Susan L. Dalrymple, John C. Lamb, Samuel R. Denmeade, Sheila Miknyoczki, Craig A. Dionne, and John T. Isaacs
Clin Cancer Res 2001 7: 2237 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Phase I Trial of Gemcitabine Combined with Radiation for the Treatment of Locally Advanced Pancreatic Adenocarcinoma

Robert A. Wolff, Douglas B. Evans, Diane M. Gravel, Renato Lenzi, Peter W. T. Pisters, Jeffrey E. Lee, Nora A. Janjan, Chusilp Charnsangavej, and James L. Abbruzzese
Clin Cancer Res 2001 7: 2246 [Abstract] [Full Text] [PDF]  

Dose-reduced Conditioning and Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors in 42 Patients

Martin Bornhäuser, Christian Thiede, Uwe Platzbecker, Andreas Jenke, Anett Helwig, Runa Plettig, Jens Freiberg-Richter, Christoph Röllig, Gabriele Geissler, Karin Lutterbeck, Uta Oelschlagel, and Gerhard Ehninger
Clin Cancer Res 2001 7: 2254 [Abstract] [Full Text] [PDF]  

Classic Kaposi’s Sarcoma Associated with Human Herpesvirus 8 Infection in a 13-Year-Old Male: A Case Report

Heather J. Landau, Bernard J. Poiesz, Samalima Dube, Jeffrey A. Bogart, Leonard B. Weiner, and Abdul-Kader Souid
Clin Cancer Res 2001 7: 2263 [Abstract] [Full Text] [PDF]  

Meningioma Treated with Interferon-, Evaluated with [¹¹C]-L-Methionine Positron Emission Tomography

Carin Muhr, Olafur Gudjonsson, Anders Lilja, Magdalena Hartman, Zhi-Jia Zhang, and Bengt Långström
Clin Cancer Res 2001 7: 2269 [Abstract] [Full Text] [PDF]  

Dendritic Cell Vaccination with MAGE Peptide Is A Novel Therapeutic Approach for Gastrointestinal Carcinomas

Noriaki Sadanaga, Hideki Nagashima, Kohjiro Mashino, Kouichirou Tahara, Hiroshi Yamaguchi, Mitsuhiko Ohta, Tatsuo Fujie, Fumiaki Tanaka, Hiroshi Inoue, Kazutou Takesako, Tsuyoshi Akiyoshi, and Masaki Mori
Clin Cancer Res 2001 7: 2277 [Abstract] [Full Text] [PDF]  

Phase II Study of Direct Intralesional Gene Transfer of Allovectin-7, an HLA-B7/ß2-Microglobulin DNA-Liposome Complex, in Patients with Metastatic Melanoma

Alison T. Stopeck, Amanda Jones, Evan M. Hersh, John A. Thompson, Deborah M. Finucane, John C. Gutheil, and Rene Gonzalez
Clin Cancer Res 2001 7: 2285 [Abstract] [Full Text] [PDF]  

A Phase I Dose Escalation and Bioavailability Study of Oral Sodium Phenylbutyrate in Patients with Refractory Solid Tumor Malignancies

Jill Gilbert, Sharyn D. Baker, M. Katherine Bowling, Louise Grochow, W. Douglas Figg, Yelena Zabelina, Ross C. Donehower, and Michael A. Carducci
Clin Cancer Res 2001 7: 2292 [Abstract] [Full Text] [PDF]  

Pharmacodynamic Model of Topotecan-induced Time Course of Neutropenia

William C. Zamboni, David Z. D’Argenio, Clinton F. Stewart, Tom MacVittie, Brian J. Delauter, Ann M. Farese, Douglas M. Potter, Nacole M. Kubat, David Tubergen, and Merrill J. Egorin
Clin Cancer Res 2001 7: 2301 [Abstract] [Full Text] [PDF]  

Temozolomide: The Effect of Once- and Twice-a-Day Dosing on Tumor Tissue Levels of the DNA Repair Protein O⁶-Alkylguanine-DNA-Alkyltransferase

Timothy P. Spiro, Lili Liu, Susan Majka, John Haaga, James K. V. Willson, and Stanton L. Gerson
Clin Cancer Res 2001 7: 2309 [Abstract] [Full Text] [PDF]  

Differential Degradation Rates of Inactivated Alkyltransferase in Blood Mononuclear Cells and Tumors of Patients after Treatment with O⁶-Benzylguanine

Lili Liu, Timothy P. Spiro, Xiusheng Qin, Susan Majka, John Haaga, Jane Schupp, James K. V. Willson, and Stanton L. Gerson
Clin Cancer Res 2001 7: 2318 [Abstract] [Full Text] [PDF]  

Cisplatin, Etoposide, and Paclitaxel with Granulocyte Colony-Stimulating Factor in Untreated Patients with Extensive-Stage Small Cell Lung Cancer: A Phase II Trial of the Southwest Oncology Group

Karen Kelly, Laura Lovato, Paul A. Bunn, Jr., Robert B. Livingston, Jeffrey Zangmeister, Sarah A. Taylor, Debasish Roychowdhury, John J. Crowley, and David R. Gandara
Clin Cancer Res 2001 7: 2325 [Abstract] [Full Text] [PDF]  

Impact of the Putative Differentiating Agent Sodium Phenylbutyrate on Myelodysplastic Syndromes and Acute Myeloid Leukemia

Steven D. Gore, Li-Jun Weng, Suoping Zhai, William D. Figg, Ross C. Donehower, George J. Dover, Michael Grever, Constance A. Griffin, Louise B. Grochow, Eric K. Rowinsky, Yelena Zabalena, Anita L. Hawkins, Kathleen Burks, and Carole B. Miller
Clin Cancer Res 2001 7: 2330 [Abstract] [Full Text] [PDF]  

Molecular Oncology:

Increased Incidence of Luteinizing Hormone-releasing Hormone Receptor Gene Messenger RNA Expression in Hormone-refractory Human Prostate Cancers

Bernd Straub, Markus Müller, Hans Krause, Mark Schrader, Carsten Goessl, Rüdiger Heicappell, and Kurt Miller
Clin Cancer Res 2001 7: 2340 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-1 Promoter Polymorphism 1G/2G Is Correlated with Colorectal Cancer Invasiveness

Giorgio Ghilardi, Maria Luisa Biondi, Jacopo Mangoni, Simona Leviti, Marco DeMonti, Emma Guagnellini, and Roberto Scorza
Clin Cancer Res 2001 7: 2344 [Abstract] [Full Text] [PDF]  

Proliferation, Apoptosis, and Survival in High-Level Microsatellite Instability Sporadic Colorectal Cancer

Julie M. Michael-Robinson, Lynne E. Reid, David M. Purdie, A-E. Biemer-Hüttmann, Michael D. Walsh, Nirmala Pandeya, Lisa A. Simms, Joanne P. Young, Barbara A. Leggett, Jeremy R. Jass, and Graham L. Radford-Smith
Clin Cancer Res 2001 7: 2347 [Abstract] [Full Text] [PDF]  

A Re-Evaluation of Carcinoembryonic Antigen (CEA) as a Serum Marker for Breast Cancer: A Prospective Longitudinal Study

Fiorella Guadagni, Patrizia Ferroni, Sandro Carlini, Sabrina Mariotti, Antonella Spila, Simona Aloe, Roberta D’Alessandro, Maria Daniela Carone, Americo Cicchetti, Andrea Ricciotti, Irene Venturo, Pasquale Perri, Franco Di Filippo, Francesco Cognetti, Claudio Botti, and Mario Roselli
Clin Cancer Res 2001 7: 2357 [Abstract] [Full Text] [PDF]  

Human Kallikrein 4 (KLK4) Is Highly Expressed in Serous Ovarian Carcinomas

Ying Dong, Aneel Kaushal, Loan Bui, Simon Chu, Peter J. Fuller, Jim Nicklin, Hemamali Samaratunga, and Judith A. Clements
Clin Cancer Res 2001 7: 2363 [Abstract] [Full Text] [PDF]  

Prognostic Value of Human Kallikrein 10 Expression in Epithelial Ovarian Carcinoma

Liu-Ying Luo, Dionyssios Katsaros, Andreas Scorilas, Stefano Fracchioli, Roberta Piccinno, Irene A. Rigault de la Longrais, David J. C. Howarth, and Eleftherios P. Diamandis
Clin Cancer Res 2001 7: 2372 [Abstract] [Full Text] [PDF]  

Higher Human Kallikrein Gene 4 (KLK4) Expression Indicates Poor Prognosis of Ovarian Cancer Patients

Christina V. Obiezu, Andreas Scorilas, Dionyssios Katsaros, Marco Massobrio, George M. Yousef, Stefano Fracchioli, Irene A. Rigault de la Longrais, Riccardo Arisio, and Eleftherios P. Diamandis
Clin Cancer Res 2001 7: 2380 [Abstract] [Full Text] [PDF]  

Prognostic and Pathologic Significance of Quantitative Protein Expression Profiling in Human Gliomas

Arnab Chakravarti, Meaghan A. Delaney, Elizabeth Noll, Peter McL. Black, Jay S. Loeffler, Alona Muzikansky, and Nicholas J. Dyson
Clin Cancer Res 2001 7: 2387 [Abstract] [Full Text] [PDF]  

Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer

Barbara Schmalfeldt, Dieter Prechtel, Kathrin Härting, Kerstin Späthe, Stefan Rutke, Elisabeth Konik, Rafael Fridman, Ursula Berger, Manfred Schmitt, Walther Kuhn, and Ernst Lengyel
Clin Cancer Res 2001 7: 2396 [Abstract] [Full Text] [PDF]  

Expression of the Endostatin Gene in Epithelial Ovarian Cancer

Kohkichi Hata, Ritsuto Fujiwaki, Kentaro Nakayama, and Kohji Miyazaki
Clin Cancer Res 2001 7: 2405 [Abstract] [Full Text] [PDF]  

Genetic Changes in Paired Atypical and Usual Ductal Hyperplasia of the Breast by Comparative Genomic Hybridization

Gyungyub Gong, Sandy DeVries, Karen L. Chew, Imok Cha, Britt-Marie Ljung, and Frederic M. Waldman
Clin Cancer Res 2001 7: 2410 [Abstract] [Full Text] [PDF]  

Gelsolin as a Negative Prognostic Factor and Effector of Motility in erbB-2-positive Epidermal Growth Factor Receptor-positive Breast Cancers

Ann D. Thor, Susan M. Edgerton, Shuqing Liu, Dan H. Moore, II, and David J. Kwiatkowski
Clin Cancer Res 2001 7: 2415 [Abstract] [Full Text] [PDF]  

MYC Messenger RNA Expression Predicts Survival Outcome in Childhood Primitive Neuroectodermal Tumor/Medulloblastoma

Michael A. Grotzer, Michael D. Hogarty, Anna J. Janss, Xueyuan Liu, Huaquing Zhao, Angelika Eggert, Leslie N. Sutton, Lucy B. Rorke, Garrett M. Brodeur, and Peter C. Phillips
Clin Cancer Res 2001 7: 2425 [Abstract] [Full Text] [PDF]  

Biological Behavior of Human Breast Cancer Micrometastases

Nancy Klauber-DeMore, Kimberly J. Van Zee, Irina Linkov, Patrick I. Borgen, and William L. Gerald
Clin Cancer Res 2001 7: 2434 [Abstract] [Full Text] [PDF]  

Her-2/neu Overexpression in Muscle-invasive Urothelial Carcinoma of the Bladder: Prognostic Significance and Comparative Analysis in Primary and Metastatic Tumors

Rafael E. Jimenez, Maha Hussain, Fernando J. Bianco, Jr., Ulka Vaishampayan, Pam Tabazcka, Wael A. Sakr, J. Edson Pontes, David P. Wood, Jr., and David J. Grignon
Clin Cancer Res 2001 7: 2440 [Abstract] [Full Text] [PDF]  

HER-2/neu and Urokinase-Type Plasminogen Activator and Its Inhibitor in Breast Cancer

Gottfried Konecny, Michael Untch, Jane Arboleda, Cindy Wilson, Stephen Kahlert, Berit Boettcher, Margrit Felber, Malgorzota Beryt, Sandra Lude, Hermann Hepp, Dennis Slamon, and Mark Pegram
Clin Cancer Res 2001 7: 2448 [Abstract] [Full Text] [PDF]  

Clinical Significance of Cyclin B1 Protein Expression in Squamous Cell Carcinoma of the Tongue

Khaled A. Hassan, Adel K. El-Naggar, Jean-Charles Soria, Dian Liu, Waun K. Hong, and Li Mao
Clin Cancer Res 2001 7: 2458 [Abstract] [Full Text] [PDF]  

Fluorescence in Situ Hybridization Evaluation of c-erbB-2 Gene Amplification and Chromosomal Anomalies in Bladder Cancer

Jun-ichi Ohta, Yasuhide Miyoshi, Hiroji Uemura, Kiyoshi Fujinami, Kunihisa Mikata, Masahiko Hosaka, Yoko Tokita, and Yoshinobu Kubota
Clin Cancer Res 2001 7: 2463 [Abstract] [Full Text] [PDF]  

Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients

Carlos G. Ferreira, Paul van der Valk, Simone W. Span, Inge Ludwig, Egbert F. Smit, Frank A. E. Kruyt, Herbert M. Pinedo, Harm van Tinteren, and Giuseppe Giaccone
Clin Cancer Res 2001 7: 2468 [Abstract] [Full Text] [PDF]  

AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon

Michael J. Zinda, Mac A. Johnson, Jonathan D. Paul, Candice Horn, Bruce W. Konicek, Zhao Hai Lu, George Sandusky, James E. Thomas, Blake Lee Neubauer, Mei T. Lai, and Jeremy R. Graff
Clin Cancer Res 2001 7: 2475 [Abstract] [Full Text] [PDF]  

Death-associated Protein 3 (Dap-3) Is Overexpressed in Invasive Glioblastoma Cells in Vivo and in Glioma Cell Lines with Induced Motility Phenotype in Vitro

Luigi Mariani, Christian Beaudry, Wendy S. McDonough, Dominique B. Hoelzinger, Elzbieta Kaczmarek, Francisco Ponce, Stephen W. Coons, Alf Giese, Rolf W. Seiler, and Michael E. Berens
Clin Cancer Res 2001 7: 2480 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Synergistic Effects of the Fenretinide (4-HPR) and Anti-CD20 Monoclonal Antibodies on Apoptosis Induction of Malignant Human B Cells

Daming Shan, Ajay K. Gopal, and Oliver W. Press
Clin Cancer Res 2001 7: 2490 [Abstract] [Full Text] [PDF]  

Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications

Enrique Casado, Jesus Gomez-Navarro, Masato Yamamoto, Yasuo Adachi, Candace J. Coolidge, Waleed O. Arafat, Shannon D. Barker, Minghui H. Wang, Parameshwar J. Mahasreshti, Akseli Hemminki, Manuel Gonzalez-Baron, Mack N. Barnes, Terri B. Pustilnik, Gene P. Siegal, Ronald D. Alvarez, and David T. Curiel
Clin Cancer Res 2001 7: 2496 [Abstract] [Full Text] [PDF]  

Analysis of Cross-Resistance of the Selective Estrogen Receptor Modulators Arzoxifene (LY353381) and LY117018 in Tamoxifen-stimulated Breast Cancer Xenografts

Jennifer MacGregor Schafer, Eun-Sook Lee, Rita C. Dardes, David Bentrem, Ruth M. O’Regan, Alexander De Los Reyes, and V. Craig Jordan
Clin Cancer Res 2001 7: 2505 [Abstract] [Full Text] [PDF]  

Selective Activation of Apoptosis Program by S-p-bromobenzylglutathione Cyclopentyl Diester in Glyoxalase I-overexpressing Human Lung Cancer Cells

Hiroshi Sakamoto, Tetsuo Mashima, Shigeo Sato, Yuichi Hashimoto, Takao Yamori, and Takashi Tsuruo
Clin Cancer Res 2001 7: 2513 [Abstract] [Full Text] [PDF]  

Stable Transfection of Urokinase-Type Plasminogen Activator Antisense Construct Modulates Invasion of Human Glioblastoma Cells

Sanjeeva Mohanam, Sushma L. Jasti, Sudha R. Kondraganti, Nirmala Chandrasekar, Yoshiaki Kin, Gregory N. Fuller, Sajani S. Lakka, Athanassios P. Kyritsis, Dzung H. Dinh, William C. Olivero, Meena Gujrati, W. K. A. Yung, and Jasti S. Rao
Clin Cancer Res 2001 7: 2519 [Abstract] [Full Text] [PDF]  

Flavopiridol Increases Sensitization to Gemcitabine in Human Gastrointestinal Cancer Cell Lines and Correlates with Down-Regulation of Ribonucleotide Reductase M2 Subunit

Christoph P. Jung, Monica V. Motwani, and Gary K. Schwartz
Clin Cancer Res 2001 7: 2527 [Abstract] [Full Text] [PDF]  

Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberto Bianco, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, and Fortunato Ciardiello
Clin Cancer Res 2001 7: 2537 [Abstract] [Full Text] [PDF]  

Inhibition of Insulin-like Growth Factor Signaling Pathways in Mammary Gland by Pure Antiestrogen ICI 182,780

T. W. Chan, M. Pollak, and Hung Huynh
Clin Cancer Res 2001 7: 2545 [Abstract] [Full Text] [PDF]  

A Hammerhead Ribozyme Suppresses Expression of Hepatocyte Growth Factor/Scatter Factor Receptor c-MET and Reduces Migration and Invasiveness of Breast Cancer Cells

Wen G. Jiang, David Grimshaw, Jane Lane, Tracey A. Martin, Roger Abounder, John Laterra, and Robert E. Mansel
Clin Cancer Res 2001 7: 2555 [Abstract] [Full Text] [PDF]  

Optimization for the Blockade of Epidermal Growth Factor Receptor Signaling for Therapy of Human Pancreatic Carcinoma

Carmen C. Solorzano, Cheryl H. Baker, Rachel Tsan, Peter Traxler, Pamela Cohen, Elisabeth Buchdunger, Jerry J. Killion, and Isaiah J. Fidler
Clin Cancer Res 2001 7: 2563 [Abstract] [Full Text] [PDF]  

Marked Antitumor Activity of a New Potent Acronycine Derivative in Orthotopic Models of Human Solid Tumors

Nicolas Guilbaud, Laurence Kraus-Berthier, Florence Meyer-Losic, Virginie Malivet, Christine Chacun, Michel Jan, François Tillequin, Sylvie Michel, Michel Koch, Bruno Pfeiffer, Ghanem Atassi, John Hickman, and Alain Pierré
Clin Cancer Res 2001 7: 2573 [Abstract] [Full Text] [PDF]  

Radiosensitization by Gemcitabine in p53 Wild-Type and Mutant MCF-7 Breast Carcinoma Cell Lines

Blaine W. Robinson and Donna S. Shewach
Clin Cancer Res 2001 7: 2581 [Abstract] [Full Text] [PDF]  

The Novel Tubulin-binding Drug BTO-956 Inhibits R3230Ac Mammary Carcinoma Growth and Angiogenesis in Fischer 344 Rats

Siqing Shan, A. Craig Lockhart, Wilfred Y. Saito, A. Merrill Knapp, Keith R. Laderoute, and Mark W. Dewhirst
Clin Cancer Res 2001 7: 2590 [Abstract] [Full Text] [PDF]  

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